AimWhite matter changes in individuals at ultra-high risk for psychosis (UHR) may be involved in the transition to psychosis. Sleep-wake disturbances commonly precede the first psychotic episode and predict development of psychosis. We examined associations between white matter microstructure and sleep-wake disturbances in UHR individuals compared to healthy controls (HC), as well as explored the confounding effect of medication, substance use, and level of psychopathology.MethodsSixty-four UHR individuals and 35 HC underwent clinical interviews and diffusion weighted imaging. Group differences on global (...) and callosal mean fractional anisotropy (FA) was tested using general linear modeling. Sleep-wake disturbances were evaluated using the subjective measures disturbed sleep index (DSI) and disturbed awakening index (AWI) from the Karolinska Sleep Questionnaire, supported by objective sleep measures from one-night actigraphy. The primary analyses comprised partial correlation analyses between global FA/callosal FA and sleep-wake measures. Secondary analyses investigated multivariate patterns of covariance between measures of sleep-wake disturbances and FA in 48 white matter regions of interest using partial least square correlations.ResultsUltra-high risk for psychosis individuals displayed lower global FA (F = 14.56, p < 0.001) and lower callosal FA (F = 11.34, p = 0.001) compared to HC. Subjective sleep-wake disturbances were significantly higher among the UHR individuals (DSI: F = 27.59, p < 0.001, AWI: F = 36.42, p < 0.001). Lower callosal FA was correlated with increased wake after sleep onset (r = −0.34, p = 0.011) and increased sleep fragmentation index (r = −0.31, p = 0.019) in UHR individuals. Multivariate analyses identified a pattern of covariance in regional FA which were associated with DSI and AWI in UHR individuals (p = 0.028), but not in HC. Substance use, sleep medication and antipsychotic medication did not significantly confound these associations. The association with objective sleep-wake measures was sustained when controlling for level of depressive and UHR symptoms, but symptom level confounded the covariation between FA and subjective sleep-wake measures in the multivariate analyses.ConclusionCompromised callosal microstructure in UHR individuals was related to objectively observed disruptions in sleep-wake functioning. Lower FA in ventrally located regions was associated with subjectively measured sleep-wake disturbances and was partly explained by psychopathology. These findings call for further investigation of sleep disturbances as a potential treatment target. (shrink)

In this survey we have investigated the experiences and attitudes of Danish physicians regarding end-of-life decisions. Most respondents have made decisions that involve hastening the death of a patient, and almost all find it acceptable to do so. Such decisions are made more often, and considered ethically more acceptable, with the informed consent of the patient than without. But both non-resuscitation decisions, and decisions to provide pain relief in doses that will shorten the patient's life, have been made and found (...) acceptable by at least 50% of the respondents, even when there is no informed consent. Furthermore, 12% have doubled morphine dosages with fixed intervals, thus providing doses substantially higher than that necessary to control pain, without the informed consent of the patient. Two per cent have helped in assisted suicide, and 5% have administered a lethal injection at the patient's request. Respectively 37% and 34% find these last two practices ethically acceptable. Amongst those that do not find them acceptable, the most important reasons to be opposed are, the doctrine of double effect, the doctrine of doing and allowing, and the view that human life is sacred. Amongst supporters, the most important reasons mentioned are, that the patient's right to self-determination should be respected, the view that a patient should not be forced to suffer, and the view that the patient has a right to be helped to a dignified death. (shrink)

ABSTRACT In this survey we have investigated the experiences and attitudes of Danish physicians regarding end‐of life decisions. Most respondents have made decisions that involve hastening the death of a patient, and almost all find it acceptable to do so. Such decisions are made more often, and considered ethically more acceptable, with the informed consent of the patient than without. But both non‐resuscitation decisions, and decisions to provide pain relief in doses that will shorten the patient's life, have been made (...) and found acceptable by at least 50% of the respondents, even when there is no informed consent. Furthermore, 12% have doubled morphine dosages with fixed intervals, thus providing doses substantially higher than that necessary to control pain, without the informed consent of the patient. Two per cent have helped in assisted suicide, and 5% have administered a lethal injection at the patient's request. Respectively 37% and 34% find these last two practices ethically acceptable. Amongst those that do not find them acceptable, the most important reasons to be opposed are, the doctrine of double effect, the doctrine of doing and allowing, and the view that human life is sacred. Amongst supporters, the most important reasons mentioned are, that the patient's right to self‐determination should be respected, the view that a patient should not be forced to suffer, and the view that the patient has a right to be helped to a dignified death. (shrink)

Artificial intelligence is increasingly permeating many types of high-stake societal decision-making such as the work at the criminal courts. Various types of algorithmic tools have already been introduced into sentencing. This article concerns the use of algorithms designed to deliver sentence recommendations. More precisely, it is considered how one should determine whether one type of sentencing algorithm (e.g., a model based on machine learning) would be ethically preferable to another type of sentencing algorithm (e.g., a model based on old-fashioned programming). (...) Whether the implementation of sentencing algorithms is ethically desirable obviously depends upon various questions. For instance, some of the traditional issues that have received considerable attention are algorithmic biases and lack of transparency. However, the purpose of this article is to direct attention to a further challenge that has not yet been considered in the discussion of sentencing algorithms. That is, even if is assumed that the traditional challenges concerning biases, transparency, and cost-efficiency have all been solved or proven insubstantial, there will be a further serious challenge associated with the comparison of sentencing algorithms; namely, that we do not yet possess an ethically plausible and applicable criterion for assessing how well sentencing algorithms are performing. (shrink)

Should public opinion determine--or even influence--sentencing policy and practice? Should the punishment of criminal offenders reflect what the public regards as appropriate? These deceptively simple questions conceal complex theoretical and methodological challenges to the administration of punishment. In the West, politicians have often answered these questions in the affirmative; penal reforms have been justified with direct reference to the attitudes of the public. This is why the contention that politicians should bridge the gap between the public and criminal justice practice (...) has widespread resonance. Criminal law scholars, for their part, have often been more reluctant to accept public input in penal practice, and some have even held that the idea of consulting public opinion constitutes a populist approach to punishment. The purpose of this book is to examine the moral significance of public opinion for penal theory and practice. For the first time in a single volume the editors, Jesper Ryberg and Julian V. Roberts, have assembled a number of respected criminologists, philosophers, and legal theorists to address the various aspects of why and how public opinion should be reflected in the way the criminal justice system deals with criminals. The chapters address the myriad complexities surrounding this issue by first weighing the justifications for incorporating public views into punishment practices and then considering the various ways this might be achieved through juries, prosecutors, restorative justice programs, and other means. (shrink)

Journal Name: Semiotica - Journal of the International Association for Semiotic Studies / Revue de l'Association Internationale de Sémiotique Volume: 2014 Issue: 198 Pages: 11-31.

Epistemic anti-individualism is the view that positive epistemic statuses fail to supervene on internal, physical or mental, properties of individuals. Intellectual humility is a central intellectual virtue in the pursuit of such statuses. After some introductory remarks, this paper provides an argument for epistemic anti-individualism with respect to a virtue-theoretic account of testimonial knowledge. An outline of a dual-aspect account of intellectual humility is then offered. The paper proceeds to argue that insofar as testimonial knowledge is concerned, this stripe of (...) epistemic anti-individualism leads to a particular account of intellectual humility. (shrink)

At the end of the 19th century Oliver Heaviside developed a formal calculus of differential operators in order to solve various physical problems. The pure mathematicians of his time would not deal with this unrigorous theory, but in the 20th century several attempts were made to rigorise Heaviside's operational calculus. These attempts can be grouped in two classes. The one leading to an explanation of the operational calculus in terms of integral transformations (Bromwich, Carson, Vander Pol, Doetsch) and the other (...) leading to an abstract algebraic formulation (Lévy, Mikusiński). Also Schwartz's creation of the theory of distributions was very much inspired by problems in the operational calculus. (shrink)

The notion of authenticity, i.e., being “genuine,” “real,” or “true to oneself,” is sometimes held as critical to a person’s autonomy, so that inauthenticity prevents the person from making autonomous decisions or leading an autonomous life. It has been pointed out that authenticity is difficult to observe in others. Therefore, judgments of inauthenticity have been found inadequate to underpin paternalistic interventions, among other things. This article delineates what justifies judgments of inauthenticity. It is argued that for persons who wish to (...) live according to the prevailing social and moral standards and desires that are seriously undesirable according to those standards, it is justified to judge that a desire is inauthentic to the extent that it is due to causal factors that are alien to the person and to the extent that it deviates from the person’s practical identity. The article contributes to a tradition of thinking about authenticity which is known mainly from Frankfurt and Dworkin, and bridges the gap between theoretical ideals of authenticity and real authenticity-related problems in practical biomedical settings. (shrink)

The threshold from unicellularity to multicellularity has been crossed only in three major living domains in evolution with any lasting success. The hard problem was to create a multicellular self. Such a self is vulnerable to breakdown due to the unavoidable appearance of mutant anarchistic cells, and stringent semiotic scaffoldings had to emerge to prevent this. While a unicellular self may go on to live practically forever, the multicellular self most often must run through an individuation process ending in the (...) death of the individual. Due to basic differences in cells of plants, fungi and animals this individuation process poses very different challenges in the three kingdoms of plants, fungi and animals, and the solutions found to these differences are discussed. In the same time as multicellularity ushered life into the epoch of mortality it logically also led to the appearance of fertilization and thereby the need for a whole new set of elaborate semiotic scaffoldings. Multicellularity also opened the door to the formation symbiotic relations where cells with different genomes might collaborate or at least coexist inside the same body. All in all multicellularity led to an enormous diversification both of morphology space and the space of sensomotoric elaborations. New means for scaffolding of this expansion and diversification of possible life forms into functional patterns called for a corresponding growth in the space of semiotic tools and initiated a growth in semiotic freedom, that has continued to our days. (shrink)

In strict opposition to the prevailing positivist conception of nature as senseless and deprived of meaning Jakob von Uexküll claimed that a certain planmässigkeit was operative in nature. This idea however might be taken to mean that organic evolution is not itself a creative process but a gradual, if majestic, unfolding of Nature's own master plan. Such an idea would threaten to restore determinism in the center of biological theory, and this would seriously contradict the vision of biosemiotics shared by (...) most of its proponents. It lies at the heart of biosemiotics and of Peircean cosmological philosophy that indeterminacy is primary, that “habit taking” or interpretation are real processes in the world, and therefore that belief in the law of necessity is unfounded. It is suggested that Uexküllian planmässigkeit is in fact reconcilable with a modern non-deterministic understanding. In a certain sense the Umwelten of animals have indeed developed in accordance to a natural planmässigkeit, but this is a plan that incessantly traps life in certain strategic choices and in the same time diversifies the dimensionality of options for dealing with these choices, i. e. “the adjacent possible” in the terms of Stuart Kauffman. (shrink)

In the past few years, we have become increasingly focused on technology use that is impulsive, unthinking, and distractive. There has been a strong push to understand such technology use in terms of dopamine addiction. The present article demonstrates the limitations of this so-called neurobehaviorist approach: Not only is it inconsistent in regard to how it understands humans, technologies, and their mutual relationship, it also pathologizes everyday human behaviors. The article proceeds to discuss dual-systems theory, which helpfully discusses impulsive technology (...) use in terms of habit instead of addiction, but can be criticized for its mentalist celebration of conscious control. Finally, the article introduces a phenomenological approach whose conceptualization of habit manifests many of the experiential qualities that we try to capture with addiction, but remains non-pathologizing and opens a space for learning: While tech addiction is bad and must be eliminated, good tech habits can be trained and cultivated. (shrink)

The use of artificial intelligence as an instrument to assist judges in determining sentences in criminal cases is an issue that gives rise to many theoretical challenges. The purpose of this article is to examine one of these challenges known as the “input problem.” This problem arises supposedly due to two reasons: that in order for an algorithm to be able to provide a sentence recommendation, it needs to be inputted with case specific information; and that the task of presenting (...) an adequate picture of a crime often turns out to be highly complex. Even though this problem has been noted since the earliest attempts at developing sentencing support systems, almost no one has considered the ethical nature of this challenge. The aim of this article is to fill that void. First, it is shown that the input problem has been subject to somewhat different interpretations. Second, several possible answers as to when and why the problem constitutes an ethical challenge are considered. Third, a few suggestions are presented as to how undesirable implications of complexity at the input stage might be ameliorated by tailoring the way sentencing algorithms are developed and used in the work of criminal courts. (shrink)

This book gives an analysis of Hertz's posthumously published Principles of Mechanics in its philosophical, physical and mathematical context. In a period of heated debates about the true foundation of physical sciences, Hertz's book was conceived and highly regarded as an original and rigorous foundation for a mechanistic research program. Insisting that a law-like account of nature would require hypothetical unobservables, Hertz viewed physical theories as images of the world rather than the true design behind the phenomena. This paved the (...) way for the modern conception of a model. Rejecting the concept of force as a coherent basic notion of physics he built his mechanics on hidden masses and rigid connections, and formulated it as a new differential geometric language.Recently many philosophers have studied Hertz's image theory and historians of physics have discussed his forceless mechanics. The present book shows how these aspects, as well as the hitherto overlooked mathematical aspects, form an integrated whole which is closely connected to the mechanistic world view of the time and which is a natural continuation of Hertz's earlier research on electromagnetism. Therefore it is also a case study of the strong interactions between philosophy, physics and mathematics. Moreover, the book presents an analysis of the genesis of many of the central elements of Hertz's mechanics based on his manuscripts and drafts. Hertz's research program was cut short by the advent of relativity theory but its image theory influenced many philosophers as well as some physicists and mathematicians and its geometric form had a lasting influence on advanced expositions of mechanics. (shrink)

. Towards a university of Halbbildung: How the neoliberal mode of higher education governance in Europe is half-educating students for a misleading future. Educational Philosophy and Theory: Vol. 50, Special Issue of Submissions from European Liberal Education Student Conference, pp. 1020-1030.

This book offers a truly interdisciplinary exploration of our patterns of engagement with politics, news, and information in current high-choice information environments. Putting forth the notion that high-choice information environments may contribute to increasing misperceptions and knowledge resistance rather than greater public knowledge, the book offers insights into the processes that influence the supply of misinformation and factors influencing how and why people expose themselves to and process information that may support or contradict their beliefs and attitudes. A team of (...) authors from across a range of disciplines address the phenomena of knowledge resistance and its causes and consequences at the macro- as well as the micro-level. The chapters take a philosophical look at the notion of knowledge resistance, before moving on to discuss issues such as misinformation and fake news, psychological mechanisms such as motivated reasoning in processes of selective exposure and attention, how people respond to evidence and fact-checking, the role of political partisanship, political polarization over factual beliefs, and how knowledge resistance might be counteracted. This book will have a broad appeal to scholars and students interested in knowledge resistance, primarily within philosophy, psychology, media and communication, and political science, as well as journalists and policymakers. The Open Access version of this book, available at www.taylorfrancis.com, has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license. (shrink)

Machery et al. claim that analytic philosophers of language are committed to a method of cases according to which theories of reference are assessed by consulting semantic intuitions about actual and possible cases. Since empirical evidence suggests that such intuitions vary both within and across cultures, these experimental semanticists conclude that the traditional attempt at pursuing such theories is misguided. Against the backdrop of Kripke’s anti-descriptivist arguments, this paper offers a novel response to the challenge posed by Machery et al., (...) arguing that they either misplace or exaggerate the role played by. The lesson is that while semantic intuitions carry evidential weight in evaluating certain subjunctive conditionals reflecting counterfactual possibilities, they neither play an epistemic role in determining the actual reference of proper names, nor in evaluating certain indicative conditionals reflecting so-called counteractual possibilities. Moreover, once an asymmetry is acknowledged in Machery et al’s vignette between the narrator and the subject’s suppositions about the actual world, a corresponding ambiguity can account for the alleged culturally determined variation in semantic intuitions. (shrink)

Semantic externalism is the view that the meanings of referring terms, and the contents of beliefs that are expressed by those terms, are not fully determined by factors internal to the speaker but are instead bound up with the environment. The debate about semantic externalism is one of the most important but difficult topics in philosophy of mind and language, and has consequences for our understanding of the role of social institutions and the physical environment in constituting language and the (...) mind. In this long-needed book, Jesper Kallestrup provides an invaluable map of the problem. Beginning with a thorough introduction to the theories of descriptivism and referentialism and the work of Frege and Kripke, Kallestrup moves on to analyse Putnam’s Twin Earth argument, Burge’s arthritis argument and Davidson’s Swampman argument. He also discusses how semantic externalism is at the heart of important topics such as indexical thoughts, epistemological skepticism, self-knowledge, and mental causation. Including chapter summaries, a glossary of terms, and an annotated guide to further reading, _Semantic Externalism_ an ideal guide for students studying philosophy of language and philosophy of mind. (shrink)

In recent years, we have witnessed the rise of a contemporary approach to cognitive psychology known as 4E cognition. According to this ‘extracranial’ view of cognition, the mind is not ensconced in the head, but dynamically intertwined with a host of different entities, social as well as technological. The purpose of the present article is to raise a concern about 4E cognition. The concern is not about whether the mind is in fact extended, but about how this condition is currently (...) portrayed in the 4E literature. It is argued that 4E scholars tend to paint an overly idealized picture of human–technology relations in which all entities are presumed to cooperate and collaborate. The article first describes the basic tenets of extended cognition and distributed cognition, two of the most thingly approaches in this new wave of cognitive psychology. It then proceeds to discuss the twin notions of cognition and representation and argues that it may be time to leave these concepts behind. Finally, it sketches out the so-called ‘dogma of harmony’ in the 4E literature and argues for the importance of making analytical room for conflictual human–technology relations. Two examples of such conflictual relations are provided: bad habits and deskilling. (shrink)

According to Sosa, knowledge is apt belief, where a belief is apt when accurate because adroit. Sosa :465–475, 2010; Judgment and agency, Oxford University Press, Oxford, 2015) adds to his triple-A analysis of knowledge, a triple-S analysis of competence, where a complete competence combines its seat, shape and situation. Much of Sosa’s influential work assumes that epistemic agents are individuals who acquire knowledge when they hit the truth through exercising their own individual skills in appropriate shapes and situations. This paper (...) explores an extension of Sosa’s framework to a social setting in which groups constitute epistemic agents over and above their individual members. The claim is that groups can be ascribed knowledge in virtue of hitting the truth through exercising their competences in appropriate shapes and situations. While knowledge at the collective level may diverge from knowledge at the individual level, the competences of groups are nothing over and above the combined competences of their members. The ensuing view thus has implications for the debate over reduction and supervenience in collective epistemology. (shrink)

Since the 1980s the concept of ANT has remained unsettled. ANT has continuously been critiqued and hailed, ridiculed and praised. It is still an open question whether ANT should be considered a theory or a method or whether ANT is better understood as entailing the dissolution of such modern ‘‘genres’’. In this paper the authors engage with some important reflections by John Law and Bruno Latour in order to analyze what it means to ‘‘do ANT,’’ and, doing so after ‘‘doing (...) ANT on ANT.’’ In particular the authors examine two post-ANT case studies by Annemarie Mol and Marilyn Strathern and outline the notions of complexity, multiplicity, and fractality. The purpose is to illustrate the analytical consequences of thinking with post-ANT. The analysis offers insights into how it is possible to ‘‘go beyond ANT,’’ without leaving it entirely behind. (shrink)

The idea of using artificial intelligence as a support system in the sentencing process has attracted increasing attention. For instance, it has been suggested that machine learning algorithms may help in curbing problems concerning inter-judge sentencing disparity. The purpose of the present article is to examine the merits of this possibility. It is argued that, insofar as the unfairness of sentencing disparity is held to reflect a retributivist view of proportionality, it is not necessarily the case that increasing inter-judge uniformity (...) in sentencing is desirable. More generally, it is shown that the idea of introducing machine learning algorithms, that produce sentencing predictions on the ground of a dataset that is built of previous sentencing decisions, faces serious problems if there exists a discrepancy between actual sentencing practice and the sentences that are ideally desirable. (shrink)

Jesper Kallestrup argues that groups can have knowledge that their members may not.

Introduction: Semiotic ScaffoldingA central idea in biosemiotic writings has been the idea of growth in semiotic freedom as a persistent trend in evolution . By semiotic freedom we mean the capacity of species or organisms to derive useful information by help of semiosis or, in other words, by processes of interpretation in the widest sense of this term. While even bacteria have a certain very limited ability to interpret cues in the medium this ability obviously becomes more developed in more (...) complex organisms, and is typically most developed in big-brained animals that are late arrivals at the evolutionary scene. The evolution of a richer semiotic capacity is of course only one among many strategies available in the evolutionary game. Yet, this particular strategy potentially ignites a self-perpetuating evolutionary dynamics, since each step taken by a species along this route potentially opens new agendas for further change:the more capable some species ar .. (shrink)

Are virtual objects real? I will claim that the question sets us up for the wrong type of conclusion: Chalmers (2017) argues that a virtual calculator (like other entities) is a real calculator when it is “organizationally invariant” with its non-virtual counterpart—when it performs calculation. However, virtual reality and games are defined by the fact that they always selectively implement their source material. Even the most detailed virtual car will still have an infinite range of details which are missing (gas, (...) engines, pistons, fuel, chemical reactions, molecules, atoms). This means that even the most detailed virtual object will still have fictional aspects. Rather than argue that virtual objects are, or aren’t, real, it is preferable to think of overlaps and continuities between the fictional and the real, where even the most painstakingly detailed virtual reality implementation of a non-virtual object is still art: a human process of selection and interpretation. Virtual reality should therefore not be philosophically understood just as a technological implementation on a trajectory to perfection, but as a cultural artifact which derives its value in part from its simplification and difference from its source material. (shrink)

This paper offers a new solution to the knowledge argument. Both a priori and a posteriori physicalists reject the claim that Mary does not know all the facts, but they do so for different reasons. While the former think that Mary gains no new knowledge of any fact, the latter think that Mary gains new knowledge of an old fact. This paper argues that on a broad understanding of what counts as physical, it is consistent with physicalism that Mary does (...) not know all the physical facts, and that on a narrow understanding, it is consistent with physicalism that Mary knows all the physical facts, but not all the facts. Either way, Mary gains new knowledge of a new fact that is not non-physical. The resultant view. (shrink)

This special issue of The Journal of Ethics is devoted to ethical considerations of the use of neuroscience in the criminal justice system. In this introduction, an overview is provided of the different topics dealt with in the volume.

A sign is something that refers to something else. Signs, whether of natural or cultural origin, act by provoking a receptive system, human or nonhuman, to form an interpretant (a movement or a brain activity) that somehow relates the system to this "something else." Semiotics sees meaning as connected to the formation of interpretants. In a biosemiotic understanding living systems are basically engaged in semiotic interactions, that is, interpretative processes, and organic evolution exhibits an inherent tendency toward an increase in (...) semiotic freedom. Mammals generally are equipped with more semiotic freedom than are their reptilian ancestor species, and fishes are more semiotically sophisticated than are invertebrates. The evolutionary trend toward the production of life forms with an increasing interpretative capacity or semiotic freedom implies that the production of meaning has become an essential survival parameter in later stages of evolution. (shrink)

A version of Birkhoff's theorem is proved by constructive, predicative, methods. The version we prove has two conditions more than the classical one. First, the class considered is assumed to contain a generic family, which is defined to be a set-indexed family of algebras such that if an identity is valid in every algebra of this family, it is valid in every algebra of the class. Secondly, the class is assumed to be closed under inductive limits.

Being the parent of a disabled child is not easy, it is experienced as a situation marked by stress, crises and grief. As Vygotsky described eighty years ago, the development of children with disabilities and the culture do not fit as they do for non-disabled children. The development of a child with disabilities is not determined by the child’s physical defect alone, but constituted by the incongruence between the physical defect and the culture. In this study, the lives of four (...) families with deafblind children were followed for two years. Interviews and observations were conducted in different settings. This study finds that because of the incongruence between the physical defect and the culture, it is difficult to reach and maintain the zone of proximal development for a child with disabilities. This study illustrates how the network of professionals and parents around the child can make a local congruence that creates a platform for the child’s development. (shrink)