This article explores histories of the science of stress and its measurement from the mid 19th century, and brings these into dialogue with critical sociological analysis of emerging responses to work stress in policy and practice. In particular, it shows how the contemporary development of biomedical and consumer devices for stress self-monitoring is based on selectively rediscovering the biological determinants and biomarkers of stress, human functioning in terms of evolutionary ecology, and the physical health impacts of stress. It considers how (...) the placement of the individual body and its environment within particular spatio-temporal configurations renders it subject to experimental investigation through standardized apparatus, electricity, and statistical normalization. Examining key themes and processes such as homeostasis, metricization, datafication, and emotional governance, we conclude that the figure of the ‘body electric’ plays a central limiting role in current technology-supported approaches to managing work stress, and that an historical account can usefully open these to collective scrutiny. (shrink)

Making sense of Kant’s claim that it is morally necessary for us to believe in the immortal soul is a historically fraught issue. Commentators typically reject it, or take one of two paths: they either restrict belief in the immortal soul to our subjective psychology, draining it of any substantive rational grounding; or make it out to be a rational necessity that morally interested beings must accept on pain of contradiction. Against these interpreters, I argue that on Kant’s view, belief (...) in our immortality is necessary because it further determines and enriches the cognitive content contained in the concept of the highest good. Through this sharpened conceptual content, we acquire the resources to withstand theoretical skepticism about our moral vocation. (shrink)

According to evolutionary accounts of distinct emotions, these emotions are shaped by natural selection to adjust the physiological, psychological, cognitive, and behavioral parameters of an organism to facilitate its capacity to respond adaptively to threats and opportunities present in the environment. This account has a number of implications, most notably: (a) each distinct emotion serves, or served, an adaptive function, and (b) emotions are comprised of multiple components, all of which should be functional. In this article, I briefly outline an (...) evolutionary approach to understanding distinct emotions, then explain how this approach could be falsified, how one’s own emotion experience differs from the observation of an emotion experience in someone else, and why variability in emotional responding should be expected. (shrink)

Events—the experiences we think we are having and recall having had—are constructed; they are not what actually occurs. What occurs is ongoing dynamic, multidimensional, sensory flow, which is somehow transformed via psychological processes into structured, describable, memorable units of experience. But what is the nature of the redescription processes that fluently render dynamic sensory streams as event representations? How do such processes cope with the ubiquitous novelty and variability that characterize sensory experience? How are event‐rendering skills acquired and how do (...) event representations change with development? This review considers emerging answers to these questions, beginning with evidence that an implicit tendency to monitor predictability structure via statistical learning is key to event rendering. That is, one way that the experience of bounded events (e.g., actions within behavior, words within speech) arises is with the detection of “troughs” in sensory predictability. Interestingly, such troughs in predictability are often predictable; these regions of predictable‐unpredictability provide articulation points to demarcate one event from another in representations derived from the actual streaming information. In our information‐optimization account, a fluent event‐processor predicts such troughs and selectively attends to them—while suppressing attention to other regions—as sensory streams unfold. In this way, usage of attentional resources is optimized for efficient sampling of the most relevant, information‐rich portions of the unfolding flow of sensation. Such findings point to the development of event‐processing fluency—whether in action, language, or other domains—depending crucially on rapid and continual cognitive reorganization. As knowledge of predictability grows, attention is adaptively redeployed. Accordingly, event experiences undergo continuous alteration. (shrink)

Immanuel Kant’s notion of weakness or frailty warrants more attention, for it reveals much about his theory of motivation and general metaphysics of mind. As the first and least severe of the three grades of evil, frailty captures those cases where an agent fails to act on their avowed recognition that the moral law is the only legitimate determining ground of the will. The possibility of such cases raises many important questions that have yet to be settled by interpreters. Most (...) importantly, should we account for the failures of weakness by appealing to the activity of reason or sensibility? I will discuss this question in light of a tendency to adopt an overly dualistic reading of Kant’s moral psychology. Focusing on Kant’s remarks on weakness from the Religion and the Metaphysics of Morals, I argue that we should understand weakness as arising from the unique difficulties of sense-dependent judgment, rather than from self-deception, flagging commitment, or overwhelming desire. The resulting account offers a unified moral psychology capable of accommodating the many features of weakness that are difficult to reconcile on other readings. (shrink)

In this essay we argue against preventing people from amassing extreme wealth via increased taxation. The first argument in favor of such a proposal, recently advanced by Ingrid Robeyns (2018), states that billionaires’ resources would be better spent addressing morally important goals such as meeting disadvantaged people’s needs and solving collective action problems. In response to this claim, we argue that billionaires are typically in a better position to benefit the poor and to solve collective action problems than public officials. (...) The second argument in favor of preventing extreme wealth accumulation, advanced by Robeyns and Robert Reich (2018), states that billionaires have an inappropriate amount of influence in public life, which undermines political equality. We argue that corporate leaders tend to be more accountable to their fellow citizens than public officials. We then consider and criticize the objection that billionaires’ success is typically a result of public investment, which entitles public officials to enforce taxes that demand a return on the public investment. (shrink)

Public health ethics is commonly analyzed within a consequentialist or rights-based perspective, but recent approaches explore public health from a virtue ethical perspective. Rozier focuses on the virtues of individual members of the public and I discuss public health professionals. MacKay emphasizes the role of the collective level, the practice and social structure of public health. The structure can be important in two ways. First, it potentially affects the cultivation of the virtues of individuals. Second, the structure itself could have (...) virtues. MacKay defends the latter notion and argues that structures become objective reality that is non-reducible to individuals. She implicitly describes public health as an actor, as having hopes and aspirations. MacKay’s account is an interesting contribution to the field. I agree with that the social structure is important but argue that it is primarily important in relation to the cultivation of individual virtues. Public health is not an agent and if it is described as such, it needs a supporting argument concerning moral group agency. I argue that there are no collectives without individuals. Future studies should focus on the links between the individual and social levels and discuss which virtues are the most important. (shrink)

Seat belt mandates seem like a paradigmatic case of justified paternalism. Even those who generally object to paternalism often concede that seat belt laws are justified. Against this near-consensus in favor of mandates, I argue that seat belt laws are unjust and public officials should not enforce them. The most plausible exceptions to a principle of anti-paternalism do not justify seat belt mandates. Some argue that seat belt mandates are not paternalistic because unbelted riders are not fully autonomous. Others claim (...) that the decision to ride unbelted harms other people. Yet these attempts to defend seat belt mandates on non-paternalistic grounds cannot overcome the case against seat belt mandates. I therefore conclude that even seat belt mandates are unjust. With this comprehensive case against seat belt mandates, I demonstrate the more general difficulties in justifying any form of coercive paternalism. (shrink)

The Idea of a unified foundation of all reality has long been core to many attempts at a fundamental ontology, as well as many arguments for the divine. In medieval India a cluster of arguments for metaphysical inheritance, causal entanglement, the impossibility of fundamental relations and more, were advanced together to show there must be an ultimate and unified ground. But foundationalism has been under attack in both recent metaphysics, and Buddhist philosophy. This article unpacks Vedānta’s defense of divine foundationalism (...) against Madhyamaka Buddhism’s metaphysical nihilism. Firstly, we look at how inheritance arguments for ultimate ground aimed to circumvent the possibility of infinite regress. Secondly, we assess three arguments that this ground is a unified modal anchor, with entangled causal power, providing a connective medium for all phenomena. We address some caveats and limitations, but go on to argue that if they are right, they circumvent the Buddhists’ ‘dualistic’ assumption that if the empirical world is mere imagined convention, it needs no explanation. Monists and nihilists are allies against excessively realist ontologies, but these arguments make a compelling case for some unified fundamental nature from which, as the Upaniṣads put it, all things emerge like sparks from a fire. (shrink)

The choice argument against sweatshop regulations states that public officials should not prohibit workers from accepting jobs that require long hours, low pay, and poor working conditions, because enforcing such regulations would be disrespectful to the workers who choose to work in sweatshops. Critics of the choice argument reply that these regulations can be justified when workers only choose to work in sweatshops because they lack acceptable alternatives and are unable to coordinate to achieve better conditions for all workers. My (...) thesis is that the presence of unacceptable alternatives to sweatshop labor or barriers to coordination cannot justify sweatshop regulations such as minimum wage and maximum hour laws. Although officials should promote alternatives to difficult and dangerous sweatshop labor, they should not do so by limiting workers’ and employers’ options through coercive regulation. And the fact that sweatshop workers may face coordination problems does not undermine the claim that sweatshop workers choose to work in sweatshops, just as other workers face coordination problems but nevertheless make occupational choices. Furthermore, efforts to restrict sweatshop workers’ choices are morally risky and may not promote workers’ wellbeing or wellbeing in general. (shrink)

A right to family privacy is considered a cornerstone of American life, and yet access to it is apportioned by race. Our notion of the “racialization of privacy” refers to the phenomenon that family privacy, including the freedom to create a family uninhibited by law, pressure, and custom, is delimited by race. Building upon racial formation theory, this article examines three examples: the Native American boarding school system (1870s to 1970s), eugenic laws and practices (early/mid 1900s), and contemporary deportation. Analysis (...) reveals that state-sponsored limitations on family privacy is a racial project that shapes the racial state. Performing an ideological genealogy with our cases, this article makes three contributions: it illustrates how the state leverages policies affecting families to define national belonging; it reveals how access to family privacy is patterned by race, ethnicity, gender, class, sexuality, and national origin; and it distills how Whiteness and a national racial hierarchy are socially constructed and maintained over time. With the racialization of privacy, we identify how the state seeks to reproduce institutionalized White supremacy and the effects this has on families. We argue that families are the linchpin in state-sponsored racial projects that construct the nation and that the racialization of privacy, as a form of inequality, is a defining characteristic of the color-line. (shrink)

This research explores the relationship of variant degrees of a country’s economic freedom to the ethical profiles of millennial business students, specifically an individual’s personal value orientation and post-conventional reasoning. Grounded in Social Identity, Personal Values, and Cognitive Moral Development theories, we construct an ethical profile to compare responses provided by millennial business students from eight countries. Our results suggest that a country’s degree of economic freedom has some association with an individual’s ethical profile, yet we also discuss other national (...) influences on an ethical profile. These results and their implications are discussed in the article. (shrink)

This article describes the ultimate ground of reality, Brahman, as a single power unfolding in concert in all things. It uses counterfactual argumentation to imply that a cosmos must consist of telic causal orders or manifested ‘powers’ as its most granular building block – and that they must be unified into a single whole. It is based on an argument for a single causally-conditioning substrate of all things recorded in India’s classical Sāṃkhya Kārikā and Brahma Sūtras; this was used by (...) scholastic Vedāntic thinkers including the non-dualist Śaṃkara and the ‘transformationist’ Bhedābheda thinker Śrīnivāsa. It takes up arguments for satkārya, the pre-existence of a thing’s various transformations in potentio within its substrate, and employs them to paint a picture of reality as an ordered yet entangled pattern of causal trajectories. These manifest as the changing world we know. While Vedānta’s main motivation for making the arguments was to prove monism, this conception of an ‘immanent cause’ of all was also seen as divine. We see how this accords with moves in contemporary analytic philosophy to shift away from a broadly Humean model of constant conjunctions (reminiscent of key Buddhist approaches) toward a Neo-Aristotelian ‘metaphysics of powers’. But we also indicate how it may go further than most modern powers-metaphysicians in proposing a deeper connection between powers and what it is for there to be a cosmos at all. (shrink)

Given the long-standing controversy about whether the brain-dead should be considered alive in an irreversible coma or dead despite displaying apparent signs of life, the ethical and policy issues posed when family members insist on continued treatment are not as simple as commentators have claimed. In this article, we consider the kind of policy that should be adopted to manage a family's insistence that their brain-dead loved one continues to receive supportive care. We argue that while it would be ethically (...) inappropriate to continue to devote scarce acute care resources to such patients in a hospital setting, it may not be ethically inappropriate for patients to receive these resources in certain other settings. Thus, if a family insists on continuing to care for their brain-dead loved at their home, we should not, from a policy perspective, interfere with the family's wishes. We also argue that healthcare professionals should make some effort to facilitate the transfer of brain-dead patients to these other settings when families insist on continued treatment despite being informed about the lack of any potential for recovery of consciousness. Our arguments are strengthened by the fact that patients in a persistent vegetative state, who, when correctly diagnosed, also have no potential for recovery of consciousness, are routinely transferred from hospitals to nursing homes or long-term care facilities where they continue to be ventilated, tube fed and to receive other supportive care. We also briefly explore the question of who should be responsible for the costs of such treatment at the long-term care facility. (shrink)

Public officials should compensate the victims of wrongful conviction and enforcement. The same considerations in favor of compensating people for wrongful conviction and enforcement in other cases support officials’ payment of reparations to the victims of unjust enforcement practices related to the drug war. First, we defend the claim that people who are convicted and incarcerated because of an unjust law are wrongfully convicted. Although their convictions do not currently qualify as wrongful convictions in the legal sense, we argue that (...) the same reasons for legally recognizing other wrongful convictions support conceiving of these cases as wrongful convictions. If so, then people who suffered wrongful convictions associated with unjust laws, like others who were wrongfully convicted, are entitled to compensation and reparation. We then argue that America’s drug laws are unjust laws. Therefore, people who were convicted of nonviolent drug offenses are entitled to compensation. (shrink)

Gaulin, McBurney, and Brakeman-Wartell (1997) found that college students reported both matrilateral and sex biases in the investment of aunts and uncles (aunts invested more than uncles). They interpreted the matrilateral bias as a consequence of paternity uncertainty. We replicated that study with Orthodox Jewish college students, selected because they come from a population we presume to have higher paternity certainty than the general population. The Orthodox sample also showed matrilateral and sex biases. Comparing the two data sets, the Orthodox (...) sample reported more investment, and slightly less matrilateral and sex biases, but the differences were not statistically significant. We did find an interaction between sex of relative and group membership, resulting from greater investment by Orthodox uncles. We interpret the results as reflecting the operation of a facultative investment mechanism whose upper limit is tuned to the maximum levels of paternity certainty found in ancestral environments. Lack of a difference in matrilateral bias between groups may result from levels of paternity certainty near to, or above, that maximum in both groups. (shrink)

Although the importance of including vulnerable populations in medical research is widely accepted, identifying how to achieve such inclusion remains a challenge. Ensuring that the language of informed consent is comprehensible to this group is no less of a challenge. Although a variety of interventions show promise for increasing the comprehensibility of informed consent and increasing a climate of exchange, consensus is lacking on which interventions should be used in which situations and current regulations provide little guidance. We argue that (...) the notion of individual autonomy — a foundational principle of informed consent — may be too narrow for some vulnerable populations by virtue of its failure to acknowledge their unique histories and current circumstances. It has a different meaning for members of structured groups like American Indians than for unstructured groups, such as African Americans, whose complicated histories foster group identity. Ensuring broad participation in research and selecting appropriate methods for obtaining informed consent — namely, methods aligned with the source of vulnerability and level of risk — require new ways of thinking that might produce guidelines for matching informed consent models and processes with subpopulations. (shrink)

BackgroundPeople with upper extremity amputations report receiving insufficient information about treatment options. Furthermore, patients commonly report not knowing what questions to ask providers. A question prompt sheet, or list of questions, can support patient-centered care by empowering patients to ask questions important to them, promoting patient-provider communication, and increasing patient knowledge. This study assessed information needs among people with UE amputations about UE vascularized composite allotransplantation and developed a UE VCA-QPS.MethodsThis multi-site, cross-sectional, mixed-methods study involved in-depth and semi-structured interviews with (...) people with UE amputations to assess information needs and develop a UE VCA-QPS. Qualitative data were analyzed by thematic analysis; quantitative data were analyzed by descriptive statistics. The initial UE VCA-QPS included 130 items across 18 topics.ResultsEighty-nine people with UE amputations participated. Most were male, had a mean age of 46 years, and had a unilateral and below-elbow amputation. Participants desired information about UE VCA eligibility, evaluation process, surgery, risks, rehabilitation, and functional outcomes. After refinement, the final UE VCA-QPS included 35 items, across 9 topics. All items were written at a ≤ 6th grade reading level. Most semi-structured interview participants reported being ‘completely’ or ‘very’ likely to use a UE VCA-QPS.ConclusionPeople with UE amputations have extensive information needs about UE VCA. The UE VCA-QPS aims to address patients’ information needs and foster patient-centered care. Future research should assess whether the UE VCA-QPS facilitates patient-provider discussion and informed decision-making for UE VCA. (shrink)

In this article, I consider the question of whether having pets is morally permissible. However, I do so indirectly by considering three objections to the practice of having pets — what I shall call the ‘restriction of freedom objection’, the ‘property objection’, and the ‘dependency objection’. The restriction of freedom objection is dismissed relatively easily. The property objection also fails to show that having pets is morally impermissible. However, my consideration of this second objection does lead to the conclusion that (...) we ought to aim at changing existing legal systems and the majority of people's attitudes towards pets such that they (pets) are no longer considered to be the personal property of the humans in whose homes they are kept. But, while it is clear that we ought to aim at ending the practice of owning pets, it is not clear whether we ought to aim at ending the practice of keeping pets. Indeed, I do not to reach a definitive conclusion about the cogency of the dependency objection. However, I argue that this lack of clarity is of little concern at this time as our present moral obligations to pets are quite clear. (shrink)

Two studies tested whether observers could differentiate between two facets of pride—authentic and hubristic—on the basis of a single prototypical pride nonverbal expression combined with relevant contextual information. In Study 1, participants viewed targets displaying posed pride expressions in response to success, while causal attributions for the success (target's effort vs. ability) and the source of this information (target vs. omniscient narrator conveying objective fact) were varied. Study 2 used a similar method, but attribution information came from both the target (...) and an omniscient narrator; the congruence of these attributions was varied. Across studies, participants tended to label expressions as authentic pride, but were relatively more likely to label them as hubristic pride when (a) contextual information indicated that targets were arrogant and (b) no mitigating information about the target's potential value as a hard-working group member (i.e., that success was actually due to effort) was presented. (shrink)

There is very little literature on the actual decision-making frameworks used by general practitioners with respect to ethical issues and virtually none on the impact of personal experiences of illness on this. This study aimed to investigate what these frameworks might be and if and how they were altered by doctors’ own illness experience. Twenty general practitioners were recruited, 10 having had a previous serious medical illness and 10 having no such history. They participated in a semi-structured interview, including case (...) vignettes, recorded and analysed using qualitative thematic analysis. Being a patient themselves altered general practitioners’ decision-making by enhancing physician empathy, increasing ease at discussing difficult topics, having a greater willingness to support patient choice and a wider ability to provide a greater diversity of therapeutic strategies, with the role of empathy being the most noticeable difference between the groups. Doctors who had not had a severe personal illnes... (shrink)

Infertility patients and patient advocates have long argued for classifying infertility as a disease, in the hopes that this recognition would improve coverage for and access to fertility treatment. However, for many fertility patients, including older women, single women and same-sex couples, infertility does not represent a true disease state. Therefore, while calling infertility a ‘disease’ may seem politically advantageous, it might actually exclude patients with ‘social’ or ‘relational’ infertility from treatment. What is needed is a new conceptual framing of (...) infertility that better reflects the profound significance of being infertile for many people and the importance of addressing infertility in order to improve their lives. In this paper, we argue that the capability approach provides this moral underpinning. The capability approach is concerned with what people are able todo, and whether they are able to act in a way that is in keeping with their own values and goals. The ability to procreate and build a family is a fundamental capacity and can be a major part of self-fulfilment, regardless of sexual orientation or family arrangement. Since the capability approach asks us to conceive of equality in terms of equal capabilities, it provides a strong ethical impetus for society to help those who cannot conceive on their own to do so with assisted reproduction. (shrink)

This article explores the rich and generative spaces poised between Gilles Deleuze’s movement-image and time-image semiotic regimes as laid out in Cinema I: The Movement-Image and Cinema II: The Time-Image. Using a transhistorical approach, this investigation provides insight into the myriad strands that cross between the proposed ‘breaks’ in cinema’s evolution of style and structure. Using the works of Loïe Fuller and Agnes Varda, as well as the theoretical support of theorists such as Walter Benjamin, Henri Bergson, Jean Epstein and (...) Gilles Deleuze himself, this research proposes a new mode of engaging with cinema’s history and semiotic evolution that re-immerses cinema within the ceaseless flow of its duration. In doing so, Deleuze’s historical break between the movement- and time-image regimes becomes an enriched and often contradictory space that offers a reimagining of cinema’s possibilities. (shrink)

In everyday conversations, people put forward versions of events and provide supporting evidence to build a credible case. In environments where there are potentially competing versions, case-building may take a more systematic format. Specifically, we conducted a rhetorical analysis to consider how in child mental health settings, families work to present a credible ‘doctorable’ reason for attendance. Data consisted of video-recordings of 28 families undergoing mental health assessments. Our findings point to eight rhetorical devices utilised in this environment to build (...) a case. The devices functioned rhetorically to add credibility and authenticate the case being built, which was relevant as the only resource available to families claiming the presence of a mental health difficulty in the child was their spoken words. In other words, the ‘problem’ was something constructed through talk and therefore the kinds of resources used were seminal in decision-making. (shrink)

The first in-depth reference in the field that combines scientific knowledge with philosophical inquiry, _The Philosophy of Science: An Encyclopedia_ is a two-volume set that brings together an international team of leading scholars to provide over 130 entries on the essential concepts in the philosophy of science. _The areas covered include:_ biology chemistry epistemology and metaphysics physics psychology and mind the social sciences key figures in the combined studies of science and philosophy. The essays represent the most up-to-date philosophical thinking (...) on timeless scientific topics such as: determinism, explanation, laws of nature, perception, individuality, time, and economics as well as timely topics like adaptation, conservation biology, quantum logic, consciousness, evolutionary psychology, and game theory. (shrink)

Reconstructions of quantum theory are a novel research program in theoretical physics which aims to uncover the unique physical features of quantum theory via axiomatization. I focus on Hardy’s “Quantum Theory from Five Reasonable Axioms” (2001), arguing that reconstructions represent a modern usage of axiomatization with significant points of continuity to von Neumann’s axiomatizations in quantum mechanics. In particular, I show that Hardy and von Neumann share similar methodological ordering, have a common operational framing, and insist on the empirical basis (...) of axioms. In the reconstruction programme, interesting points of discontinuity with historical axiomatizations include the stipulation of a generalized space of theories represented by a framework and the stipulation of analytic machinery at two levels of generality (first by establishing a generalized mathematical framework and then by positing specific formulations of axioms). In light of the reconstruction programme, I show that we should understand axiomatization attempts as being context–dependent, context which is contingent upon the goals of inquiry and the maturity of both mathematical formalism and theoretical underpinnings within the area of inquiry. Drawing on Mitsch (2022)’s account of axiomatization, I conclude that reconstructions should best be understood as provisional, practical, representations of quantum theory that are well suited for theory development and exploration. However, I propose my context–dependent re–framing of axiomatization as a means of enriching Mitsch’s account. (shrink)

This article furnishes a systematisation of the Mediaval aesthetic vocabulary. This task is developed by means of the adoption of a dynamic of intersection among the various Aristotelic species qualitatis, which are taken as the basic structural elements of the requested system. Two versions of beauty are established, which will expand into two kinds of aesthetics, one leaded by pulchritudo, with intellectualistic implications and the other leaded by formositas, which will turn into an autonomus aesthetics; both of them have let (...) a strong legacy to contemporaneus aesthetics. (shrink)

The use of anecdotes is not a viable research strategy to study animal culture. Social learning processes can often be documented with careful quantitative analyses of observational data. Unfortunately, suggestions that killer whales engage in teaching are entirely based on subjective interpretations of qualitative observations. Thus, of teaching in killer whales cannot be used to argue for the occurrence of culture in marine mammals.

In this article, I argue that the material and rhetorical connection between “parental involvement” and motherhood has the effect of making two important features of parental involvement disappear. Both of these features need to be taken into account to think through the positive and negative effects of parental involvement in public schooling. First, parental involvement is labor. In the following section of this paper, I discuss the work of feminist scholars who have brought this to light. Second, parental involvement remains (...) one of the most significant ways in which citizens participate in the public sphere. While education reform projects centered on parental involvement do show some recognition that what parents/mothers do is in fact work, even as they ignore the gendered dimensions of this work and sunnily demand that parents do ever more of it, these projects resist the recognition that parents’/mothers’ involvement is also political. (shrink)

My focus is the possibility of a unitary account of freedom that respects the major insights of both Kant and Hegel. I use Hegel’s remark from §22 in the Introduction to the Rechtsphilosophie as my central text. The argument unfolds over three parts: first, I use the passage to unpack key aspects of Hegel’s view of freedom, including its self-generating nature; second, I show how the passage can be read as a criticism of Kant; and third, I reposition Kant’s view (...) to elude this criticism. I conclude by suggesting that Hegel’s remark from §22 is better read as a criticism of empiricism that Kant would also endorse. Any significant differences between their respective accounts of freedom will thus lie further downstream from this broader unity. (shrink)

My dissertation covers a number of different topics in Kant scholarship, but is driven by one central question: how do our sense-based capacities to perceive, desire, and feel relate to our capacity to reason? I take the answer to this question to be key to understanding much about Kant’s philosophical system. For topics as diverse as the role that sensation plays in practical knowledge, the character of moral motivation, the nature of evil, or Kant’s theory that we are morally required (...) to believe in our immortality and God’s existence, I claim that the correct reading turns on a novel approach to the relation between our rational and sensitive capacities. To properly understand this relation, we must overcome the deeply entrenched thought that Kant inherits his conception of reason from the rationalists, and his conception of sense experience from the empiricists. This would be to adopt a fundamentally dualistic philosophy, on which reason and the senses are independently intelligible and sometimes even diametrically opposed. On Kant’s actual view, our capacities to perceive, feel, and desire are metaphysically interdependent with and thus not intelligible in isolation from our capacity to reason. Developing the details of this more unified position leads to satisfying philosophical accounts of a number of controversial issues in Kant scholarship that have suffered under a dualistic framework. (shrink)

Sensory organs are specialized to receive different kinds of input from the outside world. However, common features of their development suggest that they could have a shared evolutionary origin. In a recent paper, Niwa et al.1 show that three Drosophila adult sensory organs all rely on the spatial signals Decapentaplegic and Wingless to specify their position, and the temporal signal ecdysone to initiate their development. The proneural gene atonal is an important site for integration of these regulatory inputs. These results (...) suggest the existence of a primitive sensory organ precursor, which would differentiate according to the identity of its segment of origin. The authors argue that the eyeless gene controls eye disc identity, indirectly producing an eye from the sensory organ precursor within this disc. BioEssays 26:825–828, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

The discovery of conserved protein domains found in many Drosophila and mammalian developmental gene products suggests that fundamental developmental processes are conserved throughout evolution. Our understanding of development has been enhanced by the discovery of the widespread role of the homeodomain (HD). The action of HD‐containing proteins as transcriptional regulators is mediated through a helix‐turn‐helix motif which confers sequence specific DNA binding. Unexpectedly, the well conserved structural homology between the HD and the prokaryotic helix‐turn‐helix proteins contrasts with their divergent types (...) of physical interaction with DNA. A C‐terminal extension of the HD recognition helix has assumed the role that the N‐terminus of the prokaryotic helix plays for specification of DNA binding preference. However, the HD appears also capable of recognizing DNA in an alternative way and its specificity in vivo may be modified by regions outside the helix‐turn‐helix motif. We propose that this intrinsic complexity of the HD, as well as its frequent association with other DNA binding domains, explains the functional specificity achieved by genes encoding highly related HDs. (shrink)

Associative memory is the ability to link together components of stimuli. Previous evidence suggests that prior familiarization with study items affects the nature of the association between stimuli. More specifically, novel stimuli are learned in a more context-dependent fashion than stimuli that have been encountered previously without the current context. In the current study, we first acquired behavioral data from 62 human participants to conceptually replicate this effect. Participants were instructed to memorize multiple object-scene pairs and were then tested on (...) their recognition memory for the objects. Importantly, 1 day prior, participants had been familiarized with half of the object stimuli. During the test phase, the objects were either matched to the same scene as during study or swapped with a different object’s scene. Our results conceptually replicated the context-dependency effect by showing that breaking up a studied object-context pairing is more detrimental to object recognition performance for non-familiarized objects than for familiarized objects. Second, we used functional magnetic resonance imaging to determine whether medial temporal lobe encoding-related activity patterns are reflective of this familiarity-related context effect. Data acquired from 25 human participants indicated a larger effect of familiarization on encoding-related hippocampal activity for objects presented within a scene context compared to objects presented alone. Our results showed that both retrieval-related accuracy patterns and hippocampal activation patterns were in line with a familiarization-mediated context-dependency effect. (shrink)

Patient-driven drug development is an emerging approach to pharmaceutical research that is forged in rare-disease communities and patient advocacy networks. Patients and their advocates increasingly engage in drug discovery and influence early-stage drug research as clinical trial participants or through compassionate-use programs. Some advocacy groups and patients also influence which therapies are developed by financing promising treatments that otherwise would not secure funding. Though some critics of patient-driven drug development worry about the ethical and scientific implications of this new approach (...) to research, it also has several advantages over the current system. In this essay I argue that patient-driven drug development is morally permissible. (shrink)

This article will explore a clinical case study of a home visit carried out by the case manager nurse. In this case, we will discuss the dilemma of finding the balance between autonomy and beneficence from the perspective of principlist ethics, virtue ethics and the ‘ethics of care’. The main conflict in this case study deals with all proposals are unsuitable and it is not necessary for a nurse to pay him a home visit, whereas for the healthcare system it (...) is considered necessary. We could conclude that, during the home visit, the case manager aspires to achieve excellence, and throughout his clinical relationship with Francesc, searches for a series of virtues, respecting certain fundamental principles. In this way, the case managers ensure that Jaume’s care is more humanised. The case has been anonymised and confidentiality maintained. (shrink)

We consider Walker's thorough review in the context of thinking about future research on the relation between sleep and memory. We first address methodological issues including type of memory and sleep-stage dependency. We suggest a broader investigation of potential signaling molecules that may be critical to sleep-related consolidation. A brief review of the importance of the stress hormone cortisol illustrates this point.

In this preface, we introduce Roger Schwarzschild’s body of work, as well as the papers in this volume. Because Roger’s work is so diverse and comprehensive, the book is divided into four categories: papers that address the semantics of nouns and plurals; papers on focus semantics; papers on degree semantics; and papers addressing the semantics of tense and aspect. We end with compelling arguments that Roger is the best.

This volume is a tribute to Roger Schwarzschild's immense contributions in the formal semantics of nouns, focus, degrees and space, and tense and aspect. Collectively, the papers in the volume reveal parallels across ontological domains, in particular in the context of elements with internal structure, like plural sets, alternative sets, degree intervals, temporal intervals, and vectors. This research suggests that the structure of an entity could inform the semantic behavior of that entity just as much than its semantic type or (...) lexical category. And because these structures dictate the formation of semantic alternatives, it can help inform focus semantics and scalar implicature as well. Old questions on plurals, focus and degree expressions get new answers in this collection of papers in honor of Roger Schwarzchild. Roger Schwarzschild is one of the leading scholars in semantics, and the editors have been highly successful in requesting contributions by his teachers, peers and former students. Some papers have circulated in draft form for many years, and find their final home in this edited volume, which well reflects the state of the art in the field. Prof. dr. Henriëtte de Swart, Utrecht University, The Netherlands. (shrink)