Phenotypic plasticity is a crucial feature of aggressive cancer, providing the means for cancer progression. Stochastic changes in tumor cell transcriptional programs increase the chances of survival under any condition. I hypothesize that unstable chromatin permits stochastic transitions between transcriptional programs in aggressive cancers and supports non‐genetic heterogeneity of tumor cells as a basis for their adaptability. I present a mechanistic model for unstable chromatin which includes destabilized nucleosomes, mobile chromatin fibers and random enhancer‐promoter contacts, resulting in stochastic transcription. I (...) suggest potential markers for “unsettled” chromatin in tumors associated with poor prognosis. Although many of the characteristics of unstable chromatin have been described, they were mostly used to explain changes in the transcription of individual genes. I discuss approaches to evaluate the role of unstable chromatin in non‐genetic tumor cell heterogeneity and suggest using the degree of chromatin instability and transcriptional noise in tumor cells to predict cancer aggressiveness. (shrink)

In this essay, I propose that DNA‐binding anti‐cancer drugs work more via chromatin disruption than DNA damage. Success of long‐awaited drugs targeting cancer‐specific drivers is limited by the heterogeneity of tumors. Therefore, chemotherapy acting via universal targets (e.g., DNA) is still the mainstream treatment for cancer. Nevertheless, the problem with targeting DNA is insufficient efficacy due to high toxicity. I propose that this problem stems from the presumption that DNA damage is critical for the anti‐cancer activity of these drugs. DNA (...) in cells exists as chromatin, and many DNA‐targeting drugs alter chromatin structure by destabilizing nucleosomes and inducing histone eviction from chromatin. This effect has been largely ignored because DNA damage is seen as the major reason for anti‐cancer activity. I discuss how DNA‐binding molecules destabilize chromatin, why this effect is more toxic to tumoral than normal cells, and why cells die as a result of chromatin destabilization. (shrink)

One of the most lively debates on scientific understanding is standardly presented as a controversy between the so-called factivists, who argue that understanding implies truth, and the non-factivists whose position is that truth is neither necessary nor sufficient for understanding. A closer look at the debate, however, reveals that the borderline between factivism and non-factivism is not as clear-cut as it looks at first glance. Some of those who claim to be quasi-factivists come suspiciously close to the position of their (...) opponents, the non-factivist, from whom they pretend to differ. The non-factivist, in turn, acknowledges that some sort of ‘answering to the facts’ is indispensable for understanding. This paper discusses an example of convergence of the initially rival positions in the debate on understanding and truth: the use of the same substitute for truth by the quasi-factivist Kareem Khalifa and the non-factivists Henk de Regt and Victor Gijsbers. It is argued that the use of ‘effectiveness’ as a substitute for truth by both parties is not an occasional coincidence of terms, it rather speaks about a deeper similarity which have important implications for understanding the essential features of scientific understanding. (shrink)

In a series of recent publications Jerry Fodor has attacked what many believe is the core of Darwinian theory of evolution – the theory of natural selection. Not surprisingly, Fodor’s attack has provoked a strong negative reaction. Fodor’s critics have insisted both that his main argument is unsound and that his central claim that the theory of natural selection “can’t explain the distribution of phenotypic traits in biological populations” is untenable. I can generally agree with the first part of the (...) launched criticism: Fodor’s “putative argument” does rely on controversial premises which make it unsound. However, I don’t think that Fodor’s critics have succeeded in their attempts to refute his central claim. The refutation strategy that most of them have undertaken is to show examples of successful evolutionary explanations by natural selection. In what follows, two of these examples are put into scrutiny. The analysis reveals that: (1) The theory of natural selection should be only partially credited with the explanatory success of evolutionary explanations by natural selection because these explanations rely on additional empirical hypotheses which might be true or false. That means that the selectionist explanations are fallible statements the truth value of which depends crucially on the truth value of the empirical assumptions which have been premised. (2) In both cases alternative non-selectionist explanations can be found that fit the same empirical data and no reason has been given (or could be given) why these alternative explanations should be ignored a priori as inferior. The observations (1) and (2) stand against the claim that theory of natural selection is the only legitimate explanance for the distribution of phenotypic traits. This does not mean, of course, that natural selection does not play any explanatory role or that the theory of natural selection is a false theory (as Fodor is inclined to argue for). This only means that there is indeed a problem of understanding the proper explanatory role of natural selection and that this problem is not only Fodor’s problem. The paper ends with a suggestion of what should be admitted in order to get to a better understanding of the proper role that the theory of natural selection plays in evolutionary explanations. (shrink)

Inferentialism as a theory of meaning builds on the idea that what a linguistic expression means depends exclusively on the inferential rules that govern its use. Following different strategies and exploring various case studies, the authors of this collection of essays discuss under what circumstances and to what extent the central tenets of inferentialism are tenable. The essays in this volume present the results of a three-year research project "Representation and Inference" which was conducted from the beginning of 2008 to (...) the end 2010. The aim of the project was to assess the research program of inferentialism as it has been pursued recently by Robert Brandom, Mark Lance, and Jaroslav Peregrin. Earlier versions of these texts were presented at the conference "Inference, Consequence, and Meaning" held in Sofia on the 3rd and 4th of December, 2008. (shrink)

The central argument in this paper is the following: if we agree that one of the aims of explanation is to provide or increase understanding, and if we assess understanding on the basis of the inferences one can draw from the knowledge of the phenomenon which is understood, then the value of an explanation, i.e. its capacity to provide or increase understanding of the explained phenomenon, should be assessed on the basis of the extra-inferences which this explanation allows for. The (...) extra-inferences which a given explanation allows for constitute its inferential content. The analysis of the explanation’s inferential content could be applied to all kinds of explanations with the aim of assessing their goodness. I show how such an analysis helps us to better understand a number of difficulties that have puzzled contemporary philosophers of explanation: the flagpole counterexample to the deductive-nomological model of explanation, the conjunction problem, the difference between good and bad circular explanations. (shrink)

On observe une nouvelle tendance dans la philosophie des sciences cognitives, manifeste dans les écrits de Betchel et al. qui met en avant l’importance des explications mécanistes au détriment du rôle explicatif des principes. Cet article est un plaidoyer pour rétablir l’équilibre. Il met l’accent sur l’effort d’explication des effets du niveau de base, l’une des plus importantes découvertes empiriques dans l’histoire de la recherche en catégorisation. L’analyse de trois différentes périodes de cette histoire révèle que le recours aux principes (...) y a joué un rôle crucial. Cependant, afin de reconnaître pleinement le rôle explicatif des principes, nous devrions nous préparer à admettre que les explications déductives-nomologiques ne sont pas les seuls types d’explications basées sur des principes. (shrink)

Katerina Deligiorgi offers a contemporary defence of autonomy which is Kantian but engages closely with recent arguments about agency, morality, and practical reasoning.

Following François Laruelle's nonstandard philosophy and the work of Judith Butler, Drucilla Cornell, Luce Irigaray, and Rosi Braidotti, Katerina Kolozova reclaims the relevance of categories traditionally rendered "unthinkable" by postmodern feminist philosophies, such as "the real," "the one," "the limit," and "finality," thus critically repositioning poststructuralist feminist philosophy and gender/queer studies. Poststructuralist (feminist) theory sees the subject as a purely linguistic category, as _always alread_y multiple, as _always already_ nonfixed and fluctuating, as limitless discursivity, and as constitutively detached from (...) the instance of the real. This reconceptualization is based on the exclusion of and dichotomous opposition to notions of the real, the one (unity and continuity), and the stable. The non-philosophical reading of postructuralist philosophy engenders new forms of universalisms for global debate and action, expressed in a language the world can understand. It also liberates theory from ideological paralysis, recasting the real as an immediately experienced human condition determined by gender, race, and social and economic circumstance. (shrink)

Sound-symbolism is the nonarbitrary link between the sound and meaning of a word. Japanese-speaking children performed better in a verb generalization task when they were taught novel sound-symbolic verbs, created based on existing Japanese sound-symbolic words, than novel nonsound-symbolic verbs (Imai, Kita, Nagumo, & Okada, 2008). A question remained as to whether the Japanese children had picked up regularities in the Japanese sound-symbolic lexicon or were sensitive to universal sound-symbolism. The present study aimed to provide support for the latter. In (...) a verb generalization task, English-speaking 3-year-olds were taught novel sound-symbolic verbs, created based on Japanese sound-symbolism, or novel nonsound-symbolic verbs. English-speaking children performed better with the sound-symbolic verbs, just like Japanese-speaking children. We concluded that children are sensitive to universal sound-symbolism and can utilize it in word learning and generalization, regardless of their native language. (shrink)

_Interprets Kant's conception of enlightenment within the broader philosophical project of his critique of reason._.

Laruelle's version of Marxism is termed "non-Marxism" whereby the "non-" is stated to stand for bracketing out Marxism's "philosophical sufficiency" and seeking to radicalise Marxism. It stands for the Laruellian non-philosophical variant of Marxism. It is precisely the non-philosophical use of Marx that has enabled the analysis at hand, demonstrating that at the heart of patriarchy and capitalism stands philosophical reason and its treatment of the Animal (both human and non-human). Women are de-realised even as use value and what is (...) exchanged in patriarchy is abstraction or the commodified femininity, which serves the multiplication of the surplus value or rather the pure value of masculinity. Just as the “C” in the M-C-M formula can be expunged as it is a mere relay for the endless repetition of the M-M automaton, so, to paraphrase Marx, because not an atom of matter enters the composition of woman as commodity, the material woman can be excluded from the equation P(hallus)-P(hallus). The less physicality in the pure value of femininity the more perfect the finite automaton of patriarchy. The fetishised femininity, as any form of commodity, is reified abstraction. The token of femininity is exchanged only in order for masculinity to engender itself. Masculinity (or the pure value of the Phallus), speculative reason, and rationalism are endowed with the same contempt for the physical, narcissistic circularity of thought and disgust for the woman outside the signifying automaton of fetishisation. (shrink)

Pufendorf makes a clear distinction between the physical constitution of human beings and their value as human beings, stressing that the latter is justified exclusively by the regular use of the free will. According to Pufendorf, the regular use of free will requires certain inventions (divine as well as human) imposed on the free will and called moral entities. He claims that these inventions determine the moral quality of a human being as well as the standards according to which human (...) beings and their actions are able to be judged. This article examines the normative aspects of Pufendorf’s concepts of moral value and moral estimation in regard to the epistemological question of the accessibility of moral entities for human beings. In the first part, it reconstructs Pufendorf’s doctrine of moral entities and the place of moral estimation in this doctrine. In the second part, it presents Pufendorf’s account of the moral philosophy as a science in order to explain his theory of moral normativity as imposed, and the role of a person in regard to the own moral status. In the last part, it illustrates some consequences in regard to the problem of slavery in Pufendorf. (shrink)

Regulations implemented by World Athletics (WA) require female athletes with differences of sexual development to suppress their blood testosterone levels in order to participate in certain women’s sporting competitions. These regulations have been justified by reference to fairness. In this paper, we reconstruct WA’s understanding of fairness, which requires a “level playing field” where no athlete should have a significant performance advantage based on factors other than talent, dedication, and hard work over an average athlete in their category. We demonstrate (...) that by placing regulations only on testosterone levels, while ignoring physical as well as socioeconomic advantages, WA consistently fails to meet its own definition of fairness. We then discuss several ways in which this definition could be met. Our analysis shows that a categorical system, in which athletes are divided into categories based on properties leading to significant performance advantages, is best suited for meeting WA’s definition of fairness. (shrink)

I argue that the idea of the good is best understood in terms of a rather unorthodox thesis concerning actuality, namely that what is actual -as opposed to what just is, either spatio-temporally or abstractly- is properly identified as actual if it embodies a value, the value of maximal determinateness.

The paper introduces the notion of size of countable sets, which preserves the Part-Whole Principle. The sizes of the natural and the rational numbers, their subsets, unions, and Cartesian products are algorithmically enumerable as sequences of natural numbers. The method is similar to that of Numerosity Theory, but in comparison it is motivated by Bolzano’s concept of infinite series, it is constructive because it does not use ultrafilters, and set sizes are uniquely determined. The results mostly agree, but some differ, (...) such as the size of rational numbers. However, set sizes are only partially, not linearly, ordered. Quid pro quo. (shrink)

The paper examines Schiller’s argument concerning the subjective experience of adopting a morality based on Kantian principles. On Schiller’s view, such experience must be marked by a continuous struggle to suppress nature, because the moral law is a purely rational and categorically commanding law that addresses beings who are natural as well as rational. Essential for Schiller’s conclusion is the account he has of what it takes to follow the law, that is, the mental states and functions that encapsulate the (...) idea of moral self contained in Kant’s ethics. Focusing on the fundamental psychological elements and processes to which Kant’s theory appeals and on which it depends to have application, the paper defends an alternative idea of moral self to the one Schiller attributes to Kant. (shrink)

Moral judgements usually concern the moral responsibility of an acting person. Someone is considered praiseworthy or blameworthy for an action based on whether that action is in accordance with or against moral norms. On a Kantian account, the essential issue is the motivation of the acting person, as this is a criterion for being a moral cause of the action i.e. for intending it. Only moral causation permits the moral imputation of the action to the acting person, and moral motivation (...) always implies the use of practical reason as the capacity of acting in accordance with rules (categorical or hypothetical). Giving priority to one of these leads to either moral merit or moral guilt. The morally guilty person treats himself or others merely as a means rather than respecting himself or others as persons, i.e. as individuals able to act according to their own aims. We find such an account in Johann Christoph Hoffbauer’s interpretation of Kant’s theory of free will. While Kant is occasionally accused of inconsistency in claiming both that evil actions are real and imputable and that only good actions are free (and therefore imputable), Hoffbauer offers a consistent version of Kant’s theory of free will. In this paper, I analyze his interpretation, first sketching its pre-Kantian theoretical context and then discussing Hoffbauer’s Kantian interpretation of the concepts of will and the faculty of choice, using the case of a lie as an illustration. (shrink)

According to the beneficiary-pays principle, the involuntary beneficiaries of injustice ought to disgorge their unjustly obtained benefits in order to compensate the victims of injustice. The paper explores the effectiveness of the above principle in establishing a robust and unique normative connection between the rectificatory duties of the beneficiaries and the rectificatory rights of the victims of injustice. I discuss three accounts of the beneficiary-pays principle according to which the rectificatory duty of the beneficiaries towards the victims is grounded in (...) (a) their duty to oppose injustice and mitigate its effects, (b) their duty to give up benefits that are causally linked to an act of wrongdoing, or (c) their duty to not sustain wrongful harm against the victims. By criticizing these accounts, I intend to highlight the complexities of articulating a distinct rectificatory duty that applies uniquely to the beneficiaries of injustice qua beneficiaries. I conclude that, while it may seem complicated to defend the beneficiary-pays principle as an independent moral principle, it is more plausible to think of it as being derivative of more general principles such as the principle of fair play. (shrink)

Serious doubts have been raised about the coherence of theories of the sublime and the usefulness of the concept. By contrast, the sublime is increasingly studied as a key function in Kant's moral psychology and in his ethics. This article combines methodological conservatism, approaching the topic from within Kant's discussion of aesthetic judgment, with reconstruction of a conception of human agency that is tenable on Kantian grounds. I argue that a coherent theory of the sublime is possible and useful, and (...) the experience of the sublime is significant for our self-conception as agents. However, the chief interest in the sublime is not moral. (shrink)

Katerina Kolozova is a Macedonian philosopher whose publications from last two decades aim to analyze various topics using François Laruelle’s “non-philosophy” or “non-standard philosophy.” Non-philosophy could be roughly described as radicalized deconstruction: Laruelle claims that not everything can be grasped by a philosophy: for Laruelle, “philosophy is too serious an affair to be left to the philosophers alone.”1 Non-philosophy opposes the “principle of sufficient philosophy” through which philosophy determines and decides what is real. According to Laruelle, the ultimate limit (...) of philosophical thought and its self-proclaimed sufficiency lies in its inherent tendency to close itself in a transcendental system of autofetishist conceptions, which presume that one can grasp the Real (“The Real is neither capable of being known or even ‘thought,’ but can be described in axioms. [...] Even ‘immanence’ only serves to name the Real which tolerates nothing but axiomatic descriptions or formulations.”) by a philosophical thought, or that the Real could be mediated only through human thought. Laruelle criticizes this tendency of philosophy, which is usually expressing itself through the structure of “philosophical Decision.” (“To philosophize is to decide Reality and the thoughts that result from this, i.e. to believe to be able to order them in the universal order of the Principle of Reason [Logos].”) Katerina Kolozova use Laruelle’s non-philosophy to explore more explicitly political topics. In the Cut Of Th e Real (2014), she criticized certain dogmatism of poststructuralist philosophy and feminist theory, namely their symptomatic rejection of the Real and the One. In Toward a Radical Metaphysics of Socialism (2015) and The Lived Revolution (2016) Kolozova presented a rereading of Marx, whose work she found relevant for the critique of speculative philosophical dimension of the capitalist economy, embodied in the 2008 global finance crisis, and in the latter book, she explored the possibility of a new political solidarity, based on “bodies in pain.” Kolozova doesn’t call to philosophically reconstruct Marx’s thought for the current situation, but she goes back to Marx with the help of Laruelle’s non-Marxism, contrary to the usual approach of Marxist philosophers, who often try to create certain philosophical system of Marx’s work. Together with Eileen A. Joy, Kolozova edited the anthology After the “Speculative Turn” (2016), which addressed recent realist and materialist tendencies in feminist philosophy. In her most recent book, Capitalism’s Holocaust of Animals (2019), Kolozova aimed to explore broader philosophical foundations of neoliberal capitalism, and its dealing with nonhuman animals and their suffering. According to Kolozova, “We have to start by coming to terms with what we did to the animals in the constitutive act of philosophy and via proxy to all those dehumanised that belong to the species of man ‘by courtesy’ only.” . (shrink)

Hutto and Satne, Philosophia propose to redefine the problem of naturalizing semantic content as searching for the origin of content instead of attempting to reduce it to some natural phenomenon. The search is to proceed within the framework of Relaxed Naturalism and under the banner of teleosemiotics which places Ur-intentionality at the source of content. We support the proposed redefinition of the problem but object to the proposed solution. In particular, we call for adherence to Strict Naturalism and replace teleosemiotics (...) with autopoietic theory of living beings. Our argument for these adjustments stems from our analysis of the flagship properties of Ur-intentionality: specificity and directedness. We attempt to show that the first property is not unique to living systems and therefore poses a problem of where to place a demarcation line for the origin of content. We then argue that the second property is a feature ascribed to living systems, not their intrinsic part and therefore does not form a good foundation for the game of naturalizing content. In conclusion we suggest that autopoietic theory can not only provide a competitive explanation of the basic responding of pre-contentful organisms but also clarify why Ur-intentionality is attributed to them in such an intuitive manner. (shrink)

Departing from the conventional readings of Karl Marx’s Capital and other of his works, by way of François Laruelle’s “radicalization of concepts,” Katerina Kolozova identifies a theoretical kernel in Marx’s thought whose critical and interpretative force can be employed without reference to its subsequent interpretations in the philosophical mainstream. The latter entails a process of abstracting a philosophical legacy — or rather, of putting it in brackets — and then codifying a history of a learned interpretation established in supposed (...) fidelity to the theoretical project of a “master.” Interpreting the master implies a mastery of doctrinal tools, which results in establishing a catechism of the Logos of the Master. And this catechism interferes, Kolozova argues, with more direct encounters with Marx’s writings. As we know, Marx’s rigorously descriptive language unravels the radical core of capitalist economic processes and, through that unraveling, also reveals capitalism’s necessary exploitation and subjugation of human labor. Toward a Radical Metaphysics of Socialism attempts to recuperate and emancipate the notion of metaphysics in this scenario by virtue of radicalizing thought’s encounter with the Real. Kolozova argues that this metaphysical drama is at the origin of the social and economic injustices of contemporary global economic-political realities, and she illustrates this state of affairs in discussions of the problem of wage labor, automated speculation as the core of late capitalism, the post-2008 financial crisis, the status of technology in late capitalism, sexual difference and gender, and the human and non-human body’s subjugation capitalist automation. (shrink)

(2017) 'Interest and Agency', in Gabriel, Markus and Rasmussen, Anders Moe (eds.) German Idealism Today. De Guyter Verlag. -/- Abstract: Undeterred by Kant’s cautionary advice, contemporary defenders of free will advance substantive metaphysical theses in support of their views. This is perhaps unsurprising given the mixed reception of Kant’s solution of the conflict between freedom and natural necessity, which is supposed to vindicate reason’s withdrawal from speculation. Kant argues that neither libertarians nor determinists can win, because they deal with concepts (...) of unrestricted scope, and proposes instead to regiment the reference conditions of each concept and to specify the domain, ‘world’, proper to each. However, the precise character of this solution, its conceptual and metaphysical commitments, continues to be a matter of controversy among Kant scholars. In particular, there is ever-renewed concern about the incipient dualism of the position. Although I will be examining some of this material, my primary aim in this paper is not to make a contribution to the interpretative debate about the antinomy. Rather, I want to draw on two lessons from Kant’s treatment of the antinomy to argue for the importance of a certain way of putting the problem of human freedom. (shrink)

Thought experiments being central to contemporary philosophy and science, the following questions were asked in recent literature. What is their definition? Are they heuristic devices, arguments, paradoxes? Are they comparable to real experiments? Do intuition and conceivability intervene? Equally imaginative thought experiments are found in ancient, medieval, and Renaissance texts. Paying attention to prime historical examples of thought experiments, we show that historical perspectives help answer these general questions.

Departing from the premise that the poststructuralist paradigm still reigns supreme in feminist and gender theory, that is, despite the niche efforts made in the past two decades to challenge it linked to the so called “speculative” turn or the materialisms (and realisms) emerging from the feminist field itself (such as the Utrecht School, inspired by Rosi Braidotti), we set the call for papers for the issue before you in terms that would invite authors ready to challenge the dominant epistemic (...) framework. We invited papers that engage with materialism(s), realism(s), sciences and projects engaged in rethinking the post-human beyond the poststructuralist (and, we dare say, postmodern/ist) norm. -/- . (shrink)

The aim of this paper is to unravel Aristotle’s reasoning with regard to the ontological status of colours; also, to get a better understanding of his views on the production of the whole spectrum of colours; and finally, to evaluate the explanatory power of his theory of colours. The texts I mainly draw my evidence from is Aristotle’s De sensu 3 and the relevant passages from the De anima as well as from other Aristotelian treatises; in addition, I use for (...) my interpretation remarks made by Alexander of Aphrodisias in his commentary on the De sensu, in his Quaestiones and in the dubious treatise Mantissa. (shrink)

In his Foundations of a General Theory of Manifolds, Georg Cantor praised Bernard Bolzano as a clear defender of actual infinity who had the courage to work with infinite numbers. At the same time, he sharply criticized the way Bolzano dealt with them. Cantor’s concept was based on the existence of a one-to-one correspondence, while Bolzano insisted on Euclid’s Axiom of the whole being greater than a part. Cantor’s set theory has eventually prevailed, and became a formal basis of contemporary (...) mathematics, while Bolzano’s approach is generally considered a step in the wrong direction. In the present paper, we demonstrate that a fragment of Bolzano’s theory of infinite quantities retaining the part-whole principle can be extended to a consistent mathematical structure. It can be interpreted in several possible ways. We obtain either a linearly ordered ring of finite and infinitely great quantities, or a partially ordered ring containing infinitely small, finite and infinitely great quantities. These structures can be used as a basis of the infinitesimal calculus similarly as in non-standard analysis, whether in its full version employing ultrafilters due to Abraham Robinson, or in the recent “cheap version” avoiding ultrafilters due to Terence Tao. (shrink)

The ethics of policing currently neglects to provide a framework for analysing the morality of deliberate inactions to prevent harm, even though these are often adopted tactically by police as a means of preventing greater harms. In this paper we argue (a) that police have special moral obligations to prevent harm, grounded both in a contractarian account of police legitimacy and in the interpersonal morality of associations and (b) that police are morally culpable for failures to fulfil these special obligations (...) when these are neither proportionate nor necessary to the prevention of greater crime-related harms. Our claims have implications both for the morality of policing and for its regulation and governance under human rights legislation, which we argue should be reformed so as to recognise police culpability not only for inflictions of harm, but also for failures to prevent it. (shrink)

Abstract In this paper I set the debate between Kant and Schiller in terms of the role that an ideal of life can play within an autonomist ethic. I begin by examining the critical role Schiller gives to emotions in tackling specific motivational concerns in Kant's ethics. In the Kantian response I offer to these criticisms, I emphasise the role of metaphysics for a proper understanding of Kant's position whilst allowing that with respect to moral psychology, Kant and Schiller are (...) in agreement about the importance of emotions in our moral lives. I conclude by returning to the themes broached in the introduction to consider the extent to which the teleological concerns that motivate Schiller can be addressed within Kant's autonomist ethics. (shrink)

The concept of professionalism is embedded into all aspects of nursing education and practice yet is rarely critically interrogated in nursing scholarship. This paper describes how professionalism in nursing is based on whiteness. When actualized, this oppressive construct homogenizes individuals' identities to assist nurses in building and wielding power against each other and against patients, and results in dehumanization and disconnection. Foregrounding an ethic of authenticity as a practice of resistance against white professionalism offers an alternative possibility for how nursing (...) could be taught, practiced and theorized. As such a practice must begin with oneself, the authors outline a reflexive process from which to begin this work. (shrink)

The potential of surveillance practices to undermine the presumption of innocence is a growing concern amongst critics of surveillance. This paper attempts to assess the impact of surveillance on the presumption of innocence. It defends an account of the presumption of innocence as a protection against wrongful criminalisation against alternatives, and considers both the ways in which surveillance might undermine that protection and the—hitherto overlooked—ways in which it might promote it. It draws on empirical work on the causes of erroneous (...) convictions to suggest that surveillance can be used in ways that prevent innocent people being erroneously charged and convicted with crimes, by providing a source of exculpatory evidence for use in police investigations. It is argued that surveillance practices do not necessarily undermine the presumption of innocence but can be reformed in ways that both reduce the risk that they will cause wrongful criminalisation and increase their power to protect those already under suspicion. (shrink)

This paper examines the relevance and importance of the large number of examples which Aristotle uses in his "Prior Analytics." In the first part of the paper three preliminary issues are raised: First, it investigates what counts as an example in Aristotle's syllogistic, and especially whether only examples expressed in concrete terms should be considered as examples or maybe also propositions and arguments with letters of the alphabet. The second issue concerns the kinds of examples Aristotle actually uses from everyday (...) life as well as from various scientific and philosophical forms of discourse; among these, it seems that biological examples, rather than mathematical ones, have a predominant place. Finally, I discuss what Aristotle himself has to say about the use of examples, and in particular about the similarity between the use of an example and the use of induction. The second part of the paper focusses on the functions of Aristotle's logical examples. It is of course obvious that some of the examples in the Prior Analytics are used to illustrate, and thus to clarify, a definition, a logical rule, a type of argument. However, I think that Aristotle's logical examples have another function, which is philosophically more interesting, namely as integral parts of the procedure of proving something. To support this claim, I analyse three passages from the "Prior Analytics" in which examples are used either in order to prove that something is not the case, i.e. as counter-examples, or in order to prove positively that it is possible for something to be the case. At the end, I argue that for such uses of examples Aristotle uses the notion of 'ekthesis', which seems to have a wider sense than usually suggested; that is to say, it is used to refer to any proof by means of an example, and not only for the procedure which Aristotle uses to reduce imperfect to perfect syllogisms. (shrink)

This paper examines the concept of hope in the epistemology and psychology of Immanuel Kant and Johann Christoph Hoffbauer (1766-1827). The decisive question is how according to Kant hope can impair the objectivity of judgements about future and what are the positive and negative effects of this impairment. While for Kant hope is not essentially considered as an affect, he admits that it could transform into an affect and in this way it can impair the mood and its cognitive faculties (...) negatively. In my paper I examine this argumentations of Kant and their reception in the psychology and psychopathology of Hoffbauer, where hope as affect is even considered as a cause of madness and where Hoffbauer seems to suggest that the clinical state of madness can be effect of inappropriate use of the cognitive faculties of the soul. (shrink)

Appropriately specified, the question, 'why be moral?', addresses important and legitimate topics of a broadly meta-ethical nature. The aim of the paper is to use this question as a dialectical tool, in order to identify the core theoretical commitments of Kant'sethics. Becausewell-foundedworrieshavebeenraised about the question itself, I consider these first. The purpose of this preliminary discussion is to determine the sort of question we are dealing with and to introduce the main topics for discussion.