Cocaine use disorder is associated with maladaptive decision-making behavior, which strongly contributes to the harmful consequences of chronic drug use. Prior research has shown that cocaine users exhibit impaired neuropsychological test performances, particularly with regard to attention, learning, and memory but also in executive functions such as decision-making and impulse control. However, to what extent cocaine users show impaired decision-making under risk without feedback has not yet been investigated systematically. Therefore, to examine risk-taking behavior, 31 chronic cocaine users and 26 (...) stimulant-naïve healthy controls who were part of the Zurich Cocaine Cognition Study, performed the Randomized Lottery Task (RALT) with winning lotteries consisting of an uncertain and a certain prospect. Results revealed that risky decisions were associated with male sex, increased cocaine use in the past year, higher cocaine concentrations in the hair, and younger age. In addition, higher levels of cocaine in the hair and cumulative lifetime consumption were associated with risky decisions, whereas potentially confounding factors including cognition and psychiatric symptoms had no significant effect. Taken together, our results indicate that cocaine users who increased their consumption over a period of 1 year show deficits in the processing of risky information accompanied with increased risk-taking. Future research should analyse whether risky decisions could potentially serve as a prognostic marker for cocaine use disorder. (shrink)

This paper argues that data-driven medicine gives rise to a particular normative challenge. Against the backdrop of a distinction between the good and the right, harnessing personal health data towards the development and refinement of data-driven medicine is to be welcomed from the perspective of the good. Enacting solidarity drives progress in research and clinical practice. At the same time, such acts of sharing could—especially considering current developments in big data and artificial intelligence—compromise the right by leading to injustices and (...) affecting concrete modes of individual self-determination. In order to address this potential tension, two key elements for ethical reflection on data-driven medicine are proposed: the controllability of information flows, including technical infrastructures that are conducive towards controllability, and a paradigm shift towards output-orientation in governance and policy. (shrink)

Some authors have argued that legitimacy without authority is possible, though their work has not found much uptake in mainstream political philosophy. I provide an improved model how legitimate political institutions without authority are possible, the Transmission Model, which I couple with a thin substantive position, the Moral Value View. I defend the model against three common objections.

This paper surveys the status of scientific realism in relation to quantum physics, focusing on the problem of underdetermination.

American critical realism emerged in two forms: an ‘essentialist’ version defended, with some significant divergences, by George Santayana and C. A. Strong, and an ‘empirical’ version primarily defended by Roy Wood Sellars. Both forms of American critical realism aimed at an epistemologically convincing ‘representationalist’ account of perception. However, they were divided over issues of ontology. While Santayana and Strong invoked the notion of essence in order to ontologically reinforce their epistemological conceptions, Sellars attempted a more empirical, evolution-based approach. It will (...) be argued that Sellars’s view has more to recommend it because it better explains the actual mechanism of perceptual representation. (shrink)

This paper argues that economics, over the past 200 years, has become steadily more anti-philosophical and that there are three stages in the development of economic thought. Adam Smith intended economics to be a descriptive social science, rooted in an understanding of the moral and psychological processes of an individual’s decision-making and its connection to society in general. Yet, immediately after Smith’s death, economists made a clean cut and invented a totally new discipline: they switched towards a physicalist understanding of (...) human nature. Humans, like atoms, follow a natural law: they are driven by an emotion (defined as a non-emotion, rationality), namely selfishness. Thus economics became a ‘natural’ science. In the 20th century, the second reinterpretation removed all traces of humanity from the study of economics and declared economics to be a formal science like mathematics and logics. The actor in Phase 3 economics is homo economicus syntheticus, a postulate whose only connection to real humanity is the word homo. The paper asks what the results of this dramatic relocation are and why Phase 3 economics still claims descent from Smithian economics, despite the massive differences. (shrink)

One of the most common arguments in favour of the state's authority is that without the coordinating hand of political institutions, we could not achieve important moral benefits. I argue that if we understand authority correctly, then coordination cannot even in principle establish that coordinators have political authority.

Adam Smith’s is often falsely portrayed as having argued that radical selfishness is a force for the good and that this “invisible hand’ is his market mechanism. This paper argues that Smith’s real market mechanism, the sympathy manoeuvre, is a viable alternative to Schumpeterian and mainstream models of innovation in economics and also could help build a firmer theoretical basis for other approaches such as Responsible Innovation. To Smith all human activity was social and must be understood and explained in (...) terms of the sentiments involved. Discovery, for instance, is driven by three sentiments (wonder, surprise, admiration), economic activities by sympathetic imagination, the need for exchange, the need to better one’s position in life, and the need for gratitude. Through sympathetic imagination, his famous model of the impartial spectator, Smith elegantly connects the individual and society. Smith’s innovation process is thus an exercise in social construction and not a destructive process based on radical selfishness. The paper argues that this social innovation process is a viable alternative to the extant approaches that are essentially asocial and amoral (economism) or ideologically normative (Responsible Innovation). (shrink)

Was verbindet Hammer, Pinsel und Geige? Werkzeuge und Instrumente vermitteln zwischen menschlichem Körper und Materie. So genießen diese Objekte eine genuine Gemeinsamkeit, und doch gründet gerade in der Differenz beider Begriffe die abendländische Unterscheidung zwischen handwerklichen und künstlerischen bzw. musikalischen oder wissenschaftlichen Tätigkeiten. Die Beiträge des achten Bandes der Hamburger Forschungen zur Kunstgeschichte nehmen Werkzeuge und Instrumente aus einer kunsthistorischen Perspektive und im interdisziplinären Dialog in den Blick. Das Augenmerk liegt gleichermaßen auf den Techniken ihrer Handhabung, ihrer Diskursivierung in Kritik (...) und Theorie sowie ihrer Darstellung im Bild. Mit Beiträgen von: Gotlind Birkle, Martine Clouzot, Philippe Cordez, Gottfried Korff, Matthias Krüger, François Lamy, Katja Müller-Helle, Ulrich Pfisterer, Albrecht Pohlmann, François Poplin, Julia Ann Saviello, Monika Wagner. (shrink)

Statman and Orevkov independently proved that cut-elimination is of nonelementary complexity. Although their worst-case sequences are mathematically different the syntax of the corresponding cut formulas is of striking similarity. This leads to the main question of this paper: to what extent is it possible to restrict the syntax of formulas and — at the same time—keep their power as cut formulas in a proof? We give a detailed analysis of this problem for negation normal form , prenex normal form and (...) monotone formulas. We show that proof reduction to NNF is quadratic, while PNF behaves differently: although there exists a quadratic transformation into a proof in PNF too, additional cuts are needed; the elimination of these cuts requires nonelementary expense in general. By restricting the logical operators to {,,,}, we obtain the type of monotone formulas. We prove that the elimination of monotone cuts can be of nonelementary complexity . On the other hand, we define a large class of problems where cut-elimination of monotone cuts is only exponential and show that this bound is tight. This implies that the elimination of monotone cuts in equational theories is at most exponential. Particularly, there are no short proofs of Statman's sequence with monotone cuts. (shrink)

Political instrumentalism claims that the right to rule should be distributed such that justice is promoted best. Building on a distinction made by consequentialists in moral philosophy, I argue that instrumentalists should distinguish two levels of normative thinking about legitimacy, the critical and applied level. An indirect instrumentalism which acknowledges this distinction has significant advantages over simpler forms of instrumentalism that do not.

It is common in the literature to claim that legitimacy is the right to rule and that, accordingly, Hohfeldian rights analysis can be used to understand the concept. However, we argue that authors in the legitimacy literature have not generally realised the full potential of Hohfeldian analysis. We discuss extant approaches in the literature that conceptually identify legitimacy with one particular Hohfeldian incident, or, more rarely, a determinate set of incidents. Against these views, and building on parallel debates in property (...) theory, we suggest that Hohfeldian analysis pushes one towards the claim that legitimacy possesses no determinate essence. We provide a rationale for this novel view and disarm a series of objections. (shrink)

The biggest research programme within business ethics is arguably Corporate Social Responsibility and all its related streams (Corporate Citizenship, Social Justice, etc.) While there seems to be widespread agreement that business ethics is situated between the amoral or even immoral view of Milton Friedman as explicated in his 1970 New York Times paper, and the moral view expounded by R. Edward Freeman, this essay challenges that view. Friedman, maybe owed to his flamboyant writing style and crude and purely rhetorical oversimplifications (...) has been misinterpreted to advocate for managers to be completely amoral maximisers of profitability. This misinterpretation has become common wisdom, despite him clearly stating that the law and the moral standards of surrounding society must limit profit-seeking behaviour. Freeman's stakeholder theory, on the other hand, is seen as being on the other end of the continuum, arguing for selflessness—another misinterpretation, as I argue with Ed Freeman's help. Instead, I suggest that both Friedman and Freeman represent the virtuous mean of the business ethics continuum and not its extremes because they both base their theories on the idea of the free and socially embedded individual. The two vicious ends of the continuum are inhabited by the unreal, atomised, completely a-social and selfish individual on the one end, and by the equally unreal collectivised self-less individual on the other. The mainstream in business ethics has declared the collective and selfless end to be the ideal that must guide practice and research. The selfish and the selfless strawmen have prevented a proper debate in business ethics for too long. (shrink)

Is there a difference between human beings and those based on artificial intelligence that would affect their ability to be subjects of dignity? This paper first examines the philosophical notion of dignity as Immanuel Kant derives it from the moral autonomy of the individual. It then asks whether animals and AI systems can claim Kantian dignity or whether there is a sharp divide between human beings, animals and AI systems regarding their ability to be subjects of dignity. How this question (...) is answered depends crucially on one’s understanding of what constitutes human dignity and autonomy, and what requirements one places upon systems in order for them to be seen as morally autonomous. (shrink)

The plural, impure or discordant nature of time has become an important theme in recent critical social and political theory. Against Althusser’s dismissal of Sartre’s presumedly Hegelian understanding of time and history, this article establishes Jean-Paul Sartre as a key figure in this debate on the plurality of temporalities. Especially in the Critique of Dialectical Reason, Sartre understands history and the social in terms of a multiplicity of uneven and non-synchronous temporalisations, rejecting an notion of time as a universal container (...) within which events take place. The originality of Sartre’s approach is that it establishes a link between the notion of the plurality of temporalities and the problem of freedom and domination. His mature social and political theory allows us to understand temporalisation as a strategy for domination, and objective social temporality as key to a form of anonymous or structural domination. A reconstruction of this highly complex and sophisticated approach to thinking domination through time can also shed an original light on the temporal dimension of democracy and totalitarianism. (shrink)

Genome Editing Techniques are seen to be at the frontier of current research in the field of emerging biotechnologies. The latest revolutionary development, the so-called CRISPR technology, represents a paradigmatic example of the ambiguity of such techniques and has resulted in an international interdisciplinary debate on whether or not it is necessary to ban the application of this technique by means of a moratorium on its use for human germline modifications, particularly in human embryos in the reproduction process. However, given (...) that other germline engineering techniques like mitochondrial DNA transfer techniques are already permitted and applied, the question arises what lies at the root of the apparent social unease about the modification of the human germline by Genome Editing Techniques like CRISPR. Against this background, the book seeks to make a substantial contribution to the current debate about a responsible and participatory framework for research on emerging biotechnologies by analysing underlying perceptions, attitudes, arguments and the reasoning on Genome Editing Techniques. (shrink)

Advance directives (ADs) are assumed to reflect the patients’ preferences, even if these are not clearly expressed. Research into whether this assumption is correct has been lacking. This study explores to what extent ADs reflect the true wishes of the signatories.

Die Studie prüft, inwieweit Kants Geschichtsdenken auf Elemente christlicher Eschatologie zurückgreift und welche Probleme damit einhergehen. Nach einer methodischen Auseinandersetzung mit Löwith und Blumenberg interpretiert sie Texte Kants, die selten in Ausführlichkeit behandelt werden; sie stellt diese Texte in einen größeren geistesgeschichtlichen Kontext und hinterfragt dabei das Geschichtsdenken der Moderne und der Gegenwart kritisch.

The integration of ethics into the day-to-day work of research and innovation is an important but difficult challenge. However, with the Aachen method for identification, classification and risk analysis of innovation-based problems an approach from an engineering perspective is presented that enables the integration of ethical, legal and social implications into the day-to-day work of R&I practitioners. AMICAI appears in particular capable of providing a procedural guidance for R&I practitioners based on a method established in engineering science, breaking down the (...) object of consideration into partial aspects and prioritizing the innovation-based problems in dependence of potential risk. This enables the user to apply AMICAI continuously during all stages of the research and development process and to analyze and choose between certain sociotechnical alternatives. In this way, problems that affect ethical, legal, and social aspects can be understood, reflected and considered in the mostly technically focused R&D process. The paper gives a general guidance about AMICAI by describing principles and assumptions, providing the steps of analysis and application aids, giving an example application, explaining the necessary adjustments of AMICAI compared to the methodical basis of failure mode, effects, and criticality analysis and discussing the advantages and limits. AMICAI’s simple applications can stimulate interdisciplinary cooperation in the R&D process and be a starting point for the development of an “open RRI risk analysis platform” allowing society to evaluate innovation-based problems. (shrink)

Ethical concerns are motivating the search for alternative methods to obtain pluripotent stem cells without destroying human embryos. The supporters of these methods stress the importance of ensuring that the biological entities used in these alternative methods are not “disabled or sick human embryos.” In this article the authors argue that biological entities bearing anomalies or alterations that directly inhibit the appearance of neural activity (DIANA anomalies) share the moral status of human organisms fulfilling the clinical criteria for brain death. (...) By contrast, in the absence of DIANA anomalies, the moral status of a person cannot be denied. National Catholic Bioethics Quarterly 7.2 (Spring 2007): 315–335. (shrink)

The length of resolution proofs is investigated, relative to the model-theoretic measure of Herband complexity. A concept of resolution deduction is introduced which is somewhat more general than the classical concepts. It is shown that proof complexity is exponential in terms of Herband complexity and that this bound is tight. The concept of R-deduction is extended to FR-deduction, where, besides resolution, a function introduction rule is allowed. As an example, consider the clause P Q: conclude P) Q, where a, f (...) are new function symbols extending Herbrand's universe. P ()Q from Q) and Skolemization). By modification of a construction of Statman it is shown that FR-deductions may be nonelementarily shorter than R-deductions . Finally it is proved that FR-deduction has weaker effects only if clausal logic is restricted to Horn logic. (shrink)

There has been little debate in political philosophy about whether the intentions of governments matter to the legitimacy of their policies. This paper fills this gap. First, I provide a rigorous statement of political anti-intentionalism, the view that intentions do not matter to political legitimacy. I do so by building on analogous debates in moral philosophy. Second, I sketch some strategies to defend political anti-intentionalism, which I argue are promising and available to a wide range of theories of legitimacy. Third, (...) I show that the distinction has implications for debates surrounding neutrality and political liberalism. (shrink)

A collection bringing together a wide-varietyof world-renowned scholars on the import of Derrida's philosophy with respectto the current environmental crisis, our ecological relationships to 'nature'and the earth, our responsibilities with respect to climate change, pollution, and nuclear destruction, and the ethics and politics at stake in responding tothese crises.

German dialect geography developed, inter alia, as a means to compensate the shortcomings of the Young Grammarians' approach to language. In contrast to the latter, it was conceived of to be a sociolinguistic project, constituting thereby one link between the development of Soviet and German linguistics. The article tries to answer such questions as who initially participated in transferring ideas of German dialectology to the Soviet Union and what kind of motivations underlay those transfers. Combining biographical facts with systematic aspects, (...) the article surveys the filiations of some productive ideas with the help of archival sources, i.e. letters of the Soviet scholars Dinges (1891-1932) and Viktor Žirmunskij (1891-1971). Finally, I try to single out the elements in Žirmunskij dialect geography, which are specifically sociolinguistic. (shrink)

This paper presents a translation which allows one to describe constructive provability within classical first-order logic.

Der Band geht den zahlreichen Verbindungslinien von Erziehung und Philosophie in Geschichte und Gegenwart nach. Neben exemplarischen Auseinandersetzungen mit einzelnen Denker: innen von Seneca über Locke und Rousseau bis hin zu Jaspers und Foucault stehen grundlegende Aspekte möglicher Überschneidungen und Kontinuitäten zwischen Erziehungsphilosophie, philosophischer Pädagogik, Anthropologie und anderen Teil- oder Fachdisziplinen im Mittelpunkt der Beiträge. Ergänzt wird der Band durch tentative Ausblicke auf die Zukunft der Erziehungsphilosophie unter den sich verändernden Vorzeichen globaler Herausforderungen.

The performance of deep Neural Networks (NNs) in the text (ChatGPT) and image (DALL‐E2) domains has attracted worldwide attention. Convolutional NNs (CNNs), Large Language Models (LLMs), Denoising Diffusion Probabilistic Models (DDPMs)/Noise Conditional Score Networks (NCSNs), and Graph NNs (GNNs) have impacted computer vision, language editing and translation, automated conversation, image generation, and social network management. Proteins can be viewed as texts written with the alphabet of amino acids, as images, or as graphs of interacting residues. Each of these perspectives suggests (...) the use of tools from a different area of deep learning for protein structural biology. Here, I review how CNNs, LLMs, DDPMs/NCSNs, and GNNs have led to major advances in protein structure prediction, inverse folding, protein design, and small molecule design. This review is primarily intended as a deep learning primer for practicing experimental structural biologists. However, extensive references to the deep learning literature should also make it relevant to readers who have a background in machine learning, physics or statistics, and an interest in protein structural biology. (shrink)

Self-disclosures on online social networks have received increased attention in the last two decades. Researchers from different disciplines investigated manifold influencing variables, and studies applied different theories to explain why many users share very sensitive and personal information despite potential risks and negative consequences, whereas others do not. Oftentimes, it is argued that self-disclosure decisions result from a kind of rational “calculus” of risks and benefits. However, such an assumption of rationality can and has been criticized. Nevertheless, fundamental cognitive and (...) affective mechanisms that underlie self-disclosure decision making on social networks are still under-explored. By building upon previous self-disclosure theories and models, dual-and tripartite-system perspectives of decision making, and former empirical findings, we propose a Tripartite Self-Disclosure Decision model that conceptualizes inner processes of online self-disclosure decision making. Central to this model is the proposed interaction of three neural and cognitive/affective systems: a reflective, an impulsive, and an interoceptive system. We further highlight individual and environmental features, which can impact individuals’ online self-disclosure decisions by influencing the proposed inner decision-making processes targeting the aforementioned three systems. Possible short- and long-term consequences are also discussed, which in turn can affect certain model components in subsequent self-disclosure decision situations. By taking such a neurocognitive perspective, we expand current research and models, which helps to better understand potentially risky information sharing on online social networks and can support attempts to prevent users from incautious self-disclosures. (shrink)

I develop a ‘duty-plus’ approach to supererogation based on a simple intuition: if I am required to do x or y, doing x and y is a candidate for, though not necessarily, supererogation. This is an appealing view to take, located midway between two extreme positions, supererogationism and rigorism. I give a precise statement of the view through the notion of disjunctive duties, and discuss the commitments a duty-plus theorist should make, independent from the Kantian context in which this position (...) is often discussed. I also advocate the novel claim that we should take supererogation as a property of sets of actions, rather than single actions. The latter view suffers from problems in cases of concurrent acts and accumulative supererogation. (shrink)

"The Body in Language: Comparative studies of Linguistic Embodiment provides new insights into the theory of linguistic embodiment in its universal and cultural aspects. The contributions of the volume offer theoretical reflections on grammaticalization, lexical semantics, philosophy, multimodal communication and - by discussing metaphorization and metonymy in figurative language - on cognitive linguistics in general. Case studies contribute first-hand data on embodiment from more than 15 languages and present findings on the body in language in diverse cultures from various continents. (...) Embodiment fundamentally underlies human conceptualization and the present discussions reveal a wide range of target domains in conceptual transfers with the body as the source domain."--PUblisher. (shrink)

The article aims for examining the ‘technological stasis’ of the data structure in OpenStreetMap – the successful global collaborative geodata project devoted to ‘create and distribute free geographic data for the world’. Digital structures are strongly influenced by continuing stagnation. This technological stasis – the lack of change in technology – influences data in various ways, as demonstrated by the intensive discussion of the issue by computer scientists and software engineers. However, existing research describing stagnating software is often technic centred (...) and fuzzy, while critical research is barely considering issues of technological stasis in the digital context at all. Therefore, this paper aims for enriching this body of knowledge in order to shed light on aging data structures. I reframe technological stasis with a social-constructivist perspective – using the approach of Social Construction of Technology – especially with the concept of technological frames. Based on the case example of OpenStreetMap, my findings suggest that the data structure – and its stasis – is the outcome of competing understandings and perspectives, shaped by power asymmetries. Although the data structure did not significantly change for more than 10 years, I demonstrate that this is not because of a lack of motivation, nor technological difficulties of carrying out such changes. The technological stasis is rather rooted in the dominant position of few project members who are able to change the software design; it is their perception of the project that defines how data should be stored and what features are dispensable. (shrink)

This work considers Valkyries in the medieval Scandinavian mythology and literature and places them in the context of the early history of European religion. Drawing on textual and archaeological sources, a detailed review of Celtic, Etruscan and Graeco-Roman female demons of the battlefield and of death is presented, and their remarkable similarity with the Valkyries analysed against the background of Mediterranean-transalpine cultural contacts.

The article considers the relationships among three arguments that purport to establish the intrinsically contradictory or paradoxical nature of the modern project aiming at the equal consideration of all. The claim that the inevitable historical insertion of universal-egalitarian norms leads to always particular and untransparent interpretations of grammatically universal norms may be combined with the claim that the logic of determination of political communities tends to generate exclusions. The combination of these two claims lends specific force to the third argument (...) according to which equal consideration perpetually requires the non-egalitarian project of understanding individuals on their own terms. Hence, taking off from a recent debate between Christoph Menke and Jürgen Habermas, I argue that the former is right to diagnose an aporetic self-reflection in egalitarian universalism, while agreeing with the latter about the indispensability of deliberative democratic frameworks for the defence of both egalitarian and non-egalitarian norms. Key Words: Theodor Adorno • deliberative democracy • Jacques Derrida • egalitarianism • equality • Jürgen Habermas • Christoph Menke • singularity • universalism. (shrink)