El objetivo del presente trabajo es abordar el pensamiento del padre Benito Feijoo a partir del análisis de un elemento central que, sin embargo, no ha sido frecuentemente trabajado: su dimensión ética. Sostendremos que la apuesta de Feijoo por un ejercicio pleno y autónomo de la razón, por una filosofía como actividad crítica, entraña un compromiso ético y humano fundamental, representa un horizonte de lucha contra la superstición y la discriminación, que posee un valor singular indudable. Argumentaremos que esta dimensión (...) ética se articula en torno a la consideración racional de los seres humanos como iguales que se deriva del ejercicio feijoniano de _desengaño de errores comunes_ y se postula como el fundamento de todo vínculo. Para defender esta hipótesis abordaremos el proyecto filosófico de Feijoo deteniéndonos en su análisis de las relaciones humanas, de las prácticas y creencias que las estructuran, a partir del cual emerge una ética de lo cotidiano que apunta a cuestionar los fundamentos filosóficos sobre los que se construyen vínculos y modos de vivir en sociedad. Tomaremos tres ejemplos posibles en los que esta dimensión se hace tangible: (1) el alegato que Feijoo profiere en favor del pueblo judío, (2) las consideraciones que presenta sobre los pobladores nativos del continente americano y (3) la defensa que despliega respecto de las mujeres en una de sus obras centrales, el _Teatro Crítico Universal_. (shrink)

Serious games have become an important tool to train individuals in a range of different skills. Importantly, serious games or gamified scenarios allow for simulating realistic time-critical situations to train and also assess individual performance. In this context, determining the user’s cognitive load during training seems crucial for predicting performance and potential adaptation of the training environment to improve training effectiveness. Therefore, it is important to identify in-game metrics sensitive to users’ cognitive load. According to Barrouillets’ time-based resource-sharing model, particularly (...) relevant for measuring cognitive load in time-critical situations, cognitive load does not depend solely on the complexity of actions but also on temporal aspects of a given task. In this study, we applied this idea to the context of a serious game by proposing in-game metrics for workload prediction that reflect a relation between the time during which participants’ attention is captured and the total time available for the task at hand. We used an emergency simulation serious game requiring management of time-critical situations. Forty-seven participants completed the emergency simulation and rated their workload using the NASA-TLX questionnaire. Results indicated that the proposed in-game metrics yielded significant associations both with subjective workload measures as well as with gaming performance. Moreover, we observed that a prediction model based solely on data from the first minutes of the gameplay predicted overall gaming performance with a classification accuracy significantly above chance level and not significantly different from a model based on subjective workload ratings. These results imply that in-game metrics may qualify for a real-time adaptation of a game-based learning environment. (shrink)

Nursing is at the same time a vocation, a profession and a job. By nature, nursing is a moral endeavor, and being a ‘good nurse’ is an issue and an aspiration for professionals. The aim of our qualitative research project carried out with 18 nurse teachers at a university nursing school in Brazil was to identify the ethical image of nursing. In semistructured interviews the participants were asked to choose one of several pictures, to justify their choice and explain what (...) they meant by an ethical nurse. Five different perspectives were revealed: good nurses fulfill their duties correctly; they are proactive patient advocates; they are prepared and available to welcome others as persons; they are talented, competent, and carry out professional duties excellently; and they combine authority with power sharing in patient care. The results point to a transition phase from a historical introjection of religious values of obedience and service to a new sense of a secular, proactive, scientific and professional identity. (shrink)

Natalia Carrillo and Tarja Knuuttila claim that there are two traditions of thinking about idealization offering almost opposite views on their functioning and epistemic status. While one tradition views idealizations as epistemic deficiencies, the other one highlights the epistemic benefits of idealization. Both of them treat idealizations as deliberate misrepresentations, however. They then argue for an artifactual account of idealization, comparing it to the traditional accounts of idealization, and exemplifying it through the Hodgkin and Huxley model of the nerve (...) impulse. From the artifactual perspective, the epistemic benefits and deficiencies introduced by idealization frequently come in a package due to the way idealization draws together different resources in model construction. Accordingly, idealization tends to be holistic in that it is not often easily attributable to some specific parts of the model. They conclude that the artifactual approach offers a unifying view into idealization in that it is able to recover several basic philosophical insights motivating both the deficiency and epistemic benefit accounts, while being simultaneously detached from the idea of distortion by misrepresentation. (shrink)

The content-analysis of the Russian federal and regional basic legislation on the cultural policy has indicated a need in a deep revision of all existing regulatory legal acts, which support the state cultural policy implementation towards building a universal terminology and vesting the functions on the cultural policy implementation in the government as opposed to the statement of the departmental specific approach to the culture.

Different proprietary databases have been used extensively in research to assess the environmental performance and environmental risk of companies. This study explores the convergent validity of the environmental ratings of MSCI ESG STATS, Thomson Reuters ASSET4 and Global Engagement Services. The study shows that the ratings have common dimensions, but on aggregate, they do not converge. On the environmental opportunity side, KLD environmental strengths, and ASSET4 and GES environmental performance metrics correlate highly and provide convergent scores for US companies from (...) 2003–2011. On the environmental risk side, KLD environmental concerns converge with the GES environmental industry risk and company emissions from the ASSET4 database. Further analysis confirms that industry-related risks are drivers of company-specific environmental performance. (shrink)

Source: Author: Natalia Gerasimova, Inna Gerasymova The article reviews the current state of studying the problem of interpersonal conflict as a factor in adaptation, characterized by consideration of the relationship of these categories on two levels: intrapersonal conflict is studied as a driving force, a source of self-in the process of adaptation and as a leading indicator of complications adaptation. It is determined that the impact of interpersonal conflict in the course of adaptation depends on self-identity in a complex (...) interaction of external and internal factors. It is indicated that psychological content intrapersonal conflict experiences have a high degree of individual differentiation and thus determine the uniqueness of perception and interpretation of a specific person. An indicator of the transition from one level to another intrapersonal difficulties acts vulnerability to conflict self-relations context of inner experience. The nature of the adaptation of the student is determined by the internal model and solve interpersonal experiences complications, which are formed in the mind and form the basis of individual experience. ]]>. (shrink)

El presente trabajo se inscribe en el cruce que intersecta nodos centrales de la filosofía contemporánea en el llamado giro posthumano con las experiencias y producciones teóricas transfeministas. Consideramos que tal intersección se encuentra dada en la medida en que ambos términos suponen el resquebrajamiento de las lógicas identitarias en tanto políticas del deseo que promueven formas de sujeción andro-antropocéntricas y tanato-bio-políticas. Nuestro objetivo es mostrar en qué medida estos ámbitos se retroalimentan, pero enfoncándonos especialmente en dilucidar cuáles han sido (...) los aportes de los transfeminismos al pensamiento posthumanista. Concretamente, a través de abordajes metodológicos inscriptos en el horizonte de una genealogía crítica, analizaremos la implicación que las experiencias trans y el pensamiento feminista tuvieron para la postulación del dispositivo de sexualidad en Foucault y para el devenir-mujer en Deleuze y Guattari. Como resultado de tales análisis llegamos a la formulación de lo que denominamos filosóficas transfeministas en tanto prácticas de pensamiento y pensamiento en práctica que, en el ocaso de lo humano, buscan generar políticas del deseo para nuevos devenires simpoiéticos. (shrink)

Student academic dishonesty is a pervasive problem for universities all over the world. The development of innovative practices and interventions for decreasing dishonest behaviour requires understanding factors influencing academic dishonesty. Previous research showed that personal, environmental, and situational factors affect dishonest behaviour at a university. The set of factors and the strength of their influence can differ across countries. There is a lack of research on factors affecting student dishonesty in Russia. A sample of 15,159 undergraduate students from eight Russian (...) highly selective universities was surveyed to understand what factors influence their decision to engage in dishonest behaviour. Ajzen’s Theory of Planned Behaviour was employed to explain dishonest behaviour among students. The explained variance in the engagement in academic dishonesty equals 48% in the model for the full sample, and reaches 69% in the model for one of the considered institutions. The major findings of this study were: subjective norms appeared to dominate as the strongest predictor of academic dishonesty across the Russian universities; perceived behavioural control, appeared to be positively related to the dishonest behaviour. In the majority of universities, this factor was found to be insignificant. This finding indicates a specific feature of Russian students’ an ethical decision-making process discussed in the last part of the paper. (shrink)

Using social information is not indiscriminate and being able to choose what to copy and from whom to copy is critical. Dogs are able to learn socially, to recognize, and respond to dog as well as human emotional expressions, and to make reputation-like inferences based on how people behave towards their owner. Yet, the mechanisms dogs use for obtaining and utilizing social information are still to be fully understood, especially concerning whether emotional cues influence dogs’ social learning. Therefore, our main (...) aim was to test the hypothesis that an emotionally charged interaction with the demonstrator of a “V” detour task prior to testing would affect subjects’ performance, by: changing the value of the information provided by the demonstrator or changing the valence of the learning environment. Our experimental design consisted of three phases: pre-test ; emotional display ; test. Only dogs that failed in pre-test were considered for analysis. We analyzed four dependent variables: success, time to solve the task, latency to reach the fence and matching the side of demonstration. For each, we used four models to investigate the effect of demographic factors; experimental design factors ; behavior of the dog; and side chosen and matching. All models took into account all trials and the first trials only. Our findings corroborate previous studies of social learning, but present no evidence to sustain our hypothesis. We discuss the possibility of our stimuli not being salient enough in a task that involves highly motivating food and relies on long and highly distracting interval between phases. Nevertheless, these results represent an important contribution to the study of dog behavior and social cognition and pave the way for further investigations. (shrink)

Неопределенность общих параметров социальной ситуации в современной России нередко приводит в тупик работу рефлексивного самосознания. Западные читатели склонны интересоваться религиозной стороной русской мысли. Однако в ней есть также и вполне «светская» философия в своих классических формах - эпистемология, этика, политическая философия и др. Постсоветская философия в России характеризуется значительной открытостью к Западу и, в частности, к современной французской философии. Le caractère assez confus de la situation générale actuelle en Russie y engendre une atrophie de l’activité réflexive. Les Occidentaux s’intéressent souvent (...) au côté religieux de la pensée russe. Mais il y a aussi, actuellement, une philosophie « laïque » , et cela sous les formes classiques : épistémologie, éthique, philosophie politique, etc. La philosophie de la Russie postsoviétique se caractérise par une grande ouverture à l’Occident, et en particulier aux philosophes français actuels. The somewhat confused character of the general situation in Russia leads to an atrophy of reflexive activity. Westemers are often interested in the religious side of Russian thought. But there also exists today a “secular” philosophy, developed according the classical canon: i.e., epistemology, ethics, political philosophy, etc. The philosophy of post-Soviet Russia is characterized by a great openness towards the West, and particularly with respect to contemporary French philosophers. (shrink)

The most fascinating aspect of human language is grammar. Grammar is a computational system that mediates a mapping between linguistic form and meaning. Grammar is the machinery that gives rise to the unlimited expressibility of human language.

In this article, we address the case of self-tracking as a practice in which two meaningful backgrounds (physical world and technological infrastructure) play an important role as the spatial dimension of human practices. Using a (post)phenomenological approach, we show how quantification multiplies backgrounds, while at the same time generating data about the user. As a result, we can no longer speak of a unified background of human activity, but of multiple dimensions of this background, which, additionally, is perceived as having (...) no pivotal role in the process, often being hidden, situated beyond human consciousness, or taken for granted. Consequently, the phenomenological experience of the background turns into a hermeneutic practice focused on the interpretation of representations and descriptions. By adopting a (post)phenomenological approach, we show the problems and limitations of quantification of human activities occurring in self-tracking and the theoretical problems associated with the scheme of human-technology relations. (shrink)

El presente trabajo se propone abordar la recepción de la filosofía moderna europea que se desplegó en el siglo XVIII en dos instituciones fundamentales del territorio del Río de la Plata: la Universidad de Córdoba y el Colegio de San Carlos de Buenos Aires. Nuestro objetivo es analizar dicha recepción a pensando su vínculo con una manera específica de practicar la enseñanza de la filosofía en estas instituciones, entendiéndola como parte esencial del quehacer filosófico, como una búsqueda genuina de conocimiento. (...) Nos concentraremos en el caso de Baruch Spinoza —pensador perseguido y condenado a la censura— para ilustrar las diversas formas en las que nuevos autores modernos eran incorporados paulatinamente a la enseñanza de la filosofía en las aulas rioplatenses. (shrink)

In this paper we aim to think systematically about, formulate, and begin addressing some of the challenges to applying theories of moral responsibility to behaviors shaped by a particular subset of unsettling psychological complexities: namely, implicit biases.

El presente trabajo presenta una interpretación de los enunciados internos hartianos basada en la filosofía del lenguaje de Wittgenstein y la metodología del conocimiento social de Winch. Según esta lectura, la distinción entre enunciados internos y externos representa una forma de contextualismo en la teoría analítica del derecho. En el trabajo se defiende que el discurso descriptivo sobre lo que en un ordenamiento jurídico es obligatorio, permitido o prohibido es siempre un discurso interno respecto de los criterios de pertenencia de (...) ese ordenamiento. Además, se argumenta que esta forma de discurso interno no tiene una función ideológica sino cognoscitiva y permite aún distinguir entre cuestiones de validez y de legitimidad de las normas. (shrink)

Fear generalisation, a process by which conditioned fear spreads to similar but innocuous stimuli, is key in understanding why some individuals feel unsafe in objectively non-threatening situations. Both trait neuroticism and lack of predictability about the likelihood of feared consequences are associated with negative affect in the face of ambiguity and may increase the degree to which fear generalises. Undergraduates with varying degrees of neuroticism were randomised to either high- or low-instructional predictability conditions prior to fear acquisition. A fear generalisation (...) test measured risk ratings and attentional bias on a modified dot-probe paradigm. Among individuals with higher neuroticism, providing instructional predictability did not reduce fear; these individuals reported higher risk and increased attentional bias toward ambiguous stimuli. Overall, for individuals with higher neuroticism, predictability information hurt rather than helped interpretation of ambiguous stimuli, challenging a common conceptualisation of predictability as a factor that reduces fear. (shrink)

Bertrand Russell’s Critique of the Arguments for the Existence of God The paper presents Bertrand Russell’s critique of arguments for the existence of God. I divided the theistic arguments which Russell criticizes into three groups. The first group involves arguments concerning the relation between Universe and God: the First Cause argument, the Natural law argument and the argument from Design. The second group is related to the concept of God as a moral Lawmaker and it contains the argument from morality (...) and the argument from remedy for injustice. The last group of arguments pertains to the relation between God and human beings. Here, I consider Russell's reflections on the validity of the argument from religious experience and his approach to the issue of the foundation of religion. The aim of this article is to consider whether Russellian argumentation against evidence for God's existence is justified. Keywords: Bertrand Russell, existence of God, argument, philosophy of religion, evidence. (shrink)

The subject of the study is Bernardo Bertolucci's film "The Last Emperor", in particular, the coloristic of the film and the psychology of the image of the main character, which is largely revealed through the color palette and individual artistic details. The object of research is the language of cinematography, cinematographic artistic techniques. Despite the sometimes shocking images and plots, Bertolucci's films were highly appreciated by the international community and domestic film critics due to their artistic solution and topical issues (...) affecting the problems of class struggle and anti-fascist themes. The author of the article examines the image of the main character of the film, Aisingero Pu Yi, the last emperor of China and Manchukuo. The film is based on real historical events taking place in the first half of the 20th century, so the dramatic collisions of the character are not perceived by the viewer as some kind of abstract problem. Against the backdrop of the complex historical changes that China has faced, many questions of the formation and self-determination of the individual are being raised. The image of Emperor Pu Yi is revealed gradually through a comparison of two storylines and the color scheme of the film, since it is the color palette that helps to subtly and meaningfully convey the psychological content of the character. The main research methods are analytical and comparative-historical. The composition of the film and the dynamics of the change in the color palette of individual episodes are analyzed, which makes it possible to trace the evolution of the image. The author comes to the conclusion that it was the coloristic solution of the film that allowed the creators to convey the national color and historical atmosphere of China of a certain historical period and show a vivid image of the protagonist on the screen. (shrink)

El objetivo del presente trabajo es rastrear cuál es el semblante que el padre benedictino Benito Feijoo construye de la figura de Baruch Spinoza en su Teatro Crítico Universal. Creemos que es fundamental estudiar las referencias al nombre del filósofo holandés presentes en la obra feijoniana en tanto permiten delimitar un comienzo en la recepción del spinozismo en la primera ilustración española. La hipótesis que defenderemos es que Spinoza es un interlocutor constante de Feijoo, que reviste importancia, que es convocado (...) al diálogo filosófico pero, al mismo tiempo, es presentado estratégicamente de manera solapada, disimulada, distante. (shrink)

A key benefit of Bayesian reasoning is that it stipulates how to optimally integrate unreliable sources of information. The authors present evidence that humans use Bayesian inference to determine how much to trust advice from another person, based on information about that person's knowledge and strategy.

Cross-linguistic studies focus on inverse correlations (trade-offs) between linguistic variables that reflect different cues to linguistic meanings. For example, if a language has no case marking, it is likely to rely on word order as a cue for identification of grammatical roles. Such inverse correlations are interpreted as manifestations of language users’ tendency to use language efficiently. The present study argues that this interpretation is problematic. Linguistic variables, such as the presence of case, or flexibility of word order, are aggregate (...) properties, which do not represent the use of linguistic cues in context directly. Still, such variables can be useful for circumscribing the potential role of communicative efficiency in language evolution, if we move from cross-linguistic trade-offs to multivariate causal networks. This idea is illustrated by a case study of linguistic variables related to four types of Subject and Object cues: case marking, rigid word order of Subject and Object, tight semantics and verb-medial order. The variables are obtained from online language corpora in thirty languages, annotated with the Universal Dependencies. The causal model suggests that the relationships between the variables can be explained predominantly by sociolinguistic factors, leaving little space for a potential impact of efficient linguistic behavior. (shrink)

This article examines the conceptualisation of corporate social responsibility (CSR) in the context of mining multinationals (MNCs) in Argentina. It explores the suitability of CSR for addressing social, environmental and economic issues associated with mining in the country. The study is based on interviews with four stakeholder groups in the country: government, civil society, international financial organisations, and mining industry. These are analysed using content and interpretative techniques and supplemented by the content analysis of secondary data from headquarters of mining (...) MNCs. Using the concept of corporate social responsibility orientation (CSRO), the study contrasts the perceptions of major stakeholders and examines adaptation of mining companies’ CSRO to local context. It reveals that the CSRO of mining managers in Argentina differs from CSRO developed by global headquarters; and in Argentina companies “negotiate” economic, environmental and legal dimensions of CSR with the government. Although companies “negotiate” philanthropic responsibilities with the communities, ethical responsibilities are defined by the headquarters and not negotiated locally. The analysis suggests that environmental duties are the critical element of CSR in the mining sector in Argentina. This study treats environment as a separate dimension of corporate responsibility defined as to do “what is safe for the environment”. (shrink)

It is now taken for granted in many circles that substantial psychological variability exists across human populations; we do not merely differ in the ways we behave, but in the ways we think, as well. Versions of this view have been around since early interest in ‘cultural relativism’ in cultural psychology and anthropology, but Joe Henrich, Steven Heine, and Ara Norenzayan’s 2010 paper, ‘The Weirdest People in the World?’ has had an exciting and catalyzing impact on the field, getting researchers (...) involved in discussions of human nature to take cross-cultural cognitive diversity seriously. Reviewing a broad selection of comparative studies from across the behavioral sciences, in social psychology, cognitive... (shrink)

The starting point for the considerations in the article is the statement of Keiko Yamanaka that the Japanese know nothing about resistance to the bacterium represented by another human being. In the article, however, we put forward the thesis that Japanese culture has developed a collective immune system resulting not from individual but from shared systemic immunology in connection with the performance of family, professional and social functions. The analysis of Japanese ‘cultural immunology’ includes an examination of the ways of (...) functioning of the body in contemporary Japanese culture. To this end, we first discuss the relationship between humans and nature in Japanese religious-ethical tradition. Next, we examine the Japanese relationship to the body as a special part of nature. Then we analyze the tension in the Japanese culture between individual and sociocultural bodies. In conclusion, we show what the sociocultural body is and how it functions in the system of ‘cultural immunology’ in contemporary Japan. (shrink)

Since the cognitive revolution, psychologists have developed formal theories of cognition by thinking about the mind as a computer. However, this metaphor is typically applied to individual minds. Humans rarely think alone; compared to other animals, humans are curiously dependent on stores of culturally transmitted skills and knowledge, and we are particularly good at collaborating with others. Rather than picturing the human mind as an isolated computer, we can imagine each mind as a node in a vast distributed system. Viewing (...) human cognition through the lens of distributed systems motivates new questions about how humans share computation, when it makes sense to do so, and how we can build institutions to facilitate collaboration. (shrink)

Cet article présente une approche quantitative appliquée à la concurrence suffixale dans la formation des adjectifs dénominaux en russe. Le but est, dans un premier temps, d’étudier les adjectifs de haute et basse fréquence et d’établir les propriétés phonologiques, morphologiques et sémantiques des noms de base qui déterminent le choix entre les suffixes -n- et -sk- dans les deux ensembles de données grâce à des méthodes statistiques. Dans un second temps, l’objectif est de mesurer à quel point la connaissance des (...) particularités des adjectifs de haute fréquence est applicable pour prédire le suffixe des adjectifs issus des basses fréquences. (shrink)

Business Ethics, the Environment & Responsibility, EarlyView.

Колективні емоційні стани раніше досліджували переважно як чинники соціальної аномії, тоді як соціальну норму асоціювали переважно з втіленням понять у соціальні норми. Цей підхід останні роки зазнає суттєвих коректив: українські та закордонні дослідники розглядають колективні емоційні стани як соціальну норму і постійну основу для досягнення стійкого раціонального консенсуса. Більше того, дослідники вже не стільки протиставляють емоції з інтелектом, скільки виявляють все більше взаємозв’язків і взаємозалежностей між ними. Це змінює уявлення про сутність легітимації та статус мотивації у перебігу соціальних процесів. Мотивація (...) постає не стільки як надто мінлива суб’єктивна психологічна характеристика, скільки як постійна колективна характеристика соціальних спільнот. Мотивація зумовлює соціальну ідентичність через постійне спрямування людей як членів соціальних спільнот до досягнення певних спільних бажаних цілей. Легітимація також постає як процес постійного визнання людьми одне одного під час встановлення спільно визнаних соціальних норм. У такому визнанні колективні емоції відіграють вирішальну роль. Біологічні основи емоційної поведінки людей не так редукують їхню поведінку до біологічних чинників, скільки емоції сприяють сублімації цих біологічних чинників до соціально прийнятних цілей. Емоційна основа утвердження національної ідентичності має свої негативні і свої позитивні сторони: якщо негативний вплив емоцій може викликати загострення радикального націоналізму, то позитивний вплив емоцій сприяє згуртуванню нації у ситуації екзистенційних викликів – таких як війна. Легітимація справедливої війни є одним із головних завдань спрямування колективних емоцій, зокрема праведного гніву, на мотивацію до соціальної мобілізації нації до спротиву збройній зовнішній агресії. (shrink)

The article is based on a synthetic comparative analysis of two different epistemic traditions and explores indigenous and scientific epistemic cultures throughclose reading and exploration of two books. The first book, Epistemic Cultures: How the Sciences Make Knowledge, written by Austrian sociologist Karin Knorr-Cetina (1999), serves as an excellent foundational material to represent scientific epistemic tradition. The second book by cultural and linguistic anthropologist Keith Basso (1996), Wisdom Sits in Places: Landscape and Language among the Western Apache, opens a wide (...) perspective for exploration indigenous epistemic culture. Both of the books deal with questions of knowledge production and social-cultural mechanisms that surround these processes. The article seeks to explain how the differences between methodological approaches, in their distinct questions, and the variance in research subjects eventuallyleads the authors to completely dissimilar understandings of such shared notions as ‘place’ and ‘knowledge.’ Through the comparative exploration of both texts, the present analysis uncovers the meanings of these notions as articulated and presented in each of the books. (shrink)

Classic of Russian philosophy Alexandr I. Vvedensky proposed a definition of metaphysics as a study of true reality contrary to apparent one. This definition seems to be useful in contemporary issues. It's an apt definition because it describes an ancient metaphysics as good as classical tradition and concerns all branches of the philosophical knowledge. A number of philosophical subjects are connected with the difference of true and apparent reality as their foundation. For instance, Philosophical Anthropology differentiates between real and formal (...) personal existence. Epistemology discusses a problem of a criterion of real existence and notes that any language does not contain such internal criterion. The Philosophy of science analyses a conventional reality created by people, and so does the Philosophy of art. Social and Political Philosophy due to understand a nature of special phenomena which have no substance but are real and objective. Finally, contemporary Philosophy of technology concentrates on the virtual reality as a special kind of existence. So, the problem of the distinction between true and apparent reality manifests itself in all philosophical disciplines, and this fact determines a major meaning of the metaphysics in the philosophy. (shrink)

Metazoan genomes contain thousands of protein‐coding and non‐coding RNA genes, most of which are differentially expressed, i.e., at different locations, at different times during development, or in response to environmental signals. Differential gene expression is achieved through complex regulatory networks that are controlled in part by two types of trans‐regulators: transcription factors (TFs) and microRNAs (miRNAs). TFs bind to cis‐regulatory DNA elements that are often located in or near their target genes, while miRNAs hybridize to cis‐regulatory RNA elements mostly located (...) in the 3′ untranslated region of their target mRNAs. Here, we describe how these trans‐regulators interact with each other in the context of gene regulatory networks to coordinate gene expression at the genome‐scale level, and discuss future challenges of integrating these networks with other types of functional networks. (shrink)