Segmentation of post-operative glioblastoma multiforme (GBM) is essential for the planning of Tumor Treating Fields (TTFields) treatment and other clinical applications. Recent methods developed for pre-operative GBM segmentation perform poorly on post-operative GBM MRI scans. In this paper we present a method for the segmentation of GBM in post-operative patients. Our method incorporates an ensemble of segmentation networks and the Kullback–Leibler divergence agreement score in the objective function to estimate the prediction label uncertainty and cope with noisy labels and inter-observer (...) variability. Moreover, our method integrates the surgery type and computes non-tumorous tissue delineation to automatically segment the tumor. We trained and validated our method on a dataset of 340 enhanced T1 MRI scans of patients that were treated with TTFields (270 scans for train and 70 scans for test). For validation, we developed a tool that uses the uncertainty map along with the segmentation result. Our tool allows visualization and fast editing of the tissues to improve the results dependent on user preference. Three physicians reviewed and graded our segmentation and editing tool on 12 different MRI scans. The validation set average (SD) Dice scores were 0.81 (0.11), 0.71 (0.24), 0.64 (0.25), and 0.68 (0.19) for whole-tumor, resection, necrotic-core, and enhancing-tissue, respectively. The physicians rated 72% of the segmented GBMs acceptable for treatment planning or better. Another 22% can be edited manually in a reasonable time to achieve a clinically acceptable result. According to these results, the proposed method for GBM segmentation can be integrated into TTFields treatment planning software in order to shorten the planning process. To conclude, we have extended a state-of-the-art pre-operative GBM segmentation method with surgery-type, anatomical information, and uncertainty visualization to facilitate a clinically viable segmentation of post-operative GBM for TTFields treatment planning. (shrink)

The present chapter examines the philosophical problem of how it is possible, metaphysically and practically speaking, to develop a good moral character when one adheres to the view that a persisting self does not exist. It extracts answers from two thinkers who reject the concept of enduring identity, the Indian philosopher Vasubandhu (4th to 5th centuries CE) and the Western philosopher Derek Parfit (1942–2017). The first section of the chapter outlines some of Vasubandhu’s and Parfit’s shared assumptions concerning the nature (...) of the self and that of personal identity. In section 2, the focus shifts to the distinct ways in which each philosopher advances his understanding of the moral agent. Section 3 suggests that besides formulating different accounts of selfless agency, the ways in which Vasubandhu and Parfit grappled with the problem of agency reveal different approaches to addressing the question of human nature, and consequently, different ways of resolving the difficulties involved in becoming a good person. These differences become apparent in two practices that are relevant to crafting a moral character and that the two thinkers treat, moral commitment and the cultivation of virtue, which are discussed in the final part of the chapter. (shrink)

Throughout the history of philosophy, ethics has often been a source of guidance on how to live a meaningful life. Accordingly, when the ethical foundations of mindfulness are considered, an important question arises concerning the role of meditation in providing meaning. The present article proposes a new theoretical route for understanding the links between mindfulness meditation and meaningfulness by employing the terminology of Susan Wolf’s contemporary philosophical account of a meaningful life. It opens by examining the question of what kinds (...) of life-meanings are made available by Buddhist doctrine, considering the two alternatives of a cosmic, human-independent meaning of life versus the subjective meanings that humans give to their individual lives. After surveying current psychological theories that aim to explain the correlation between mindfulness as a trait and meaning in life, all of which see mindfulness as a mediating factor in the production of meaning, I argue that Wolf’s framework offers a promising theoretical basis for clarifying the relationship between mindfulness and meaning in that it explains why mindfulness has a direct bearing on meaning in life. I then show that mindfulness meditation, as understood in Buddhism, can respond to some of the philosophical worries that arise from Wolf’s theory, specifically her concern with the standards for securing the objective value of meaningful activities and projects. My claim is that mindfulness meditation is representative of a broader class of activities that are non-subjectively valuable insofar as they are required for any exploration of objective meaning or standards of values, as well as for engagement in objectively valuable projects and activities. (shrink)

_NeuroAnalysis _investigates using the neural network and neural computation models to bridge the divide between psychology, psychoanalysis, and neuroscience when diagnosing mental health disorders and prescribing treatment. Avi Peled builds on Freud's early attempts to explain the neural basis of mental health by introducing neural computation as a bridging science to explain psychiatric disorders. Peled describes the brain as a complex system of interconnected units and goes on to suggest that conscious experience, feelings, and mood are emergent properties arising from (...) these complex organisations. This model describes mental health disorders in terms of perturbation to the optimal brain organisation, and demonstrates how particular disorders can be identified through a specific breakdown pattern of the brain’s organisation. This fresh approach to the diagnosis of psychiatric disorders will interest students, professors, and researchers of psychoanalysis, neuroscience, and their related fields. (shrink)

This book is the first devoted to modern biology's innovators and iconoclasts: men and women who challenged prevailing notions in their fields.

Is Buddhism’s attitude towards accepted forms of knowledge sceptical? Are Pyrrhonian scepticism and classical Buddhist scholasticism related in their respective applications and expressions of doubt? In what way and to what degree is Critical Buddhism an offshoot of modern scepticism? Questions such as these as well as related issues are explored in the present collection, which brings together examinations of systematic doubt in the traditions of Buddhism from a variety of perspectives. What results from the perceptive observations and profound analytical (...) insights of the seven essays is a rich and multi-faceted picture of two families of philosophical systems—scepticism and Buddhism—that seem both akin and at odds, both related and distant at the same time. (shrink)

Background: Nurses engaging in research are held to research ethics standards. Research aim: Examine experiences, behaviors, and perceptions of nurses in Israel regarding research ethics and explore possible related factors. Research design: An original investigator-designed self-administered questionnaire measured five variables: (a) ethics in research, (b) encountered research misconduct during the course of one’s studies, (c) the inclination to fabricate data, (d) the inclination to select or omit data, and (e) knowledge of research misconduct in the workplace. Additionally, demographic data were (...) collected. Participants and research context: The questionnaire was completed by 151 Israeli registered nurses. 10.2% hold a PhD, 34 % hold an MA, 42.2% hold a BA, and 13.6% with no academic degree. Ethical considerations: The study was approved by the University’s ethics committee; anonymity and consent of the respondents were respected. Findings: Registered nurses’ level of studies achieved was significantly associated with a lower inclination to fabricate data, with one exception—PhD nurses were more inclined to fabricate data than nurses with a Master’s degree. A trend was found in which a higher level of studies is associated with higher knowledge of research misconduct in the workplace. Discussion: Results indicate that nurses’ perceptions of research ethics change throughout their academic studies, indicating a positive influence of level of studies, research experience, and work experience on ethics perceptions. Nevertheless, PhD nurses showed a greater inclination to actually select, omit, or even fabricate data than MA nurses. This may be related to pressure to publish. Conclusion: PhD nursing programs should include ethics training. Academic faculty members should serve as role models regarding research integrity. Research ethics deserves further emphasis on all levels of nurse education in Israel, as well as in the nurses’ code of ethics and related documents. This may positively impact ethical research practices. (shrink)

Living with others is a key factor shaping our urban life. Their bodily presence scaffolds our social world and is involved in the way the built environment appears to us. In this article we highlight the influence of the embodied presence of other human beings on the constitution of a special type of urban architecture — the extraordinary architectural space. Our analysis, which lies at the intersection between architecture, phenomenology and cognitive science, suggests that being in the direct presence of (...) others constitutes this extraordinary architectural space in the sense that it transforms the built setting into a negotiated place and reveals for the subject some of its extraordinary properties. The architectural examples we discuss show that these intersubjective advantages are often embedded in and encouraged by the design of such built objects. (shrink)

The following discussion considers three aspects of the Sciences-versus-Humanities divide: the historical evolution of disciplines in the modern period through the beginning of the twenty-first century; the epistemology of the sciences versus that of the Humanities as defined and practiced in that same period; and the ways in which the two cultures interact with each other and with religion and faith today. It finds that while it may feel ancient and natural, the historical divide between what are called the Humanities (...) and the Sciences is really quite new and contingent; that no single “scientific” epistemology exists but rather many “epistemic virtues” replace each other over time, often overlapping between the Sciences and Humanities, and that, finally, as the Humanities/sciences divide increasingly weakens or becomes complicated, as is happening today, knowledge and faith are juxtaposed to a greater degree. (shrink)

This article presents a novel theory of noncombatant immunity that can serve as a practical guide for soldiers in the field. It improves on existing theories by justifying why and when an innocent...

This review, based on analysis of the abstracts of 271 academic publications, critically examines the development of girlhood studies within a specific sociocultural context – Israeli society. By examining one particular context the authors hope to contribute to the discourse on the worldwide evolution of girlhood studies. The following research questions were posed: How did the body of literature on Israeli girls develop over time? What is the distribution of disciplines and topics represented? Who are the girls at the focus (...) of the writing? What are the methodological and paradigmatic approaches adopted? The findings point to the tentative development of a girlhood studies perspective that began in the 1980s and expanded over time, revealing the spread and reclaiming of feminist theoretical tenets as embodied in the study of girls. The review both sheds light on the pace and the manner in which Western feminist ideas spread to a specific local arena, and identifies unique local influences impacting this process. (shrink)

Normative theorizing in language involves a reflective consideration on the role that language plays in the shaping and reshaping of social and political orders. This is a complex endeavor resulting from the complex nature of the politics of language, in which change is constant and often unpredictable, and in which there exist an irreducible tension between linguistic and moral difference, on the one hand, and a need for societal interdependence on the other hand. The theoretical, conceptual, and methodological challenges emanating (...) from these realities suggest the usefulness of an adaptive approach to the normative theorizing of the political life of language. (shrink)

The Abhidharmakośabhāṣya (Treasury of Metaphysics with Self-Commentary) is a pivotal treatise on early Buddhist thought composed around the fourth or fifth century by the Indian Buddhist philosopher Vasubandhu. This work elucidates the Buddha’s teachings as synthesized and interpreted by the early Buddhist Sarvāstivāda school (“the theory that all [factors] exist”), while recording the major doctrinal polemics that developed around them, primarily those points of contention with the Sautrāntika system of thought (“followers of the scriptures”). Employing the methodology and terminology of (...) the Buddhist Abhidharma system, the Abhidharmakośabhāṣya offers a detailed analysis of fundamental doctrines, such as early Buddhist theories of mind, cosmology, the workings of karman, meditative states and practices, and the metaphysics of the self. One of its unique features is the way it presents the opinions of a variety of Buddhist and Brahminical schools that were active in classical India in Vasubandhu’s time. The work contains nine chapters (the last of which is considered to have been appended to the first eight), which proceed from a description of the unawakened world via the path and practices that are conducive to awakening and ultimately to the final spiritual attainments which constitute the state of awakening. In its analysis of the unawakened situation, it thus covers the elements which make up the material and mental world of sentient beings, the wholesome and unwholesome mental states that arise in their minds, the structure of the cosmos, the metaphysics of action (karman) and the way it comes into being, and the nature of dispositional attitudes and dormant mental afflictions. In its treatment of the path and practices that lead to awakening, the treatise outlines the Sarvāstivāda understanding of the methods of removing defilements through the realization of the four noble truths and the stages of spiritual cultivation. With respect to the awakened state, the Abhidharmakośabhāṣya gives a detailed description of the different types of knowledge and meditational states attained by practitioners who reach the highest stages of the path. (shrink)

Classical presentations of the Buddhist path prescribe the cultivation of various good qualities that are necessary for spiritual progress, from mindfulness and loving-kindness to faith and wisdom. Examining the way in which such qualities are described and classified in early Buddhism—with special reference to their treatment in the Visuddhimagga by the fifth-century Buddhist thinker Buddhaghosa—the present article employs a comparative method in order to identify the Buddhist catalog of virtues. The first part sketches the characteristics of virtue as analyzed by (...) neo-Aristotelian theories. Relying on these accounts, the second part considers three lists from early Buddhism as possible catalogs of virtue: the components of ethical conduct, the 37 factors that contribute to awakening, and the wholesome or beautiful mental factors. I then raise the question of why the Buddhist tradition developed several classifications of virtue, whereas the Western tradition of virtue ethics used a single category. Appealing to the connection between the virtues and living well in the eudaimonistic version of virtue ethics, I propose that one of the reasons why Buddhism developed multiple lists of virtues is its pluralistic acceptance of different modalities of living well and associated practices, in MacIntyre’s sense of the term. These modalities and practices are not equal, but are ordered hierarchically. Accordingly, I conclude that Buddhist ethics ought to be seen as a pluralist-gradualist system rather than a universalist theory. (shrink)

'Daring, learned and humane... A revelatory restoration of wonder' Stephen Greenblatt. We no longer think, like the ancient Chinese did, that the world was hatched from an egg, or, like the Maori, that it came from the tearing-apart of a love embrace. The Greeks told of a tempestuous Hera and a cunning Zeus, but we now use genes and natural selection to explain fear and desire, and physics to demystify the workings of the universe. Science is an astounding achievement, but (...) are we really any wiser than the ancients? Has science revealed the secrets of fate and immortality? Has it provided protection from jealousy or love? There are those who believe that science has replaced faith, but must it also be a death knell for mythology? Evolutions brings to life the latest scientific thinking on the birth of the universe and the solar system, the journey from a single cell all the way to our human minds. Reawakening our sense of wonder and terror at the world around us and within us, Oren Harman uses modern science to create new and original mythologies. Here are the Earth and the Moon presenting a cosmological view of motherhood, a panicking Mitochondrion introducing sex and death to the world, the loneliness of consciousness emerging from the memory of an octopus, and the birth of language in evolution summoning humankind's struggle with truth. Science may not solve our existential puzzles, but like the age-old legends, its magical discoveries can help us continue the never-ending search. (shrink)

AimBased on the Theory of Reasoned Action, we examined whether attitudes of nurses from different ethnic groups, subjective norms, behavioral intentions, assessments of relationships and communication were associated with their perceptions of the quality of perinatal care provided to lesbian women.BackgroundNurses administer healthcare, provide pertinent information and consultation to lesbians from pregnancy planning through birth.IntroductionDuring the past few decades, worldwide, there has been a rise in lesbian-parenting. Despite the changes in Israeli society’s public and legal reality, intolerance and discrimination to (...) the homosexual population is still prevalent in Israel’s healthcare system.MethodsA cross-sectional study conducted between 12/2015-4/2016. Of the 270 nurses approached, 184 completed a self-report anonymous questionnaire.FindingsThis is an important and timely study reflecting nurses’ perceptions of the quality of perinatal care provided to lesbians. The study findings reflect that attitudes, subjective norms, behavioral intentions, assessments of relationships and communication of nurses from different ethnic groups are associated with their perceptions of the quality of perinatal care provided to the lesbians. The hierarchical regression analysis demonstrated that attitudes, subjective norms, behavioral intentions, assessments of relationships and communication of nurses contributed 56% to the variance of nurses’ perception of their own quality of perinatal care.DiscussionTRA conceptualization predicted the quality of care of nurses from different ethnic groups treating lesbians in a perinatal setting.ConclusionTRA provides a useful framework for understanding and predicting the motivational effect of health care personnel with the lesbian population, being at risk for stigmatization and receiving less quality perinatal care.Implications for nursing and heath policyOur findings revealed the importance of formulating a recognized policy in the field of LGBT medicine at the national level. Further training of nurses as to the lesbians’ unique health needs, might improve the nurses’ relationships and communication as well as the quality of perinatal nursing care. (shrink)

In his recent papers, entitled Intelligence without Representation and Intelligence without Reason, Brooks argues for mobile robots as the foundation of AI research. This article argues that even if we seek to investigate complete agents in real-world environments, robotics is neither necessary nor sufficient as a basis for AI research. The article proposes real-world software environments, such as operating systems or databases, as a complementary substrate for intelligent-agent research and considers the relative advantages of software environments as test beds for (...) AI. First, the cost, effort, and expertise necessary to develop and systematically experiment with software artifacts are relatively low. Second, software environments circumvent many thorny but peripheral research issues that are inescapable in physical environments. Brooks's mobile robots tug AI toward a bottom-up focus in which the mechanics of perception and mobility mingle inextricably with or even supersede core AI research. In contrast, the softbots (software robots) I advocate facilitate the study of classical AI problems in real-world (albeit, software) domains. For example, the UNIX softbot under development at the University of Washington has led us to investigate planning with incomplete information, interleaving planning and execution, and a host of related high-level issues. (shrink)

Innovations, such as symbolic artifacts, are a product of cognitive abilities but also of cultural context. Factors that may determine the emergence and retention of an innovation include the population's pre-existing cultural repertoire, exposure to relevant ways of thinking, and the invention's utility. Thus, we suggest that the production of symbolic artifacts is not guaranteed even in cognitively advanced societies.

“There is grandeur in this view of life, with its several powers, having been originally breathed into a few forms or into one; and that, whilst this planet has gone cycling on according to the fix...

It has come to my attention that a number of formulations in the section “Disciplinary Landscape: Cytology and Genetics” of my article “Method as a Function of Disciplinary Landscape: C.D. Darlington and the History of Cytology 1925–1950,” Journal of the History of Biology, 39, 2006, pp. 165–197, do not provide due credit to a source. While Franz Schrader, “Three Quarter Centuries of Cytology,” Science 107 : 155–159, is cited in the article, his reminiscences and analysis of the historical development of (...) cytology provided a helpful historiographical context, as well as specific insights, for my article and should have been more fully acknowledged. (shrink)

A famous portrait of Erasmus by Hans Holbein depicts the scholar with his hands resting on a volume identified as his ‘Herculean Labours’. Erasmus associated this adage with the effort expended and ingratitude encountered by the philologist, and made it central to his self-presentation. In this article, its origins are traced to Erasmus’s encounter with Aldus Manutius, the venetian printer-humanist who published his Adagia in 1508. The impact of Aldus on Erasmus is shown to be significant, affecting his entire ideology (...) of humanism, including its relationship to print and its religious purpose. This article challenges distinctions between the Italian and the Northern Renaissance that are unhelpful for understanding Erasmus’s development. In light of its findings, it also proposes a new interpretation of Holbein’s painting. (shrink)

The very juxtaposition of the terms “physical science” and “social sciences” in the same sentence is indicative of the definitive trend now present in both physical science and in the thinking of the physical scientist. The two fields of human interest represented by physical science and the social sciences have drawn closer together, have coalesced at least in those areas of implication deducible from the fields themselves and this conjunction is fraught with consequences important to both fields.

This article focuses on the pendulum-like change in the way people read and use text, which was triggered by the introduction of new reading and writing technologies in human history. The paper argues that textual features, which characterized the ancient pre-print writing culture, disappeared with the establishment of the modern-day print culture and has been “revived” in the digital post-modern era. This claim is based on the analysis of four cases which demonstrate this textual-pendulum swing: (1) The swing from concrete (...) iconic-graphic representation of letters and words in the ancient alphabet to abstract phonetic representation of text in modern eras, and from written abstract computer commands “back” to the concrete iconic representation in graphic user interfaces of the digital era; (2) The swing from scroll reading in the pre-print era to page or book reading in the print era and “back” to scroll reading in the digital era; (3) The swing from a low level of authorship in the pre-print era to a strong authorship perception in the print era, and “back” to a low degree of authorship in the digital era; (4) The swing from synchronic representation of text in both visual and audio formats during the pre-print era to a visual representation only in print, and “back” to a synchronic representation in many environments of the digital era. We suggest that the print culture, which is usually considered the natural and preferred textual environment, should be regarded as the exception. (shrink)

Contemporary realities of global population movement increasingly bring to the fore the challenge of quality and equitable health provision across language barriers. While this linguistic challenge is not unique to immigration contexts and is likewise shared by health systems responding to the needs of aboriginal peoples and other historical linguistic minorities, the expanding multilingual landscape of receiving societies renders this challenge even more critical, owing to limited or even non‐existing familiarity of modern and often monolingual health systems with the particular (...) needs of new linguistic minorities. The centrality of language to health beliefs, attitudes, practices, cultural scripts, and conceptual frameworks emphasizes its pivotal role in the healthcare process, and consequently in the adverse effects of treatment that is language‐insensitive and unaware. Such an attitude on the part of medical authorities risks considerable epistemic injustice in the form of a (mis)judgement of patients’ intelligence, credibility, and rationality based on the language that they speak and the manner in which they speak it, consequently impacting the quality and equity of care provided. This danger, I argue, may be effectively countered by fostering among the participants in the healthcare process a sense of epistemic humility through greater metalinguistic awareness. Outlining a range of operative steps that can be used to facilitate this. I argue that the reality of language barriers in the healthcare process, while not entirely eliminable, may nevertheless be successfully addressed, in order to mitigate the challenge of quality and equitable healthcare provision in multilingual societies. (shrink)

Psychotherapy is provided by professionals, trained, supervised and certified by other professionals, all the way back to Freud and similar founding fathers. Even though methods and styles vary, pa...

This article explores the relationship between the bodily presence of other humans in the lived urban world and the experience of everyday architecture. We suggest, from the perspectives of phenomenology and architecture, that being in the company of others changes the way the built environment appears to subjects, and that this enables us to perform simple daily tasks while still attending to the built environment. Our analysis shows that in mundane urban settings attending to the environment involves a unique attentional (...) mode, which does not rely on concentrating on, or appreciating the architectural objects, but rather on social attention and on the subject’s kinesthesis in relation to the built environment. (shrink)