A general conceptual framework for large-scale neocortical dynamics based on data from many laboratories is applied to a variety of experimental designs, spatial scales, and brain states. Partly distinct, but interacting local processes (e.g., neural networks) arise from functional segregation. Global processes arise from functional integration and can facilitate (top down) synchronous activity in remote cell groups that function simultaneously at several different spatial scales. Simultaneous local processes may help drive (bottom up) macroscopic global dynamics observed with electroencephalography (EEG) or (...) magnetoencephalography (MEG). A local/global dynamic theory that is consistent with EEG data and the proposed conceptual framework is outlined. This theory is neutral about properties of neural networks embedded in macroscopic fields, but its global component makes several qualitative and semiquantitative predictions about EEG measures of traveling and standing wave phenomena. A more general “metatheory” suggests what large-scale quantitative theories of neocortical dynamics may be like when more accurate treatment of local and nonlinear effects is achieved. The theory describes the dynamics of excitatory and inhibitory synaptic action fields. EEG and MEG provide large-scale estimates of modulation of these synaptic fields around background levels. Brain states are determined by neuromodulatory control parameters. Purely local states are dominated by local feedback gains and rise and decay times of postsynaptic potentials. Dominant local frequencies vary with brain region. Other states are purely global, with moderate to high coherence over large distances. Multiple global mode frequencies arise from a combination of delays in corticocortical axons and neocortical boundary conditions. Global frequencies are identical in all cortical regions, but most states involve dynamic interactions between local networks and the global system. EEG frequencies may involve a “matching” of local resonant frequencies with one or more of the many, closely spaced global frequencies. Key Words: binding problem; cell assemblies; coherence; EEG; limit cycles; neocortical dynamics; pacemakers; phase locking; spatial scale; standing waves; synchronization. Footnotes1 The relationship between the synaptic action fields proposed in the target article and cell assemblies is clarified with Figure R1 (p. 416) of the Response. (This figure was not available to Commentators. (shrink)

The authors argue that the time is ripe for national and corporate leaders to move consciously towards the development of global ethics. This papers presents a model of global ethics, a rationale for the development of global ethics, and the implications of the model for research and practice.

Some patients with damaged striate cortex have blindsight-the ability to discriminate unseen stimuli in their clinically blind visual field defects when forced-choice procedures are used. Blindsight implies a sharp dissociation between visual performance and visual awareness, but signal detection theory indicates that it might be indistinguishable from the behavior of normal subjects near the lower limit of conscious vision, where the dissociations could arise trivially from using different response criteria during clinical and forced-choice tests. We tested the latter possibility with (...) a hemianopic subject during yes-no and forced-choice detection of static and moving targets. His response criterion differed significantly between yes-no and forced-choice responding, and the difference was sufficient to produce a blindsight-like dissociation with bias-sensitive measures of performance. When measured independently of bias, his sensitivity to static targets was greater in the forced-choice than in the yes-no task (unlike normal control subjects), but his sensitivity to moving targets did not differ. Differences in response criterion could therefore account for dissociations between yes-no and forced-choice detection of motion, but not of static pattern. The results explain why patients with blindsight are apparently more often ''aware'' of moving stimuli than of static stimuli. However, they also imply that blindsight is unlike normal vision near threshold, and that pattern- and motion-detection in blindsight may depend on different sets of neural mechanisms during yes-no and forced-choice tests. (shrink)

Normal children learn tens of thousands of words, and do so quickly and efficiently, often in highly impoverished environments. In How Children Learn the Meanings of Words, I argue that word learning is the product of certain cognitive and linguistic abilities that include the ability to acquire concepts, an appreciation of syntactic cues to meaning, and a rich understanding of the mental states of other people. These capacities are powerful, early emerging, and to some extent uniquely human, but they are (...) not special to word learning. This proposal is an alternative to the view that word learning is the result of simple associative learning mechanisms, and it rejects as well the notion that children possess constraints, either innate or learned, that are specifically earmarked for word learning. This theory is extended to account for how children learn names for objects, substances, and abstract entities, pronouns and proper names, verbs, determiners, prepositions, and number words. Several related topics are also discussed, including naïve essentialism, children's understanding of representational art, the nature of numerical and spatial reasoning, and the role of words in the shaping of mental life. Key Words: cognitive development; concepts; meaning; semantics; social cognition; syntax; theory of mind; word learning. (shrink)

W. V. Quine was the most important naturalistic philosopher of the twentieth century and a major impetus for the recent resurgence of the view that empirical science is our best avenue to knowledge. His views, however, have not been well understood. Critics charge that Quine’s naturalized epistemology is circular and that it cannot be normative. Yet, such criticisms stem from a cluster of fundamental traditional assumptions regarding language, theory, and the knowing subject – the very presuppositions that Quine is at (...) pains to reject. Through investigation of Quine’s views regarding language, knowledge, and reality, the author offers a new interpretation of Quine’s naturalism. The naturalism/antinaturalism debate can be advanced only by acknowledging and critiquing the substantial theoretical commitments implicit in the traditional view. Gregory argues that the responses to the circularity and non-normativity objections do just that. His analysis further reveals that Quine’s departure from the tradition penetrates the conception of the knowing subject, and he thus offers a new and engaging defence of Quine’s naturalism. (shrink)

This article addresses the need to problematize “cases” in science and technology studies work, as a middle-range theory issue. The focus is not on any one case study per se, but on why case studies exist and endure in STS. Case studies are part of a specific problematization in the field. We therefore explore relations between motivation for the use of cases, their constitution, and ways they can be invoked to make particular kinds of arguments in STS. We set out (...) to examine the case as an object that links together research practices, intellectual debates, and programmatic concerns in our own work. Based on our experiences and on this reflection on the links between cases and questions in STS, we propose a number of casemaking strategies that shift and enrich the deployment of ethnographic cases as an epistemic tool in STS. (shrink)

In the first decade of the twenty-first century, biofuels were recognized as an important element in the overall strategy to reduce climate-forcing greenhouse gases, especially carbon dioxide. Yet scientific research to more fully realize the potential of agricultural crops for liquid transportation fuel requires the coordination of many separate projects housed in different disciplines. Studies predicting and documenting adverse social impacts of plant-based ethanol and biodiesel led to the inclusion of social science components within research teams seeking to develop biofuels. (...) A 2008 rise in global food prices became a centerpiece of this research, leading to a search for non-food crops that could serve as energy feedstocks. Although coordinated scientific research teams have made significant strides toward incorporating social dimensions and broader impacts into what was originally a purely biophysical research effort, a simplistic diagnosis of the tension between agricultural production for food use and agricultural production intended for energy production continues to prevail. Some of the hard questions in the global development of the agricultural sector have been obscured as a result. (shrink)

This review of ethical implications of the professionalisation of sport argues that conventional sports ethics, which in the spirit of amateurism emphasise concepts of fair play, are increasingly inappropriate in professional sport. The formalist position, that fair play requires playing within the rules, is explored as are notions of playing to the rules, gamesmanship and cheating. It is argued that ethical problems in elite sport increase as a result of external factors including the celebrity of sportspeople, a tarnished image of (...) some administrators, influences of external stakeholders , and the expectations of fans. Hence a worryingly negative picture of declining ethical standards in the face of internal and external pressures emerges, with little prospect of sports reforming from within, despite that appearing to be in a sport's best interests. (shrink)

How does personality influence the relationship between appraisals and emotions? Recent research suggests individual differences in appraisal structures: people may differ in an emotion's appraisal pattern. We explored individual differences in interest's appraisal structure, assessed as the within-person covariance of appraisals with interest. People viewed images of abstract visual art and provided ratings of interest and of interest's appraisals (novelty–complexity and coping potential) for each picture. A multilevel mixture model found two between-person classes that reflected distinct within-person appraisal styles. For (...) people in the larger class (68%), the novelty–complexity appraisal had a stronger effect on interest; for people in the smaller class (32%), the coping potential appraisal had a stronger effect. People in the larger class were significantly higher in appetitive traits related to novelty seeking (e.g., sensation seeking, openness to experience, and trait curiosity), suggesting that the appraisal classes have substantive meaning. We conclude by discussing the value of within-person mixture models for the study of personality and appraisal. (shrink)

Like Plato, Protagoras held that young children learn virtue from fine examples in poetry. Unlike Plato, Protagoras taught adults by correcting the diction of poets. In this paper I ask what his standard of correctness might be, and what benefit he intended his students to take from exercises in correction. If his standard of correctness is truth, then he may intend his students to learn by questioning the content of poems; that would be suggestive of Plato’s program in Republic III. (...) But his standard is more likely to be the accurate use of language; in that case he would intend his students to learn to express their thoughts clearly enough that their audience would understand what they were saying. That standard would be independent of the truth of what they are saying; and that would be a precursor to modern techniques by which we try to teach speaking and writing. Truth is not so easy to escape, however, and we shall see that Protagoras’ exercise must assume that the poet is trying to tell the truth. (shrink)

This paper considers traditional debates and position regarding time and the future in relation to Einstein's physics of space-time.

In lieu of an abstract, here is a brief excerpt of the content:The Myth of Renaissance Atheism and the French Tradition of Free Thought PAUL OSKAR KRISTELLER WITHIN THE VAST AND COMPLEX area of Renaissance philosophy, the thought of Pietro Pomponazzi and of the entire Italian school of Aristotelianism of which he is the best known representative has not yet been studied in all its aspects? Apart from a number of recent studies, mostly Italian or American, there is an (...) important body of French studies on the subject that are distinguished by their ample documentation and by a general and consistent tendency of interpretation and that have exercised a predominant influence in this field of research. The fountainhead of this French scholarship on Renaissance Aristotelianism is E. Renan's book on Averroes and Averroism, a remarkable achievement for its time, and a classical study still worth reading after more than a hundred years have passed since it was first published. 2 It is generally recognized that Renan's conclusions about Averroes himself and about the Latin Averroism of the thirteenth century have been superseded by the later studies of P. Mandonnet and others? It is less well known that, for the This paper was read many years ago at the New England Conference on the Renaissance at Brown University, and at the Universit~ de Fribourg. It was published as "El Mito del Ateismo Renacentista y la Tradici6n Francesa del Librepensamiento" in Notas y Estudios de Filoso]la, ed. Prof. Juan Adolfo Vazquez, IV, 13 (Tucums Argentina, 1953), pp. 1-14. The present version has been only slightly revised, and I hope to return to the subject on a later occasion. Among recent studies, I should like to mention G. Spini, Ricerca dei l.,ibertini (Rome, 1950) and D. C. Allen Doubt's Boundless Sea (Baltimore, 1964), who follow on the whole the view criticized in this paper, and L. Febvre, Le problhme del lincroyance au XVI ~ si~cle (Paris, 1947) and R. H. Popkin, "Skepticism and the Counter-Reformation in France," Archiv ]iir Re]ormationsgeschichte LI (1960), 58-88, who seem to concur with my view. See also a paper by Popkin~"Skepticism, Theology and the Scientific Method in the 17th century," in Problem8 in the Phdosophy o] Science, ed. I. Lakatos and A. Musgrave (Amsterdam: North Holland Publishing Co., 1968). 1See now B. Nardi, Saggi sull'Aristotelismo Padovano dal secolo XIV al XVI (Florence, 1958) and Studi su Pietro Pomponazzi (Florence, 1965); J. H. Randall, The School o] Padua and the Emergence o] Modern Science (Padua, 1961); P. Pomponazzi, De ]ato, de libero arbitrio et de praedestinatione, ed. R. Lemay (Lugano, 1957); Tractatus de immortalitate animae, ed. G. Morra (Bologna, 1954); Corsi inediLi dell'insegnamento padovano I, Super libello de substantia orbis et quaestiones quattuor, ed. A. Poppi (Padua, 1966); P. O. Kristeller, "A New Manuscript Source for Pomponazzi's Theory of the Soul from his Paduan Period," Revue Internationale de Philosophie, V: 2 (16, 1951), 144-157,and "Two Unpublished Questions on the Soul by Pietro Pomponazzi," Medievalia et Humanistica, IX (1955), 76-101,and X (1956), 151. See also: G. Di Napoli, L'immortalit~ dell'anima nel Rinascimento (Turin, 1963); E. GiN ~L,, 3 son, Autour de Pomponazzi, Archives d histoire doctrinale et litt~raire du Moyen Age, c,,,, LXIII (1961, pub. 1962), 163-279and Laffaire de limmortalit~ de ls ~ Venise au debut 9,, du XVI si~cle, in Umanesimo europeo e umanesimo veneziano, ed. V. Branca (Florence, 1963), 31-61. Relevant are also the unpublished Columbia dissertations by William F. Edwards (on Zabarella), Martin Pine (on Pomponazzi and his critics) and Edward Mahoney (on Agostino Nifo). Averro$s et l Averro~me (Paris, 1852). 8Siger de Brabant et l'averroisme latin au XIII ~ si$cle (2nd ed.; Paris, 1908-11); F. Van [233] 234 HISTORY OF PHILOSOPHY history of Italian Aristotelianism after the thirteenth century, this book by Renan has never been completely superseded, but still constitutes the general basis for a large part of the later literature on the subject. Recent studies have added numerous details, but have failed to correct numerous errors and misconceptions. The main thesis of Renan's book on which we shall focus our attention in this paper is the following: Paduan Averroism... (shrink)

This contribution offers a sense of the scope and transdisciplinary relevance of the philosophy of British mathematician and philosopher Alfred North Whitehead by providing an overview of the three main phases of his career. The contribution goes on to distinguish process thought from the substance thought which dominated modern philosophy, and to outline some of the ways in which Whitehead has influenced thought from across the full spectrum of academic disciplines.

Unobservable properties that are specific to individuals, such as their proper names, can only be known by people who are familiar with those individuals. Do young children utilize this “familiarity principle” when learning language? Experiment 1 tested whether forty-eight 2- to 4-year-old children were able to determine the referent of a proper name such as “Jessie” based on the knowledge that the speaker was familiar with one individual but unfamiliar with the other. Even 2-year-olds successfully identified Jessie as the individual (...) with whom the speaker was familiar. Experiment 2 examined whether children appreciate this principle at a general level, as do adults, or whether this knowledge may be specific to certain word-learning situations. To test this, forty-eight 3- to 5-year-old children were given the converse of the task in Experiment 1—they were asked to determine the individual with whom the speaker was familiar based on the speaker’s knowledge of an individual’s proper name. Only 5-year-olds reliably succeeded at this task, suggesting that a general understanding of the familiarity principle is a relatively late developmental accomplishment. (shrink)

Shaun Nichols (this issue) correctly points out that current theories of the development of mindreading say nothing about children's intuitions concerning indeterminist choice. That is, there are numerous theories of how children make sense of belief, desire, and action, but none that appeal to any notion of free will. Nichols suggests two alternatives for why this is the case. It could either be (a) an --outrageous oversight-- on the part of developmental psychologists or (b) a principled omission, reflecting a consensus (...) that the notion of indeterminist choice is absent from children's mindreading processes. Nichols charitably favors the sec- ond alternative. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Examining the Ethics of Human Subjects ResearchPaul S. Appelbaum (bio)The work of the Advisory Committee on Human Radiation Experiments confirms once again the value of combining empirical and normative approaches to problems in clinical and research ethics. The Committee, like its predecessor, the President’s Commission for the Study of Ethical Problems in Medicine and Biomedical and Behavioral Research, spent relatively modest sums of money gathering targeted data to inform (...) its deliberations. The results of the Committee’s research, which are discussed by Nancy Kass and Jeremy Sugarman in this issue of the Kennedy Institute of Ethics Journal, enhance our understanding of the current ethical status of human subjects research, helping to focus attention on areas of particular concern, and lay the basis for future research and policy development.My comments here focus on the two major empirical studies conducted by the Committee—the Research Proposal Review Project and the Subject Interview Study. I will underscore just a few of the primary findings from these studies, consider their limitations, and explore their implications. Readers interested in the details of the studies should consult the Committee’s Final Report (ACHRE 1995), on which I rely in part and which provides additional information on the methodology and findings of the studies.Research Proposal Review ProjectWhat can be learned from the Committee’s review of 125 federally-funded human research studies? In answering that question, one cannot ignore the irony inherent in the Committee’s decision to review documents related to institutional review board (IRB) consideration of the selected protocols. The single most frequent complaint about the current system for protecting human subjects is that IRBs focus almost exclusively on review of consent forms and other research documents, as if they bore some close relationship to what actually transpires between investigators and potential research subjects. Only a small number of studies examine the research consent process. Nevertheless, existing data strongly [End Page 283] suggest that subject recruitment often involves an extended process of courtship, during which the information contained in consent forms is only a small part of the information passed between investigators and subjects (Benson, Roth, and Winslade 1985; Lidz et al. 1984).Indeed, the second of the Committee’s studies—the Subject Interview Study, which is discussed below—appears to confirm these findings. In-depth interviews with 99 individuals who reported that they were former or current research subjects suggest that “[f]or many, the decision to participate seemed to have been made before the consent form was given to them, and they signed it almost as a formality” (ACHRE 1995 [GPO, p. 742; Oxford, p. 471]). 1 Why, then, did the Committee focus its attention on documents that in many cases seem to play only a tangential role in the consent process? As is the case with IRBs around the country, the answer appears to be that consent forms and related documents are the only easily available window on consent transactions. In addition, under the current system, consent forms constitute the part of the process that IRBs can influence most easily. Consequently, it suits almost everyone’s needs—except perhaps those of the research subjects—to pretend that they reflect what actually transpires in the recruitment process. To the Committee’s credit, it was well aware of this dilemma. Nonetheless, it struggled to wring valid lessons from these limited data in its Final Report.Perhaps the most interesting finding from the Research Proposal Review Project is just how poor so many consent forms are. Given the disproportionate emphasis that many IRBs place on the content of the forms, one would expect that investigators by now would have learned to design documents that meet objective standards of adequacy, such as those applied by the Committee. Indeed, except in the most unusual circumstances, doing so would virtually guarantee that the IRB will ask no further questions about subject recruitment procedures. Although the data justify the inference that many investigators do not yet understand which information is essential to communicate to potential subjects, nor have learned how to do so effectively, they also force us to a still more radical conclusion. If the IRBs were doing their jobs, the Committee... (shrink)

The possibilities of a realistic interpretation of quantum mechanics are investigated by means of a statistical analysis of experiments performed on the simplest type of quantum systems carrying spin or helicity. To this end, fundamental experiments, some new, for measuring polarization are reviewed and (re)analyzed. Theunsharp reality of spin is essential in the interpretation of some of these experiments and represents a natural motivation for recent generalizations of quantum mechanics to a theory incorporating effect-valued measures as unsharp observables and generalized (...) systems of imprimitivity. (shrink)

In their article Little, Jordens, and Sayers developed the notion of “discourse communities”—as groups of people who share an ideology and common “language”—with the support of seminal ideas from M.M. Bakhtin. Such communities provide benefits although they may also impose constraints. An ethical community would open to others’ discourse and be committed to critique. Those commitments may counter the limitations of discourse communities. Since their paper was published in 2003, the notion of “discourse communities” has been widely adopted and applied (...) in healthcare and beyond. Their ideas were influential in the founding of an ethics centre in Sydney and contributed to articulating the values which underpin this journal. This commentary notes that an ethical community is fragile in responding to current onslaughts on truth and meaning—potencies inherent in discourse communities. The essay takes Bakhtin’s ideas further to explore intrinsic forces at play in dialogue, language, and art. This leads to discussing the centrality of ethics in Bakhtin’s thought. For him, the essence of discourse is a dialogic exchange which comprises both art and ethics. It is art in that self and other are created in the exchange. It is ethical in that “I” am answerable to the other, as a phenomenological reality, in the moment of intersubjectivity. (shrink)

: With the advent of the Genetic Age comes a unique new set of problems and ethical decisions. There is a tendency to take the scientific developments presented by modern genetics at face value, as if the science itself were value-neutral and not influenced by cultural and religious images. One example of the fallout of the Genetic Age is the development of a "genetic self," the idea that our essential selfhood lies in our genes. It is important to understand the (...) assumptions of the Genetic Age, the development of genetic selfhood, and the broader cultural trends and assumptions that underlie modern genetic thinking. It is equally important, however, to shape a reaction to the concept of a genetic self. Judaism has long carried on a unique discussion about the nature of selfhood in different times and places and about the relation of the corporeal self to the essential self. Insights from Judaism therefore may help to craft a reaction to the modern genetic self that incorporates the best of modern genetics as well as the integrity of a more transcendent selfhood. (shrink)

The "genetic bomb" marks a turn in the history of humanity. The accident is a new form of warfare. It is replacing revolution and war. Sarajevo triggered the First World War. New York is what Sarajevo was. September 11th opened Pandora's box. The first war of globalization will be the global accident, the total accident, including the accident of science. And it is on the way. In 1968, Virilio abandoned his work in oblique architecture, believing that time had replaced space (...) as the most important point of reflection because of the dominance of speed. We were basically on the verge of converting space time into space speed... Speed facilitates the decoding of the human genome, and the possibility of another humanity: a humanity which is no longer extra-territorial, but extra-human. Crespuscular Dawn expands Virilio's vision of the implosion of physical time and space, onto the micro-level of bioengineering and biotechnology. In this cat-and-mouse dialogue between Sylvere Lotringer and Paul Virilio, Lotringer pushes Virilio to uncover the historical foundations of his biotech theories. Citing various medical experiments conducted during World War II, Lotringer asks whether biotechnology isn't the heir to eugenics and the "science for racial improvement" that the Nazis enthusiastically embraced. Will the endocolonizataion of the body come to replace the colonization of one's own population by the military? Both biographical and thematic, the book explores the development of Virilio's investigation of space and time that would ultimately lay the foundation for his theories on biotechnology and his startling declaration that after the colonization of space begins the colonization of the body. (shrink)

Inflected words in Finnish show a range of interdependent stem and suffix alternations which are conditioned by syllable structure and stress. In a penetrating study, Anttila (1997) shows how the statistical preferences among optional alternants of the Genitive Plural can be derived from free constraint ranking. I propose an analysis which covers the rest of the nominal morphology and spells out the phonological constraints that interact to produce the alternations, and show how it supports a stratal version of OT phonology.

Charles Peirce is often credited for being among the first, perhaps even the first, to develop a scientific metaphysics of indeterminism. After rejecting the received view that Peirce developed his views from Darwin and Maxwell, I argue that Peirce's view results from his synthesis of Immanuel Kant's critical philosophy and George Boole's contributions to formal logic. Specifically, I claim that Kant's conception of the laws of logic as the basis for his architectonic, when combined with Boole's view of probability, yields (...) Peirce's metaphysics of probabilistic laws. Indeterminism provides, therefore, an excellent illustration of how Peirce attempted to use logic to clarify metaphysical problems.Since everyone must have conceptions of things in general, it is most important that they should be carefully constructed. I shall enter into no criticism of the different methods of metaphysical research, but shall merely say that in the opinions of several great thinkers, the only successful mode yet lighted upon is that of adopting our logic as our metaphysics. (W1: 490, 1866)2. (shrink)