Several of the essays in this collection discuss the `binding problem', the problem of explaining in neurophysiological terms how it is that we see the various perceptual qualities of a physical object, such as its shape, colour, location and motion, as features of a single object. The perceived object seems to us a unitary thing, but its sensory properties are diverse and turn out to be processed in different areas of the brain. How then does the brain manage the (...) integration? Readers of the essays in this collection may find themselves suffering from an analogous binding problem about the study of consciousness, though this problem is conceptual rather than perceptual, and here the difficulty is to achieve the integration rather than to understand how an effortless integration is achieved. Consciousness is the ideal topic for inter-disciplinary investigation. It is a central concern of such diverse disciplines as neurophysiology, evolutionary biology, psychology, cognitive science, philosophy and theology, among others, yet none of these disciplines has come close to providing full answers to the central questions that consciousness raises. Inter-disciplinary investigation seems an obvious way forward, but it generates the conceptual binding problem that this collection displays. The standard of the essays is very high, but it is extraordinarily difficult to integrate their content into anything like a single picture. We are all apparently talking about the same phenomenon, the conscious awareness of the world that each of us enjoys first-hand, but it is quite unclear how to see the very different things we say about this phenomenon as part of a single picture, or even as parts of different but compatible pictures. Having raised the binding problem for the inter-disciplinary study of consciousness, I hasten to say that I will not attempt even a partial substantive solution here: that is left as an exercise for the readers of this book. (shrink)

Divergent evolution can explain how many proteins containing structurally similar domains, which perform a variety of related functions, have evolved from a relatively small number of modules or protein domains. However, it cannot explain how protein domains with similar, but distinguishable, functions and similar, but distinguishable, structures have evolved. Examples of this are the RNA‐binding proteins containing the RNA‐binding domain (RBD), and a newly established protein group, the cold‐shock domain (CSD) protein family. Both protein domains contain conserved RNP (...) motifs on similar single‐stranded nucleic acid‐binding surfaces. Apart from the RNP motifs, which have a similar function, the two families show little similarity in topology or amino acid sequence. This can be considered an interesting example of convergent evolution at the molecular level. Previously, a β‐sheet surface was found to interact with RNA in non‐homologous proteins from yeast, phage and man, revealing that this mode of RNA binding may be a widely recurring theme. (shrink)

Cognitive functions like perception, memory, language, or consciousness are based on highly parallel and distributed information processing by the brain. One of the major unresolved questions is how information can be integrated and how coherent representational states can be established in the distributed neuronal systems subserving these functions. It has been suggested that this so-called ''binding problem'' may be solved in the temporal domain. The hypothesis is that synchronization of neuronal discharges can serve for the integration of distributed neurons (...) into cell assemblies and that this process may underlie the selection of perceptually and behaviorally relevant information. As we intend to show here, this temporal binding hypothesis has implications for the search of the neural correlate of consciousness. We review experimental results, mainly obtained in the visual system, which support the notion of temporal binding. In particular, we discuss recent experiments on the neural mechanisms of binocular rivalry which suggest that appropriate synchronization among cortical neurons may be one of the necessary conditions for the buildup of perceptual states and awareness of sensory stimuli. (shrink)

A new formalism for predicate logic is introduced, with a non-standard method of binding variables, which allows a compositional formalization of certain anaphoric constructions, including donkey sentences and cross-sentential anaphora. A proof system in natural deduction format is provided, and the formalism is compared with other accounts of this type of anaphora, in particular Dynamic Predicate Logic.

When my grandfather, David Oppenheim, and my grandmother, Amalie Pollak, decided to marry, my grandfather's parents doubted the wisdom of their son's decision to marry a woman three years older than he was.

The reconciliation of theories of concepts based on prototypes, exemplars, and theory-like structures is a longstanding problem in cognitive science. In response to this problem, researchers have recently tended to adopt either hybrid theories that combine various kinds of representational structure, or eliminative theories that replace concepts with a more finely grained taxonomy of mental representations. In this paper, we describe an alternative approach involving a single class of mental representations called “semantic pointers.” Semantic pointers are symbol-like representations that result (...) from the compression and recursive binding of perceptual, lexical, and motor representations, effectively integrating traditional connectionist and symbolic approaches. We present a computational model using semantic pointers that replicates experimental data from categorization studies involving each prior paradigm. We argue that a framework involving semantic pointers can provide a unified account of conceptual phenomena, and we compare our framework to existing alternatives in accounting for the scope, content, recursive combination, and neural implementation of concepts. (shrink)

In Sovereignty across Generations, Ferrara attempts a dual feat. He demonstrates that political liberalism needs a nuanced doctrine of constituent power to be brought in line with traditional democratic concerns. At the same time, he argues that political liberalism is capable of making constituent power safe for democracy, in reining in its unruly and unbound character. By distinguishing between ‘the people’ and the electorate, Ferrara develops a transtemporal conception of the constituent subject, allowing moderate transformation but in effect binding (...) all future time-slices of the people. In my comment, I address two issues with this. First, I ask how such accounts deal with the fact of immigration. It is not clear whether a historically indexed constituent subject has the normative power to bind new citizens arriving with quite distinct historical baggage. A second question is whether Ferrara’s Rawlsian-Michelmanian take is different from, and superior to, the Habermasian account of constituent power, especially to Habermas’s constructive views on supranational constitution-making. Both questions address whether Ferrara’s historically indexed account is sufficiently open to future developments. (shrink)

This paper contains a discussion of how the concept of compositionality is to be extended from context invariant to context dependent meaning, and of how the compositionality of natural language might conflict with context dependence. Several new distinctions are needed, including a distinction between a weaker (e-) and a stronger (ec-) concept of compositionality for context dependent meaning. The relations between the various notions are investigated. A claim by Jerry Fodor that there is a general conflict between context dependence and (...) compositionality is considered. There is in fact a possible conflict betwee ec-compositionality and context dependence, but not of the kind Fodor suggests. It turns on the presence of so-called unarticulated constituents, in John Perry’s sense. Because of this phenomenon, on some semantic accounts there might be a variation in the meaning of a complex expression between contexts without any corresponding variation in any of the syntactic parts of that complex. The conflict can be resolved in several ways. One way is to make the unarticulated context dependence explicit only in the meta-language, which makes it into an unarticulated constituent account. A recent argument by Jason Stanley against such accounts is discussed. According to Stanley, certain readings of English sentences involving binding of contextual variables, are unavailable in these theories. After considering a reply to Stanley by François Recanati, I present an outline of a fully compositional theory, of the unarticulated constituent variety, which does deliver these readings. Concluding remarks on, inter alia, the semantics/pragmatics distinction. (shrink)

In Navigating Everyday Life, Peter Adams explores the moments when everyday experience seems to open up spaces beyond what we normally experience. Adams draws on two philosophical concepts: finitude, the things that bind a person to a situation, and transcendence, the things that lie beyond these boundaries.

ABSTRACT When patients refuse to receive medical treatment, the consequences of honouring their decisions can be tragic. This is no less true of patients who autonomously decide to refuse treatment. I distinguish three possible implications of these autonomous decisions. According to the Permissibility Claim, such a decision implies that it is permissible for the patient who has made the autonomous decision to forego medical treatment. According to the Anti‐Paternalism Claim, it follows that health‐care professionals are not morally permitted to treat (...) that patient. According to the Binding Claim it follows that these decisions are binding on health‐care professionals. My focus is the last claim. After arguing that it is importantly different from each of the first two claims, I give two arguments to show that it is false. One argument against the Binding Claim draws a comparison with cases in which patients autonomously choose perilous positive treatments. The other argument appeals to considered judgments about cases in which disincentives are used to deter patients from refusing sound treatments. (shrink)

A very rapid cellular event that follows chemotactic stimulation of leucocyte and cellular slime mould amoebae is a massive polymerization of G to F actin and its association with the cytoskeleton. In the cellular slime moulds this event occurs within 3–5 sec of cell surface binding of chemoattractants. It is correlated with rapid pseudopodium extension and may be a cell orientation mechanism. Curiously, before an amoebae moves away in the direction of its new pseudopodium it rounds up or “cringes” (...) for 10–20 sec, an event correlated with a massive actin depolymerization. Transduction of the chemotactic signal involves Ca2+ release from internal stores by inositol trisphosphate. (shrink)

Peter Ludlow presents the first book on the philosophy of generative linguistics, including both Chomsky's government and binding theory and his minimalist ...

Deamination of adenosine in RNA to form inosine has wide ranging consequences on RNA function including amino acid substitution to give proteins not encoded in the genome. What determines which adenosines in an mRNA are subject to this modification reaction? The answer lies in an understanding of the mechanism and substrate recognition properties of adenosine deaminases that act on RNA (ADARs). Our recent publication of X‐ray crystal structures of the human ADAR2 deaminase domain bound to RNA editing substrates shed considerable (...) light on how the catalytic domains of these enzymes bind RNA and promote adenosine deamination. Here we review in detail the deaminase domain‐RNA contact surfaces and present models of how full length ADARs, bearing double stranded RNA‐binding domains (dsRBDs) and deaminase domains, could process naturally occurring substrate RNAs. (shrink)

ABSTRACT:The UN Framework on Human Rights and Business comprises the State’s duty to protect human rights, the corporate responsibility to respect human rights, and the duty to remedy abuses. This paper focuses on the corporate responsibility to respect. It considers how to overcome obstacles, arising out of national and international law, to the development of a legally binding corporate duty to respect human rights. It is argued that the notion of human rights due diligence will lead to the creation (...) of binding legal duties and that principles of corporate and tort law can be adapted to this end. Furthermore, recent legal developments accept an “enlightened shareholder value” approach allowing corporate managers to consider human rights issues when making decisions. The responsibility to respect involves adaptation of shareholder based corporate governance towards a more stakeholder oriented approach and could lead to the development of a new, stakeholder based, corporate model. (shrink)

The paper examines important discrepancies between major figures influencing the intellectual development of biosemiotics. It takes its perspective from the work of Gregory Bateson. Unlike C. S. Peirce and J. von Uexküll, Bateson begins with a strong notion of interaction. His early writings were about reciprocity and social exchange, a common topic among anthropologists of the time, but Bateson’s approach was unique. He developed the notion of meta-patterns of exchange, and of the “abduction” of these metapatterns to a variety of (...) other phenomena, in both biology and in game theory. Later, Bateson’s concept of ecology of mind, the product of interactive phenomena, was modified by a non-purposive cybernetics. Biosemiotics has yet to adopt Bateson’s interactive stance, which is absent from Peirce’s approach to communication, of Uexküll’s functional cycles, and of Hoffmeyer’s discussion of the relation between culture and environment. Rather than pursuing notions of appropriate “subjectivity” through changed ethical response to ecological conditions (Hoffmeyer’s discussion of empathy), the paper discusses the advantages of an approach that continues to focus on conditions of paradox and pathology. Specifically, Bateson’s resolution of the relation between culture and environment arises from situations of blocked communication where ecological bonds become binds. (shrink)

This textbook offers the first unified treatment of wave propagation in electronic and electromagnetic systems and introduces readers to the essentials of the transfer matrix method, a powerful analytical tool that can be used to model and study an array of problems pertaining to wave propagation in electrons and photons. It is aimed at graduate and advanced undergraduate students in physics, materials science, electrical and computer engineering, and mathematics, and is ideal for researchers in photonic crystals, negative index materials, left-handed (...) materials, plasmonics, nonlinear effects, and optics. Peter Markos and Costas Soukoulis begin by establishing the analogy between wave propagation in electronic systems and electromagnetic media and then show how the transfer matrix can be easily applied to any type of wave propagation, such as electromagnetic, acoustic, and elastic waves. The transfer matrix approach of the tight-binding model allows readers to understand its implementation quickly and all the concepts of solid-state physics are clearly introduced. Markos and Soukoulis then build the discussion of such topics as random systems and localized and delocalized modes around the transfer matrix, bringing remarkable clarity to the subject. Total internal reflection, Brewster angles, evanescent waves, surface waves, and resonant tunneling in left-handed materials are introduced and treated in detail, as are important new developments like photonic crystals, negative index materials, and surface plasmons. Problem sets aid students working through the subject for the first time. (shrink)

It has consistently been shown that agents judge the intervals between their actions and outcomes as compressed in time, an effect named intentional binding. In the present work, we investigated whether this effect is result of prior bias volunteers have about the timing of the consequences of their actions, or if it is due to learning that occurs during the experimental session. Volunteers made temporal estimates of the interval between their action and target onset , or between two events (...) . Our results show that temporal estimates become shorter throughout each experimental block in both conditions. Moreover, we found that observers judged intervals between action and outcomes as shorter even in very early trials of each block. To quantify the decrease of temporal judgments in experimental blocks, exponential functions were fitted to participants’ temporal judgments. The fitted parameters suggest that observers had different prior biases as to intervals between events in which action was involved. These findings suggest that prior bias might play a more important role in this effect than calibration-type learning processes. (shrink)

Intermediate filament (IF) protein tetramers contain two DNA‐ and core‐histone‐binding motifs in rotational symmetry in one and the same structural entity. We propose that IF protein oligomers might displace histone octamers from nucleosomes in the process of transcription initiation and elongation, to deposit them transiently on their α‐helical coiled‐coil domains. We further propose that structurally related proteins of the karyoskeleton, constructed from an α‐helical domain capable of coiled‐coil formation and a basic DNA‐binding region adjacent to it, may be (...) similarly involved in nucleosome activation. These proteins would function as auxiliary factors that disrupt nucleosomal structure to permit transcription and other DNA‐dependent processes to proceed expiditiously. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:diacritics 35.1 (2005) 99-118MuseSearchJournalsThis JournalContents[Access article in PDF]Klossowski's AlternativePeter CanningThe sympathy that binds friends together into an extended family (a socius or community of allies), countering the impulse to tear each other apart, stops at the gate where the stranger is received with courtesy or turned away. Is it safe to let the other in, past the frontier of my territory, my extended Self? An ancient Greek proverb says (...) that "a friend is a second self"—which echoes the reversible sense of the word guest in ancient Indo-European languages (*hosti-pets-, "guest-master"), which continues into modern French hôte, "host" or "guest." This reciprocity actualizes the inclusive "or": one is guest or host in a reciprocal relation of hospitality. The friend is another self in that each becomes master of the other's house when received by the other as guest. Nor is the relation of hospitality limited to friendship; for according to an archaic tradition the Other, the "stranger sent from god" (as Homer says) is also to be received as guest-master of one's house.These are mythic and etymological conditions, probably idealized and in any case obsolete—what does the archaic institution of hospitality (supposing it was ever practiced in its ideal form) have to do with the crisis of social relation today?In what follows I propose an extended Klossowskian response to this question. But as a preliminary abbreviation let us turn the question around: is any social relation, today or any other day, even possible without passing through—or holding open—the moment of hospitality, of reception of the other, friend or stranger?When I let the other cross my threshold and penetrate the precinct of my home, my family, my own and proper extension of Self, when I give him my friendship and trust, it is then he becomes dangerous to me.1 Menelaus gave Paris his trust as an honored guest, whereupon his guest-friend abducted his wife, instigating the Trojan War.What is the psychic situation conditioned by receiving the other inside my Self? Taken literally, topologically, it is that the other as stranger becomes a part of me, inside me, that is, outside my control. What is inside and what is out, who is me and who is not-me? What and where is the psyche; what is its topology? Does it have an interior and exterior separated by a border between? "To see in the human soul a place [lieu, locus]—no longer to regard the human person otherwise than cohabited by the powers that can take possession of it: exterior powers, autonomous, those evoked by the Gospel—the ornate house that awaits the visit of demons and which, visited, is the parable [End Page 99] of the soul of each among us; this mental topology... the pathos itself [being] only a topos" [Monnoyer 35].Psyche and home are not only analogous or parabolic but the same situation, the same structure. Hospitality is a practice of that patho-logical identity, and a parable of psyche as locus of the Other.* * *Preliminary to entering further into this topic, it is necessary to raise another Klossowskian problem, of equal urgency (and intersecting that of hospitality): the place of perversion.Rather than take space to justify Klossowski's numerous equivocal apologias for the "singular case" of Sade (or Nietzsche),2 theorist of perversion, rhetorician, metteur en scène anxious to infect others with his unspeakable visions (demonic forms of perversion itself) and provoke them to institute the secret cult and practice of his theories—let us take up directly the matter of a definition: what is perversion? More to the point: what is its logic?Freud derives perversion from narcissism: to take one's own body as the object of the drive (or as object of desire), that is, as the object of eros and thanatos, self-love and self-destruction. But all drive passes by way of this loop from the body to itself—to the point that it becomes a question of how one is ever to get... (shrink)

This paper explores the mereology of structural universals, using the structural richness of a non-classical mereology without unique fusions. The paper focuses on a problem posed by David Lewis, who using the example of methane, and assuming classical mereology, argues against any purely mereological theory of structural universals. The problem is that being a methane molecule would have to contain being a hydrogen atom four times over, but mereology does not have the concept of the same part occurring several times. (...) This paper takes up the challenge by providing mereological analysis of three operations sufficient for a theory of structural universals: Reflexive binding, i.e. identifying two of the places of a universal; Existential binding, i.e. the language-independent correlate of an existential quantification; and Conjunction. (shrink)

This paper contains a discussion of how the concept of compositionality is to be extended from context invariant to context dependent meaning, and of how the compositionality of natural language might conflict with context dependence. Several new distinctions are needed, including a distinction between a weaker (e-) and a stronger (ec-) concept of compositionality for context dependent meaning. The relations between the various notions are investigated. A claim by Jerry Fodor that there is a general conflict between context dependence and (...) compositionality is considered. There is in fact a possible conflict betwee ec-compositionality and context dependence, but not of the kind Fodor suggests. It turns on the presence of so-called unarticulated constituents, in John Perry’s sense. Because of this phenomenon, on some semantic accounts there might be a variation in the meaning of a complex expression between contexts without any corresponding variation in any of the syntactic parts of that complex. The conflict can be resolved in several ways. One way is to make the unarticulated context dependence explicit only in the meta-language, which makes it into an unarticulated constituent account. A recent argument by Jason Stanley against such accounts is discussed. According to Stanley, certain readings of English sentences involving binding of contextual variables, are unavailable in these theories. After considering a reply to Stanley by François Recanati, I present an outline of a fully compositional theory, of the unarticulated constituent variety, which does deliver these readings. Concluding remarks on, inter alia, the semantics/pragmatics distinction. (shrink)

Frege uses Greek letters in two different ways in his Begriffsschrift. One way is the familiar use of bound variables, in conjunction with variable-binding operators, to mark and close argument-places. The other, which is quite unfamiliar, employs letters to mark places for operators to reach into, without thereby closing these places. Frege thereby invents a powerful and compact notation for functional operations which can be recommended even today. His regrettable double use of Greek letters obscured his invention, and this, (...) together with the fact that in the Grundgesetze he no longer has need of function-valued functions, explains why the device was overlooked and has not passed into general use. (shrink)

This article provides a Taoist reading of Camus’ posthumously published novel, The first man. With its focus on the early life of the central character, Jacques Cormery, The first man is a semi-autobiographical account of learning and transformation, but it is, like so many other stories of its kind, one sustained by complex tensions: between the comfort of the familiar and the promise of the new; between possibility and despair; between resistance and acceptance. A theme that binds some of the (...) key educational elements of the book together is love: Jacques’s love of his mother and his elementary school teacher and their love for him; love of learning; and love of ‘home’. A Taoist theoretical framework is helpful in understanding the nature of this love and its pedagogical significance. In particular, the book exemplifies the importance of the figure of the mother—both in the person of Jacques’s mother and more symbolically in the notion of ‘the Great Mother’. The article concludes with thoughts on the value of literature for educational inquiry. (shrink)

Oxygenated derivatives of cholesterol (oxysterols) are widely distributed in nature, being found in the blood and tissues of animals and man as well as in foodstuff. They exhibit many biological activities which are of potential physiological, pathological or pharmacological importance. Many oxysterols have been found to be potent inhibitors of cholesterol biosynthesis and one or more oxysterols may play a role as the physiologic feedback regulator of cholesterol synthesis. Oxysterols also inhibit cell replication and have cytotoxic properties effects which suggest (...) that these sterols may participate in the regulation of cell proliferation and may be potentially useful as therapeutic agents for cancer. Furthermore, there is considerable evidence that oxysterols may be involved in the pathogenesis of atherosclerosis. Although the mechanism of action of oxysterols in all these instances is not well understood, the existence of cytosolic and microsomal proteins which bind oxysterols with high affinity and specificity suggests that this group of compounds may represent a family of intracellular regulatory molecules. (shrink)

In the fifth century before the Christian era, the Chinese philosopher Mozi, appalled at the damage caused by war in his time, asked: "What is the way of universal love and mutual benefit?" He answered his own question: "It is to regard other people's countries as one's own." The ancient Greek iconoclast Diogenes, when asked what country he came from, is said to have replied: "I am a citizen of the world." In the late 20th century John Lennon sang that (...) it isn't hard to "Imagine there's no countries . . . Imagine all the people/Sharing all the world." Until recently, such thoughts have been the dreams of idealists, devoid of practical impact on the hard realities of a world of nation states. But now we are beginning to live in a global community. Almost all the nations of the world have reached a binding agreement about their greenhouse gas emissions. The global economy has given rise to the World Trade Organisation, the World Bank and the International Monetary Fund; institutions that take on, if imperfectly, some functions of global economic governance. An international criminal court is beginning its work. Changing ideas about military intervention for humanitarian purposes shows we are in the process of developing a global community prepared to accept its responsibility to protect the citizens of states that cannot or will not protect them from massacre or genocide. In ringing declarations and resolutions, most recently at the United Nations Millennium Summit, the world's leaders have recognised that relieving the plight of the world's poorest nations is a global responsibility - although their deeds are yet to match their words. (shrink)

To understand the intracellular mechanisms that control exocytosis it is necessary to have access to the cell interior. This is achieved by plasma membrane permeabilisation or by application of patch‐pipettes. These conditions permit control over the cytosol composition and also allow leakage of soluble factors that may have roles in the exocytotic mechanism. Different permeabilisation methods allow different extents of leakage and therefore provide complementary data. The exocytotic machinery itself remains intact and can be activated by providing Ca2+ and/or a (...) guanine nucleotide. In some cells there is evidence for the participation of two guanine nucleotide‐binding proteins (Gp and GE), as well as a Ca2+ ‐binding protein. In others Ca2+ is the only requirement. In a number of cell types, ATP is not required for the late steps in the secretory pathway. (shrink)

Protein–protein interactions are thought to be mediated by domains, which are autonomous folding units of proteins. Recently, a second type of interaction has been suggested, mediated by short segments termed linear motifs, which are related to recognition elements of intrinsically disordered regions. Here, we propose a third kind of protein–protein recognition mechanism, mediated by disordered regions longer than 20–30 residues. Bioinformatics predictions and well‐characterized examples, such as the kinase‐inhibitory domain of Cdk inhibitors and the Wiskott–Aldrich syndrome protein (WASP)‐homology domain 2 (...) of actin‐binding proteins, show that these disordered regions conform to the definition of domains rather than motifs, i.e., they represent functional, evolutionary, and structural units. Their functions are distinct from those of short motifs and ordered domains, and establish a third kind of interaction principle. With these points, we argue that these long disordered regions should be recognized as a distinct class of biologically functional protein domains. (shrink)

The process of protein folding in the cell is now known to depend on the action of other proteins. These proteins include molecular chaperones, Which interact non‐covalently with proteins as they fold and improve the final yields of active protein in the cell. The precise mechanism by which molecular chaperones act is obscure. Experiments reported recently(1) show that for one molecular chaperone (Cpn60, typified by the E. coli protein GroEL), the folding reaction is driven by cycles of binding and (...) release of the co‐chaperone Cpn10 (known as GroES in E. coli). These alternate with binding and release of the unfolded protein substrate. These cycles come about because of the opposite effects of Cpn10 and unfolded protein on the Cpn60 complex: the former stabilises the ADP‐bound state of Cpn60, whereas the latter stimulates ADP‐ATP exchange. This model proposes that the substrate protein goes through multiple cycles of binding and release, and is released into the cavity of the Cpn60 complex where it can undergo folding without interacting with other nearby folding intermediates. This is consistent with the ability of Cpn60 proteins to enhance folding by blocking pathways to aggregation. (shrink)

Disturbances of consciousness, including fluctuations in attention and awareness, are a common and clinically important symptom in dementia with Lewy bodies. In the present study we investigate potential mechanisms of such disturbances of consciousness in a clinicopathological study evaluating specific components of the cholinergic system. [3H]Epibatidine binding to the high-affinity nicotinic receptor in the temporal cortex differentiated DLB cases with and without DOC, being 62–66% higher in those with DOC. The were no differences between DLB patients with or without (...) DOC in 125I-labeled α-bungaratoxin binding to the low-affinity nicotinic receptor, [3H]pirenzepine binding to the muscarinic M1 receptor, or in choline acetyltransferase activity. These findings provide support for the hypothesis that cholinergic activity is an important neural correlate if consciousness and suggest a mechanism of DOC in DLB involving alterations in the nicotinic receptor, composed of predominantly α4 and β2 subunits. (shrink)

Consistent with Ruchkin and colleagues' proceduralist account, recent research on grouping and verbal-spatial binding in immediate memory shows continuity across short- and long-term retention, and activation of classes of information extending beyond those typically allowed in modular models. However, Ruchkin et al.'s account lacks well-specified mechanisms for the retention of serial order, binding, and the control of activation through attention.

Multisensory Environment and Sensory Deprivation in the Treatment of Reception Defects This article deals with two types of alternative therapy and treatment methods. They are considered to be used in media education, in the treatment of reception defects, such as abuse, narcosis, neurosis, frustration, fetishism and superimposition. Purpose of this article is to summarize and discuss not only these media reality reception defects, but also to object them in two ways - multisensory environment within special pedagogic treatment, sensory deprivation within (...) alternative psychiatric therapy. Methodology in this study is to consider them as using media in the way of organic reception and therefore included in media anthropology, education and ethics. Within media reality a system reception feedback is needed, therefore the method "anything goes" for this use is explained. The aim of this article is to bind alternative media based methods with the research of reception of the media reality and the outstanding media anthropological issues: therapy, education, ethics, philosophy, etc. The scientific aim not only of this study, but also of author's whole work is to sustain the whole - media anthropological view - by using partial methods for media reality analysis and proving its relevance in disputing other theories being enclosed within media discourse. Also the ethics - code of dealing with technological extensions of human competence - the media - is a part of the organic reception. As the conclusion a need of such kind of research, education and treatment is objected and the examples of author's effort are explained. There is strongly recommended to create and use other media anthropology based equipment: Hitchhiker's Guide to Media Reality, A Chronicle of Abused media, blogs, a textbook, etc. (shrink)

What is the point of art, and why does it matter to us human beings? The answer that I will give in this paper, following on from an earlier paper on the same subject, is that art matters because our being actively engaged with art, either in its production or in its appreciation, is part of what it is to live well. The focus in the paper will be on the dispositions—the virtues of art production and of art appreciation—that are (...) necessary for this kind of active engagement with art. To begin with, I will argue that these dispositions really are virtues and not mere skills. Then I will show how the virtues of art, and their exercise in artistic activity, interweave with the other kinds of virtue which are exercised in ethical and contemplative activity. And finally, I will argue that artistic activity affords, in a special way, a certain kind of emotional sharing that binds us together with other human beings. (shrink)

Serpins are members of a family of structurally related protein inhibitors of serine proteinases, with molecular masses between 40 and 100kDa. In contrast to other, simpler, proteinase inhibitors, they may interact with proteinases as inhibitors, as substrates, or as both. They undergo conformational interconversions upon complex formation with proteinase, upon binding of some members to heparin, upon proteolytic cleavage at the reactive center, and under mild denaturing conditions. These conformational changes appear to be critical in determining the properties of (...) the serpin. The structures and stabilities of these various forms may differ significantly. Although the detailed structural changes required for inhibition of proteinase have yet to be worked out, it is clear that the serpin does undergo a major conformational change. This is in contrast to other, simpler, families of protein inhibitors of serine proteinases, which bind in a substrate‐like or product‐like manner. Proteolytic cleavage of the serpin can result in a much more stable protein with new biological properties such as chemo‐attractant behaviour. These structural transformations in serpins provide opportunities for regulation of the activity and properties of the inhibitor and are likely be important in vivo, where serpins are involved in blood coagulation, fibrinolysis, complement activation and inflammation. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:BOOK REVIEWS 841 message may seem, however clearly at odds with the Weltgeist. What Professor Mitchell's position calls for-to the delight I am sure, of Fr. Copleston-is a universal, unified, sanctificatory, and legitimate teacher of the Christian message: a Church which is one, holy, Catholic, and Apostolic. NICHOLAS INGHAM, O.P. Providence College Providence, Rhode Island Morals as Founded on Natural Law. By STEPHEN THERON. European University Studies. New York: (...) Peter Lang, 1987. 218 pp. $32 (cloth). This is a hard book to read, though it need not be. The author assumes a knowledge of other writings that few (apart from himself) are likely to have, and his English is sometimes tortuous in the extreme. A little more polishing of the sentence structure and a little more explanation of references would have made the book immeasurably. more readable. There would still be flaws in it nevertheless, flaws that concern the content of the book and not its form. Theron's aim is to establish morality on an external authoritative law, namely the authoritative law of God. Towards achieving this he devotes the first chapter to criticizing R.M. Hare, since Hare has a theory of autonomy in morals, or a theory where the prescriptiveness of a law or moral norm is self· imposed and not derived from something outside the autonomously choosing individual. Theron's criticism of Hare, apart from the obscurity of several of the references (obscure, that is, unless one already knows Hare's work more or less inside out), rests on distortions or unsympathetic interpretations of what Hare says. To say that, for Hare, " all that is essential to good living is the extrinsic, fortuitous character of its being commended" (p. 31) is to misrepresent Hare's whole point about the mea,ning of good, for which the a.ct of commending is of the essence and cannot be something extrinsic. And to say that, apart from what can be derived from logic, the rest of Hare's theory is "all a matter of who commends the loudest" (ibid..) is so gross a distortion that one can only wonder if Theron has paid any attention at all to what Hare has written about the nature of moral reasoning. As for Theron's own theory, he says that morality is grounded on a divine legislative authority to which, like children with respect to parents, we just ' find ' ourselves bound. But how are we bcmnd, or BOOK REVIEWS what persuades us that we should submit and obey this authority? Theron denies the applicability of this question, since he says that to seek a ground for this authority is to fall into an infinite regress. Yes indeed if authority can only be grounded by appeal to some other authority. But why should this be so? Because 0£ the nature of reason, says Theron, or how do we justify our acceptance 0£ and obedience to reason? Reason itself cannot do this. "... reason only has the authority of law and even truth if God gives it that authority," and "as one cannot appeal to reason to invalidate reason one cannot appeal to it to validate it" (p. 161). For Theron, what is :first for us. is not reason but divine authority, which is just somehow an ineradicable given. This would make morals, to say nothing of philosophy simply, dependent on divine law, not, as his title declares, on natural law. That title is indeed misleading since it is clear that, in Theron's eyes, natural law, or the law of our natural reason, is derivative and secondary, dependent for its lawfulness on the prior recognition of divine law. But all this must be false. Our recognition of divine law and of its binding force presupposes the validity of the workings of our own reason, for only by reason can we have this recognition. But if we could only admit the validity of our own reason after we have recognized the divine and reason's dependence on it, then we really are caught in an infinite regress, for this recognition would itself have to presuppose the prior validity of reason. And so on and so on. What is first for... (shrink)

For Kant and his followers, pure reason can be practical, and its substantive practical command is, broadly speaking, that we treat ourselves and others as worthy of respect as free and equal. If those who have defended the Kantian morality system are correct, this moral imperative will not be authoritative and inescapable simply because we don't know how to coherently reweave our practical commitments so as to leave it out, but because it is presupposed by the possibility of practical reason. (...) On this model, the rational authority of moral dictates would be understood as absolute and universal. ;But what if Kant and his followers have been wrong? What if the search for practical unconditionality turned out to be vain? Kant himself would most likely react to this news by pronouncing that, without a priori necessity, there could be no moral necessity, and without moral necessity, there could be no purity of motive, and without purity of motive, there could be no moral worth, and without moral worth, there could be no legitimate ascriptions of praise and blame. In short, for Kant and his orthodox followers, without unconditionality, the morality system would collapse. ;I will argue that the search for a priori necessity behind moral law is indeed hopeless, but that this does not entail the collapse of the morality system. It does however force us to conceive a new way of accounting for practical normativity in the absence of unconditionality. It also requires that, in order to preserve morality, we find a defensible place for it as a contingent subset of ethics broadly construed. My answer is to provide a new account of morality, and practical normativity in general, against the backdrop of neopragmatism. My hope is to provide an alternative story which preserves the Kantian insight that practical necessity is driven by rational authority, but which does not presuppose unconditionality to explain the latter's force and inescapability. In short I will attempt to show that ethical principles, when considered in linguistic space, need not be a priori necessary to bind individuals in a genuinely authoritative sense. (shrink)

A detailed analysis of joint-contribution of premises and conclusions in classically valid sequents is presented in terms of hypergraphs. In (Saint-Germier, P., Verdée, P., & Villalonga, P. T. (2024). _Relevant entailment and logical ground. Philosophical Studies_ (pp. 1–43). https://doi.org/10.1007/s11098-024-02101-1 ), this idea of joint-contribution is introduced and motivated as a method for characterizing four kinds of relevant validity, in the sense of selecting the relevantly valid sequents among the classically valid sequents. The account in (Saint-Germier, P., Verdée, P., & Villalonga, (...) P. T. (2024). _Relevant entailment and logical ground. Philosophical Studies_ (pp. 1–43). https://doi.org/10.1007/s11098-024-02101-1 ) is built on a calculus, called \(\textsf{GLK}^{\hbox {a}}\), which proves grounding claims for (enthymematically) valid sequents. In the present paper an adequate representation of \(\textsf{GLK}^{\hbox {a}}\) is given in terms of hypergraphs. The hypergraphs are a kind of diagrammatic proofs for Classical Propositional Logic, entirely based on the grounds of premises and conclusions. The hypergraphs and their visualization provide insights into the relations between premises and conclusions and into the way validity is produced by the binding of premises and conclusions via their partial grounds. They visualize the network of elements of the sequent that contribute to its logical validity. Non-contributing (i.e. irrelevant) premises and conclusions are then specified to be those that are disconnected from the network, however one constructs the graphs. (shrink)

This book explores this crucial phenomenon thereby introducing urgent questions of human interaction, the binding and breaking of time and space, and the entanglement of the material and the immaterial.