T‐bet and Eomes are two related transcription factors (TFs) that regulate the differentiation of cytotoxic lymphocytes such as Natural Killer (NK) cells and CD8 T cells. Recent genome‐wide analyses suggest they have complementary roles in instructing the transcriptional program of NK cells, although their DNA binding sites appear to be very similar. In this essay, we discuss the mechanisms that could specify their action, addressing their expression profile, the cofactors they interact with, as well as their roles in the epigenetic (...) regulation of chromatin accessibility. Based on the recent literature on these TFs, we propose different models to describe how they regulate gene expression in NK cells at steady state, or in the context of activation or exhaustion. We also discuss recent findings in the field of CD8 T cell differentiation and residency, where Eomes and T‐bet appear to be major regulators, and the parallels that can be drawn between mechanisms of NK and CD8 T cell differentiation and trafficking. (shrink)

Bart Pattyn: Needless to say, we are more than pleased with the willingness of Michael Walzer to be here in Leuven. After the stimulating lecture yesterday we now have the opportunity to pose some questions to Michael Walzer in the same room where we talked with his friend, Harry Frankfurt, as well as with Bernard Williams. I have asked Professor Selling to moderate this discussion which I am sure he will do with a firm hand.Joseph Selling: We have (...) two papers which Prof. Walzer, and many of you, have read in advance. Perhaps we can take the questions from the authors of those papers and then take other questions. (shrink)

Formal topology aims at developing general topology in intuitionistic and predicative mathematics. Many classical results of general topology have been already brought into the realm of constructive mathematics by using formal topology and also new light on basic topological notions was gained with this approach which allows distinction which are not expressible in classical topology. Here we give a systematic exposition of one of the main tools in formal topology: inductive generation. In fact, many formal topologies can be presented in (...) a predicative way by an inductive generation and thus their properties can be proved inductively. We show however that some natural complete Heyting algebra cannot be inductively defined. (shrink)

Philosophers, political theorists, and all readers seriously interested in the possibility of a moral life will find sustenance and inspiration in this book.

Nous entendons relever un défilancé par Erwin Panofsky, en montrant que la genèse d’une conception moderne et créatrice de l’art passe aussi par le platonisme et sa translatio renaissante. Cette réélaboration se paye cependant d’un prix métaphysique lourd : l’oblitération du noûs dans la hiérarchie des êtres et la dégradation de la noétique néoplatonicienne en une psychique de l’idea. Nous étudions ici comment l’âme, dans la Theologia platonica de Marsile Ficin, assume les trois grands prédicats traditionnellement attachés au noûs : (...) vie, être et intelligence ; et comment, surtout, sur cette base métaphysique, a pu émerger une théorie créatrice de l’idea, libérée de la tutelle de l’intellect – théorie qui met en œuvre une relation de la noétique à la poétique inversée par rapport au célèbre schéma aristotélicien de Métaphysique Thèta, 7, et qui initie ce que l’on pourrait appeler « noétique démiurgique ». (shrink)

Pauchant's book emerges from a forum on International Management, Ethics, and Spirituality, the first of its kind to be held at an internationally recognized business school, and represents the thinking of six CEOs and six scholars of ethics and spirituality from Australia, Canada, the United States, and Switzerland.

BLWith new text and full apparatus criticusThe Eudemian Ethics was one of two ethical treatises which Aristotle wrote on the subject of ethica or `matters to do with character'. Although the two works cover much the same ground, the Nicomachean Ethics is better known; the poor manuscript tradition of the Eudemian Ethics has made correct translation and interpretation of the text extremely difficult. The subject of the work is the choice of a certain means of conduct, made by a `man (...) of practical wisdom', between two extremes of behaviour: asceticism and yielding to uncontrolled impulses. Aristotle also stresses the notion of moral intention and the importance of virtue of character. This new Oxford Classical Text of the Eudemian Ethics is the result of many years of work. After Sir David Ross's death, his original text was substantially reworked and revised by his friend and colleague R. R. Walzer, who was aided in the revision by his former pupil Mrs Jean Mingay, who continued his work after his death in 1974. Mrs Mingay was fortunate in being able to make use of previously unpublished contributions from D. J. Allan after his death in the late seventies, and more recently has been helped in her work by the suggestions of Professor D. A. Russell, David Robinson, and Christopher Rowe. (shrink)

Valorising the biocultural heritage of common goods could enable peasant farmers to achieve socially and economically inclusive sustainability. Increasingly appreciated by consumers, peasant heritage products offer small farmers promising opportunities for economic, social and territorial development. Identifying the obstacles and levers of this complex, multi-scale and multi-stakeholder objective requires an integrative framework. We applied the panarchy conceptual framework to two cases of participatory research with small quinoa producers: a local fair in Chile and quinoa export production in Bolivia. In both (...) cases, the “commoning” process was crucial both to bring stakeholders together inside their communities and to gain outside recognition for their production and thus achieve social and economic inclusion. Despite the differences in scale, the local fair and the export market shared a similar marketing strategy based on short value chains promoting quality products with high identity value. In these dynamics of biocultural heritage valorisation, the panarchical approach revealed the central place as well as the vulnerability of the community territory. As a place of both anchoring and opening, the community territory is the privileged space where autonomous and consensual control over the governance of common biocultural resources can be exercised. (shrink)

In times of social and moral crises, sport has often been called to boost individual moral development. By the same token, outdoor activities are viewed as good educational practices to enhance environmental responsibility. However, the present paper argues that these physical activities are currently following the same technological development trend as the mainstream society, and challenges this trend itself in terms of sustainability by critically asking this question: Do outdoor activities really enhance environmental responsibility? The research supporting this paper is (...) based on a qualitative inquiry using interviews with outdoor activities practitioners: mountain guides and white water sports instructors. The findings of this research show that environmental responsibility development depends on the sport contexts. It is fostered in slow and none-technological activities and lowered in fast and technological activities. The paper concludes with the following paradox reached by the preliminary research results: the birth of modern technology calls for greater need of environmental responsibility, but it may also prevent its development at the same time. (shrink)

BLWith new text and full apparatus criticus The Eudemian Ethics was one of two ethical treatises which Aristotle wrote on the subject of ethica or `matters to do with character'. Although the two works cover much the same ground, the Nicomachean Ethics is better known; the poor manuscript tradition of the Eudemian Ethics has made correct translation and interpretation of the text extremely difficult. The subject of the work is the choice of a certain means of conduct, made by a (...) `man of practical wisdom', between two extremes of behaviour: asceticism and yielding to uncontrolled impulses. Aristotle also stresses the notion of moral intention and the importance of virtue of character. This new Oxford Classical Text of the Eudemian Ethics is the result of many years of work. After Sir David Ross's death, his original text was substantially reworked and revised by his friend and colleague R. R. Walzer, who was aided in the revision by his former pupil Mrs Jean Mingay, who continued his work after his death in 1974. Mrs Mingay was fortunate in being able to make use of previously unpublished contributions from D. J. Allan after his death in the late seventies, and more recently has been helped in her work by the suggestions of Professor D. A. Russell, David Robinson, and Christopher Rowe. (shrink)

Résumé La « question de l’animal » est au cœur des débats contemporains sur la subjectivité moderne et sa déconstruction. En prenant pour point de départ les références de Jacques Derrida à la plaidoirie de Montaigne pour les animaux de l’« Apologie de Raimond Sebond », nous tentons de montrer les différences de fond qui opposent les projets des deux penseurs. Pour Derrida, l’animal se présente au sujet humain comme une figure de l’altérité radicale, interdisant toute tentative d’établir une continuité (...) homogène. Tout en mettant le rationaliste dogmatiste au défi de connaître les « ressorts internes » qui animent les animaux, Montaigne souligne aussi l’homogénéité des comportements animaux et humains et la parenté qui les unit, tous deux étant assujettis, quoique sous des modalités différentes, à une même nature. L’animal représente enfin, selon Montaigne, un modèle pour l’homme, celui d’une appropriation à soi et à sa condition corporelle. (shrink)

This article is about the concept of professional transition that is a specific moment in the careers that are no longer linear. We characterize professional transitions from the explanation of the activity in mobilizing a dual theoretical framework: the one of professional didactics and the other of communicative action (Habermas). Respondents subjects are nurses who become health health framework in care unit. The main results presented show that this transition has value for each test subject so that they dominate unusual (...) work situations, potential source of professional development. These professional situations demand new skills and the development of professional identity. (shrink)

Simone Weil (1909-1943) foi filósofa, escritora, ativista política e humanista. Nasceu em Paris, no seio de família judaica. Formou-se em filosofia pela Université de Sorbonne e se tornou a primeira mulher catedrática da França. Militou fervorosamente pela causa dos trabalhadores fabris e, posteriormente, lutou na Guerra Civil Espanhola. Faleceu aos trinta e quatro anos por motivos de saúde.[1] [1] Para mais informações, vide texto disponível em:. Acesso em: 25 de junho de 2019.

L’œuvre de Copernic est à la fois tournée vers l’avenir par le système héliocentrique du monde qu’elle inaugure, et vers le passé par sa fidélité au principe du mouvement réel circulaire et uniforme des astres, hérité de Ptolémée, et à la conception du monde fini ayant pour limite la sphère des fixes et hiérarchisé ayant pour centre le Soleil, héritée des Pythagoriciens. Dès lors, est-elle à bon droit nommée « révolution copernicienne » selon l’expression consacrée ou bien doit-elle être rigoureusement (...) pensée comme réforme de l’astronomie ptoléméenne? La question engage la remise en chantier du concept de révolution scientifique. Celle-ci est-elle, selon son concept kuhnien, un changement de paradigme pour un groupe scientifique dans un domaine de recherche – auquel cas l’œuvre de Copernic serait une révolution scientifique en substituant au paradigme géocentrique de l’astronomie son paradigme héliocentrique? Ou bien est-elle, selon Kant qui a élaboré le premier son concept, une transformation dans la façon de penser, qui instaure une science – auquel cas cette œuvre serait bien plutôt une réforme scientifique, l’astronomie étant une science déjà instaurée dans l’Antiquité? (shrink)

What kinds of political arrangements enable people from different national, racial, religious, or ethnic groups to live together in peace? In this book one of the most influential political theorists of our time discusses the politics of toleration. Michael Walzer examines five "regimes of toleration"—from multinational empires to immigrant societies—and describes the strengths and weaknesses of each regime, as well as the varying forms of toleration and exclusion each fosters. Walzer shows how power, class, and gender interact with (...) religion, race, and ethnicity in the different regimes and discusses how toleration works—and how it should work—in multicultural societies like the United States. Walzer offers an eloquent defense of toleration, group differences, and pluralism, moving quickly from theory to practical issues, concrete examples, and hard questions. His concluding argument is focused on the contemporary United States and represents an effort to join and advance the debates about "culture war," the "politics of difference," and the "disuniting of America." Although he takes a grim view of contemporary politics, he is optimistic about the possibility of coexistence: cultural pluralism and a common citizenship can go together, he suggests, in a strong and egalitarian democracy. (shrink)

Liang Shuming, considered to be the Last Confucian, was a Buddhist.

This paper revisits Fleeming Jenkin’s anonymous review of Charles Darwin’s _Origin of Species_, published in the _North British Review_ in June 1867. This review is usually revered for its impact on Darwin’s theory of descent with modification. Its classical interpretation states that Jenkin, a Professor of Engineering at the University of Edinburgh, made a compelling case against natural selection based on the fact of “blending inheritance” and the “swamping” of advantageous variations. Those themes, however, are strikingly absent from Jenkin’s text. (...) They were later read into Jenkin’s text by scholars trying to explain how Darwinian selection was reconciled with Mendelian genes and the birth of the Modern Synthesis. While many scholars have tried to measure Jenkin’s effect on Darwin, the value of the 1867 review remains unclear. This paper re-examines its content and concludes that Jenkin’s “able review” was in fact written by an engineer whose competencies in biology were very low. Focusing on the figure of the shipwrecked white sailor isolated on an island inhabited by Black people, this paper also underlines the racial assumptions behind Jenkin’s review. “Blending inheritance” is thus a theme linked to theoretical reworkings on the question of race and skin colors, taking its root in Galton’s typology of heredity. Darwin was probably mostly unimpressed by Jenkin’s review. The problems raised by the review were not so much “blending inheritance” and “swamping” but a conundrum of problems related to the effects of intercrossing on variation and reversion. (shrink)

While "natural history" is practically synonymous with the name of Buffon, the term itself has been otherwise overlooked by historians of science. This essay attempts to address this omission by investigating the meanings of "physique," "natural philosophy," and "history," among other terms, with the purpose of understanding Buffon's actual objectives. It also shows that Buffon never claimed to be a Newtonian and should not be considered as such; the goal is to provide a historical analysis that resituates Buffon's thought within (...) his own era. This is done, primarily, by eschewing the often-studied question of time in Buffon. Instead, this study examines the nontemporal meanings of the word "history" within the naturalist's theory and method. The title of his Natural History is examined both as an indicator of the kind of science that Buffon was hoping to achieve and as a source of great misinterpretation among his peers. Unlike Buffon, many of his contemporaries actually envisioned the study of nature from a Baconian perspective where history was restricted to the mere collection of facts and where philosophy, which was the implicit and ultimate goal of studying nature, was seen, at least for the present, as unrealizable. Buffon confronts this tendency insofar as his Histoire naturelle claims to be the real physique that, along with describing nature, also sought to identify general laws and provide clear insight into what true knowledge of nature is or should be. According to Buffon, history (both natural and civil) is not analogous to mathematics; it is a nonmathematical method whose scope encompasses both nature and society. This methodological stance gives rise to the "physicization" of certain moral concepts--a gesture that was interpreted by his contemporaries as Epicurean and atheist. In addition, Buffon reduces a number of metaphysically tainted historical concepts (e.g., antediluvian monuments) to objects of physical analysis, thereby confronting the very foundation of natural theology. In Buffon, as this essay makes clear, natural history is paving the way for a new physique (science of natural beings), independent from mathematics and from God, that treats naturalia in a philosophical and "historical" manner that is not necessarily "temporal. ". (shrink)

Cet ouvrage a pour enjeu de débattre du schéma théorique forgé par Alfred Schütz, promoteur de l'idée de sociologie phénoménologique (puisant son cadre analytique dans une lecture de la sociologie compréhensive weberienne, de la philosophie de la durée bergsonienne, et de la phénoménologie husserlienne). Les catégories princeps de la recherche sont dès lors celles de conscience, de temporalité et de signification. La structure phénoménologique de l'expérience sociale, l'essence de la compréhension intersubjective, les perspectives offertes par les tenants d'une sociologie formiste (...) en matière d'entendement de l'interaction, sont les thèmes majeurs de ce débat. Dans le cadre de cette lecture, Thierry Blin tente d'établir les principes d'une sociologie phénoménologique formiste ou structurale, permettant ainsi de fonder à nouveaux frais une sociologie de l'action. (shrink)

Presenting a series of historical portraits of Bantu, Thierry Secretan recounts his investigation into the compounds that housed the black labor of the gold mines of the Rand, around Johannesburg. The use of a « pass » to control the black miners prefigured the apartheid system. From 1904 to 1939,Alfred Martin Duggan-Cronin, an Irish guard at one of the compounds, began to photograph the different kind of people doing the hard labor in the mines. The results were some 7200 (...) exposures and working prints, on 13 /18 cm negatives. Hundreds of enlargements were exhibited from 1925 onward in a gallery in his own home in Kimberley. These photographs were rediscovered in 1998 by Thierry Secretan, who is still attempting to save them front slow destruction: they constitute an extraordinary catalogue of the Bantu cultures. (shrink)

. The effort in providing constructive and predicative meaning to non-constructive modes of reasoning has almost without exception been applied to theories with full classical logic [4]. In this paper we show how to combine unrestricted countable choice, induction on infinite well-founded trees and restricted classical logic in constructively given models. These models are sheaf models over a $\sigma$ -complete Boolean algebra, whose topologies are generated by finite or countable covering relations. By a judicious choice of the Boolean algebra we (...) can directly extract effective content from $\Pi_2^0$ -statements true in the model. All the arguments of the present paper can be formalised in Martin-Löf's constructive type theory with generalised inductive definitions. (shrink)

This classic work examines the issues surrounding military theory, war crimes, and the spoils of war from the Athenian attack on Melos to the My Lai massacre.

Jesuits in China adopted key Confucian terms to express Christian notions; for example, Tian 天 or Shangdi 上帝 was considered an equivalent for God, and guishen 鬼神 for angels. A Terms controversy started among the Jesuits and other missionaries and developed into the famous Rites Controversy. However, all the missionaries agreed in rejecting the Neo-Confucian concept of Taiji 太極, which was believed to be materialistic, pantheistic, or atheistic. The Flemish Jesuit François Noël, after a careful study of Neo-Confucian texts, interpreted (...) Taiji with the Western concept of nature, and even claimed that it held theistic meaning. We shall analyze and evaluate here this early Western attempt in giving a positive meaning to Taiji. (shrink)