Ataxia‐telangiectasia (A‐T) is a pleiotropic recessive disorder characterized cerebellar ataxia, immunodeficiency, specific developmental defects, profound predisposition to cancer and acute radiosensitivity. Functional inactivation of single gene product, ATM, accounts for this compound phenotype. We suggest that ATM acts as a sensor of reactive oxygen species and/or oxidative damage cellular macromolecules, including DNA. In turn, ATM induces signalling through multiple pathways, thereby coordinating acute phase stress responses with cell cycle checkpoint control and repair of oxidative damage. Absence of ATM is proposed (...) to limit the repair of insidious oxidative damage that can occur under normal physiological conditions, ultimately leading to apoptosis of particularly sensitive cells, such as neurons and thymocytes. (shrink)

ʻEdut be-Hosef -- Derekh ʻets ha-ḥayim -- Refuʼat ha-nefesh -- ha-Tapuaḥ.

I argue that there is an affective injustice in gendered and racialized oppression. To account for this, we must deny the opposition of affect and intentionality often assumed in the philosophy of emotion and the affective turn: while affect and intentionality are not opposed in principle, affective intentionality may be refused uptake in oppressive practices. In section 1, I read Merleau‐Ponty’s theory of the body schema as a theory of affect that accommodates my account of affective injustice and aligns with (...) accounts of affect transmission and circulation in feminist philosophies of the affective turn. This is crucial for understanding Fanon’s contribution to the theory of the body schema, in which it is susceptible to historical‐racial “affective disorders.” In sections 2–4, I distinguish three types of affective injustice: affective marginalization, exploitation, and violence. In section 2 I develop an intersectional feminist account of this distinction drawing on Lorde and Lugones and raise questions about the limits of framing the issue of affective injustice in terms of intentionality as opposed to a more psychoanalytic conceptual vocabulary that accommodates the displacement of affective force. In sections 3 and 4, I explore these affective injustices through an analysis of Fanonian concepts, showing how the theory of the body schema can accommodate not only affective intentionality but also the oppressive disjunction of affect and intentionality, as well as forms of affective injustice that exceed the oppressive disabling of sense‐making and involve the exploitative and violent displacement of affective force. (shrink)

kerekh 1. Ba-halakhah uve-agadah -- kerekh 2. [without special title].

Anger gaslighting is behavior that tends to make someone doubt herself about her anger. In this paper, I analyze the case of anger gaslighting, using it as a paradigm case to argue that gaslighting can be an affective injustice (not only an epistemic one). Drawing on Marilyn Frye, I introduce the concept of “uptake” as a tool for identifying anger gaslighting behavior (persistent, pervasive uptake refusal for apt anger). But I also demonstrate the larger significance of uptake in the study (...) of affective injustice: just as the concept of credibility names the epistemic behavior whereby we take someone seriously as an epistemic being, the concept of uptake names the uniquely affective cooperative behavior whereby we take someone seriously as an affective being. I answer Miranda Fricker’s epistemic notion of a prejudicial credibility economy with the affective notion of prejudicial uptake economies: uptake, like credibility, can be produced in a deficit for one social group relative to a surplus for another. Deviating from the parallels with Fricker, for whom the injustice of epistemic injustice is due to prejudice in the motives or character of individuals, as well as from accounts that ground it in aptness or affective goods, I suggest that the injustice of anger gaslighting behavior can be located at the structural scale of power relationships between social groups, in the tradition of Iris Marion Young. Anger gaslighting behavior counts as unjust wherever it (re)produces prejudicial uptake economies. Adapting sociological concepts of feeling rules and the emotion work they demand, I introduce the concepts of “uptake rules” and “uptake work” to further enable analysis of uptake economies as affective social structures, and to suggest a site for resistant or reparative affective agency. (shrink)

I begin by reviewing recent research by Merleau-Ponty scholars opposing aspects of the critique of Merleau-Ponty made by Meltzoff and colleagues based on their studies of neonate imitation. I conclude the need for reopening the case for infant self-other indistinction, starting with a re-examination of Merleau-Ponty’s notion of indistinction in the Sorbonne lectures, and attending especially to the role of affect and to the non-exclusivity of self-other distinction and indistinction. In undertaking that study, I discover the importance of understanding self-other (...) distinction and indistinction in terms of their affective significance. For Merleau-Ponty, self-other indistinction is a virtual or imaginary participation in others’ orientations that he defines as an affective phenomenon. Further, Merleau-Ponty’s account of the advent of the body proper—the aspect of the body image that circumscribes the body as a distinct and private space—theorizes it as an affective innovation. Rather than being a fact of which we at first are ignorant and gradually grow to recognize, distinction from others in the sense that is important to Merleau-Ponty is a situation that must be cultivated and maintained through the negotiation of affective intimacy. Understanding indistinction and distinction in terms of the affective forces that sustain them explains how it is possible for them to coexist. (shrink)

One of the narratives of anger as a pandemic emotion is not diagnostic, but celebratory: anger at racial injustice made a social and political breakthrough during the pandemic. What this breakthrough narrative celebrates is that people who had previously been moved only to alarmed scrutiny of the anger itself and the project of quelling it began instead, not merely to approve of this anger, but to to be oriented and instructed by it, permitting the anti-racist anger of others to sensitize (...) them to the insults and injuries that provoked it. The breakthrough narrative implies that anger is a moral sentiment that can be instructive, not only for the angry person herself, but also for others. This suggests a phenomenonological puzzle: under what description of affective intentionality and its interpersonal and social triangulation would the breakthrough be possible? I draw on Marilyn Frye’s account of anger uptake and Merleau-Ponty’s phenomenology of the body schema to give an account of the conditions of possibility for the breakthrough narrative. Along the way, I offer an account of uniquely affective hermeneutical injustices, the uniquely affective variety of power at stake in them, and the reparative gesture required to remedy them. (shrink)

What resources does Merleau-Ponty’s account of the body schema offer to the Fanonian one? First I show that Merleau-Ponty’s theory of the body schema is already a theory of affect: one that does not oppose affects to intentionality, positioning them not only as sense but as force, cultivating affective agencies rather than constituting static sense content. Then I argue that by foregrounding the role of affect in both thinkers, we can understand the way in which the historical-racial schema innovates, anticipating (...) and influencing feminist theories of the affective turn – especially Sara Ahmed’s theory of affective economies. The historical-racial schema posits the constitution of affective agencies on a sociogenic scale, and these affective economies in turn account for the possibility of the collapse of the body schema into a racial epidermal schema, a disjunction of affective intentionality Fanon calls “affective tetanization.” Quelles ressources l’analyse du schéma corporel faite par Merleau-Ponty fournit-elle au schéma historico-racial proposé par Fanon? En premier lieu, je vise à montrer que la théorie du schéma corporel de Merleau-Ponty est déjà une théorie de l’affect : une théorie qui n’oppose pas les affects à l’intentionnalité, qui ne les considère pas seulement comme un sens, mais comme une force, en cultivant des agentivités affectives plutôt qu’en constituant des contenus de sens statiques. Ensuite, j’affirmerai qu’en mettant en premier plan le rôle de l’affect chez ces deux penseurs, nous pouvons comprendre les innovations qu’apporte le schéma historico-racial, en anticipant et en influençant les théories féministes du tournant affectif – surtout la théorie de Sara Ahmed au sujet des économies affectives. Le schéma historico-racial établit la constitution d’agentivités affectives sur une échelle sociogénique, et ces économies affectives expliquent à leur tour la possibilité d’une dégradation du schéma corporel en schéma épidermique racial, une disjonction de l’intentionnalité affective que Fanon appelle « tétanisation affective ».Quali risorse può offrire la nozione merleau-pontiana di schema corporeo a quella di Fanon? In primo luogo, mi propongo di mostrare che la teoria dello schema corporeo elaborata da Merleau-Ponty è allo stesso tempo una teoria dell’affetto: una teoria che non oppone la dimensione degli affetti all’intenzionalità, poiché li considera non solo come senso ma come forze, in quanto implicano delle agentività affettive piuttosto che costituire meri contenuti statici di senso. Intendo quindi sostenere che mettendo in evidenza il ruolo dell’affetto in questi due autori sia possibile comprendere il portato innovativo dello schema storico-razziale, che anticipa e influenza le teorie femministe legate all’affective turn – e in particolare la teoria delle economie affettive elaborata da Sara Ahmed. Lo schema storico-razziale afferma la costituzione di agentività affettive a un livello sociogenetico, mentre le economie affettive rendono conto della possibilità del collasso dello schema corporeo in uno schema razziale epidermico, una disgiunzione dell’intenzionalità affettiva che Fanon definisce “tetanizzazione affettiva”. (shrink)

Prior research on engineering students’ understandings of ethics and social responsibility has produced mixed and sometimes conflicting results. Seeking greater clarity in this area of investigation, we conducted an exploratory, longitudinal study at four universities in the United States to better understand how engineering undergraduate students perceive ethics and social responsibility and how those perceptions change over time. Undergraduate engineering students at four U.S. universities were surveyed three times: during their 1st (Fall 2015), 5th (Fall 2017), and 8th semesters (Spring (...) 2019). The students who completed all three surveys (_n_ = 226) comprise the sample that was analyzed in this paper for changes in their scores on five instruments: Fundamentals of Engineering/Situational Judgment, Moral Disengagement, ABET Engineering Work and Practice Considerations, Macroethics, and Political and Social Involvement Scale. We found that students modestly increased their knowledge of ethics and ability to apply that knowledge in situations calling for them to exercise judgment. In addition, they consistently indicated that health and safety considerations in engineering were of highest importance. They also showed steady levels of social consciousness over time, in contrast to other studies which detected a culture of increasing disengagement in engineering students throughout the four years of their undergraduate studies. (shrink)

My aim in this paper is to introduce a theory of affective labor as byproductive, a concept I develop through analysis of the phenomenology of various affective labor practices in dialog with feminist scholarship, both on gendered and racialized labor, and on affect and emotion. I motivate my theory in the context of literature on affective and emotional labor in philosophy and the social sciences, engaging the post-Marxist literature on affective and immaterial labor and emphasizing feminist critiques. I argue that (...) affective labor is not only the work of producing affects for others to consume or the reproductive work that rejuvenates and sustains labor power and social life, but also the work of metabolizing waste affects and affective byproducts. Thus, byproductive labor is a neologism I develop to bring into view an affective economy and indeed a political economy of affects to the side of the distinction between productive and reproductive labor in its paid and unpaid variants. I make three central c... (shrink)

Theories of the liberal tradition have relied on independence as a norm of personhood. Feminist theorists such as Eva Kittay in Love's Labor have been instrumental in critiquing normative independence. I explore the role of corporeal vulnerability in Kittay's account of personhood, developing a comparison to the role it plays in Thomas Hobbes's Leviathan. Kittay's crucial contribution in Love's Labor is that once we acknowledge the facts of corporeal vulnerability, we must not only acknowledge but also affirm dependency in a (...) genuinely inclusive affirmation of personhood. While endorsing Kittay's “dependency critique,” I discover difficulties that beleaguer Kittay's development of new norms of personhood. I trace these to a dependency of Kittay's account on a crucial premise of the liberal model it resists. I argue that in order to affirm dependency in a manner that departs more thoroughly from the criticized aspects of liberal personhood, we must cease to position it in a dichotomy of power and vulnerability. I suggest that attending to the corporeality of vulnerability can aid us in developing the terms of a discourse affirming relational personhood while undermining that dichotomy. (shrink)

What goods are produced by affective labor? And at what cost—are there uniquely affective costs to this sort of production? If we assume that, like any variety of labor, affective labor has the potential for exploitation, we should ask what risks of exploitation are unique to it. Are these dangers of paid, commodified affective labor only? How should we understand the political economy organized around the production and circulation of affects and the racialization and gendering of affective labor?In this article, (...) I suggest that in order to understand the risks of exploitation indigenous to affective labor, we must consider the way in which the production of affects functions according to a logic of transmission... (shrink)

A new view of the functional role of the left anterior cortex in language use is proposed. The experimental record indicates that most human linguistic abilities are not localized in this region. In particular, most of syntax (long thought to be there) is not located in Broca's area and its vicinity (operculum, insula, and subjacent white matter). This cerebral region, implicated in Broca's aphasia, does have a role in syntactic processing, but a highly specific one: It is the neural home (...) to receptive mechanisms involved in the computation of the relation between transformationally moved phrasal constituents and their extraction sites (in line with the Trace-Deletion Hypothesis). It is also involved in the construction of higher parts of the syntactic tree in speech production. By contrast, basic combinatorial capacities necessary for language processing – for example, structure-building operations, lexical insertion – are not supported by the neural tissue of this cerebral region, nor is lexical or combinatorial semantics. The dense body of empirical evidence supporting this restrictive view comes mainly from several angles on lesion studies of syntax in agrammatic Broca's aphasia. Five empirical arguments are presented: experiments in sentence comprehension, cross-linguistic considerations (where aphasia findings from several language types are pooled and scrutinized comparatively), grammaticality and plausibility judgments, real-time processing of complex sentences, and rehabilitation. Also discussed are recent results from functional neuroimaging and from structured observations on speech production of Broca's aphasics. Syntactic abilities are nonetheless distinct from other cognitive skills and are represented entirely and exclusively in the left cerebral hemisphere. Although more widespread in the left hemisphere than previously thought, they are clearly distinct from other human combinatorial and intellectual abilities. The neurological record (based on functional imaging, split-brain and right-hemisphere-damaged patients, as well as patients suffering from a breakdown of mathematical skills) indicates that language is a distinct, modularly organized neurological entity. Combinatorial aspects of the language faculty reside in the human left cerebral hemisphere, but only the transformational component (or algorithms that implement it in use) is located in and around Broca's area. Key Words: agrammatism; aphasia; Broca's area; cerebral localization; dyscalculia; functional neuroanatomy; grammatical transformation; modularity; neuroimaging; syntax; trace deletion. (shrink)

Beyond Scandal will give you the resources to talk to your kinds about: Sex, Gossip, Lying, Politics, Scandal, Friendship, Values, Leadership, Dirty Jokes.

Determining Risk Factors and Demographic Patterns of Suicide in Tehran Suicide refers to the death of a person that is primarily achieved by self-harm. Today, it is considered one of the major public health issues. One of the important risk factors associated with attempted suicide is social relations. This study is a descriptive and analytical study that aims to identify the suicide rate, the risk factors in suicide, and the methods of suicide. The findings show that there is a significant (...) relationship between suicide and demographic variables that include age, sex, educational level, adherence to religion, and occupation. This research also shows the psychological factors that lead to suicide include depression, addiction, lack of social activities, and mental disorders caused by chronic disease. (shrink)

Informed by ABET accreditation criteria and broader societal needs, ethics has been emphasized as important for engineering professionals. Engineering students are thus exposed to professional ethics and related concerns throughout their college experiences both within and beyond the formal engineering curriculum, but little is known about what learning experiences and lessons engineering students view as most memorable and salient as they approach graduation. Therefore, this paper answers the following research questions: RQ1) What types of experiences do senior engineering students report (...) as salient learning experiences for their ethical and moral formation as they approach graduation? and RQ2) What do students learn from the most commonly discussed types of experiences? To address these questions, we conducted semi-structured interviews with senior engineering students and performed inductive thematic analysis on the resulting transcripts. Among various types of experiences that students reported as influencing their ethical and moral perspectives, this paper highlights work experiences, formal education, and family environment as the most frequently mentioned. Our results suggest that work experiences were especially significant for students’ learning of engineering ethics in a professional context, followed by academic experiences as a source of both professional/ethical and more general moral lessons. Many students also described family and friends as influential, especially as related to their general perceptions of morality. Based on these findings, a variety of educational implications are discussed. (shrink)

While Merleau-Ponty’sPhenomenology of Perceptionrelies on the descriptive register of the body proper, his Sorbonne lectures on child psychology investigate the genesis of the experience of a body as one’s own. I demonstrate the uniqueness of Merleau-Ponty’s account of the narcissistic affect and sociality involved in this developmental process, distinguishing his account vis-à-vis Wallon’s and Lacan’s studies of the mirror stage. I conclude that in Merleau-Ponty’s account, (1) the experience of the body proper is not singular, but encompasses a range of (...) phenomenological variation; and (2) the genesis of the body proper is not confined to the mirror stage. The production of bodily boundaries is an ongoing process identified not only with its advent in childhood, but also with adult emotional life. The boundaries between inner and outer domains of perception are not merely discovered, but must be negotiated and cultivated in the intercorporeal affective dramas of adult life. (shrink)

In this paper I argue that a Bio-Social conception of “race” is a socially salient conception within the United States. This conception is “socially salient” in the sense that is demonstrative of public understanding and public use of the race concept within context of the United States and its member institutions. This conception is “Bio-Social” in the sense that a set of biological and social properties form the necessary conditions for “race” and “racial group membership.” I explain that these biological (...) and social properties are the social interpretation of ancestral relations to geographically and culturally specified groups. (shrink)

Name der Zeitschrift: Naharaim Jahrgang: 10 Heft: 2 Seiten: 247-272.

Binz et al. highlight the potential of meta-learning to greatly enhance the flexibility of AI algorithms, as well as to approximate human behavior more accurately than traditional learning methods. We wish to emphasize a basic problem that lies underneath these two objectives, and in turn suggest another perspective of the required notion of “meta” in meta-learning: knowing what to learn.

This article aims to explain proportional equality and the way to comprehend the inequality of treatment found in Aristotle’s theory of justice. One of the ethical principles in a fair distribution of goods is equality, which is commonly understood as equality of treatment and outcomes. Surpassing this common understanding, if not in reverse, Aristotle offers proportional equality, in the sense that a fair distribution of goods must take into consideration balance or suitability between the goods distributed and the quality or (...) virtue of the recipients.This would mean that not everyone or only those who are worthy are entitled to obtain the goods being distributed. It seems that Aristotle’s theory of justice implies inequality of treatment according to excellence.In light of this, how should this unequal treatment be understood? Through qualitative analysis, this article suggests teleological reasoning, a model of thought that proceeds from the telos or goal and works backwards to Þ nd out the right means or suitable subjects to realize that end. The article, therefore, begins with the description of Aristotle’s theory of justice, proportional equality, and teleological reasoning. In the final section, I will consider the inequality of treatment by analyzing concrete cases of various subsidies provided by modernstates. The fnding shows that Aristotle’s theory of justice is significant in guaranteeing the realization of the goal of goods being distributed Key-words: justice, proportional equality, unequal treatment, subsidy, teleological reasoning, Aristotle Abstrak: Artikel ini bertujuan menjelaskan kesamaan proporsional dan cara memahami ketidaksamaan perlakuan yang muncul dalam teori keadilan Aristoteles. Salah satu prinsip etis pembagian barang yang adil adalah kesamaan, yang secara umum dipahami sebagai kesamaan perlakuan dan hasil. Berbeda dan bahkan melampaui pemahaman umum, Aristoteles menawarkan kesamaan proporsional, dalam arti bahwa pembagian barang yang adil harus mempertimbangkan keseimbangan atau kesesuaian antara barang yang dibagikan dengan kualitas atau keutamaan para penerima. Itu berarti, tidak semua orang atau hanya orang-orang yang dianggap layak berhak mendapatkan barang yang didistribusikan. Tampaknya, teori keadilan Aristoteles mengisyaratkan ketidaksamaan perlakuan atau membuat perbedaan berdasarkan keunggulan. Bagaimana kita memahami ketidaksamaan perlakuan ini? Lewat analisis kualitatif, artikel ini mengajukan pemikiran teleologis, sebuah model pemikiran yang bertolak dari tujuan dan bekerja ke belakang untuk menemukan sarana-sarana yang tepat atau subjek-subjek yang cocok untuk merealisasikan tujuan tersebut. Karena itu artikel akan dimulai dengan uraian tentang inti teori keadilan Aristoteles, kesamaan proporsional, dan pemikiran teleologis. Padabagian akhir, saya akan mempertimbangkan ketidaksamaan perlakuan dengan menganalisis kasus konkret berbagai model subsidi yang diberikan oleh negara-negara modern. Temuan menunjukkan bahwa teorikeadilan Aristoteles penting untuk menjamin terealisasinya tujuan barang-barang yang dibagikan. Kata-Kata Kunci: keadilan, kesamaan proporsional, ketidaksamaan perlakuan, pemikiran teleologis, subsidi, Aristoteles. (shrink)

This paper explores the Shanghai 2010 World Expo to show how spectacle serves a governing function of the Chinese developmental state. I introduce soil exegesis as a method to excavate sedimented power relations of spectacle, undergirding the expo’s presentation. This approach investigates how spectacle is a state-territorializing project and pedagogical venture that relies on and denies the state socialist-era’s waste, to produce a ‘new nature’ and perform socio-technical management of crisis and crowds. Dynamic rearrangement of soil quality and composition facilitated (...) the urban redevelopment zone of sustainable futures, while interactive-technocratic environments inserted visitor bodies into expo surveillance systems and infrastructure without reference to the embedded political ecology of the mass event within Shanghai and beyond. The article concludes by considering ethical legacies of the event and the ways ‘sustainable spectacle’ operates through waste administration and environmental performance that ‘greenwash’ the socialist past and obstruct other governing arrangements. (shrink)

Speeches and persuasion dominate Plato’s Crito. This paper, paying particular attention to the final passage in the dialogue, shows that the focus on speeches, persuasion and allusions to many other elements of rhetoric is an integral part of Plato’s severe criticism of democracy, one of the main points of the Crito. Speeches allow members of a democracy – represented in our dialogue by Crito – firstly to break the law for self-interested reasons while considering themselves still to be law-abiding citizens, (...) and secondly to feel that they are in a tolerant society preferring logos/persuasive speech above bia/compulsion. Socrates counters Crito’s speeches with speeches of his own, not only to defeat him at his own game, but also to make him aware how dangerous the game is. Real knowledge is preferable to speeches, but a democracy without speeches and rhetoric is doomed. (shrink)

Orientation affective, différence et « écrasante proximité » dans l’analyse merleau-pontyenne de la profondeur pureJe montre ici que la théorie de Merleau-Ponty sur l’expérience particulière d’une « profondeur pure » peut être comprise comme une orientation affective précédant l’orientation perceptive, et explique son rôle dans la proposition d’une « nouvelle conception de l’intentionnalité ». Le corps-monde comme relation de différenciation est repensé comme la différenciation intime et pré-objective de cette dimension affective. Je pense, contrairement à Toadvine (2009), que la position (...) de Merleau-Ponty dans la Phénoménologie de la perception, peut être distinguée de la conception sartrienne de l’intentionnalité comme annihilation. La dimension provocatrice de ma lecture sur la profondeur pure vis-à-vis des discours érudits sur Merleau-Ponty est discutée en conclusion, et je pose en particulier la question de savoir s’il peut être utile de lire Merleau-Ponty comme un penseur de la différence.Orientamento affettivo, differenza e “schiacciante prossimità” nell’analisi merleau-pontyana della pura profonditàNel mio saggio, illustro la descrizione che Merleau-Ponty propone della particolare esperienza della “pura profondità” come un’orientazione affettiva che precede l’orientamento percettivo e ipotizzo il suo ruolo nel quadro del progetto merleau-pontiano di costruire una “nuova concezione dell’intenzionalità”. La relazione differenziante tra corpo e mondo è riformulata come quella differenziazione intima e pre-oggettiva che caratterizza tale dimensione affettiva; ciò supporta la mia ipotesi, in opposizione a Toadevine (2009), che la posizione sostenuta da Merleau-Ponty in Fenomenologia della Percezione può essere distinta dalla proposta sartriana d’intendere l’intenzionalità in termini di annichilamento. Concludo il saggio con una discussione delle possibili provocazioni che la mia lettura della teoria della pura profondità potrebbe sollevare nella comunità scientifica merlau-pontiana, soffermandomi in particolare sull’interrogativoriguardo alla possibilità di leggere produttivamente Merleau-Ponty come un pensatore della differenza. (shrink)