The recent in vitro derivation of gamete‐like cells from mouse embryonic stem (mES) cells is a major breakthrough and lays down several challenges, both for the further scientific investigation and for the bioethical and biolegal discourse. We refer here to these cells as gamete‐like (sperm‐like or oocyte‐like, respectively), because at present there is still no evidence that these cells behave fully like bona fide sperm or oocytes, lacking the fundamental proof, i.e. combination with a normally derived gamete of the opposite (...) sex to yield a normal individual. However, the results published so far do show that these cells share some defining features of gametes. We discuss these results in the light of the bioethical and legal questions that are likely to arise would the same process become possible with human embryonic stem (hES) cells. (shrink)

The recent in vitro derivation of gamete‐like cells from mouse embryonic stem (mES) cells is a major breakthrough and lays down several challenges, both for the further scientific investigation and for the bioethical and biolegal discourse. We refer here to these cells as gamete‐like (sperm‐like or oocyte‐like, respectively), because at present there is still no evidence that these cells behave fully like bona fide sperm or oocytes, lacking the fundamental proof, i.e. combination with a normally derived gamete of the opposite (...) sex to yield a normal individual. However, the results published so far do show that these cells share some defining features of gametes. We discuss these results in the light of the bioethical and legal questions that are likely to arise would the same process become possible with human embryonic stem (hES) cells. (shrink)

The recent in vitro derivation of gamete‐like cells from mouse embryonic stem (mES) cells is a major breakthrough and lays down several challenges, both for the further scientific investigation and for the bioethical and biolegal discourse. We refer here to these cells as gamete‐like (sperm‐like or oocyte‐like, respectively), because at present there is still no evidence that these cells behave fully like bona fide sperm or oocytes, lacking the fundamental proof, i.e. combination with a normally derived gamete of the opposite (...) sex to yield a normal individual. However, the results published so far do show that these cells share some defining features of gametes. We discuss these results in the light of the bioethical and legal questions that are likely to arise would the same process become possible with human embryonic stem (hES) cells. (shrink)

The extent to which machine metaphors are used in synthetic biology is striking. These metaphors contain a specific perspective on organisms as well as on scientific and technological progress. Expressions such as “genetically engineered machine”, “genetic circuit”, and “platform organism”, taken from the realms of electronic engineering, car manufacturing, and information technology, highlight specific aspects of the functioning of living beings while at the same time hiding others, such as evolutionary change and interdependencies in ecosystems. Since these latter aspects (...) are relevant for, for example, risk evaluation of uncontained uses of synthetic organisms, it is ethically imperative to resist the thrust of machine metaphors in this respect. In addition, from the perspective of the machine metaphor viewing an entity as a moral agent or patient becomes dubious. If one were to regard living beings, including humans, as machines, it becomes difficult to justify ascriptions of moral status. Finally, the machine metaphor reinforces beliefs in the potential of synthetic biology to play a decisive role in solving societal problems, and downplays the role of alternative technological, and social and political measures. (shrink)

Crossing the boundaries - between nature and artifact and between inanimate and living matter - is a major feature of the convergence between nanotechnology and biotechnology. This paper points to two symmetric ways of crossing the boundaries: chemists mimicking nature's structures and processes, and synthetic biologists mimicking synthetic chemists with biological materials. However to what extent are they symmetrical and do they converge toward a common view of life and machines? The question is addressed in a historical perspective. (...) Both biomimetic chemistry and synthetic biology can be described as descendants of an ambitious program developed by Stéphane Leduc who coined the phrase 'synthetic biology' in the early twentieth century. The main intention of this genealogy is to emphasize that although making life in a test tube is a recurrent project there are subtle nuances in the underlying metaphysical assumptions. This comparison is meant to contribute to a better understanding of the cultural issues at stake in the convergence between nano and biotechnologies. It suggests that the demarcation line between life and inanimate matter remains a hot issue, and that all traffics across the borders do not proceed from the same metaphysical assumptions. (shrink)

This dissertation is a critique of synthetic ethical naturalism (SEN). SEN is a view in metaethics that comprises three key theses: first, there are moral properties and facts that are independent of the beliefs and attitudes of moral appraisers (moral realism); second, moral properties and facts are identical to (or constituted only by) natural properties and facts (ethical naturalism); and third, sentences used to assert identity or constitution relations between moral and natural properties are expressions of synthetic, a (...) posteriori necessities. The last of these theses, which distinguishes SEN from other forms of ethical naturalism, is supported by a fourth: the semantic contents of the central moral predicates such as 'morally right' and 'morally good' are fixed in part by features external to the minds of speakers (moral semantic externalism). Chapter 1 introduces SEN and discusses the most common motivations for accepting it. The next three chapters discuss the influential "Moral Twin Earth" argument against moral semantic externalism. In Chapter 2, I defend this argument from the charge that the thought experiment upon which it depends is defective. In Chapters 3 and 4, I consider two attempts to amend SEN so as to render it immune to the Moral Twin Earth argument. I show that each of these proposed amendments amounts to an abandonment of SEN. Chapter Five explores Richard Boyd's proposal that moral goodness is a "homeostatic property cluster." If true, Boyd's hypothesis could be used to support several metaphysical, epistemological, and semantic claims made on behalf of SEN. I advance three arguments against this account of moral goodness. In the sixth chapter, I argue that moral facts are not needed in the best a posteriori explanations of our moral beliefs and moral sensibility. Because of this, those who accept a metaphysical naturalism ought to deny the existence of such facts or else accept skepticism about moral knowledge. In Chapter 7, I consider a counterargument on behalf of SEN to the effect that moral facts are needed in order to explain the predictive success of our best moral theories. I show that this argument fails. (shrink)

Researchers and practitioners are increasingly using machine‐generated synthetic data as a tool for advancing health science and practice, by expanding access to health data while—potentially—mitigating privacy and related ethical concerns around data sharing. While using synthetic data in this way holds promise, we argue that it also raises significant ethical, legal, and policy concerns, including persistent privacy and security problems, accuracy and reliability issues, worries about fairness and bias, and new regulatory challenges. The virtue of synthetic data (...) is often understood to be its detachment from the data subjects whose measurement data is used to generate it. However, we argue that addressing the ethical issues synthetic data raises might require bringing data subjects back into the picture, finding ways that researchers and data subjects can be more meaningfully engaged in the construction and evaluation of datasets and in the creation of institutional safeguards that promote responsible use. (shrink)

The recent publications reported in 2022 reveal the possibility of obtaining mouse embryos without the need for egg or sperm. These ‘artificial embryos’ can recapitulate some stages of development ex utero – from neurulation to organogenesis – without implantation. Synthetic mouse embryos might serve as a valuable model to gain further insights into early developmental stages. Indeed, it is expected for these models to be replicated by employing human cells. This promising research raises ethical issues and expands the horizon (...) of ethics in regard to the development of the human embryo. From this point of view, we state some of the new open venues for bioethical research. (shrink)

If complexity is a necessary but not sufficient premise for the existence and expression of the living, anticipation is the distinguishing characteristic of what is alive. Anticipation is at work even at levels of existence where we cannot refer to intelligence. The prospect of artificially generating aesthetic artifacts and ethical constructs of relevance to a world in which the natural and the artificial are coexistent cannot be subsumed as yet another product of scientific and technological advancement. Beyond the artificial, the (...) synthetic conjures the understanding of aesthetics and ethics no longer from the perspective of the How? type of question, but rather the Why? Given the current infatuation with synthetic biology (i.e., making life from non-life), there is a practical consequence to such considerations. Synthetic life, as any other form of life, implies the possibility of evolution. Anticipation, which is the underlying factor of evolution, is thus expected. At the level of human existence, anticipation is expressed, for instance (but not exclusively), in aesthetic forms and ethical values. This translates, in turn, into an argument for the role aesthetics and ethics play in the process. Consequently, to qualify as life, the synthesis of the physical and the living will have to efficiently handle ambiguity. Current computational facilities, regardless of their nature or performance, operate exclusively in the semiotic domain of the well defined non-ambiguous. (shrink)

Researchers and practitioners are increasingly using machine-generated synthetic data as a tool for advancing health science and practice, by expanding access to health data while—potentially—mitigating privacy and related ethical concerns around data sharing. While using synthetic data in this way holds promise, we argue that it also raises significant ethical, legal, and policy concerns, including persistent privacy and security problems, accuracy and reliability issues, worries about fairness and bias, and new regulatory challenges. The virtue of synthetic data (...) is often understood to be its detachment from the data subjects whose measurement data is used to generate it. However, we argue that addressing the ethical issues synthetic data raises might require bringing data subjects back into the picture, finding ways that researchers and data subjects can be more meaningfully engaged in the construction and evaluation of datasets and in the creation of institutional safeguards that promote responsible use. (shrink)

Synthetic biologists are extremely concerned with responsible research and innovation. This paper critically assesses their culture of responsibility. Their notion of responsibility has been so far focused on the identification of risks, and in their prudential attitude synthetic biologists consider that the major risks can be prevented with technological solutions. Therefore they are globally opposed to public interference or political regulations and tend to self-regulate by bringing a few social scientists or ethicists on board. This article emphasizes that (...) ethics lies beyond prudence and requires a cultural evaluation of the modes of existence of the various microorganisms designed by synthetic biologists, independently of their potential applications. (shrink)

Synthetic biology is designing and creating biological tools and systems for useful purposes. It uses knowledge from biology, such as biotechnology, molecular biology, biophysics, biochemistry, bioinformatics, and other disciplines, such as engineering, mathematics, computer science, and electrical engineering. It is recognized as both a branch of science and technology. The scope of synthetic biology ranges from modifying existing organisms to gain new properties to creating a living organism from non-living components. Synthetic biology has many applications in important (...) fields such as energy, chemistry, medicine, environment, agriculture, national security, and nanotechnology. The development of synthetic biology also raises ethical and social debates. This article aims to identify the place of ethics in synthetic biology. In this context, the theoretical ethical debates on synthetic biology from the 2000s to 2020, when the development of synthetic biology was relatively faster, were analyzed using the systematic review method. Based on the results of the analysis, the main ethical problems related to the field, problems that are likely to arise, and suggestions for solutions to these problems are included. The data collection phase of the study included a literature review conducted according to protocols, including planning, screening, selection and evaluation. The analysis and synthesis process was carried out in the next stage, and the main themes related to synthetic biology and ethics were identified. Searches were conducted in Web of Science, Scopus, PhilPapers and MEDLINE databases. Theoretical research articles and reviews published in peer-reviewed journals until the end of 2020 were included in the study. The language of publications was English. According to preliminary data, 1,453 publications were retrieved from the four databases. Considering the inclusion and exclusion criteria, 58 publications were analyzed in the study. Ethical debates on synthetic biology have been conducted on various issues. In this context, the ethical debates in this article were examined under five themes: the moral status of synthetic biology products, synthetic biology and the meaning of life, synthetic biology and metaphors, synthetic biology and knowledge, and expectations, concerns, and problem solving: risk versus caution. (shrink)

:This article explores the ethical issues that have been identified in emerging technologies, from early genetic engineering to synthetic biology. The scientific advances in the field form a continuum, and some ethical considerations can be raised time and again when new developments occur. An underlying concern is the cumulative effect of scientific advances and ensuing technological innovation that can change our understanding of life and humanity.

In this article I discuss the ethics of synthetic biology from a broadly deontological perspective, evaluating its morality in terms of the integrity of nature, the dignity of life and the relationship between God and his creation. Most ethical analyses to date have been largely consequentialist in nature; they reveal a dual use dilemma, showing that synbio has potential for great good and great evil, possibly more so than any step humanity has taken before. A deontological analysis may (...) help to resolve this dilemma, by evaluating whether synbio is right or wrong in itself. I also assess whether deontology alone is a sufficient methodological paradigm for the proper evaluation of synbio ethics. (shrink)

This editorial introduces a special issue of Bioethics focusing on the ethical implications of synthetic biology for human health. It highlights the proactive approach of synthetic biology researchers in engaging with ethical considerations early on, hoping to avoid public backlash similar to that experienced with genetically modified foods. The editorial outlines the key ethical questions raised by synthetic biology, including its implications for the moral status of life, conceptualization of risks and benefits, and potential impacts on future (...) generations. The editorial summarizes the contributions of various authors who explore different ethical perspectives on synthetic biology. These perspectives range from examining issues of social justice and biodiversity to philosophical debates about the creation of life and the nature of health and disease. The editors aim to provide a multifaceted analysis of synthetic biology's potential benefits and concerns, ultimately hoping to inform future policy-making and public discourse about this emerging technology. (shrink)

Artificial intelligence is becoming increasingly entwined with our daily lives: AIs work as assistants through our phones, control our vehicles, and navigate our vacuums. As these objects become more complex and work within our societies in ways that affect our well-being, there is a growing demand for machine ethics—we want a guarantee that the various automata in our lives will behave in a way that minimizes the amount of harm they create. Though many technologies exist as moral artifacts, the (...) development of a truly ethical AI system is highly contentious; theorists have proposed and critiqued countless possibilities for programming these agents to become ethical. Many of these arguments, however, presuppose the possibility that an artificially intelligent system can actually be ethical. In this essay, I will explore a potential path to AI ethics by considering the role of imagination in the deliberative process via the work of John Dewey and his interpreters, showcasing one form of reinforcement learning that mimics imaginative deliberation. With these components in place, I contend that such an artificial agent is capable of something very near ethical behavior—close enough that we may consider it so. (shrink)

Synthetic biology is an emerging technology that aims to design and engineer DNA and molecular structures of single cell organisms. Existing organisms can be altered, novel organisms can be created. In doing so, synthetic biology makes use of specific technoscientific understandings of living beings. This volume sets out to explore and assess synthetic biology and its notions of life from philosophical, ethical, social, and legal perspectives. Contents Concepts, Metaphors, Worldviews.- Public Good and Private Ownership.Social and Legal Ramifications.- (...) Opportunities, Risks, Governance. Target Groups Scholars of sociology, philosophy, theory of science, history of science, biology, engineering Politicians and policymakers The Editor Dr. Joachim Boldt is Deputy Director at the Institut für Ethik und Geschichte der Medizin in Freiburg, Germany. (shrink)

This paper attempts to sort out some of the current tensions and ambiguities inherent in the field of bioethics as it continues to mature. In particular it focuses on the question of the methodological relevance of theory or ethical principles to the domain of clinical ethics. I offer an approach to reasoning about moral conflict that combines the insights of contemporary moral theorists, the philosophy of American pragmatism, and the skills of rhetorical deliberation. This synthetic approach locates a (...) proper role for moral theory in the practice of clinical ethics, thus linking abstract philosophical ideas about morality, humanity, suffering, and health to specific deeds, actions, and decisions in the concrete lives of particular individuals. The aim of this synthetic approach of bioethical inquiry is a rapprochement between theoretical knowledge in moral philosophy and the contextualized, relational, and practical understanding of what morality demands of us in our daily lives. I argue for a conception of bioethical inquiry that takes morality to be a study of certain practical, socially embedded concerns about matters of right and wrong, good and evil, as well as a study of the moral theories by which these actual concerns can be explored and critically evaluated. (shrink)

Maintaining the coherence of the distinction between nature and artefact has long been central to environmental thinking. By building genomes from scratch out of 'bio-bricks', synthetic biology promises to create biotic artefacts markedly different from anything created thus far in biotechnology. These new biotic artefacts depart from a core principle of Darwinian natural selection – descent through modification – leaving them with no causal connection to historical evolutionary processes. This departure from the core principle of Darwinism presents a challenge (...) to the normative foundation of a number of leading positions in environmental ethics. As a result, environmental ethicists with a commitment to the normative significance of the historical evolutionary process may see synthetic biology as a moral 'line in the sand'. (shrink)

Cartesian separation and enlightenment have led to a widespread conceptual separation of science and technology. Consequently a certain philosophical tradition holds pure science as a metaphysical striving for irrefutable truth that is morally neutral and only ( dirty?) applications as morally accountable. An opposite extreme position holds scientists responsible for everything that is done with their discoveries. Based on an interpretation of science to be a social construct and the observation that moral criteria are the results of social processes the (...) paper demonstrates by the example of synthetic chemistry that science is not an elite end in itself and as such is not free from obligation to moral criteria. The moral responsibility of a scientist, which arises from his professional expertise, is limited to the available knowledge of his discipline. The moral responsibility, which he carries beyond that as responsible acting human, derives from the cultural identity and the normative values under which his action is carried out. This conclusion is illustrated by the examples of DDT, Aspirin and Heroin. (shrink)

We attempt to justify the use of synthetic biology in response to the climate crisis, based on the premise that it is impossible to avert runaway climate change without sequestering sufficient greenhouse gases (GHG), which could only become possible through Negative Emissions Technologies (NETs). Then, moving from a consequentialist standpoint, we acquiesce to how the consequences of using NETs through synthetic biology are preferable to the catastrophic consequences of runaway climate change. In conclusion, we show how our analysis (...) of synthetic biology resonates with a zoecentric view of climate science and ethics. (shrink)

The paper presents some considerations regarding the doctoral thesis entitled Ethical Provocations in Synthetic Biology, defended by Olivia Macovei under the scientific supervision of PhD. Prof. Viorel Guliciuc, at ”Stefan cel Mare” University of Suceava, Romania. This thesis explores the ethical implications of synthetic biology, a cutting-edge scientific field that raises philosophical questions across ontological, epistemological, anthropological, and ethical domains. The author examines synthetic biology's aim to create new living structures from existing biological components, distinguishing it from (...) artificial biology. The research analyzes the field's impact on various levels, including its ontological implications for life creation, epistemological shift towards pragmatic truth, anthropological considerations regarding posthuman evolution, and ethical concerns about researcher responsibility and technology accessibility. The work contributes to developing a prospective ethics for evaluating emerging technologies, employing an analytical philosophy approach while incorporating hermeneutical elements. (shrink)

Cho and Martinez-Martin (2023) provide a compelling critique of the profound influence that data sourcing for artificial intelligence (AI) has on the healthcare sector. They emphasize the need for...

Understanding natural phenomena is an important aim of science. Since the turn of the millennium the notion of scientific understanding has been a hot topic of debate in the philosophy of science. A bone of contention in this debate is the role of truth and representational accuracy in scientific understanding. So-called factivists and non-factivists disagree about the extent to which the theories and models that are used to achieve understanding must be true or accurate. In this paper we address this (...) issue by examining a case from the practice of synthetic chemistry. We investigate how understanding is obtained in this field by means of an in-depth analysis of the famous synthesis of periplanone B by W. Clark Still. It turns out that highly idealized models—that are representationally inaccurate and sometimes even inconsistent—and qualitative concepts are essential for understanding the synthetic pathway and accordingly for achieving the synthesis. We compare the results of our case study to various factivist and non-factivist accounts of how idealizations may contribute to scientific understanding and conclude that non-factivism offers a more plausible interpretation of the practice of synthetic chemistry. Moreover, our case study supports a central thesis of the non-factivist theory of scientific understanding developed by De Regt, namely that scientific understanding requires intelligibility rather than representational accuracy, and that idealization is one way to enhance intelligibility. (shrink)

This essay offers a preliminary philosophy ofchemistry as a profession focusing on professionalethics. First, I look at how well chemistry fits themodel of a liberal profession. I then explore therelationship between epistemology and ethics. Therelationship between chemistry and society isdiscussed in the context of the two-dimensionalclassification of research developed by Donald Stokesin his book Pasteur's Quadrant. Finally, Iraise the questions of an appropriate moral ideal forchemistry and the ethical conflicts that can occurwhen chemists simultaneously fulfill more than (...) one role. (shrink)

Training artificial intelligence (AI) systems requires vast quantities of data, and AI developers face a variety of barriers to accessing the information they need. Synthetic data has captured researchers’ and industry’s imagination as a potential solution to this problem. While some of the enthusiasm for synthetic data may be warranted, in this short paper we offer critical counterweight to simplistic narratives that position synthetic data as a cost-free solution to every data-access challenge—provocations highlighting ethical, political, and governance (...) issues the use of synthetic data can create. We question the idea that synthetic data, by its nature, is exempt from privacy and related ethical concerns. We caution that framing synthetic data in binary opposition to “real” measurement data could subtly shift the normative standards to which data collectors and processors are held. And we argue that by promising to divorce data from its constituents—the people it represents and impacts—synthetic data could create new obstacles to democratic data governance. (shrink)

This article provides an overview of the relation between synthetic biology and philosophy as understood from within the Ethics, Philosophy and Responsible Innovation programme of BrisSynBio (a BBSRC/EPSCR Synthetic Biology Research Centre). It also introduces the special issue of NanoEthics devoted to synthetic biology and philosophy.

The prelims comprise: Introduction Metatheoretical and Methodological Issues Applied and Synthetic Ethics Traditional and Emerging Issues Conclusion Websites and Other Resources.

Recent developments in synthetic biology are described and characterized as moving the era of biotechnology into platform technologies. Platform technologies enable rapid and diffuse innovations and simultaneous product development in diffuse markets, often targeting sectors of the economy that have traditionally been thought to have little relationship to one another. In the case of synthetic biology, pharmaceutical and biofuel product development are occurring interactively. But the regulatory and ethical issues associated with these two applications share very little overlap. (...) As such, there is some risk that focus on traditional medical applications, for which the ethical expertise is highly developed, will overshadow the ethical issues that arise in connection with land use and its attendant socioeconomic consequences, especially in the developing world. The 2010 report of the Presidential Commission for the Study of Bioethics exhibits this tendency. (shrink)

While a distinction should be made between wicked problems as first defined by Churchman and Rittel and Webber and problems that are merely challenging and difficult to solve, in this contribution, I argue that climate change and the resulting destruction of nature could be explained as a wicked problem. One of the proposed solutions to climate change, making use of synthetic biology for nature conservation, has the potential to be classified not only as a wicked solution but as a (...) solution that spawns a number of other wicked problems. I will examine the ethical issues raised by synthetic biology as a wicked solution to this super wicked problem from the perspective of Christian ethics, drawing in particular on the resources available in Christian ecotheology and, specifically, notions of interdependence, relationality, responsible stewardship, and global justice. (shrink)

In the context of synthetic biology, scientists and bioengineers talk of living beings as being 'living machines'. This categorisation of the envisaged new life forms has given rise to the ethical concern that their moral status may be seen as different from that of natural or only partially artificial living beings. The paper discusses the notion of a living being and the notion of a machine in order to arrive at a conclusion to the question of whether this categorisation (...) is warranted or not. For this reason, it also looks back to the history of the comparison of living beings to machines and tries to show what motivated the analogy. In the end, though, it is argued that one should stop short of categorising living beings as machines, even if there are areas of analogy between living beings and machines. Finally, the idea that the envisaged artificial synthetic living beings could be regarded as some kind of machines is rejected. (shrink)

Educational literature has tended to focus, explicitly and implicitly, on two kinds of task orientation: the ability either to focus on a single task, or to multi-task. A third form of orientation characterises many highly successful people. This is the ability to combine several tasks into one: to ‘kill two birds with one stone’. This skill characterises people with initiative, who exercise judgment, deliberation and creative imagination in their personal organisation. The motivation to work in this way indicates personal commitment (...) rather than mere compliance. Focusing on its development educationally implies a shift from either/or, linear, methodical, mechanical and technicist thinking to encouraging individual and collective responsibility, initiative and risk-taking, resulting in unpredictable outcomes. The emphasis on judgment renders the issues as ethical rather than narrowly instrumental. Dominant ethical approaches are, therefore, considered in relation to this in terms of its application for teaching. (shrink)

Despite the multidisciplinary dimension of the kinds of research conducted under the umbrella of synthetic biology, the US-based founders of this new research area adopted a disciplinary profile to shape its institutional identity. In so doing they took inspiration from two already established fields with very different disciplinary patterns. The analogy with synthetic chemistry suggested by the term ‘synthetic biology’ is not the only model. Information technology is clearly another source of inspiration. The purpose of the (...) paper, with its focus on the US context, is to emphasize the diversity of views and agendas coexisting under the disciplinary label synthetic biology, as the two models analysed are only presented as two extreme postures in the community. The paper discusses the question: in which directions the two models shape this emerging field? Do they chart two divergent futures for synthetic biology? (shrink)

Replies to commentaries on my 2012 article ‘Synthetic Biology Needs a Synthetic Bioethics,’ note that I do not, in fact, call for some ‘new’ kind of ethics. The focus then and now is on integrating questions that relate to distributive justice and environmental quality more faithfully into the topics that have come to preoccupy mainstream bioethics as institutionalized in medical schools and medical research institutions.

Paul Thompson argues that current synthetic biology amounts to synthetic genomics, comprising a ‘platform’ technology, and that Christopher Preston's deontological objections based on its supposed rejection of the historical process of evolution miscarry. This makes it surprising that Thompson's normative ethic consists in a deontological appeal to Kantian duties of imperfect obligation. Construed as obligations subject to choice, such constraints risk being excessively malleable where the ethical objections to deployment of this technology concern land rights and/or exploitation. Thompson's (...) advocacy of processes ‘more beneficial’ well illustrates another vulnerability; processes more beneficial than ones that undermine livelihoods could be best avoided themselves, although ones more beneficial than the status quo may not. He well argues that non-deontological arguments should not be confined to human survival, but neglects stances that are either biocentric, consequentialist, or both. Yet a truly synthetic bioethics would be likely to embody these characteristics. (shrink)

Next SectionOne of the indisputable signs of the progress made in organic chemistry over the last two hundred years is the increased ability of chemists to manipulate, control, and design chemical reactions. The technological expertise manifest in contemporary synthetic organic chemistry is, at least in part, due to developments in the theory of organic chemistry. By appealing to a notable chemist's attempts to articulate and codify the heuristics of synthetic design, this paper investigates how understanding (...) theoretical organic chemistry facilitates progress in synthetic organic chemistry. The picture that emerges of how the applications of organic chemistry are grounded in its theory is contrasted with both standard and some more contemporary philosophical accounts of the applications of science. IntroductionTotal Synthesis as Applied ScienceUnderstanding Organic ChemistryThe Heuristics of Synthetic DesignAn Example: LongifoleneConclusion. (shrink)

:This article analyzes the ethics of synthetic biology from a consequentialist perspective, examining potential effects on food and agriculture, and on medicine, fuel, and the advancement of science. The issues of biosafety and biosecurity are also examined. A consequentialist analysis offers an essential road map to policymakers and regulators as to how to deal with synbio. Additionally, the article discusses the limitations of consequentialism as a tool for analysing synbioethics. Is it possible to predict, with any degree of (...) plausibility, what the consequences of synthetic biology will be in 50 years, or in 100, or in 500? Synbio may take humanity to a place of radical departure from what is known or knowable. (shrink)

Theorists analyzing the concept of disease on the basis of the notion of dysfunction consider disease to be dysfunction requiring. More specifically, dysfunction-requiring theories of disease claim that for an individual to be diseased certain biological facts about it must be the case. Disease is not wholly a matter of evaluative attitudes. In this paper, I consider the dysfunction-requiring component of Wakefield’s hybrid account of disease in light of the artifactual organisms envisioned by current research in synthetic biology. In (...) particular, I argue that the possibility of artifactual organisms and the case of oncomice and other bred or genetically modified strains of organism constitute a significant objection to Wakefield’s etiological account of the dysfunction requirement. I then develop a new alternative understanding of the dysfunction requirement that builds on the organizational theory of function. I conclude that my suggestion is superior to Wakefield’s theory because it (a) can accommodate both artifactual and naturally evolved organisms, (b) avoids the possibility of there being a conflict between what an organismic part is supposed to do and the health of the organism, and (c) provides a nonarbitrary and practical way of determining whether dysfunction occurs. (shrink)

This article aims to make an analysis of the cultural and anthropological issues raised by synthetic biology. The novelty of the field makes it relatively difficult to compose a comprehensive analysis, even for philosophers with experience, but who are not familiar with the specifics of the field. The article will follow the synthesis of the models of ethical decision applicable in the field of ethical evaluation of technologies from a cultural and anthropological perspective, their critical analysis and will highlight (...) the limitations of each model, as well as a possible synthesis of a model of ethical evaluation of technologies. Afterwords, it can be decided whether a particular technology - such as those involved in synthetic biology - poses risks to the environment, to those involved in research, to future generations, to humanity as a whole or to present or future ecosystems. (shrink)

In this paper, we examine the use of the term ‘life’ in the debates within and about synthetic biology. We review different positions within these debates, focusing on the historical background, the constructive epistemology of laboratory research and the pros and cons of metaphorical speech. We argue that ‘life’ is used as buzzword, as folk concept, and as theoretical concept in inhomogeneous ways. Extending beyond the review of the significant literature, we also argue that ‘life’ can be understood as (...) aBurstwordin two concrete senses. Firstly, terms such as life easily turn into fuzzy, foggy and buzzy clouds of nonsense, if their use is not appropriately reflected. In these cases, the semantic orientation is detonated. This is theBurstword Icharacteristic of the concept of ‘life’ that we reveal for its unclear terminological use. Secondly, and in contrast toBurstword I, we show that the concept of ‘life’ can be used in a methodologically controlled way. We call this kind of useBurstword II. Here the concept of ‘life’ fulfils the function of expanding an inadequately narrow disciplinary or conceptual focus in different discursive contexts. In this second sense, ‘life’ receives an important operational function, for instance as a transdisciplinary research principle. It turns out that the innovative function and paradigm-changing power of metaphorical speech belong here as well. Finally, we illustrate three ethically relevant examples that show how ‘life’ can be applied asBurstword IIin the context of synthetic biology. (shrink)

Advances at the interface between the biological sciences and engineering are giving rise to emerging research fields such as synthetic biology. Harnessing the potential of synthetic biology requires timely and adequate translation into clinical practice. However, the translational research enterprise is currently facing fundamental obstacles that slow down the transition of scientific discoveries from the laboratory to the patient bedside. These obstacles including scarce financial resources and deficiency of organizational and logistic settings are widely discussed as primary impediments (...) to translational research. In addition, a number of socio-ethical considerations inherent in translational research need to be addressed. As the translational capacity of synthetic biology is tightly linked to its social acceptance and ethical approval, ethical limitations may—together with financial and organizational problems—be co-determinants of suboptimal translation. Therefore, an early assessment of such limitations will contribute to proactively favor successful translation and prevent the promising potential of synthetic biology from remaining under-expressed. Through the discussion of two case-specific inventions in synthetic biology and their associated ethical implications, we illustrate the socio-ethical challenges ahead in the process of implementing synthetic biology into clinical practice. Since reducing the translational lag is essential for delivering the benefits of basic biomedical research to society at large and promoting global health, we advocate a moral obligation to accelerating translational research: the “translational imperative.”. (shrink)

Based on a nuanced understanding of immersion and sense of presence as two key aesthetic effects that the application of virtual reality to cinema is believed to innovate, this paper develops the concept of synthetic vision as fundamental to understanding the visual experience of VR media, particularly VR documentaries. The concept contends that viewers’ experience in VR is based on two visions that seemingly contradict each other: first, a disembodied vision that transports them to a simulated world, and second, (...) an embodied vision guaranteed by the freedom to control kinesthetic movement and direction of gaze. This serves to advance the idea that immersion and SoP are not unified but rather multifaceted concepts premised on a nuanced understanding of the varying relationships between the technological system of VR, its media content, and its user. For the concept of synthetic vision points to the paradoxical coexistence of viewers’ presence in the virtual world and their structural absence from the world that lays the groundwork for their immersive experience. By classifying three generic categories of contemporary VR documentaries, and by examining the aesthetic and ethical underpinnings VR brings to each of them, I argue that it hinges upon what kind of cinematic conventions and genres are remediated to determine the effective synthesis of the two visions. The varying effects of synthetic vision in the three subgenres of VR documentary stress that immersion and SoP have different political and ethical consequences of media witnessing. In the conclusion, I recapitulate multiple implications that the concept of synthetic vision has in regards to both the studies on VR and the recently flourishing investigation into cinematic VR artifacts. (shrink)

In May of 2009, the Stockholm Convention added nine chemicals to its list of banned or restricted chemicals. While some businesses may be tempted to see further limitations on chemical production of persistent organic pollutants as an inconvenient hindrance, I argue that business ought to see strengthened rules as an opportunity to improve efficiency and to become more competitive in the global market place both financially and ethically. By re-examining not only product design but also products purchased, every company can (...) reduce their ecological footprint at a molecular level. And as more companies demand a greener supply chain, consumers also benefit from greater availability of greener products. (shrink)

New health technologies are rapidly emerging from various areas of bioscience research, such as gene editing, regenerative medicine and synthetic biology. These technologies raise promising medical possibilities but also a range of ethical considerations. Apart from the issues involved in considering whether novel health technologies can or should become part of mainstream medical treatment once established, the process of research translation to develop such therapies itself entails particular ethical concerns. In this paper I use synthetic biology as an (...) example of a new and largely unexplored area of health technology to consider the ways in which novel health technologies are likely to emerge and the ethical challenges these will present. I argue that such developments require us to rethink conventional attitudes towards clinical research, the roles of doctors/researchers and patients/participants with respect to research, and the relationship between science and society; and that a broader framework is required to address the plurality of stakeholder roles and interests involved in the development of treatments based on novel technologies. (shrink)

This is the fifth book by Professor Alan E Singer on business ethics and strategy. This book emphasizes aspects that are thought to be most likely to rise to prominence in the years to come. These include ecological-understandings at the conceptual level and the participation at the practical level in a distributed system of global governance system that strives to uphold all of the human goods, including the positive and negative freedoms, but in a reasonably balanced way. In a (...) section on justice and politics, several issues related to social and environmental justice are duly viewed from both a theoretical perspective and from a corporate (strategic) perspective. A further section focuses upon the governance and ethical implications of what James Martin (founder of the 21st Century School at the University of Oxford) has called the technologies of sorcery: synthetic biology, nanotechnology, robotics and artificial general intelligence. The final section of the book applies a stable organizing framework to the teaching of ethics in business and politics. This book will be of interest to students and practitioners across a wide spectrum of academic subjects and professions. (shrink)

One of the main functions that introductory chemistry courses have fulfilled during the past century has been to provide evidence for the general validity of 'the atomic hypothesis.' A second function has been to demonstrate that an analytical approach has wide applicability in rationalizing many kinds of phenomena. Following R.G. Collingwood, these two functions can be recognized as related to a philosophical 'cosmology' (worldview, weltanshauung) that became dominant in the later Renaissance. Recent developments in many areas of science, and (...) in chemistry, have emphasized the central importance of understanding synthetic, developmental, and evolutionary aspects of nature. This paper argues that these scientific developments, and changes in other aspects of culture, amount to a widespread shift to an alternative cosmology, a quite different general worldview. To the extent that this is the case, introductory chemistry courses ought to be changed in fundamental ways. Rather that having a main focus on analysis to microscopic components, introductory chemistry instruction should emphasize current scientific understanding of the (synthetic) evolutionary origins of the present world. This altered approach would provide good preparation for future professional work, while also making better contact with the perceived concerns of students. (shrink)