The intellectual origins of molecular biology are usually traced back to the 1930s. By contrast, molecular biology acquired a social reality only around 1960. To understand how it came to designate a community of researchers and a professional identity, I examine the creation of the first institutes of molecular biology, which took place around 1960, in four European countries: Germany, the United Kingdom, France, and Switzerland. This paper shows how the creation of these institutes was linked to (...) the results of post-war economic reconstruction. Then, it compares how the promoters of these different institutional projects delimited the goals of their discipline, reflected on its history, and suggested how research should be organised. I show how they carefully positioned their new discipline within the emerging national science policy discourse of the 1950s, and aligned it with the current vision of scientific modernity. In particular, I discuss how they articulated the meaning of molecular biology with respect to five common themes: the role of physics in the atomic age, the relations between fundamental research and medical applications, the 'Americanisation' of scientific research, the value of science in the reconstruction of national identities, and the drive towards interdisciplinary research. This paper thus demonstrates that beyond the local and national accounts there is a European history of molecular biology. (shrink)

The intellectual origins of molecular biology are usually traced back to the 1930s. By contrast, molecular biology acquired a social reality only around 1960. To understand how it came to designate a community of researchers and a professional identity, I examine the creation of the first institutes of molecular biology, which took place around 1960, in four European countries: Germany, the United Kingdom, France, and Switzerland. This paper shows how the creation of these institutes was linked to (...) the results of post-war economic reconstruction. Then, it compares how the promoters of these different institutional projects delimited the goals of their discipline, reflected on its history, and suggested how research should be organised. I show how they carefully positioned their new discipline within the emerging national science policy discourse of the 1950s, and aligned it with the current vision of scientific modernity. In particular, I discuss how they articulated the meaning of molecular biology with respect to five common themes: the role of physics in the atomic age, the relations between fundamental research and medical applications, the ‘Americanisation’ of scientific research, the value of science in the reconstruction of national identities, and the drive towards interdisciplinary research. This paper thus demonstrates that beyond the local and national accounts there is a European history of molecular biology. (shrink)

The aim of this work is to evaluate the role played by Alfonso Luis Herrera and Isaac Ochoterena in the institutionalization of academic biology in Mexico in the early 20th century. As biology became institutionalized in Mexico, Herrera's basic approach to biology was displaced by Isaac Ochoterena's professional goals due to the prevailing political conditions at the end of 1929. The conflict arose from two different conceptions of biology, because Herrera and Ochoterena had different discourses (...) that were incommensurable, not only linguistically speaking, but also socioprofessionally. They had different links to influential groups related to education, having distinct political and socioprofessional interests. The conflict between Herrrera and Ochoterena determined the way in which professional biology education has developed in Mexico, as well as the advancement in specific research subjects and the neglect of others. (shrink)

RESUMOO presente artigo analisa processos de alterização na biologia humana e na biomedicina. A alterização é entendida aqui como o processo cultural de produção de alteridades por meio da delimitação, rotulação e categorização das formas possíveis de ser outro, desde um determinado marco de referência sócio-histórico. Ainda que a alterização faça parte de qualquer processo de delimitação de categorias de identidade no seio de uma cultura - e, nesse sentido, possa apresentar visões do outro tanto positivas quanto negativas -, aqui (...) nos interessamos especificamente na alterização como fator de marginalização e exclusão social de diferentes grupos humanos. São analisados diversos processos de alterização operantes nos discursos e nas práticas das ciências biomédicas ao longo de sua história recente, os quais têm conduzido à exclusão social de diferentes categorias de outros, ou a tratá-los como inferiores, em pretendidas bases científicas, ou em função de determinadas práticas institucionalizadas dentro da comunidade científica. Exemplos típicos de grupos marginalizados pelas ciências ocidentais ao longo de sua história incluem as raças não europeias, as mulheres, os homossexuais e os "pobres". O principal objetivo do presente artigo é analisar, na história recente das ciências biomédicas, esses processos de alterização que têm conduzido à marginalização de tais grupos e a considerá-los como inferiores. ABSTRACTThis article analyzes processes of "othering" in human biology and biomedicine. Othering is understood here as the cultural process of production of otherness by means of the delimitation, tagging, and categorization of the possible ways of being "other" within a given socio-historical context. Although othering can be considered as a constitutive aspect of any process of delimitation of identities within a given culture - and in this sense it can present both positive and negative views of the "other" -, in the present article we are specifically interested in processes of othering that lead to the marginalization and social exclusion of different human groups. We will analyze processes of othering, which have operated in the discourses and practices of biomedical sciences throughout their recent history, that have led to the social exclusion of different categories of "others", or to treating them as inferior, and that have supposedly scientific bases or as a consequence of the institutionalization of certain practices within the scientific community. Typical examples of these "others", marginalized by the Western sciences throughout their history, are the non-European "races", women, gay and lesbian people, and the "poor". The main objective of this article is to analyze, in the recent history of the biomedical technosciences, these different processes of othering that have led to the marginalization of such "others" and to treating them as inferior. (shrink)

Este artículo tiene por objetivo general indagar acerca de los procesos de institucionalización de una nueva disciplina científica. En particular, se analizan los desplazamientos que se producen entre disciplinas al emerger una nueva: la biología molecular. Se presenta en este artículo el caso del Instituto Nacional de Tecnología Agropecuaria (INTA) de Argentina, institución creada en 1956 para realizar investigaciones, innovaciones y extensionismo para el sector agropecuario. De esa manera, el trabajo presenta los cambios en las disciplinas de las que provienen (...) los investigadores del INTA, desde su creación en 1956 hasta 2010. La investigación que se presenta se centra en un análisis cuantitativo en relación a las disciplinas de origen de los investigadores que se incorporaron a la institución. Al mostrar los desplazamientos entre disciplinas, este artículo pretende contribuir al estudio sobre los conflictos entre las mismas. Pues se sugiere que la emergencia de una nueva disciplina no implica solamente la apertura de nuevas profesiones, instituciones, temas y técnicas de investigación, sino también el desplazamiento de otras anteriormente instaladas, y que tales desplazamientos estarían en la raíz de las tensiones que se registran en la institucionalización de una nueva disciplina. This article aims to investigate the process of institutionalization of a new scientific discipline. In particular, the displacements that occur between disciplines with the emergence of a new one: molecular biology. The case presented in this article is the National Institute of Agricultural Technology (INTA) of Argentina, institution created in 1956 for research, innovation and extension to the agricultural sector. Thus, the paper presents the changes in the disciplines from which INTA's researchers come, since its inception in 1956 until 2010. The research presented in this article focuses on a quantitative analysis in relation to the disciplines of origin of the researchers who joined the institution. By showing the displacements between disciplines, this article aims to contribute to the study of the conflicts between them. For it suggests that the emergence of a new discipline involves not only the opening of new professions, institutions, research subjects and techniques, but also the displacement of other previously installed. These displacements would be at the root of the tensions that occur in the institutionalization of a new discipline. (shrink)

This article examines the changing status of tropical biology by considering the origins and early development of the Barro Colorado Island Biological Laboratory. Today the laboratory is part of a large diversified tropical research center operated by the Smithsonian Institution. However, for most of its history the laboratory led a tenuous existence. Both the early problems and eventual success of the institution can only be explained by considering the interaction of various intellectual, institutional, and broader social factors.

Biology is seen not merely as a privileged oppressor of women but as a co-victim of masculinist social assumptions. We see feminist critique as one of the normative controls that any scientist must perform whenever analyzing data, and we seek to demonstrate what has happened when this control has not been utilized. Narratives of fertilization and sex determination traditionally have been modeled on the cultural patterns of male/female interaction, leading to gender associations being placed on cells and their components. (...) We also find that when gender biases are controlled, new perceptions of these intracellular and extracellular relationships emerge. (shrink)

Historians agree that the second half of the twentieth century saw widespread changes in the structure of biological science in universities. This shift was, and continues to be, characterized by the de-differentiation of nineteenth and early twentieth century disciplines, with increasing emphasis on the methods and authority of molecular fields. Yet we currently lack appreciation of the dynamics that underpinned these changes, and of their tangible effects on the working practices of those involved. In this article we examine the wholesale (...) reform of biological science at the University of Manchester, England, that occurred in two successive steps in 1986 and 1993. We examine how reform was enabled by economic and political factors, as staff seized upon national pressures; in so doing, we emphasize how this reform was shaped by a generational view of the biological sciences as a one field, unified by molecular techniques. We assess how the success of these reforms was tied to new management policies that rewarded research activity in molecular fields, and refigured teaching as a punishment for research inactivity. We close by showing how our analysis fits amongst, and can contribute to, ‘big picture’ debates in the history and sociology of knowledge. (shrink)

The second half of the nineteenth century was a crucial moment for the institutionalization of psychology from European experimental studies that became increasingly popular in the United States. The relationship between pragmatist philosophy and biology is deeply linked to psychology, and in particular to the physiological and Darwinian psychology elaborated by William James. This article focuses on a portion of the much broader debate involving some of the leading American exponents of the new psychology with the intention of (...) highlighting important methodological and theoretical issues that arose concerning the relationship between biology and philosophy within an evolutionary framework, issues in some ways still relevant today. (shrink)

Institutionalizing the Just War provides a new approach to theorizing the morality of war and argues that sound moral principles regarding war-making must take into account the fact that the validity of moral principles can depend upon existing institutions and social practices.

This study examines whether microfinance institutions (MFIs) that serve women borrowers at the base of the economic pyramid are likely to adopt a written code of positive organizational ethics (POE). Using econometric analysis of operational and economic data of a sample of MFIs from across the world, we find that two contextual factors—poverty level and lack of women’s empowerment—moderate the influence of an MFI’s percentage of women borrowers on the probability of the MFI having a POE code. MFIs that serve (...) more women borrowers are more likely to adopt a POE code, especially in negative contexts (where women borrowers face poverty and disempowerment and are therefore susceptible to abuse). This study provides evidence that MFIs can build positive ethical strength in negative contexts. (shrink)

Grounded upon the late 1970s phrase "institutionalizing ethics into business," I present a multi-component model and research agenda to enhance our understanding of organizations' efforts to integrate ethics into the daily decision-making process of employees. Three research foci are emphasized: (I) the need to establish consistent categorical frameworks to describe business organizations' efforts in the field, (2) the study of the interrelationships between the various components presented in the model, and (3) the exploration of the linkage between organizational efforts to (...) institutionalize ethics and ethical employee behavior. Research and organizational implications evolving from these research foci are discussed. (shrink)

Mammals are usually considered unproblematic as biological individuals. This article contends the opposite. Once we consider pregnancy, criteria for biological individuality are not easily applicab...

How does evolutionary biology fit with Thomas Kuhn's famous distinction between puzzle solving and paradigm shifts in science?

Emergent research in metagenomics has unveiled large quantities of previously unknown and unclassified prokaryotic DNA. As these prokaryotes constitute the vast majority of microbial life in environmental samples, some microbiologists and commentators in scientific media have referred to this expansive unknown as ‘biological dark matter’, translating the rhetorical power of dark matter from the physical to the life sciences. Engaging literatues and approaches from across the philosophy, history, and social studies of science, we explore the cultural significance of the dark (...) matter theory in the physical sciences and examine the implications of its conceptual reworking in biology, through critically engaging the political narratives folded within dark matter’s genealogies. ‘Dark matter’ designates both zones of importance and zones of turbulence, simultaneously emphasizing microbiologists’ creativity whilst constructing new ways of relating to microbiota. Such a situation, we propose, also invites theoretical analysis as it calls for a conceptual reconsideration of the gene and its fundamental role within the life sciences. (shrink)

The biological functions debate is a perennial topic in the philosophy of science. In the first full-length account of the nature and importance of biological functions for many years, Justin Garson presents an innovative new theory, the 'generalized selected effects theory of function', which seamlessly integrates evolutionary and developmental perspectives on biological functions. He develops the implications of the theory for contemporary debates in the philosophy of mind, the philosophy of medicine and psychiatry, the philosophy of biology, and (...) class='Hi'>biology itself, addressing issues ranging from the nature of mental representation to our understanding of the function of the human genome. Clear, jargon-free, and engagingly written, with accessible examples and explanatory diagrams to illustrate the discussion, his book will be highly valuable for readers across philosophical and scientific disciplines. (shrink)

This case study of unobtrusive mobilizing by Southern California Rape Crisis Center uses archival, observational, and interview data to explore how a feminist organization worked to change police, schools, prosecutor, and some state and national organizations from 1974 to 1994. Mansbridge's concept of street theory and Katzenstein's concepts of unobtrusive mobilization and discursive politics guide the analysis. SCRCC's theme of “All We Do Comes from Victims” reflects the source of its initiatives, that is, victims who came to them for help. (...) Employing strategies of discursive politics and “occupy and indoctrinate,” members used a narrative method of “storytelling” to mobilize support and produce change. Our results increase understanding of how institutionalized women's movement organizations mobilize over time as they create meaning and commitment for members and outsiders. The authors call for more research on narrative as a women's movement strategy and on feminist organizations that are situated inside institutional contexts. (shrink)

The French and German political economies have been significantly reconfigured over the past two decades. Although the changes have often been more piecemeal than revolutionary, their cumulative effects are profound. The authors characterize the changes that have taken place as involving the institutionalization of new forms of dualism and argue that what gives contemporary developments a different character from the past is that dualism is now explicitly underwritten by state policy. They see this outcome as the culmination of a (...) sequence of developments, beginning in the field of industrial relations, moving into labor market dynamics, and finally finding institutional expression in welfare state reforms. Contrary to theoretical accounts that suggest that institutional complementarities support stability and institutional reproduction, the authors argue that the linkages across these realms have helped to translate employer strategies that originated in the realm of industrial relations into a stable, new, and less egalitarian model with state support. (shrink)

The subject of sexuality among elderly patients with dementia was examined, focusing on two main aspects: the sexual behaviour of institutionalized elderly people with dementia; and the reactions of other patients, staff and family members to this behaviour. The behaviour was found to be mostly heterosexual and ranged from love and caring to romance and outright eroticism. Reactions varied, being accepting of love and care but often objecting to erotic behaviour. Understanding of the sexual needs of elderly people should become (...) an integral part of the training and continued education of health care staff, thus helping to resolve conflicts and clarify common misconceptions. (shrink)

While the idea of worker-owned cooperatives is centuries-old, the network of over 300 such enterprises in the Basque region of Spain and founded upon Catholic social justice teachings, is the most successful and impressive in history. The central claim of this paper is that the worker-owned, Mondragon cooperatives demonstrate not only how economic institutions can be structured so as to promote the common good but also how participation in them can engender a concern for the common good among individual participants (...) in those institutions, which spills over into their broader participation as citizens in the larger community. The paper advances this thesis by, first, providing a brief history of the Mondragon cooperatives, from their founding in the 1950s by Father Jose Arizmendiarrieta, the parish priest in the village of Mondragon, trained in economics. Second, it outlines the central principles of Catholic social justice teachings regarding economy that form the foundation for the Mondragon cooperatives and how those teachings have been institutionalized in the cooperatives’ democratic managerial practices and their creative financial structures. While Father Arizmendiarrieta drew mainly from Pope Leo XIII’s Rerum Novarum, this paper shows how Mondragon’s policies and practices are also in keeping with later Church teachings, as put forward especially by Popes John Paul II, Benedict XVI, and Francis I. Third, the paper contrasts the understanding of the common good in Catholic social teachings and the Mondragon cooperatives, on the one hand, to the notion of the common good found in mainstream classical and neoclassical economics. The latter sees society as merely the sum of its individual members and hence the common good as but the sum of individual goods, or aggregate utility. The former, by contrast, sees society as a living organism, the whole of which is greater than the sum of its parts, and hence it understands the common good as greater than the sum of individual goods, but also including the organic relationships among individuals. Fourth, the paper describes how participation in the cooperatives engenders, cultivates, and deepens worker-members’ sense and understanding of the common good and their commitment to it. (shrink)

I consider Katherine Hawley's commitment account of interpersonal trustworthiness alongside her sceptical challenge regarding the value of philosophically modelling institutional trustworthiness as distinct from reliability. I argue, pace Hawley's challenge, that there would be significant diagnostic and explanatory loss if we were to content ourselves with ideas of institutional (un)reliability alone; and I offer an illustrative case where institutional unreliability is only the half of it, indicating that when it comes to certain kinds of institutional dysfunction, we do need philosophical (...) models of institutional ‘distrustworthiness’ if we are to achieve a proper diagnosis. (shrink)

Often, knowledge engineers become so involved in the development process of the expert system that they fail to look further down the road toward the expert system's institutionalization within the organization. Institutionalization is an important component of the expert system planning process. More specifically, the legal issues associated with expert systems development and deployment are critical institutionalization factors. This paper looks at some expert system institutionalization guidelines, and then focuses on legal considerations.

The impressive variation amongst biological individuals generates many complexities in addressing the simple-sounding question what is a biological individual? A distinction between evolutionary and physiological individuals is useful in thinking about biological individuals, as is attention to the kinds of groups, such as superorganisms and species, that have sometimes been thought of as biological individuals. More fully understanding the conceptual space that biological individuals occupy also involves considering a range of other concepts, such as life, reproduction, and agency. There has (...) been a focus in some recent discussions by both philosophers and biologists on how evolutionary individuals are created and regulated, as well as continuing work on the evolution of individuality. (shrink)

Advances in biology, genetic research and operant behavior modification have thrown into question the status of human freedom of self-determination, i.e., the ability to conceive and understand rules and the ability to act in accordance with or in opposition to them. An argument based on biological and psychological research is sometimes claimed to show that all human behavior is determined by genetic make-up and environment and that freedom of self-determination is an illusion. An analysis of human action and of (...) the scientific enterprise, however, shows such determinism to be inconsistent and hence untenable. (shrink)

Justin Garson has recently argued that proper functions are proximal activities of traits selected by phylogenetic or ontogenetic selection processes, and that traits are dysfunctional only if they cannot perform their proper functions for constitutional reasons. We partially agree with Garson, but reject the view that functions are proximal activities, as well as his account of dysfunctions. Instead, we propose our own theory that biological functions are selected dispositions and that a trait is dysfunctional in virtue of not having the (...) dispositions for which it was selected. This account can explain both defects (or dysfunctions in Garson’s sense) and dysfunctions due to environmental factors. Moreover, it offers a neat way to explain the graduality of dysfunction. (shrink)

In a world that peers over the brink of disaster more often than not it is difficult to find specific assignments for the scholarly community. One speaks of peace and brotherhood only to realize that for many the only real hope of making a contribution may seem to be in a field of scientific specialization seemingly irrelevant to social causes and problems. Yet the history of man since the beginnings of science in the days of the Greeks does not support (...) this gloomy thesis. Time and again we have seen science precipitate social trends or changes in the humanistic beliefs that have a significant effect on the scientific community. Not infrequently the theoretical scientist, triggered by society's changing goals and understandings, finds ultimate satisfaction in the work of his colleagues in engineering and the other applied fields. Thus the major debate in mid-nineteenth century in which the evidence of natural history and geology at variance with the Biblical feats provided not only courage to a timid Darwin but the kind of audience that was needed to fit his theories into the broad public dialogue on these topics. The impact of "Darwinism" was felt far beyond the scientific community. It affected social thought, upset religious certainties and greatly affected the teaching of science. (shrink)

We expect Big Data methods to contribute to research with results that are not inferior to those attained in other ways but possibly better, or hard or impossible to generate in other ways. Those who apply these methods may also aspire to augment the arsenal of research methods, offer surrogates for existing research designs, and re-orient research. Moreover, we can critically examine the institutional, societal and political effects of the Big Data methods and the conditions for the solid institutionalization (...) of these methods in social and political research. To reach its primary objective, this article elaborates conclusions on how Big Data methods, not only by means of their ‘social life’ but also by their ‘political life’, may influence the institutionalization of social and political research. To reach its secondary objective, the article re-examines a study of budgetary legislation in 13 countries carried out by means of Big Data methods to draw conclusions concerning the augmentation of the arsenal of research methods, the surrogation of existing research designs, and the re-orientation of research. (shrink)

Over the past two decades, Cuba has become a recognized global leader in sustainable agriculture. This paper explores how this process of agricultural transition has taken place, and argues that it has largely been led by research institutes, non-state organizations and the Cuban government, which have all contributed to the institutionalization of agroecology in both policy and practice. This process has been highly effective in terms of the numbers of people using agroecological techniques. However, although these techniques have been (...) widely adopted by farmers across the country, this paper suggests that many still perceive maximizing production to be a higher priority than maintaining a commitment to agroecological ideals. For these farmers, agroecological farming is viewed primarily as a pragmatic decision rather than an ideological or moral one, and they may thus be susceptible to shifting back to conventional production if this option became politically and economically feasible. (shrink)

Philosophers have expressed concerns about elite capture at various stages of the democratic decision‐making process. However, there has been no sustained normative analysis of government‐driven feedback platforms that enable different actors to formulate recommendations for revising or canceling existing laws and policies. My article addresses and fills this gap. I contend that government‐driven feedback platforms serve a dual purpose of influencing the policy‐making process and demonstrating that decisions are open to revision. I also argue that these feedback platforms are intended (...) to generate a normatively salient, forward‐looking, and balanced integration of technical knowledge and local knowledge, establishing the epistemic foundation for future deliberation. I then provide three normative standards that serve as a guide to balance expert knowledge with citizens' experience and values. (shrink)

Synthetic biology is an emerging engineering discipline that attempts to design and rewire biological components, so as to achieve new functions in a robust and predictable manner. The new tools and strategies provided by synthetic biology have the potential to improve therapeutics for neurodegenerative diseases. In particular, synthetic biology will help design small molecules, proteins, gene networks, and vectors to target disease‐related genes. Ultimately, new intelligent delivery systems will provide targeted and sustained therapeutic benefits. New treatments will (...) arise from combining ‘protect and repair’ strategies: the use of drug treatments, the promotion of neurotrophic factor synthesis, and gene targeting. Going beyond RNAi and artificial transcription factors, site‐specific genome modification is likely to play an increasing role, especially with newly available gene editing tools such as CRISPR/Cas9 systems. Taken together, these advances will help develop safe and long‐term therapies for many brain diseases in human patients. (shrink)

Post-foundational politics and democracy -- Agonism and democracy -- A typology of agonistic democracy -- Agonistic democracy and the question of institutions -- Agonistic democracy and the limits of popular participation -- Populism, representation, and the popular will -- Political liberalism, contingency and agonistic pluralism -- Liberalism, agonism, and democracy.

An approach to the philosophy of biology in the 21st century requires going beyond its epistemological side, betting on pragmatic aspects, in the sense of the social impact of the instrumentalization of biological developments. These advances have both beneficial and harmful consequences for humanity. Among the latter, it is its use for military conflicts, as a result of advances in biotechnology. The objective of this work is to address the role of biological knowledge in wars, analyzing some especially relevant (...) cases such as bioterrorism, but also other types of conflicts in which biology, broadly understood with its different branches, plays an important role. First, I will introduce the most important concepts in the relationship between biology and war, taking into account historical precedents in this area. Secondly, since biology enters in military conflicts, I will address the case of bioterrorism as one of the most pressing problems in that it is one of the forms that war is currently taking, as well as one of its derivatives, “agroterrorism”, which consists in causing the destruction of crops or the death of livestock that feeds the population. In this regard, I will examine other ways of resolving conflicts in which biological factors play an important role in establishing dominance between two or more nations or populations facing each other, paying special attention to agriculture and livestock. Regarding the possible theoretical models to analyze these conflicts, I will focus on the relationship between pure, applied science and technology, the methodological models of design sciences and ethical and moral reflection. (shrink)