Results for 'late endosome'

975 found
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  1.  20
    Late endosomal and lysosomal trafficking during integrin‐mediated cell migration and invasion.Elena Rainero & Jim C. Norman - 2013 - Bioessays 35 (6):523-532.
    Recently it has become clear that trafficking of integrins to late endosomes is key to the regulation of integrin expression and function during cell migration. Here we discuss the molecular machinery that dictates whether integrins are sorted to recycling endosomes or are targeted to late endosomes and lysosomes. Integrins and other receptors that are sorted to late endosomes are not necessarily degraded and, under certain circumstances, can be spared destruction and returned to the cell surface to drive (...)
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  2.  20
    ER contact sites direct late endosome transport.Ruud H. Wijdeven, Marlieke L. M. Jongsma, Jacques Neefjes & Ilana Berlin - 2015 - Bioessays 37 (12):1298-1302.
    Endosomes shuttle select cargoes between cellular compartments and, in doing so, maintain intracellular homeostasis and enable interactions with the extracellular space. Directionality of endosomal transport critically impinges on cargo fate, as retrograde (microtubule minus‐end directed) traffic delivers vesicle contents to the lysosome for proteolysis, while the opposing anterograde (plus‐end directed) movement promotes recycling and secretion. Intriguingly, the endoplasmic reticulum (ER) is emerging as a key player in spatiotemporal control of late endosome and lysosome transport, through the establishment of (...)
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  3.  26
    ALIX‐ing phospholipids with endosome biogenesis.Ivan Dikic - 2004 - Bioessays 26 (6):604-607.
    Endosomes, which comprise a diverse population of membrane vesicles and tubules, sort proteins and lipids to various cellular destinations. The organization and functions of these pleiomorphic cellular organelles have been extensively studied. Matsuo et al.1 now provide new exciting evidence on the role of lysobiphosphatidic acid (LBPA), a resident phospholipid of internal vesicles of the late endosome, in the control of membrane invagination and endosome biogenesis. In vivo, LBPA functions are controlled by the adaptor protein Alix and (...)
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  4.  40
    Arf6 and the 5'phosphatase of synaptojanin 1 regulate autophagy in cone photoreceptors.Ashley A. George, Sara Hayden, Gail R. Stanton & Susan E. Brockerhoff - 2016 - Bioessays 38 (S1):119-135.
    Abnormalities in the ability of cells to properly degrade proteins have been identified in many neurodegenerative diseases. Recent work has implicated synaptojanin 1 (SynJ1) in Alzheimer's disease and Parkinson's disease, although the role of this polyphosphoinositide phosphatase in protein degradation has not been thoroughly described. Here, we dissected in vivo the role of SynJ1 in endolysosomal trafficking in zebrafish cone photoreceptors using a SynJ1‐deficient zebrafish mutant, nrca14. We found that loss of SynJ1 leads to specific accumulation of late endosomes (...)
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  5.  24
    The biogenesis of lysosomes: Is it a kiss and run, continuous fusion and fission process?Brian Storrie & Michel Desjardins - 1996 - Bioessays 18 (11):895-903.
    Molecules are transferred to lysosomes, the major, acid pH, digestive compartment in eukaryotic cells, by a complex series of pathways that converge at a late endosome/prelysosomal compartment. Here, we discuss the relationship between this compartment and the lysosome. We propose that lysosomes are maintained within cells by a repeated series of kiss and run, transient fusion and fission processes with the late endosome/prelysosome compartment. Directionality to these processes may be conferred by pH gradients and retrieval mechanisms. (...)
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  6.  30
    Intracellular trafficking of lysosomal membrane proteins.Walter Hunziker & Hans J. Geuze - 1996 - Bioessays 18 (5):379-389.
    Lysosomes are the site of degradation of obsolete intracellular material during autophagy and of extracellular macromolecules following endocytosis and phagocytosis. The membrane of lysosomes and late endosomes is enriched in highly glycosylated transmembrane proteins of largely unknown function. Significant progress has been made in recent years towards elucidating the pathways by which these lysosomal membrane proteins are delivered to late endosomes and lysosomes. While some lysosomal membrane proteins follow the constitutive secretory pathway and reach lysosomes indirectly via the (...)
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  7.  9
    Ubiquitin‐mediated endosomal stress: A novel organelle stress of early endosomes that initiates cellular signaling pathways.Akinori Endo, Masayuki Komada & Yukiko Yoshida - 2024 - Bioessays 46 (11):2400127.
    Cells utilize diverse organelles to maintain homeostasis and to respond to extracellular stimuli. Recently, multifaceted aspects of organelle stress caused by various factors have been emerging. The endosome is an essential organelle, functioning as the central hub for membrane trafficking in cooperation with the ubiquitin system. However, knowledge regarding endosomal stress, which refers to organelle stress of the endosome, is currently limited. We recently revealed ubiquitin‐mediated endosomal stress of early endosomes (EEs) and its responsive signaling pathways. These findings (...)
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  8.  18
    Aberrant post‐translational modifications in endosomal trafficking are potential therapeutic targets to avert therapy resistance in solid cancers.Winona Onglao, Yeesim Khew-Goodall, Leila Belle & Ana Lonic - 2022 - Bioessays 44 (2):2100192.
    Drugs targeting a single TK/RTK in the treatment of solid cancers has not had the same success seen in blood cancers. This is, in part, due to acquired resistance in solid cancers arising from a range of mechanisms including the upregulation of compensatory RTK signalling. Rather than attempting to inhibit individual compensatory RTK—requiring knowledge of which RTKs are upregulated in any given tumour—strategies to universally inhibit signalling from multiple RTKs may represent an effective alternative. Endosomal trafficking of RTKs is a (...)
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  9.  13
    Sorting of cargo in the tubular endosomal network.Jachen A. Solinger & Anne Spang - 2022 - Bioessays 44 (12):2200158.
    Intercellular communication is an essential process in all multicellular organisms. During this process, molecules secreted by one cell will bind to a receptor on the cognate cell leading to the subsequent uptake of the receptor‐ligand complex. Once inside, the cell then determines the fate of the receptor‐ligand complex and any other proteins that were endocytosed together. Approximately 80% of endocytosed material is recycled back to the plasma membrane either directly or indirectly via the Golgi apparatus and the remaining 20% is (...)
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  10.  53
    Ion flux and the function of endosomes and lysosomes: pH is just the start.Cameron C. Scott & Jean Gruenberg - 2011 - Bioessays 33 (2):103-110.
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  11. Michelle facos.Late Nineteenth Century - 1998 - Analecta Husserliana 53:123.
  12.  23
    Reflections on the Nobility of Spirit in Romanian Philosophy.Titus Lateş - 2017 - Dialogue and Universalism 27 (4):127-136.
    At the turn of the 17th century, in Romanian philosophy the nobility of spirit is seen as a certain but intermediate value, to be cherished while man waits for his divine reward, which is everlasting life, as presented in Divanul [The Divan] by Dimitrie Cantemir. Two hundred and fifty years later, man is regarded as having evolved from the animal forms of life in Mihai Ralea’s systematic presentation Explicarea omului [An Explanation of Man], and the sole meaning of nobility is (...)
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  13. Mass media: Visualizing the last supper in.Late Medieval Italian Plays - 2006 - Mediaevalia 27:185.
     
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  14.  11
    The Frankfurt School and its Critics.the Late Tom Bottomore - 2002 - Routledge.
    The Institute of Social Research, from which the Frankfurt School developed, was founded in the early years of the Weimar Republic. It survived the Nazi era in exile, to become an important centre of social theory in the postwar era. Early members of the school, such as Adorno, Horkheimer and Marcuse, developed a form of Marxist theory known as Critical Theory, which became influential in the study of class, politics, culture and ideology. The work of more recent members, and in (...)
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  15.  9
    A History of Child Psychoanalysis.the Late Pierre Geissmann & Claudine Geissmann - 1998 - Routledge.
    Child analysis has occupied a special place in the history of psychoanalysis because of the challenges it poses to practitioners and the clashes it has provoked among its advocates. Since the early days in Vienna under Sigmund Freud child psychoanalysts have tried to comprehend and make comprehensible to others the psychosomatic troubles of childhood and to adapt clinical and therapeutic approaches to all the stages of development of the baby, the child, the adolescent and the young adult. Claudine and Pierre (...)
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  16. Constructions of gender and class.in A. Late F. Ifteenth-Century & Alemannic Pharmaceutical Bestiary - 2008 - Mediaevalia 29:157.
  17.  7
    Hē Ischys kai to Dikaio.Stergios Mētas, Kōnstantinos N. Stratēlatēs & Achilleus K. Aimilianidēs (eds.) - 2019 - Leukōsia, Kypros: Nomikes Ekdoseis Hippasus.
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  18.  19
    Microfranchising to Alleviate Poverty: An Innovation Network Perspective. [REVIEW]Laté Lawson-Lartego & Lars Mathiassen - 2020 - Journal of Business Ethics 171 (3):545-563.
    In 2015, the United Nations Sustainable Development Goals set an ethical imperative: end extreme poverty and hunger by 2030. Microfranchising can contribute to this critical effort by offering nonprofit organizations and businesses an opportunity to rapidly scale entrepreneurship within Base of the Pyramid markets. However, while abundant literature exists on traditional franchising, we know little about how to leverage microfranchising in resource-scarce contexts to alleviate poverty. To address this gap, we report a longitudinal case study of a microfranchise network aimed (...)
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  19.  12
    Collected Works of Jeremy Bentham Correspondence: Volume 12: July 1824 to June 1828.Luke O'Sullivan & the Late Catherine Fuller (eds.) - 1968 - Oxford University Press UK.
    This twelfth volume of Correspondence contains authoritative and fully annotated texts of all known letters sent both to and from Bentham between July 1824 and June 1828. The 301 letters, most of which have never before been published, have been collected from archives, public and private, in Britain, the United States of America, Switzerland, France, Japan, and elsewhere, as well as from the major collections of Bentham Papers at University College London Library and the British Library.In mid-1824 Bentham was still (...)
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  20.  15
    The Correspondence of Jeremy Bentham:Volume 12: July 1824 to June 1828: Volume 12: July 1824 to June 1828.Luke O'Sullivan & the Late Catherine Fuller (eds.) - 1968 - Clarendon Press.
    Jeremy Bentham, the philosopher and reformer, was at the height of his fame and influence in the 1820s. The 301 letters in this volume, many of which are previously unpublished, contain correspondence with international leaders such as Simn Bolvar, the 'Liberator', and Bernardino Rivadavia of Buenos Aires, British statesmen such as Robert Peel and Henry Brougham, and leading intellectuals such as John Stuart Mill and Sarah Austin.
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  21. The Inadvertent Conception and Late Birth of the Free-Will Problem.Susanne Bobzien - 1998 - Phronesis 43 (2):133-175.
    ABSTRACT: In this paper I argue that the ‘discovery’ of the problem of causal determinism and freedom of decision in Greek philosophy is the result of a combination and mix-up of Aristotelian and Stoic thought in later antiquity; more precisely, a (mis-)interpretation of Aristotle’s philosophy of deliberate choice and action in the light of Stoic theory of determinism and moral responsibility. The (con-)fusion originates with the beginnings of Aristotle scholarship, at the latest in the early 2nd century AD. It undergoes (...)
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  22.  18
    Plato's Late Ontology: A Riddle Resolved: With a New Introduction and the Essay, "Excess and Deficiency at Statesman 283c-285c".Kenneth M. Sayre - 1983 - [Las Vegas]: Parmenides.
    A new edition of a classic work compares Plato's dialogues to Aristotle's depiction of them. Reprint.
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  23.  34
    Organicism in the Late Nineteenth and Early Twentieth Centuries.D. C. Phillips - 1907 - Journal of the History of Ideas.
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  24.  37
    In Pursuit of Precision: The Calibration of Minds and Machines in Late Nineteenth-century Psychology.Ruth Benschop & Douwe Draaisma - 2000 - Annals of Science 57 (1):1-25.
    A prominent feature of late nineteenth-century psychology was its intense preoccupation with precision. Precision was at once an ideal and an argument: the quest for precision helped psychology to establish its status as a mature science, sharing a characteristic concern with the natural sciences. We will analyse how psychologists set out to produce precision in 'mental chronometry', the measurement of the duration of psychological processes. In his Leipzig laboratory, Wundt inaugurated an elaborate research programme on mental chronometry. We will (...)
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  25.  38
    Helping Motives in Late Modern Society: values and attitudes among nursing students.May-Karin Rognstad, Per Nortvedt & Olaf Aasland - 2004 - Nursing Ethics 11 (3):227-239.
    This article reports a follow-up study of Norwegian nursing students entitled ‘The helping motive -an important goal for choosing nursing education’. It presents and discusses a significant ambiguity within the altruistic helping motive of 301 nursing students in the light of classical and modern virtue ethics. A quantitative longitudinal survey design was used to study socialization and building professional identity. The follow-up study began after respondents had completed more than two-and-a-half years of the three-year educational programme. Data were collected using (...)
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  26.  29
    5 Metaphysics: The late period.Donald Rutherford - 1994 - In Nicholas Jolley, The Cambridge Companion to Leibniz. New York: Cambridge University Press. pp. 124.
  27.  19
    The Physical World of Late Antiquity.William P. D. Wightman - 1964 - Philosophical Quarterly 14 (54):87.
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  28. Doctrines of explanation in late scholasticism and in the mechanical philosophy.Steven Nadler - 1998 - In Daniel Garber & Michael Ayers, The Cambridge history of seventeenth-century philosophy. New York: Cambridge University Press. pp. 2--513.
     
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  29. On Peirce's late proof of pragmaticism.A. Pietarinen & Lauri Snellman - 2006 - Acta Philosophica Fennica 78:275.
     
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  30. Gordon Baker's late interpretation of Wittgenstein.P. M. S. Hacker - 2007 - In Guy Kahane, Edward Kanterian & Oskari Kuusela, Wittgenstein and His Interpreters: Essays in Memory of Gordon Baker. Oxford: Wiley-Blackwell. pp. 88--122.
    Gordon Baker and I had been colleagues at St John’s for almost ten years when we resolved, in 1976, to undertake the task of writing a commentary on Wittgenstein’s Philosophical Investigations. We had been talking about Wittgenstein since 1969, and when we cooperated in writing a long critical notice on the Philosophical Grammar in 1975, we found that working together was mutually instructive, intellectually stimulating and great fun. We thought that we still had much to say about Wittgenstein’s philosophy, and (...)
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  31.  30
    Early vigilance and late avoidance of threat processing: Repressive coping versus low/high anxiety.Manuel G. Calvo & Michael W. Eysenck - 2000 - Cognition and Emotion 14 (6):763-787.
  32. Probabilistic cause, edge conditions, late preemption, and discrete cases.Igal Kvart - 2003 - In Phil Dowe & Paul Noordhof, Cause and Chance: Causation in an Indeterministic World. New York: Routledge. pp. 163-188.
  33.  37
    Organicism in the Late Nineteenth and Early Twentieth Centuries.D. C. Phillips - 1970 - Journal of the History of Ideas 31 (3):413.
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  34. Adorno on late capitalism-Totalitarianism and the welfare state.Deborah Cook - 1998 - Radical Philosophy 89:16-26.
     
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  35.  50
    Violence, Weak Ontology, and Late-Modernity.Stephen K. White - 2009 - Political Theory 37 (6):808-816.
    This essay responds to the characterization Ted Miller offers (in his December 2008 essay in Political Theory) of the kind of nonfoundationalism I have referred to as "weak ontology," and that Gianni Vattimo frequently calls "weak thought." Miller argues that such a position embodies, first, a philosophy of history in which strong ontologies (e.g., religion) are assessed categorically as passé, and, second, are associated essentially with violence. I show that while these characterizations may be appropriate for Vattimo's thought, they are (...)
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  36.  82
    Deep Ethical Pluralism In Late Foucault.Brian Lightbody - 2008 - Minerva - An Internet Journal of Philosophy 12:102-118.
    In the essay “What is Enlightenment?”, Foucault espouses a novel and emancipatory“philosophical ethos” which challenges individuals to undertake an ongoing, aesthetic project oftotal self-transformation. By advocating a view of the self---and moreaccurately the relationship one has to oneself --as a free creation on the part of thesubject, Foucault seems to be espousing a pluralistic ethical position. However, I argue that whilethis interpretation is not entirely false, it is not altogether accurate either. Quite simply, it is toobroad in scope. Instead, I (...)
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  37.  24
    Antiqui and Moderni in Late Medieval Thought.William J. Courtenay - 1987 - Journal of the History of Ideas 48 (1):3.
  38.  16
    Atomism in Late Nineteenth-Century Physical Chemistry.George M. Fleck - 1963 - Journal of the History of Ideas 24 (1):106.
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  39.  21
    “Why do we measure mankind?” Marketing anthropometry in late-Victorian Britain.Elise Smith - 2020 - History of Science 58 (2):142-165.
    In the late nineteenth century, British anthropometrists attempted to normalize the practice of measuring bodies as they sought to collate data about the health and racial makeup of their fellow citizens. As the country’s leading anthropometrists, Francis Galton and Charles Roberts worked to overcome suspicion about their motives and tried to establish the value of recording physical dimensions from their subjects’ perspective. For Galton, the father of the eugenics movement, the attainment of objective self-knowledge figured alongside the ranking of (...)
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  40.  18
    Remarks upon a late book, entitled, The fable of the bees.William Law - 1725 - London: Routledge/Thoemmes Press.
    This scarce antiquarian book is a facsimile reprint of the original. Due to its age, it may contain imperfections such as marks, notations, marginalia and flawed pages. Because we believe this work is culturally important, we have made it available as part of our commitment for protecting, preserving, and promoting the world's literature in affordable, high quality, modern editions that are true to the original work.
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  41.  15
    Art and Ceremony in Late Antiquity.Michael McCormick & Sabine G. MacCormack - 1984 - American Journal of Philology 105 (4):494.
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  42.  42
    Revolutionary China and Its Late-Capitalist Fate.Christopher Connery - 2015 - Historical Materialism 23 (2):257-286.
    This essay examines several works that contribute to an understanding of the nature of contemporary Chinese capitalism and its historical development. Core issues include the character of the bureaucracy, which has had a distinctive relationship to capital formation, and the character of the working class. The periodisation of Chinese capitalism and the relation between the pre- and post-reform periods are pressing political and analytical concerns. This essay suggests the advantages of a clearer focus on the dynamics of depoliticisation in understanding (...)
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  43.  43
    Internal clausulae in Late Latin Prose as Evidence for the Displacement of Metre by Word-Stress.Ralph G. Hall & Steven M. Oberhelman - 1986 - Classical Quarterly 36 (02):508-.
    In several recent studies we have developed precise statistical methodologies which have demonstrated that the cursus mixtus was the dominant rhythmical system for final clausulae in Latin prose from the third century a.d. to the fifth. The cursus mixtus consisted of four standard metrical forms derived from the richer variety of Cicero's Asiatic tradition – cretic-spondee, dicretic, cretic-tribrach and ditrochee –, which were structured according to three accentual patterns – planus, tardus and velox. The latter are differentiated by the number (...)
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  44.  18
    (1 other version)2. Methodology in Late Nineteenth-and Early Twentieth-Century Analytic Philosophy.Scott Soames - 2014 - In Analytic Philosophy in America: And Other Historical and Contemporary Essays. Princeton, NJ: Princeton University Press. pp. 35-59.
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  45.  17
    Colonial Encounters in Late-Victorian England: Pandita Ramabai at Cheltenham and Wantage 1883–6.Antoinette Burton - 1995 - Feminist Review 49 (1):29-49.
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  46. Pietro Bembo, Rome and late-15th-century philology: A reading of the dialogue'De Virgilii Culice et Terentii Fabulis'.M. Campanelli - 1997 - Rinascimento 37:283-319.
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  47. Government Centrlization in Late Second and Third Century A.D. Asia Minor: A Working Hypothesis.James T. Chlup - 2009 - Classical World: A Quarterly Journal on Antiquity 103 (1).
     
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  48.  37
    Ghost Stories in Late Renaissance France: Walking by Night by Timothy Chesters (review).Stuart Clark - 2013 - Common Knowledge 19 (2):389-389.
  49.  39
    The Tribunate in the Late Republic.P. S. Derow - 1990 - The Classical Review 40 (02):379-.
  50.  29
    Giovanni Marliani and Late Medieval PhysicsMarshall Clagett.Dana Durand - 1942 - Isis 34 (2):166-168.
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