The relationship between Fisher's fundamental theorem of natural selection and the ecological environment of density regulation is examined. Using a linear model, it is shown that the theorem holds when density regulation is caused by exploitative competition and that the theorem fails with interference competition. In the latter case the theorem holds only at the limit of zero population density and/or at the limit where the competitively superior individuals cannot monopolise the resource. The results are discussed in relation to population (...) dynamics and life history evolution, where evidence suggests that the level of interference competition in natural populations is so high that the fundamental theorem does not apply. (shrink)

One of the guiding ideas in modern environmentalist thought is that we shouldn’t interfere with nature. It’s better to leave it alone. Many of the arguments offered in favor of this presumption against environmental interference are epistemic. One such argument focuses on ineffectiveness. It says that conservation interventions often do not accomplish their goals. A second argument says that well-intentioned interference in nature produces many harmful unintended consequences. I show that these arguments do not justify the presumption against environmental interference. (...) Both arguments depend on stronger claims, such as the claim that conservation interventions do more harm than good overall. Yet, evidence-based conservation studies do not support the idea that conservation interventions generally do not work, or that they do more harm than good. These facts seriously undermine the presumption against environmental interference. (shrink)

Grammatical gender processing during language production has classically been studied using the so-called picture-word interference (PWI) task. In this procedure, participants are presented with pictures they must name using target nouns while ignoring superimposed written distractor nouns. Variations in response times are expected depending on the congruency between the gender values of targets and distractors. However, there have been disparate results in terms of the mandatory character of an agreement context to observe competitive gender effects and the interpretation of the (...) direction of these effects in Romance languages, this probably due to uncontrolled variables such as animacy. In the present study, we conducted two PWI experiments with European Portuguese speakers who were asked to produce bare nouns. The percentage of animate targets within the list was manipulated: 0, 25, 50, and 100%. A gender congruency effect was found restricted to the 0% list (all targets were inanimate). Results support the selection of gender in transparent languages in the absence of an agreement context, as predicted by the Gender Acquisition and Processing (GAP) hypothesis (Sá-Leite et al.,2019), and are interpreted through the attentional mechanisms involved in the PWI paradigm, in which the processing of animate targets would be favored to the detriment of distractors due to biological relevance and semantic prioritization. (shrink)

Purpose. The aim of this article is an analysis of the main versions of the biodeterminist tradition of re­solving the issue of the nature of gender identity, as well as identification of the advantages of the new version of biodeterminism, which involves elements of social constructivism. Theoretical basis. Social norms determine the extent to which a person has the right to independently determine his or her gender identity, and even more so, to change his or her body according to such (...) gender concepts. Social norms regulate gender relations in society and direct the gender behavior of individuals. However, social norms do not create either the human body, or those biological laws, according to which it functions. Originality. The biodetermist theories of the gender were analyzed from the position of "week" social constructivism. The role of social norms as a factor of gender self-certification, as well as a factor of control over social interference in the functioning of human corporeality is considered. The role of modern medicine as an increasingly influential institutional means of control over the functioning of human corporeality, and therefore, indirectly, and for the implementation of gender identity self-identification is revealed. Conclusions. According to the "week" social constructivism the gender emerges as an integral result of biological, psychological and social construction. The role of personality in the design of the gender has historically grown, but this role can never exclude the influence of biological and social factors that are increasingly becoming the nature of biological and social technologies. Personality can become a victim of these technologies, but he/she can program them, or at any rate selectively use, combine, or to some extent adjust existing biological and social technologies. (shrink)

This aricle discusses the similarity between the propagation of pathogens (viruses and worms) on computer networks and the proliferation of pathogens in cellular organisms (organisms with genetic material contained within a membrane-encased nucleus). It introduces several biological mechanisms which are used in these organisms to protect against such pathogens and presents security models for networked computers inspired by several biological paradigms, including genomics (RNA interference), proteomics (pathway mapping), and physiology (immune system). In addition, the study of epidemiological models (...) for disease control can inspire methods for controlling the spread of pathogens across multiple nodes of a network. It also presents results based on the authors’ research in immune system modeling. (shrink)

Synthetic biology is a new biotechnology that is developing at an impressive pace and attracting a considerable amount of attention from outside the scientific community as well. In this article, two main philosophically and ethically relevant characteristics of this field of research will be laid bare, namely its reliance on mechanistic metaphors to denominate simple forms of life and its appeal to the semantic field of creativity. It is argued that given these characteristics synthetic biology can be understood as a (...) prime example of a kind of human interference with reality that German philosopher Hannah Arendt called “fabrication.” This kind of self-world-relation contrasts to “action,” a relation that introduces, among other things, the idea of an inherent value of the object acted upon. Taking up this latter perspective, one scientific and two ethical challenges to synthetic biology’s take on the realm of life are identified. (shrink)

The automatic tendency to anthropomorphize our interaction partners and make use of experience acquired in earlier interaction scenarios leads to the suggestion that social interaction with humanoid robots is more pleasant and intuitive than that with industrial robots. An objective method applied to evaluate the quality of human–robot interaction is based on the phenomenon of motor interference (MI). It claims that a face-to-face observation of a different (incongruent) movement of another individual leads to a higher variance in one’s own movement (...) trajectory. In social interaction, MI is a consequence of the tendency to imitate the movement of other individuals and goes along with mutual rapport, sense of togetherness, and sympathy. Although MI occurs while observing a human agent, it disappears in case of an industrial robot moving with piecewise constant velocity. Using a robot with human-like appearance, a recent study revealed that its movements led to MI, only if they were based on human prerecording (biological velocity), but not on constant (artificial) velocity profile. However, it remained unclear, which aspects of the human prerecorded movement triggered MI: biological velocity profile or variability in movement trajectory. To investigate this issue, we applied a quasi-biological minimum-jerk velocity profile (excluding variability in the movement trajectory as an influencing factor of MI) to motion of a humanoid robot, which was observed by subjects performing congruent or incongruent arm movements. The increase in variability in subjects’ movements occurred both for the observation of a human agent and for the robot performing incongruent movements, suggesting that an artificial human-like movement velocity profile is sufficient to facilitate the perception of humanoid robots as interaction partners. (shrink)

Insight into animal biology and development provided by classical genetic analysis of the model organism Drosophila melanogaster was an incentive to develop advanced genetic tools for this insect. But genetic systems for the over one million other known insect species are largely undeveloped. With increasing information about insect genomes resulting from next generation sequencing, RNA interference is now the method of choice for reverse genetics, although it is constrained by the means of delivery of interfering RNA. A recent advance to (...) ensure sustained delivery with minimal experimental intervention or trauma to the insect is to exploit commensal bacteria for symbiont‐mediated RNA interference. This technology not only offers an efficient means for RNA interference in insects in laboratory conditions, but also has potential for use in the control of human disease vectors, agricultural pests and pathogens of beneficial insects. (shrink)

In this short contribution we explore the historical roots of recent synthetic approaches in biology and try to assess their real potential, as well as identify future hurdles or the reasons behind some of the main difficulties they currently face. We suggest that part of these difficulties might not be just the result of our present lack of adequate technical skills or understanding, but could spring directly from the nature of the biological phenomenon itself. In particular, if life is (...) conceived as autonomy in open-ended evolution, which would help to explain the highly complex and dynamic organization of the simplest known organisms (i.e., genetically-instructed cellular metabolisms), external synthetic implementations of such systems, or interventions on them, are bound to interfere with some of their characteristic transformation processes, both at the ontogenetic and phylogenetic scales. In any case, this will prove very revealing and productive, technologically and scientifically speaking, since the knowledge gathered from those implementations/interventions will be extremely valuable in establishing our capacities and limitations to fully comprehend, utilize, and expand the living domain as we know it today. (shrink)

In the case of synthetic biology, the responsibility of humanity for the creation of new technologies that interfere with the processes of natural selection and evolution of species can be invoked, thus annihilating the complex ecological balances and possibly leading to uncontrollable genetic mutations. The big ethical questions are raised by the fact that viral genetic material is hybridized with synthetic genetic material, as well as with the genetic material that underlies the DNA of various living cells, that might interfere (...) with synthetic genetic material - either due to errors in the handling of genetic content or the inability to predict the evolution of synthetic biological systems, an evolution beyond any mathematical modeling that would allow the estimation of biological risks given by the appearance of new species - partially or totally synthetic - and especially by their spread in ecosystems. In this article we will plead for an ethical modeling of technology and a wider communication between ethicist and bio-engineers in order to estimate the directions of technological evolution, especially in the case of synthetic biology. (shrink)

Mammalian synthetic biology holds the promise of providing novel therapeutic strategies, and the first success stories are beginning to be reported. Here we focus on the latest generation of mammalian transgene control devices, highlight state‐of‐the‐art synthetic gene network design, and cover prototype therapeutic circuits. These will have an impact on future gene‐ and cell‐based therapies and help bring drug discovery into a new era. The inventory of biological parts that are essential for life on this planet is becoming increasingly (...) complete. The postgenomic era has provided encyclopedic information on gene‐function correlations and systems biology is now delivering comprehensive details on the dynamics of biochemical reaction networks in living organisms. The time has come to reassemble these catalogued items and design new biological devices and systems with novel and useful functionality in a rational and systematic manner. This is the premise of synthetic biology, a constructive systems biology discipline likely to become the life science revolution of the 21st century. (shrink)

We used agent-based modelling to highlight the advantages and disadvantages of several management styles in biology, ranging from centralized to egalitarian ones. In egalitarian groups, all team members are connected with each other, while in centralized ones, they are only connected with the principal investigator. Our model incorporated time constraints, which negatively influenced weakly connected groups such as centralized ones. Moreover, our results show that egalitarian groups outperform others if the questions addressed are relatively simple or when the communication among (...) agents is limited. Complex epistemic spaces are explored best by centralized groups. They outperform other team structures because the individual members can develop their own ideas with less interference of the opinions of others. The optimal ratio between time spent on experimentation and dissemination varies between different organizational structures. Furthermore, if the evidence is shared only after a relevant degree of certainty is reached, all investigated groups epistemically profit. We discovered that the introduction of seminars to the model changes the epistemic performance in favour of weakly connected teams. Finally, the abilities of the principal investigator do not seem to outperform cognitive diversity, as group performances were not strongly influenced by the increase of her abilities. (shrink)

From a scientific approach, this work explores the moral implications of genetic engineering and argues for corrective genetic interference.

Many studies have shown that about three biological motions can be maintained in working memory. However, no study has yet analyzed the difficulties of experiment materials used, which partially affect the ecological validity of the experiment results. We use the perspective of system anatomy to decompose BM, and thoroughly explore the influencing factors of difficulties of BMs, including presentation duration, joints to execute motions, limbs to execute motions, type of articulation interference tasks, and number of joints and planes involved (...) in the BM. We apply the change detection paradigm supplemented by the articulation interference task to measure the BM working memory capacity of participants. Findings show the following: the shorter the presentation duration, the less participants remembered; the more their wrist moved, the less accurate their memory was; repeating verbs provided better results than did repeating numerals to suppress verbal encoding; the more complex the BM, the less participants remembered; and whether the action was executed by the handed limbs did not affect the WMC. These results indicate that there are many factors that can be used to adjust BM memory load. These factors can help sports psychology professionals to better evaluate the difficulty of BMs, and can also partially explain the differences in estimations of BM WMC in previous studies. (shrink)

This paper looks at the commodification of interferon, marketed by Hoffmann La Roche as Roferon A in 1986, as a case study that helps us understand the role of pharmaceutical industry in cancer research, the impact of molecular biology on cancer therapy, and the relationships between biotech start-ups and established pharmaceutical firms. Drawing extensively on materials from the Roche company archives, the paper traces interferon’s trajectory from observed phenomenon to product. Roche embraced molecular biology in the late 1960s to prepare (...) for the moment when the patents on some of its bestselling drugs were going to expire. The company funded two basic science institutes to gain direct access to talents and scientific leads. These investments, I argue, were crucial for Roche’s success with recombinant interferon, along with more mundane, technical and regulatory know-how held at Roche’s Nutley base. The paper analyses in some detail the development process following the initial success of cloning the interferon gene in collaboration with Genentech. It looks at the factors necessary to scale up the production sufficiently for clinical trials. Using Alfred Chandler’s concept of ‘organizational capabilities’, I argue that the process is better described as ‘mobilisation’ than as ‘translation’. (shrink)

Synthetic biologists are extremely concerned with responsible research and innovation. This paper critically assesses their culture of responsibility. Their notion of responsibility has been so far focused on the identification of risks, and in their prudential attitude synthetic biologists consider that the major risks can be prevented with technological solutions. Therefore they are globally opposed to public interference or political regulations and tend to self-regulate by bringing a few social scientists or ethicists on board. This article emphasizes that ethics lies (...) beyond prudence and requires a cultural evaluation of the modes of existence of the various microorganisms designed by synthetic biologists, independently of their potential applications. (shrink)

The laser scanning confocal microscope (LSCM)LSCM: laser scanning confocal microscope; FISH: fluorescence in situ hybridisation; DiO6: 3,3′‐dihexyloxacarbocyanine iodide; NBD‐ceramide: 6‐((N‐(7‐nitrobenz‐2‐oxa‐1,3‐diazol‐4‐yl)amino)‐caproyl)sphingosine; DiO: 3,3′‐dioctadecyloxacarbocyanine perchlorate; DiI: 1,1′‐dioctadecyl‐3,3,3′,3′‐tetramethyl‐indocarbocyanine perchlorate; CCD: charge‐coupled device; DIC: differential interference contrast; FURA2: (‐(2‐(5‐carboxyoxazol‐2‐yl)‐6‐aminobenzofuran‐5‐oxy)‐2‐)2′‐amino‐5′‐methylphenoxy)‐ethane‐N,N,N′,N′‐ tetraacetic acid, sodium salt);BCECF: 2′,7′‐bis‐(carboxyethyl)‐5‐(and‐6‐)‐carboxyfluorescein;fluo‐3: 1‐(2‐amino‐5‐(2,7‐dichloro‐6‐hydroxy‐3‐oxo‐3H‐xanthen‐9‐yl)‐2‐(2′amino‐5′‐methylphenoxy)‐ethane‐N,N, N′,N′,‐tetraacetic acid, ammonium salt; DAPI: 4′,6‐diamidino‐2‐phenylindole, dihydrochloride; PET: positron emission tomogrophy; CT: computer‐assisted tomogrophy; CiD: cubitus interruptus dominus; MRC: Medical Research Council; TOTO‐1: benzothiazolium‐4‐quinolinium dimer; YOYO‐1: benzoxazolium‐4‐quinolinium dimer; ex.: excitation wavelength; em.: emission wavelength. is now established as an invaluable tool in (...) developmental biology for improved light microscope imaging of fluorescently labelled eggs, embryos and developing tissues. The universal application of the LSCM in biomedical research has stimulated improvements to the microscopes themselves and the synthesis of novel probes for imaging biological structures and physiological processes. Moreover the ability of the LSCM to produce an optical series in perfect register has made computer 3‐D reconstruction and analysis of light microscope images a practical option. (shrink)

Background: By organizing and activating our passions with both hormones and experiences, the heart and mind of sexual behavior, sexual motivation, and sexual preference is the brain, the organ of learning. Despite decades of progress, this incontrovertible truth is somehow lost in the far-too-often biologically deterministic interpretation of genetic, hormonal, and anatomical scientific research into the biological origins of sexual motivation. Simplistic and polarized arguments are used in the media by both sides of the seemingly endless debate over sexual (...) orientation, equality, and human rights with such catch phrases as ‘‘born gay’’ contrasted against attempts of ‘‘reparative therapy’’ or ‘‘pray the gay away’’. Though long abandoned in practically every other area of psychology, this remnant of the nature-nurture controversy remains despite its generally acknowledged insufficiency in explaining any adult aspect of the human condition within the scientific community. Methods: This theoretical review article identifies three factors: 1) good intentions with regard to the argument from immutability; 2) false dichotomies limiting intellectual progress by oversimplification of theory and thus hypothesis, and most dangerously, interpretation and; 3) Tradition: a historical separation of the disciplines of biology and psychology, which, to this day, interferes with the effective translation of well-conducted science into good public understanding and policy. Results: Studies clearly demonstrate that progress toward sexual-orientation equality is being made, if slowly, despite the apparent irrelevance of the ‘‘born gay’’ argument from immutability. Evidence is further provided supporting the inadequacy of polarized, dichotic theories of sexual development, particularly those pitting ‘‘blank slate learning’’ against a fated, deterministic biological perspective. Results of this review suggest that an emerging interactionist perspective will promote both better scientific progress and better public understanding, hopefully contributing to progress toward nondiscriminatory public policy. Conclusion: Accepting that the brain is a highly plastic, modularly dimorphic, developmentally biased organ of learning, one which is organized and activated by both hormones and experiences across the lifespan, is essential for doing ‘‘good science’’ well. Interactionist theories of psychosexual development provide an empirically sound, strong, yet modifiable foundation for testable hypotheses exploring biologically biased sexual learning. Keywords: Brain; conditioning; controversy; dichotomy; differentiation; discrimination; equality; sex; sexual; orientation; learning; learned sexuality; born gay; hedonic evaluation; immutability; imprinting; incentive motivation; interactionism; predispositions; theory; therapy (Published: 15 March 2012) Citation: Socioaffective Neuroscience & Psychology 2012, 2 : 17334 - DOI: 10.3402/snp.v2i0.17334. (shrink)

Exact definitions in physical and biological terms of the coefficients in Volterra's (1926, 1931) original competition equations are indispensable for the understanding of the system. In agreement with Volterra's own, but not quite sufficient specifications, it is tried in this paper to give more precise definitions of the parameters used by Volterra. This leads to some consequences; i.a. that there does not exist a principle of competitive exclusion. In order to allow for competitive exclusion — or for stabilization — (...) the Volterra equations need additional biophysical specifications and mathematical modifications. Some such modifications are proposed, for instance for aggressive interference as a function of population numbers. (shrink)

In this article, we aim to describe the crucial role of the somatic marker hypothesis (SMH) in the interaction between what we term the ‘emotional imperative’ and the interference of reason during the decision-making process in António Damásio’s work Descartes’ Error: Emotion, Reason, and the Human Brain. Firstly, we examine the interaction between reasoning, emotions, and human action, with emphasis on the cognitive processes underlying decisionmaking. Next, we explore the influence of emotional and biological factors on SMH, going beyond (...) cost-benefit analysis, highlighting the relevance of memory and mental representations in the decision-making process. Subsequently, we address the influence of SMH, emotions, and feelings on decisions, especially in scenarios of risk and immediate reward, emphasizing the need to consider immediate and future implications. Following this, we investigate somatic markers in neural terms, discussing whether they are innate or acquired and their influence on social behavior and brain lesions. Finally, we analyze the relationship between brain processes, such as the prefrontal cortices, and the interpretation of bodily sensations, emotional responses, and decisionmaking, accentuating the importance of these regions in assimilating somatic markers and their influence on thoughts, perceptions, and behaviors. We conclude that SMH is seen as a biological mechanism that integrates emotional and cognitive information, shaping evaluations and choices. -/- . (shrink)

The essential biological processes that sustain life are catalyzed by protein nano-engines, which maintain living systems in far-from-equilibrium ordered states. To investigate energetic processes in proteins, we have analyzed the system of generalized Davydov equations that govern the quantum dynamics of multiple amide I exciton quanta propagating along the hydrogen-bonded peptide groups in α-helices. Computational simulations have confirmed the generation of moving Davydov solitons by applied pulses of amide I energy for protein α-helices of varying length. The stability and (...) mobility of these solitons depended on the uniformity of dipole-dipole coupling between amide I oscillators, and the isotropy of the exciton-phonon interaction. Davydov solitons were also able to quantum tunnel through massive barriers, or to quantum interfere at collision sites. The results presented here support a nontrivial role of quantum effects in biological systems that lies beyond the mechanistic support of covalent bonds as binding agents of macromolecular structures. Quantum tunneling and interference of Davydov solitons provide catalytically active macromolecular protein complexes with a physical mechanism allowing highly efficient transport, delivery, and utilization of free energy, besides the evolutionary mandate of biological order that supports the existence of such genuine quantum phenomena, and may indeed demarcate the quantum boundaries of life. (shrink)

The discovery of RNA interference in 1998 has made a lasting impact on biological research. Identifying the regulatory role of small RNAs changed the modes of molecular biological inquiry as well as biologists' understanding of genetic regulation. This article examines the early years of small RNA biology's success story. I query which factors had to come together so that small RNA research came into life in the blink of an eye. I primarily look at scientific repertoires as facilitators (...) of rapid scientific change. I show that for a short period of time, between the years 1998 and 2002, different model organism communities, investigative strategies, technological innovations, and research interests could be successfully aligned to take small RNA research off the ground. I discuss how the keystone discoveries were situated in specific experimental traditions and what strategies were employed to establish these discoveries as more general phenomena. Providing thus a practice-based approach of rapid scientific change, I ask how to relate the change in propositional bits of scientific knowledge with changes in scientific practice. (shrink)

Transformations in the biological, medical and legal processes of infertility, substantial modifications in family structure and the advancement of methods and techniques of reproductive technology will affect the next step in both legal and medical terms to address the regulation of bioethics and law in Kosovo. There is a need to establish perspectives in both ethical and professional terms, since the Republic of Kosovo is in the process of drafting a Civil Code. Many of these issues have been raised (...) and addressed during the review and evaluation of family law in the context of harmonisation and inclusion of this law in the Civil Code of the Republic of Kosovo. During the several meetings of official members with different interest groups regarding family law, the need has been raised to regulate family law to be included in the Civil Code for motherhood and fatherhood in the case of reproduction with biomedical assistance, as well as for the birth contract as a donation for another person (so-called surrogate motherhood). These bioethical and legal issues indicate the urgent need for legal harmonisation of a multidimensional platform specifically based on the principles of public health and universal human rights Conclusion. These bio-ethical and legal interferences indicate the urgent need for legal harmonization of a multidimensional platform specifically designed based on the principles of public health and universal human rights. (shrink)

All information results from a process, intrinsic to living beings, of info-autopoiesis or information self-production; a sensory commensurable, self-referential feedback process immanent to Bateson’s ‘difference which makes a difference’. To highlight and illustrate the fundamental nature of the info-autopoietic process, initially, two simulations based on one-parameter feedback are presented. The first, simulates a homeostatic control mechanism (thermostat) which is representative of a mechanistic, cybernetic system with very predictable dynamics, fully dependent on an external referent. The second, simulates a homeorhetic process, (...) inherent to biological systems, illustrating a self-referenced, autonomous system. Further, the active incorporation/interference of viral particles by prokaryotic cells and the activation of CRISPR-Cas can be understood as info-autopoiesis at the most fundamental cellular level, as well as constituting a planetary network of self-referenced information. Moreover, other examples of the info-autopoietic nature of information are presented to show the generality of its applicability. In short, info-autopoiesis is a recursive process that is sufficiently generic to be the only basis for information in nature: from the single cell, to multi-cellular organisms, to consideration of all types of natural and non-natural phenomena, including tools and artificial constructions. (shrink)

Throughout most of human history women have been defined by their biological role in reproduction, seen first and foremost as gestators, which has led to the reproductive system being subjected to outside interference. The womb was perceived as dangerous and an object which husbands, doctors and the state had a legitimate interest in controlling. In this article, we consider how notions of conflict surrounding the womb have endured over time. We demonstrate how concerns seemingly generated by the invisibility of (...) reproduction and the inaccessibility of the womb have translated into similar arguments for controlling women, as technology increases the accessibility of the female body and the womb. Developments in reproductive medicine, from in vitro fertilisation (IVF) to surrogacy, have enabled women and men who would otherwise have been childless to become parents. Uterus transplants and ‘artificial wombs’ could provide additional alternatives to natural gestation. An era of ‘womb technology’ dawns. Some argue that such technology providing an alternative to ‘natural’ gestation could be a source of liberation for female persons because reproduction will no longer be something necessarily confined to the female body. ‘Womb technology’, however, also has the potential to exacerbate the labelling of the female body as a source of danger and an ‘imperfect’ site of gestation, thus replaying rudimentary and regressive arguments about controlling female behaviour. We argue that pernicious narratives about control, conflict and the womb must be addressed in the face of these technological developments. (shrink)

Although the biological bases of forgetting remain obscure, the consensus among cognitive psychologists emphasizes interference processes, rejecting decay in accounting for memory loss. In contrast to this view, recent advances in understanding the neurobiology of long-term memory maintenance lead us to propose that a brain-wide well-regulated decay process, occurring mostly during sleep, systematically removes selected memories. Down-regulation of this decay process can increase the life expectancy of a memory and may eventually prevent its loss. Memory interference usually occurs during (...) certain active processing phases, such as encoding and retrieval, and will be stronger in brain areas with minimal sensory integration and less pattern separation. In areas with efficient pattern separation, such as the hippocampus, interference-driven forgetting will be minimal, and, consequently, decay will cause most forgetting. (shrink)

“A boundary [peras] is not that at which something stops, but, as the Greeks recognized, the boundary is that from which something begins its presencing.” Martin Heidegger -/- Place, as Aristotle defines it, is to be sharply distinguished from merely geometrical space. Places, unlike geometrical spaces, are not indifferent to that which they contain. Indeed, they seem to have a kind of power. For unless something interferes, things gravitate naturally toward places that suit them. This power that Aristotle attributes to (...) place is obvious not only in the case of elemental bodies, but much more so in the case of animals, whose very existence depends upon their inhabitation of a suitable place. A fish out of water soon ceases to be a fish, and, in general, living substances can only preserve and maintain themselves given the stable existence of several characteristic environmental conditions. That is why it is surprising that standard readings of Aristotle on the concept of place have focused almost exclusively on its explicit treatment in the Physics, and have largely failed to address his usage of the concept of place in other writings. -/- My aim in this essay was to elucidate the conception of place at work in Aristotle's biological treatises. A consideration of the role played by place in Aristotle’s biological treatises assists in retrieving a richer and more complex conception of place than is indicated by a tradition of commentators who have looked primarily or exclusively to his explicit comments on the subject in the Physics. It reveals that the Aristotelian approach is not merely of antiquarian interest but can be a valuable resource for recent thinkers – in the context of environmental philosophy, phenomenology, feminist theory and the social sciences – who are working on issues centered around the philosophy of place. (shrink)

Two experiments, one on school-aged children and one on adults, explored the mechanisms underlying responses to an image prime followed by graspable objects that were, in certain cases, dangerous. Participants were presented with different primes and objects representing two risk levels . The task required that a natural/artifact categorization task be performed by pressing different keys. In both adults and children graspable objects activated a facilitating motor response, while dangerous objects evoked aversive affordances, generating an interference-effect. Both children and adults (...) were sensitive to the distinction between biological and non-biological hands, however detailed resonant mechanisms related to the hand-prime gender emerged only in adults. Implications for how the concept of “dangerous object” develops and the relationship between resonant mechanisms and perception of danger are discussed. (shrink)

The article presents and critically discusses the concept of environmental interventionism, which treats interference in the functioning of ecosystems to protect free-living animals from suffering as a general ethical obligation. The strong version of this approach postulates the need to help animals suffering from natural phenomena, and the extreme version recommends the permanent reconstruction of animal bodies using biotechnology. The dispute between proponents and opponents of this concept can be reduced to a fundamental dispute over the primacy of two sets (...) of ethical values: the individual values of particular animals, characteristic of the animal welfare stance, and the values attached to the supra-individual manifestations of the biosphere, characteristic of the environmentalist ethic. The arguments presented in the article justify the application of the principles of environmental ethics in order to protect the biosphere against the contemporary ecological crisis and clearly result from Author’s full acceptance of the assumptions of ethical naturalism. The paper attempts to show that the arguments for the validity of interventionism are based on partially erroneous assumptions and questionable conclusions. These include: ignoring knowledge of the advanced cognitive abilities of many groups of animals and their implications for ethical obligations towards them; clinging to an archaic, individualistic vision of the functioning of the biosphere; super-naturalising the approach to individual suffering; and making an unjustified transfer between intrinsic and instrumental values ascribed to animals. By basing the hierarchy of animals and their life interests used to prioritize interventionism on the arbitrary opinions of humans, this concept is clearly anthropocentric. The article presents arguments for recognising the strong and extreme version of instrumentalism as harmful from the point of view of environmental ethics and biosphere protection. (shrink)

In his insightful review, Eugene V. Koonin discusses various aspects of CRISPR-Cas systems with a strong focus on their qualities as "adaptive immune systems". The CRISPR-Cas system is most famous for its application as a gene-editing tool. Koonin provides a deeper insight into its biological function in bacteria, which is to immunize the cell against parasite DNA. I shall comment on one issue discussed in the text, in two steps. First, I shall elaborate on CRISPR-Cas systems and their supposed (...) Lamarckian character. Criteria for calling biological phenomena genuinely Lamarckian will be narrowed down and then applied to the CRISPR-Cas system, considering interference-driven spacer acquisition as an instantiation of a truly Lamarckian paradigm. Second, I shall consider whether Lamarckian and "canonical" instances of inheritance are a case of theoretical pluralism, being two non-reducible, yet interconnected paradigms. (shrink)

This article explores the development of a novel biomedical research organism, and its potential to remake the species and spaces of translational medicine. The humanized mouse is a complex experimental object in which mice, rendered immunodeficient through genetic alteration, are engrafted with human stem cells in the hope of reconstituting a human immune system for biomedical research and drug testing. These chimeric organisms have yet to garner the same commentary from social scientists as other human–animal hybrid forms. Yet, they are (...) rapidly being positioned as central to translational medicine in immunological research and pharmaceutical development. This article explores the complex relations between species and spaces they seek to enact. Humanizing mice simultaneously moves these animal forms towards the intimate geographies of corporeal equivalence with humans and the expansive geographies of translational research. These multiple trajectories are achieved by the way humanized mice function as both uncertain ‘epistemic things’ and as expansive ‘collaborative things’, articulating mouse genetics with other research, notably stem cell science. In the context of post-genomics, their indeterminacy is critical to their collaborative value; their expansive potential follows as much from their biological openness as from specific expectations. Yet, these new research organisms have both accumulative and disruptive capacities, for there are patterns of interference between these trajectories, remaking boundaries between experimental practices and clinical contexts. (shrink)

This article offers the results of emergy analysis used to evaluate four different soybean production systems in Brazil that were divided into two main categories: biological models (organic and ecological farms) and industrial models (green-revolution chemical farms and herbicide with no-tillage farms). The biological models show better environmental, economical, and social performance indicators; however, at the national level, discussion of transgenic soybean seed release considers only industrial models without any mention of biological models. Classic emergy analysis shows (...) biological options are the better alternatives but does not explain why decisions taken by farmers and government in Brazil were in opposition to these options. New research is proposed to identify and quantify the external forces that strongly interfere in the definition of public policy for soybean production. New parameters are proposed to enrich emergy methodology: Renewability of each input was considered in emergy calculations and negative externalities were included as additional services. (shrink)

Mental disorders have been suggested to differ from somatic diseases because they lack an organic correlate. We show that this argument is both empirically wrong and theoretically irrelevant, because diseases are defined by functional impairments and not biological variation. Due to human diversity, a multitude of functions can be defined, and any selection of medically relevant functional impairments is necessarily value-based. We suggest that such values include individual survival and living in a shared world with others, and that their (...) definition requires public debate and a critical reflection by Philosophical Anthropology. However, the presence of functional impairments that are generally relevant for human life and survival only fulfils the so-called disease criterion, which is necessary but not sufficient to diagnose a clinically relevant malady. This would only be justified if such functional impairments cause individual harm, either because they are accompanied by suffering (the illness criterion) or because they interfere with basic activities of daily living such as personal hygiene and food intake (the sickness criterion of a clinically relevant malady). We apply this theory to mental disorders, conclude that only a fraction of such “disorders” currently listed in international classifications of diseases are clinically relevant mental maladies, suggest focusing on the needs of persons with such maladies and recommend avoiding “pathologization” of human diversity. (shrink)

The article concentrates on attempts of treating the maternal perspective as valuable in moral philosophy. The author traces the evolution of maternal behaviours in history and reconstructs the development of ethical theories determining women’s proper role in society. She raises the question why none of the philosophers gave any consideration to the maternal experience. Her conclusion is that traditional philosophical discourse assumes motherhood as just part of a wide group of issues determined as,,family”. Classical philosophers claim that maternal love is (...) natural and innate so it cannot be valuable. Their analyses fail to take account of maternal experience as a source of moral virtues like self-sacrifice, patience, responsibility, care or devalues this terms as not so important as male virtues like impartiality, non-interference, justice or individual’s autonomy. The author presents an alternative, new, female approach to morality. Simone de Beauvoir, Lucy Irigaray and Adrienne Rich criticize classical vision of motherhood in Western culture. They challenge traditional conviction of producing children as a natural destiny of all women determined by inborn maternal instinct. They treat maternal function in category of independent and deliberate choice. This new perspective replace traditional approach describing motherhood in terms of reproduction and,,natural obligation”. Motherhood in modern thinking is something more than biological production of children. The figure of mother could become an important symbol in ethics and various aspects of our culture. Acceptance of women’s culture would show that women have the same moral and social authority as man. In conclusion the author emphasize the need to present motherhood as a remarkable philosophical and moral value in modern ethics. (shrink)

Cancer drugs are broadly classified into two categories: cytotoxic chemotherapies and targeted therapies that specifically modulate the activity of one or more proteins involved in cancer. Major advances have been achieved in targeted cancer therapies in the past few decades, which is ascribed to the increasing understanding of molecular mechanisms for cancer initiation and progression. Consequently, monoclonal antibodies and small molecules have been developed to interfere with a specific molecular oncogenic target. Targeting gain‐of‐function mutations, in general, has been productive. However, (...) it has been a major challenge to use standard pharmacologic approaches to target loss‐of‐function mutations of tumor suppressor genes. Novel approaches, including synthetic lethality and collateral vulnerability screens, are now being developed to target gene defects in p53, PTEN, and BRCA1/2. Here, we review and summarize the recent findings in cancer genomics, drug development, and molecular cancer biology, which show promise in targeting tumor suppressors in cancer therapeutics. (shrink)

Musical improvisation is the expressive capacity of a performer fostered by access to their own “productive” or “reproductive” tonal imagery: a field of consciousness that includes experiences, images that are internal, combined, distorted, associated, or in competition between themselves. In the highly original form of life that is jazz, narrating means directing time: a time of epiphanies and introversions, of intuitions and revelations, of syncopated rhythms and aesthetic insights, which appear and disappear on the edges of interference between consciousness and (...) the unconscious. The performing urgency of gestures, voices, and sounds, although arranged in the same scene, highlights the difference in individual time. In this intense activity of opposition and resolution the experience becomes an unstable territory that rests on the capacity of the body to remember, decide, anticipate, and invent. The ego reveals itself to be an emerging representation of our nerve structures and, even if conscious organization continues to be attributed to it, its role is not at all crucial. Unity, if anything, means coordination. The conscious ego is the expression of the body. In its ultimate form its unity is a biological problem. (shrink)

Electronic machinic phenomena yield fascinating links with biological processes. Either in the macro-micro-structure of binary encoded information ‐ bytes on media ‐ to the processual flow programs execute on hardware while operating it. Observing micro-electronic worlds akin to living entities: electronic voltages running throughout electronic architectures pipelining data to memory registers; operating systems executing programs on electronic substrates; data flows taking place in machines and in communications protocols within networks. Static art-sci constructs explore and visualize these observations as 2D (...) drawings (Neon Paleolitikos Drawings, 2017‐present) or 3D sculptures (Binary and Biological Sculpture Series, 2018‐present), creatively exposing their inherent rhythmic organization of information, while dynamic installations (Phoenix.Wolfanddotcom.info, Wolfanddotcom, Half-Plant, 2017, Ant Ennae Labyrinths, 2019‐present) propose immersive interference mechanisms that attempt user entanglement in non-human environments. Seven aesthetic case examples are introduced and explored, observing and seeking resonances between micro-granular electronic, biological and hybrid data as source synthesis. This research proposes a look at bio-electronic aggregates on Neon Paleolitikos strata. After the Anthropocene, Neon Paleolitikos is an imaginary epoch dating since the decline of mankind until the zenith of bio-electronic life forms: operational symbioses combined among ruins of silica, transistors, algorithms, cells, plants, animals and electricity. (shrink)

Many nonhuman animals have the emotional capacities to form caring relationships that matter to them, and for their immediate welfare. Drawing from care ethics, we argue that these relationships also matter as objectively valuable states of affairs. They are part of what is good in this world. However, the value of care is precarious in human-animal interactions. Be it in farming, research, wildlife ‘management’, zoos, or pet-keeping, the prevention, disruption, manipulation, and instrumentalization of care in animals by humans is ubiquitous. (...) We criticize a narrow conception of welfare that, in practice, tends to overlook non-experiential forms of harm that occur when we interfere with caring animals. Additionally, we point out wrongs against caring animals that are not just unaccounted for but denied by even an expansive welfare perspective: The instrumentalization of care and caring animals in systems of use can occur as a harmless wrong that an approach purely focused on welfare may, in fact, condone. We should therefore adopt an ethical perspective that goes beyond welfare in our dealings with caring animals. (shrink)

This paper explores the implications of extended and distributed cognition theory for our notions of personal identity. On an extended and distributed approach to cognition, external information is under certain conditions constitutive of memory. On a narrative approach to personal identity, autobiographical memory is constitutive of our diachronic self. In this paper, I bring these two approaches together and argue that external information can be constitutive of one’s autobiographical memory and thus also of one’s diachronic self. To develop this claim, (...) I draw on recent empirical work in human-computer interaction, looking at lifelogging technologies in both healthcare and everyday contexts. I argue that personal identity can neither be reduced to psychological structures instantiated by the brain nor by biological structures instantiated by the organism, but should be seen as an environmentally-distributed and relational construct. In other words, the complex web of cognitive relations we develop and maintain with other people and technological artifacts partly determines our self. This view has conceptual, methodological, and normative implications: we should broaden our concepts of the self as to include social and artifactual structures, focus on external memory systems in the (empirical) study of personal identity, and not interfere with people’s distributed minds and selves. (shrink)

Medical interventions such as methadone treatment for drug addicts or “chemical castration” for sex offenders have been used in several jurisdictions alongside or as an alternative to traditional punishments, such as incarceration. As our understanding of the biological basis for human behaviour develops, our criminal justice system may make increasing use of such medical techniques and may become less reliant on incarceration. Academic debate on this topic has largely focused on whether offenders can validly consent to medical interventions, given (...) the coercive environment of the criminal justice system. Both sides in this debate share the assumption that administering medical interventions to offenders without their valid consent would be unethical. Recently, Thomas Douglas has mounted a formidable challenge to this “consent requirement”. Essentially, his argument rests on a comparison between prison and medical interventions. Douglas asks: if the state is entitled to impose a prison sentence on a criminal without the criminal’s consent, why is consent required for the imposition of a medical intervention? The most obvious way of defending the consent requirement against Douglas’s challenge appeals to the fact that incarceration merely interferes with the right to free movement, but medical interventions interfere with the right to bodily integrity. This argument rests on what Douglas calls the “robustness claim”—the claim that the right to bodily integrity is more robust than the right to freedom of movement. In other words, the right to freedom of movement loses its protective force in a wider range of circumstances than the right to bodily integrity. Douglas’s article seeks to undermine the robustness claim, by arguing that neither case-based intuitions, nor theoretical considerations support this claim. In this article, I will attempt to raise some doubts about Douglas’s challenge to the consent requirement and the robustness claim. (shrink)

We respond to a number of objections raised by John Harris in this journal to our argument that we should pursue genetic and other biological means of morally enhancing human beings (moral bioenhancement). We claim that human beings now have at their disposal means of wiping out life on Earth and that traditional methods of moral education are probably insufficient to achieve the moral enhancement required to ensure that this will not happen. Hence, we argue, moral bioenhancement should be (...) sought and applied. We argue that cognitive enhancement and technological progress raise acute problems because it is easier to harm than to benefit. We address objections to this argument. We also respond to objections that moral bioenhancement: (1) interferes with freedom; (2) cannot be made to target immoral dispositions precisely; (3) is redundant, since cognitive enhancement by itself suffices. (shrink)

Published in 1981, “The Maximin Strategy in Modern Obstetrics” offered two claims—first, that obstetrical interventions ought to be assessed not singly, but rather as packages of interconnected measures that could cumulatively increase risks of harm; and second, that many of these interventions, considered either singly or as a package, lacked a sound evidence base. The first claim has been well supported by later literature, although the term “cascade effect” has proven a more felicitous descriptor for the phenomenon of interventions that (...) trigger the use of other interventions to monitor, prevent, or treat possible side-effects. The second claim was initially supported in a very inadequate way, since the “Maximin” article appeared before an understanding of the methods of systematic reviews of medical evidence had been widely promulgated. Despite these defects, subsequent, rigorously conducted systematic reviews have tended to confirm the impression first offered in 1981, that practices that support physiologic childbearing and the innate, hormonally driven capacities of childbearing women and their fetuses/newborns are much more in keeping with the available evidence than practices involving common or routine high-technology interference with physiologic processes. Harm may occur either directly, through high-technology interventions, or when such procedures distract attention and resources from safe, effective biological processes and lower-technology measures. Surveys indicate a lack of knowledge of this evidence among childbearing women, signaling a serious ethical deficiency in shared decision-making processes and perhaps the skills and knowledge of maternity care clinicians. (shrink)

This article presents and reflects upon artistic artworks at the intersection of virtual and physical computer systems with wet (biological) systems, in reference to Roy Ascott’s ‘moist theory’. It is divided into two sections. The first section offers contextualization by pointing to Darcy Ribeiro’s considerations of differentiations among Brazilians, thus leading to an expectation of miscegenation that assimilates and incorporates races and beliefs in a syncretic way. To this background is added a theoretical framework based on semiotics entwined with (...) mathematics and physics from a set of authors. Both aspects are intertwined with visceral sensations and feelings which emerged from immersible field researches. Glimpses of the 1997 Xingu expedition are introduced as an example of such immersible field research to unveil aspects related with moist theory. The second section presents four case studies that illustrate all of the concepts previously mentioned. Here, syncretism is understood as a field for events that engender the artworks. These artworks are created as metaphorical journeys aimed at expressing potential shamantic experiences and configured as a set of symbiotic systems. Two of these artworks explore neural connections; their research involves computer devices that allow human interferences in the behaviours of autonomous agents in virtual reality simulations. The resultant systems are artificially alive organisms in flux with the rhythms of the autonomous programmed processes; these change each time they run within the computer, allowing the user to symbiotically interfere in the algorithmic nature of artificial ‘seeds’. These poetic realms are metaphors of the flow of life itself. Summing up, they are technoetic artworks that could only arise from the Brazilian melting pot of cultural, racial and theoretical mixtures. (shrink)

In our daily lives we conceive of our surroundings as an objectively given reality. The world is perceived through our senses, and ~hese provide us, so we believe, with a faithful image of the world. But occ~ipnally we are forced to realize that our senses deceive us, e. g., by illusions. For a while it was believed that the sensation of color is directly r~lated to the frequency of light waves, until E. Land (the inventor of the polaroid camera) showed (...) in detailed experiments that our perception of, say, a colored spot depends on the colors of its surrounding. On the other hand, we may experience hallucinations or dreams as real. Quite evidently, the relationship between the "world" and our "brain" is intricate. Another strange problem is the way in which we perceive time or the "Now". Psychophysical experiments tell us that the psychological "Now" is an extended period of time in the sense of physics. The situation was made still more puzzling when, in the nineteen-twenties, Heisenberg and others realized that, by observing processes in the microscopic world of electrons and other elementary particles, we strongly interfere with that world. The outcome of experiments - at least in general - can only be predicted statistically. What is the nature ofthis strange relationship between "object" and "observer"? This is another crucial problem of the inside-outside or endo-exo dichotomy. (shrink)

"... chronicles the story of U.G. Krishnamurti, the Cosmic Naxalite, from his troubled childhood to his disillusionment with many of the leading spiritual teachers of the twentieth century and his catastrophic personal life. In 1967, UG underwent a series of biological mutations that left him in the 'natural state'--functioning without the interference of thought. With no fixed address, no followers and no organization, UG spent the next thirty years travelling the world with an uncompromising message: that 'mind is a (...) myth' and dthe human condition should be demystified and de-psyhologized and viewed in purely physiological terms."--Cover. (shrink)

Two conflicting tendencies may be discerned in Pythagorean ethics as applied to the environment: on the one hand, a sense of reverence for nature and kinship with all life that opposed killing and other forms of interference in the natural world, and on the other hand, a doctrine of the separability of soul and body which denigrates the body and the external world of which it is apart. The prescriptive content of Pythagorean ethics includes prohibitions against taking life, even in (...) sacrifices to the gods, and against eating anything that has been killed. Pollution of certain kinds is forbidden. These strictures were based on an organic, cyclical view of the world, emphasizing its harmony and balance. The Pythagoreans investigated some questions that would today be called ecological. Perhaps most importantly, they evinced a genuine respect for living things, deriving in part from the belief that animals and plants contain the reborn souls of human beings. These doctrines may have been derived from the attitudes and practices of ancestral hunters and gatherers in southeast Europe, with traditional Greek religion serving as the means of transmission from tribaI cultures to c1assical philosophy. The followers of Pythagoras split into two schools: a “scientific” school that neglected biology and therefore ecology, and a “religious” school that emphasized purity of soul and rejected any concern with physical nature. The more “environmentalist”teachings were gradually abandoned as the Pythagoreans accommodated themselves to the general attitudes of Greco-Roman culture. For instance, the objections to animal sacrifice, and to most plants as food, were dropped. The divorce of body and soul in later Pythagorean thought, wherever its influence was strong, brought with it indifference not only to the body, but to all the rest of the natural environment. (shrink)

How should we punish criminal offenders? One prima facie attractive punishment is administering a mandatory neurointervention—interventions that exert a physical, chemical or biological effect on the brain in order to diminish the likelihood of some forms of criminal offending. While testosterone-lowering drugs have long been used in European and US jurisdictions on sex offenders, it has been suggested that advances in neuroscience raise the possibility of treating a broader range of offenders in the future. Neurointerventions could be a cheaper, (...) and more effective method of punishment. They could also be more humane. Nevertheless, in this paper we provide an argument against the use of mandatory neurointerventions on offenders. We argue that neurointerventions inflict a significant harm on an offender that render them a morally objectionable form of punishment in a respect that incarceration is not. Namely, it constitutes an objectionable interference with the offender’s mental states. However, it might be thought that incarceration also involves an equally objectionable interference with the offender’s mental states. We show that even if it were the case that the offender is harmed to the same extent in the same respect, it does not follow that the harms are morally equivalent. We argue that if one holds that intended harm is more difficult to justify than harm that is unintended but merely foreseen, this means neurointerventions could be morally objectionable in a significant respect that incarceration is not. (shrink)

The laws of vital phenomena are to a high degree in contradiction with the principle of absolute causality. Hence the problem arises, what position and rank this principle occupies in biology. The solution of this contradiction might be found in a relaxation of the principle, or in its broadening or by means of the addition of a second heterogenic principle of relationship.The first solution is today rather in favour, since modern physics, especially based on the ”Uncertainty Principle” ofHeisenberg, is inclined (...) to repudiate a strictly causal connection of events in the realm of atomic processes.Broadening of the principle of causality is aimed at to a certain degree by the doctrine of holism. According to this theory biological axioms, principles, and laws are the more universal and the more widely valid, and physical laws should be deduced from them by simplification .The third way is followed by vitalistic doctrines.The ”trialistic” doctrine, presented by the author, represents a development of vitalistic theory. It does not content itself with establishing the fact of the heterogenity of causal and biological laws, but tries to go beyond this and to understand, why the laws of the organic world are of just their special kind and not of another. Moreover it attempts to fit these distinctive principles into the universal system of laws. The trialistic theory divides the wholeness of events into three fundamentally different ”dimensions”, into ”matter”, ”psyche” and ”spirit”, or within the special sphere of living forms into: material, vital and organismic ”dimension”. While in the material sphere the causal connection remains dominant, solely and absolutely, the spiritual or organismic ”dimension” is ruled by ”finality”, a mode of connection of a special kind, caracterized by an active influence on the present of the non-realised future.The interposition of a neutral sphere opens up the possibility of understanding the interweaving of causal and final laws, without interference with one another.Les lois des apparitions de la vie sont difficilement conciliables avec le principe d'une causalité absolue. Le problème se pose donc de savoir, quelle position et quel rÔle ce principe occupe en biologie. La solution de cette contradiction pourrait Être trouvée dans une atténuation ou un élargissement de ce principe comme tel ou par l'adjonction d'un second principe de liaison hétérogène.La première solution est en faveur aujourd'hui depuis que la physique moderne, s'appuyant principalement sur la „Unsicherheitsrelation” deHeisenberg, tend à renoncer à une liaison strictement causale de ce qui se passe dans le domaine des processus atomiques.L'élargissement du principe de causalité est désiré en un certain sens par le holisme. Selon cette théorie les axiomes, les principes et les lois biologiques sont plus universels et d'une valeur plus étendue et il faut en déduire les règles physiques par dérivation simplifiante .La troisième solution nous est donnée par les doctrines vitalistes.La théorie présentée par l'auteur, appelée „trialiste”, met en avant un développement de la doctrine vitaliste. Il ne lui suffit pas de s'arrÊter à l'existence de l'hétérogénité des lois causales et biologiques, mais elle veut aller plus loin, afin de savoir pourquoi les règles déterminant l'organisme sont telles et pas autres. Et elle cherche à mettre de l'ordre dans les principes déterminants en les ènboÎtant dans le système universel de lois. La théorie trialiste divise l'univers des événements en trois „dimensions” qui sont: Matière, „Psyché” et Esprit, ou dans le domaine spécial des formes vivantes en: Matière, Dimension vitale et Dimension organismique. Tandis que dans la dimension matérielle la connexion causale est uniquement et absolument valable, la dimension spirituelle ou organismique est régie par la „Finalité”, un mode de connexion d'un genre spécial, désigné par une influence active du présent par le futur non réalisé.L'interposition d'une sphère neutre nous amène à la possibilité de comprendre l'enchaÎnement es lois causales et finales sans que les unes détruisent les autres. (shrink)

There exist several phenomena breaking the classical probability laws. The systems related to such phenomena are context-dependent, so that they are adaptive to other systems. In this paper, we present a new mathematical formalism to compute the joint probability distribution for two event-systems by using concepts of the adaptive dynamics and quantum information theory, e.g., quantum channels and liftings. In physics the basic example of the context-dependent phenomena is the famous double-slit experiment. Recently similar examples have been found in (...) class='Hi'>biological and psychological sciences. Our approach is an extension of traditional quantum probability theory, and it is general enough to describe aforementioned contextual phenomena outside of quantum physics. (shrink)

The Christian tradition has always taken a generally negative view of abortion, but the moral basis and perceived implications of this negative view have varied greatly. In the early Church abortion and contraception were often seen as broadly equivalent, both involving interference with the natural reproductive process (and an association with sexual immorality which even led some to see contraception as the more sinful of the two). But the tendency to conflate abortion with contraception, and even on similar grounds with (...) male masturbation, declined in the face of the biological discovery of the mother's role as more than just an incubator for the male "seed" - with the recognition of conception as a distinct and crucial event, abortion became generally seen as morally far more serious than contraception, potentially involving threat to an innocent life and therefore, arguably, equivalent to homicide. When seen as homicide, abortion has naturally been subject to an almost total prohibition, the only generally agreed exception being where it is necessary to save the mother's life. Within the Roman Catholic communion, moreover, even this exception has tended to be countenanced only when sanctioned by the doctrine of double effect - where the abortion is not directly intended, but is only a foreseen but unintended consequence of a surgical intervention whose primary intention is to save the mother's life (e.g. the removal of a cancerous uterus or of a fallopian tube containing an ectopic pregnancy). (shrink)