Cancers rely on multiple, heterogeneous processes at different scales, pertaining to many biomedical fields. Therefore, understanding cancer is necessarily an interdisciplinary task that requires placing specialised experimental and clinical research into a broader conceptual, theoretical, and methodological framework. Without such a framework, oncology will collect piecemeal results, with scant dialogue between the different scientific communities studying cancer. We argue that one important way forward in service of a more successful dialogue is through greater integration of applied sciences (experimental and clinical) (...) with conceptual and theoretical approaches, informed by philosophical methods. By way of illustration, we explore six central themes: (i) the role of mutations in cancer; (ii) the clonal evolution of cancer cells; (iii) the relationship between cancer and multicellularity; (iv) the tumour microenvironment; (v) the immune system; and (vi) stem cells. In each case, we examine open questions in the scientific literature through a philosophical methodology and show the benefit of such a synergy for the scientific and medical understanding of cancer. (shrink)

You meet someone new; you like them; you send them to your Facebook page. But how accurate is this representation of you? We all want to look our best, which is why we are drawn to the ability to fudge things a bit online. How does this projection of who we are distort us into who we want to be? Facebook allows us to hide our flaws that are all too visible in real life. We can embellish or correct what (...) we said earlier, edit out what we don’t like about ourselves, and only show photos where our chin is down and the lighting is blown out just enough to hide the bump on our nose. Our prospective employers can even turn to Facebook to assess our desirability. So might the constructed aesthetic of Facebook affect our approach to ethics – to interacting with other people? Does the way we design ourselves on Facebook directly impact the other people in our lives? Is each of us really just a rough draft that needs immediate editing? What about Facebook makes it possible to achieve genuine beauty? (shrink)

Abstract:The term stakeholder is a powerful one. This is due, to a significant degree, to its conceptual breadth. The term means different things to different people and hence evokes praise or scorn from a wide variety of scholars and practitioners. Such breadth of interpretation, though one of stakeholder theory’s greatest strengths, is also one of its most prominent theoretical liabilities. The goal of the current paper is like that of a controlled burn that clears away some of the underbrush of (...) misinterpretation in the hope of denying easy fuel to the critical conflagration that would raze the theory. We aim to narrow its technical meaning for greater facility of use in management and organizational studies. By elaborating a number of common misinterpretations – critical and friendly – of the theory, we hope to render a stronger and more convincing theory as a starting place for future research. (shrink)

The JSTOR Archive is a trusted digital repository providing for long-term preservation and access to leading academic journals and scholarly literature from around the world. The Archive is supported by libraries, scholarly societies, publishers, and foundations. It is an initiative of JSTOR, a not-for-profit organization with a mission to help the scholarly community take advantage of advances in technology. For more information regarding JSTOR, please contact [email protected].

Although death statutes permitting physicians to declare brain death are relatively uniform throughout the United States, academic debate persists over the equivalency of human death and brain death. Alan Shewmon showed that the formerly accepted integration rationale was conceptually incomplete by showing that brain-dead patients demonstrated a degree of integration. We provide a more complete rationale for the equivalency of human death and brain death by defending a deeper understanding of the organism as a whole and by using a novel (...) strategy with shared objectives to justify death determination criteria. Our OaaW account describes different types of OaaW, defining human death as the loss of status as a human OaaW. We defend human death as similar to nonhuman death in terms of wakefulness, but also distinct in terms of the sui generis properties, particularly conscious awareness. We thereby defend the equivalency of brain death and human death using a resulting neurocentric rationale. (shrink)

The standard inferentialist approaches to modal logic tend to suffer from not being able to uniquely characterize the modal operators, require that introduction and elimination rules be interdefined, or rely on the introduction of possible-world like indexes into the object language itself. In this paper I introduce a hypersequent calculus that is flexible enough to capture many of the standard modal logics and does not suffer from the above problems. It is therefore an ideal candidate to underwrite an inferentialist theory (...) of meaning for modal operators. Here I treat specifically the modal logics K, D, T, S4, B, and S5. I show that the calculi are adequate for each set of models, and show that they meet a large set of criteria that are generally thought necessary for a calculus to underwrite a theory of meaning. (shrink)

This book, the first to explore religious education and post-modernity in depth, sets out to provide a much needed examination of the problems and possibilities post-modernity raises for religious education.

Due to the COVID-19 pandemic, most employees face increasing career-related stress, particularly those who work in multinational corporations, because the international travel constraints prevent them from going back to their families. Hence, it is imperative to investigate the critical impact of employees’ occupational burnout on career-related outcomes. In response, this research explores the moderating effect of OB on the relationships between career competencies and career sustainability. To achieve a more comprehensive understanding of relevant issues, we adopted a mixed-method research design (...) that includes both qualitative and quantitative analyses. Findings indicate that all the three dimensions of CCs were positively related to CS; moreover, OB negatively moderated the individual relationships of CC and BC with CS. The main contribution of this study is to enrich the existing career literature by addressing the critical moderating role of OB in the links of CC and BC individually with CS. Practical implications are also discussed in this study. (shrink)

In this book about metaphysics the author defends a realistic view of universals, characterizing the notion of universal by considering language and logic, the idea of possibility, hierarchies of universals, and causation. He argues that neither language nor logic is a reliable guide to the nature of reality and that basic universals are the fundamental type of universal and are central to causation. All assertions and predications about the natural world are ultimately founded on these basic universals. A distinction is (...) drawn between unified particulars and arbitrary particulars ; unified particulars are the terms of causal relations and thus the real constituents of the world. The world is not made up of events but of unified particulars and basic universals. (shrink)

In this paper I return to Hegel's dispute with Kant over the conceptual ordering of external and internal purposiveness to distinguish between two conceptions of teleology at play in the contemporary function debate. I begin by outlining the three main views in the debate (the etiological, causal role and organizational views). I argue that only the organizational view can maintain the capacity of function ascriptions both to explain the presence of a trait and to identify its contribution to a current (...) system, for it is the only view that considers teleology as a natural cause. To establish how teleology can be considered as a natural cause, advocates of the organizational view return to Kant's analysis of internal purposiveness. However, while Kant identifies the requirements that an object must meet to satisfy the demands of teleological judgment, I suggest that he denies that we can know whether they are truly met. I argue that Hegel's philosophy of nature is better equipped to determine how internal purposiveness can be considered as a natural cause, for it grounds organization in a form of purposiveness that is more fundamental than a designer's intention. (shrink)

This commentary critically examines a recent qualitative study, published in this issue of Neuroethics, on the attitudes of family caregivers toward evidence of covert consciousness in brain-injured patients.

This article discusses the relationship between a deconstructivist method in science and technology studies and the more recent moves towards a reconstructivist engagement with science and science policy making. Drawing on examples from the author's own research, the article identifies three forms of engagement and their relative utility and limitations. The article argues that these are typical of STS work that seeks direct engagement with science policy making and which could form the basis for a more "serviceable STS" that retains (...) its critical and independent perspective on science. The paper concludes by arguing that the analysis has important implications for the ways in which STS expertise can articulate with science policy making. (shrink)

In the early months of 2020, the deadly Covid-19 disease spread rapidly around the world. In response, national and regional governments implemented a range of emergency lockdown measures, curtailing citizens’ movements and greatly limiting economic activity. More recently, as restrictions begin to be loosened or lifted entirely, the use of so-called contact tracing apps has figured prominently in many jurisdictions’ plans to reopen society. Critics have questioned the utility of such technologies on a number of fronts, both practical and ethical. (...) However, little has been said about the ways in which the normative design choices of app developers, and the products that result therefrom, might contribute to ethical reflection and wider political debate. Drawing from scholarship in critical design and human–computer interaction, this paper examines the development of a QR code-based tracking app called Zwaai (‘Wave’ in Dutch), where its designers explicitly positioned the app as an alternative to the predominant Bluetooth and GPS-based approaches. Through analyzing these designers’ choices, this paper argues that QR code infrastructures can work to surface a set ofethical–political seams, two of which are discussed here—responsibilizationandnetworked (im)permanence—that more ‘seamless’ protocols like Bluetooth actively aim to bypass, and which may go otherwise unnoticed by existing ethical frameworks. (shrink)

The modern slavery literature engages with history in an extremely limited fashion. Our paper demonstrates to the utility of historical research to modern slavery researchers by explaining the rise and fall of the ethics-driven market category of “free-grown sugar” in nineteenth-century Britain. In the first decades of the century, the market category of “free-grown sugar” enabled consumers who were opposed to slavery to pay a premium for a more ethical product. After circa 1840, this market category disappeared, even though considerable (...) quantities of slave-grown sugar continued to arrive into the UK. We explain the disappearance of the market category. Our paper contributes to the on-going debates about slavery in management by historicizing and thus problematizing the concept of “slavery”. The paper challenges those modern slavery scholars who argue that lack of consumer knowledge about product provenance is the main barrier to the elimination of slavery from today’s international supply chains. The historical research presented in this paper suggests that consumer indifference, rather than simply ignorance, may be the more fundamental problem. The paper challenges the optimistic historical metanarrative that pervades much of the research on ethical consumption. It highlights the fragility of ethics-driven market categories, offering lessons for researchers and practitioners seeking to tackle modern slavery. (shrink)

Volume 52, Issue 8, July 2020, Page 811-815.

In this superbly argued and deeply engaging book, Andrew Linzey not only shows that animals can and do suffer but also that many of the justifications for inflicting animal suffering in fact provide grounds for protecting them.

Recent work on emergence in physics has focused on the presence of singular limit relations between basal and upper-level theories as a criterion for emergence. However, over-emphasis on the role of singular limit relations has somewhat obscured what it means to say that a property or behaviour is emergent. This paper argues that singular limits are not central to emergence and develops an alternative account of emergence in terms of the failure of basal explainability. As a consequence, emergence and reduction, (...) long held to be two sides of the same coin in the emergentist tradition, are largely decoupled. (shrink)

Violent conflict between individuals and groups was as common in the ancient world as it has been in more recent history. Detested in theory, it nevertheless became as frequent as war between sovereign states. The importance of such ‘_stasis_’ was recognised by political thinkers of the time, especially Thucydides and Aristotle, both of whom tried to analyse its causes. Violence, Civil Strife and Revolution in the Classical City, first published in 1982, gives a conspectus of _stasis_ in the societies of (...) Greek antiquity, and traces the development of civil strife as city-states grew in political, social and economic sophistication. Aristocratic rivalry, tensions between rich and poor, imperialism and constitutional crisis are all discussed, while special consideration is given to the attitudes of the participants and the theoretical explanations offered at the time. In conclusion, civil strife in the ancient world is compared to more recent conflicts, both domestic and international. (shrink)

Machine generated contents note: 1. Introduction; 2. Peace; 3. Rule of law; 4. Human rights; 5. Democracy; 6. Liberty; 7. The institutional ethos of the EU; 8. Towards the EU as a just institution; 9. Concluding proposals.

This volume brings together original research that throws new light on how standards of behavior for medical practitioners are articulated in different religious, social, and political contexts.

A new introduction to Kant, guiding the student through the key concepts of his work by examining the overall development of his ideas.

Some cases of prosopagnosia involve a highly circumscribed loss of A-consciousness. When seen in this way they offer further support for the arguments made in Block's target article.

Key Philosophers in Conversation is a fascinating collection of interviews presenting the ideas of some of the worlds leading contemporary philosophers. Each interview features a discussion with a key philosopher looking at philosophical issues such as; the philosophy of mind, ethics, science, political philosophy and the history of philosophy. Those interviewed are; W.V.O Quine, Michael Dummet, Mary Warnock, Hilary Putnam, Alasdair MacIntyre, Daniel Dennett, Martha Nussbaum, Roger Scruton, Bernard Williams, Jean Hampton, Richard Dawkins, Derek Parfit, Peter Strawson, David Gauthier, Hugh (...) Mellor, John Cottingham, Adam Morton, Stefan Korner, Richard Sorabji and Nancy Cartwright. This book offers an excellent insight to contemporary philosophy and is ideal for anyone seeking an introduction to what is happening in Philosophy today. (shrink)