We have synthesized a 582,970-base pair Mycoplasma genitalium genome. This synthetic genome, named M. genitalium JCVI-1.0, contains all the genes of wild-type M. genitalium G37 except MG408, which was disrupted by an antibiotic marker to block pathogenicity and to allow for selection. To identify the genome as synthetic, we inserted "watermarks" at intergenic sites known to tolerate transposon insertions. Overlapping "cassettes" of 5 to 7 kilobases (kb), assembled from chemically synthesized oligonucleotides, were joined by in vitro recombination to produce intermediate (...) assemblies of approximately 24 kb, 72 kb ("1/8 genome"), and 144 kb ("1/4 genome"), which were all cloned as bacterial artificial chromosomes in Escherichia coli. Most of these intermediate clones were sequenced, and clones of all four 1/4 genomes with the correct sequence were identified. The complete synthetic genome was assembled by transformation-associated recombination cloning in the yeast Saccharomyces cerevisiae, then isolated and sequenced. A clone with the correct sequence was identified. The methods described here will be generally useful for constructing large DNA molecules from chemically synthesized pieces and also from combinations of natural and synthetic DNA segments. 10.1126/science.1151721. (shrink)

We conduct an experiment with 459 nonprofessional investors to examine whether they evaluate companies differently based on management’s stated purpose for undertaking corporate social responsibility activities in the presence versus absence of a company-specific negative event. Specifically, we vary whether or not management intends to achieve financial returns from CSR activities in addition to promoting social good. We address investors’ decision processes by investigating whether their judgments are mediated by perceptions of future cash flows and/or the underlying ethical culture of (...) the company. Results show that absent a negative event, investment judgments are stronger when CSR activities are intended to achieve financial returns, through expectations of higher future cash flows. However, when a negative event occurs, we find a moderating effect of independent assurance of CSR disclosures. When disclosures are not assured, investors prefer CSR undertaken only for societal benefit, mediated by perceptions of a stronger ethical culture. However, when disclosures are assured, ethical culture is viewed similarly regardless of management’s intention to achieve financial returns from CSR activities. This suggests that management’s willingness to obtain independent assurance on disclosures is viewed as a positive ethical signal. Thus, assurance complements disclosure of CSR activities by contributing to protection against the impact of negative events. (shrink)

Facing an increasing number and variety of issues with social salience, firms must determine how to engage with issues that likely have a significant impact on them. Integrating issues management and salience theories, the authors find that firms engage with socially contested issues—where there is a high degree of societal disagreement—in a different manner from issues that have social consensus, or high agreement. Examining social issue resolutions filed by shareholders from 1997 to 2009, the study finds that socially contested issues, (...) as well as those issues with social consensus, are both likely to result in engagement by the firm. For social issues with consensus, a firm is more likely to opt for a low level of shareholder engagement whereas resolutions regarding contested issues lead to engaging shareholders at a higher level. These findings shed new light on the IM and issue salience literature streams that have suggested firms will react differently to these types of issues, even while they remain largely untested. Finally, firms become less engaged with perennial issues over time. rather than more, providing new guidance to researchers, shareholder activists, and firms alike. To the authors’ knowledge, such fined-grained insight into expected levels of firm engagement with social issue salience has not been put forth previously. (shrink)

Because no single person or group holds knowledge about all aspects of research, mechanisms are needed to support knowledge exchange and engagement. Expertise in the research setting necessarily includes scientific and methodological expertise, but also expertise gained through the experience of participating in research and/or being a recipient of research outcomes. Engagement is, by its nature, reciprocal and relational: the process of engaging research participants, patients, citizens and others brings them closer to the research but also brings the research closer (...) to them. When translating research into practice, engaging the public and other stakeholders is explicitly intended to make the outcomes of translation relevant to its constituency of users. In practice, engagement faces numerous challenges and is often time-consuming, expensive and ‘thorny’ work. We explore the epistemic and ontological considerations and implications of four common critiques of engagement methodologies that contest: representativeness, communication and articulation, impacts and outcome, and democracy. The ECOUTER methodology addresses problems of representation and epistemic foundationalism using a methodology that asks, “How could it be otherwise?” ECOUTER affords the possibility of engagement where spatial and temporal constraints are present, relying on saturation as a method of ‘keeping open’ the possible considerations that might emerge and including reflexive use of qualitative analytic methods. This paper describes the ECOUTER process, focusing on one worked example and detailing lessons learned from four other pilots. ECOUTER uses mind-mapping techniques to ‘open up’ engagement, iteratively and organically. ECOUTER aims to balance the breadth, accessibility and user-determination of the scope of engagement. An ECOUTER exercise comprises four stages: engagement and knowledge exchange; analysis of mindmap contributions; development of a conceptual schema ; and feedback, refinement and development of recommendations. ECOUTER refuses fixed truths but also refuses a fixed nature. Its promise lies in its flexibility, adaptability and openness. ECOUTER will be formed and re-formed by the needs and creativity of those who use it. (shrink)

What a pleasure to have such subtle thinkers and scholars as Bill Martin and Andrew Cutrofello reflect on the relation of irony and comedy to politics and philosophy through their commentary on my new book. To set the tone, Martin begins with a koan, or a parody of one, “What if a tree told a joke in the woods and there was no one there to hear it?” He means, I believe, to sound a warning on the limits of irony (...) in our serious, or perhaps, Martin would say, our seriously idiotic, times. By the end of his discussion, Martin wonders if perhaps a politics of irony might not lead to greater cynicism in our morally upside-down times and if those Wall Street rip-off artists merit something more than satire—they may .. (shrink)

BackgroundEngagement is important within cohort studies for a number of reasons. It is argued that engaging participants within the studies they are involved in may promote their recruitment and retention within the studies. Participant input can also improve study designs, make them more acceptable for uptake by participants and aid in contextualising research communication to participants. Ultimately it is also argued that engagement needs to provide an avenue for participants to feedback to the cohort study and that this is an (...) ethical imperative. This study sought to explore the participants’ experiences and thoughts of their engagement with their birth cohort study.MethodsParticipants were recruited from the Children of the 90s (CO90s) study. Qualitative semi-structured interviews were conducted with 42 participants. The interviews were transcribed verbatim, and uploaded onto Nvivo software. They were then analysed via thematic analysis with a constant comparison technique.ResultsParticipants’ experiences of their engagement with CO90s were broadly based on three aspects: communication they received from CO90s, experiences of ethical conduct from CO90s and receiving rewards from CO90s. The communication received from CO90s, ranged from newsletters explaining study findings and future studies, to more personal forms like annual greeting cards posted to each participant. Ethical conduct from CO90s mainly involved participants understanding that CO90s would keep their information confidential, that it was only involved in ‘good’ ethical research and their expectation that CO90s would always prioritise participant welfare. Some of the gifts participants said they received at CO90s included toys, shopping vouchers, results from clinical tests, and time off from school to attend data collection (Focus) days. Participants also described a temporality in their engagement with CO90s and the subsequent trust they had developed for the cohort study.ConclusionThe experiences of engagement described by participants were theorized as being based on reciprocity which was sometimes overt and other times more nuanced. We further provide empirical evidence of participants’ expectation for a reciprocal interaction with their cohort study while highlighting the trust that such an interaction fosters. Our study therefore provides key insights for other cohort studies on what participants value in their interactions with their cohort studies. (shrink)

In Bamboozled (2000), Spike Lee’s satire about a modern TV minstrel show, an auditioning actor named Honeycutt tells the show’s writer, Pierre Delacroix, “I even do Shakespeare shit. . . . To be or not to be, you know? That’s the motherfuckin’ question. . . . There’s a scene where this brother was—Laertes was asking the king, that he wanted to go to Paris and shit. The king asked his daddy, and his daddy say, ‘He hath, my lord, wrung from (...) me by laboursome petition. . . .’” Impatiently, Delacroix interrupts: “Was there any more to it, or was that pretty much . . . ?” Delacroix’s interruption of Honeycutt’s Polonius ironically echoes Polonius’s interruption of the speech of the First Player: “This is too .. (shrink)

This work was supported, in part, by a Stem Cell Network grant to Françoise Baylis and Jason Scott Robert and a CIHR grant to Françoise Baylis. We sincerely thank Alan Fine, Rich Campbell, Cynthia Cohen, and Tim Krahn for helpful comments on an earlier draft of this paper. Thanks are also owed to Tim Krahn for his research assistance. An earlier version of this paper was presented to the Department of Bioethics and the Novel Tech Ethics research team. We (...) thank the participants at each of these meetings for their helpful comments. (shrink)

Although traditionally, nursing research has paid little attention to geographical approaches, recent years have witnessed some initial research interest in the dynamic between nursing, space and place. Such research potentially represents the foundations of what may be termed a ‘geography of nursing’. Although, to date, some novel and valuable perspectives have been gained into the spatial features of nursing, no consideration has been given to the theoretical development of, and basis for, a geography of nursing. Furthermore, no consideration has been (...) given to philosophical heritage; the treatment of space and place in human geography and the insights that this may provide for the new field of research. In this context, this paper provides an historical review of geographical research and traces the evolution of how space and place have been conceptualized and operationalized by it. The paper outlines the emergence of a health geography subdiscipline and its own changing and diverse perspectives. In the final section, the central themes of the current geography of nursing are considered and, reflecting back on the theoretical concerns of contemporary human geography, the paper outlines some philosophies and theories on which future geography of nursing could be based. From a disciplinary perspective, one potential role of the geography of nursing is argued to be the maintenance of the relationship between health geography and mainstream health service and medical concerns, but in a place‐sensitive, patient‐sensitive and qualitative form. (shrink)

Andrews argues for a pluralistic folk psychology that employs different kinds of practices and different kinds of cognitive tools (including personality trait attribution, stereotype activation, inductive reasoning about past behavior, and ...

In the paper Randomizations of Scattered Sentences, Keisler showed that if Martin’s axiom for aleph one holds, then every scattered sentence has few separable randomizations, and asked whether the conclusion could be proved in ZFC alone. We show here that the answer is “yes”. It follows that the absolute Vaught conjecture holds if and only if every \-sentence with few separable randomizations has countably many countable models.

Using an image taken by Reuters' photographer Nicky Loh during the 2009 earthquake in Sumatra, this article rethinks in positive terms the experience of being captivated by photographs, including `disaster' photographs that are often described as problematically spectacularizing. In order to do this I bring together two propositions, that of the photograph as a uniquely articulated prosthetic stare on the one hand, and as an inorganic but powerful `agent' or `actor' on the other. My main theoretical resources come from Donna (...) Haraway's well-known 1988 essay `Situated knowledges' and Maurice Merleau-Ponty's 1961 essay `Eye and mind'. (shrink)

We examine the claim that the methodology of psychology leads to a bias in animal cognition research against attributing “anthropomorphic” properties to animals . This charge is examined in light of a debate on the role of folk psychology between primatologists who emphasize similarities between humans and other apes, and those who emphasize differences. We argue that while in practice there is sometimes bias, either in the formulation of the null hypothesis or in the preference of Type-II errors over Type-I (...) errors, the bias is not the result of proper use of the Neyman and Pearson hypothesis testing method. Psychologists’ preference for false negatives over false positives cannot justify a preference for avoiding anthropomorphic errors over anthropectic errors. (shrink)

The study of animal cognition raises profound questions about the minds of animals and philosophy of mind itself. Aristotle argued that humans are the only animal to laugh, but in recent experiments rats have also been shown to laugh. In other experiments, dogs have been shown to respond appropriately to over two hundred words in human language. In this introduction to the philosophy of animal minds Kristin Andrews introduces and assesses the essential topics, problems and debates as they cut (...) across animal cognition and philosophy of mind. She addresses the following key topics: what is cognition, and what is it to have a mind? What questions should we ask to determine whether behaviour has a cognitive basis? the science of animal minds explained: ethology, behaviourist psychology, and cognitive ethology rationality in animals animal consciousness: what does research into pain and the emotions reveal? What can empirical evidence about animal behaviour tell us about philosophical theories of consciousness? does animal cognition involve belief and concepts; do animals have a ‘Language of Thought’? animal communication other minds: do animals attribute ‘mindedness’ to other creatures? moral reasoning and ethical behaviour in animals animal cognition and memory. Extensive use of empirical examples and case studies is made throughout the book. These include Cheney and Seyfarth’s ververt monkey research, Thorndike’s cat puzzle boxes, Jensen’s research into humans and chimpanzees and the ultimatum game, Pankseep and Burgdorf’s research on rat laughter, and Clayton and Emery’s research on memory in scrub-jays. Additional features such as chapter summaries, annotated further reading and a glossary make this an indispensable introduction to those teaching philosophy of mind, animal cognition. It will also be an excellent resource for those in fields such as ethology, biology and psychology. (shrink)

Andrews Reath presents a selection of his best essays on various features of Kant's moral psychology and moral theory, with particular emphasis on his conception of rational agency and his conception of autonomy. Together the essays articulate Reath's original approach to Kant's views about human autonomy, which explains Kant's belief that objective moral requirements are based on principles we choose for ourselves. With two new papers, and revised versions of several others, the volume will be of great interest to (...) all students and scholars of Kant and of moral philosophy. (shrink)

The admiration of the Soviet Union amongst Britain's interwar scientific left is well known. This article reveals a parallel story. Focusing on the biologists Julian Huxley and Lancelot Hogben and the scientific journalist J.G. Crowther, I show that a number of scientific thinkers began to look west, to the US. In the mid- to late 1930s and into the 1940s, Huxley, Crowther and Hogben all visited the US and commented favourably on Roosevelt's New Deal, in particular its experimental approach to (...) politics (in the form of planning). Huxley was first to appreciate the significance of the experiment; he looked to the Tennessee Valley Authority as a model of democratic planning by persuasion that could also be applied in Britain. Crowther, meanwhile, examined the US through the lens of history of science. InFamous American Men of Science(1937) and in lectures at Harvard University, he aimed to shed light on the flaws in the Constitution which were frustrating the New Deal. Finally, Hogben's interest in the US was related to his long-standing opposition to dialectical materialism, and when he finally saw the US at first hand, he regarded it as a model for how to bring about a planned socialist society through peaceful persuasion. (shrink)

The randomization of a complete first-order theory [Formula: see text] is the complete continuous theory [Formula: see text] with two sorts, a sort for random elements of models of [Formula: see text] and a sort for events in an underlying atomless probability space. We study independence relations and related ternary relations on the randomization of [Formula: see text]. We show that if [Formula: see text] has the exchange property and [Formula: see text], then [Formula: see text] has a strict independence (...) relation in the home sort, and hence is real rosy. In particular, if [Formula: see text] is o-minimal, then [Formula: see text] is real rosy. (shrink)

I argue that the behavior of other agents is insufficiently described in current debates as a dichotomy between tacit theory and simulation theory. I introduce two questions about the foundation and development of our ability both to attribute belief and to simulate it. I then propose that there is one additional method used to predict behavior, namely, an inductive strategy.

ABSTRACT Pediatric psychologists have much to contribute to growing efforts to mitigate the impact of parent mental and behavioral health problems on children’s health and development. However, providing parent-focused psychological services within the pediatric setting brings many new ethical considerations and challenges. Guided by the American Psychological Association’s Ethics Code, this paper presents an ethical case for providing these types of services, followed by a comprehensive analysis of the unique ethical challenges likely to be encountered when doing so. Recommendations are (...) offered to support the ethical delivery of parent-focused psychological services in pediatric settings. (shrink)

This article explores a set of questions about the ‘idea of freedom’ that Kant introduces in the fourth paragraph of Groundwork III. I develop a reading that supports treating it as a normative notion and brings out its normative content in some detail. I argue that we should understand the idea as follows: that it is a general feature of reasoning and judgement that it understands itself to be a correct or sound application of the normative standards of the relevant (...) domain of cognition, not influenced by irrelevant or external factors. Reasoning and judgement are thus normatively committed to these standards of correctness. A second and related concern is to explore connections between the idea of freedom and Kant’s conception of autonomy and to identify different points at which autonomy plays a role in the argument of Groundwork III. In the final section, I mine the idea of freedom for a set of normative commitments specific to rational agency that play a foundational role in Kant’s moral conception. (shrink)

The essays in this volume offer an approach to the history of moral and political philosophy that takes its inspiration from John Rawls. All the contributors are philosophers who have studied with Rawls and they offer this collection in his honour. The distinctive feature of this approach is to address substantive normative questions in moral and political philosophy through an analysis of the texts and theories of major figures in the history of the subject: Aristotle, Hobbes, Hume, Rousseau, Kant and (...) Marx. By reconstructing the core of these theories in a way that is informed by contemporary theoretical concerns, the contributors show how the history of the subject is a resource for understanding present and perennial problems in moral and political philosophy. This outstanding collection will be of particular interest to historians of moral and political philosophy, historians of ideas, and political scientists. (shrink)

We build a new spectrum of recursive models (SRM(T)) of a strongly minimal theory. This theory is non-disintegrated, flat, model complete, and in a language with a finite structure.

Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 This paper builds upon an essay I published in Cosmos and History in June of 2014, in which nonexistence is seen as the engine, axis and source of existence. 1 Here I propose a speculative bottom-up theory of everything originating from nothing, including how top-down theories, such as general relativity and quantum mechanics, might approximate my instinct. I share how any one can intuitively experience scientific theories. Normal 0 false false false (...) EN-US X-NONE X-NONE. (shrink)

Frans de Waal (1948-2024) transformed our understanding of primate cognition and social behavior, shaping the perspectives of scientists, philosophers, and the general public through his groundbreaking research and engaging popular books.

This paper develops an interpretation of what is essential to kant's doctrine of the highest good, Which defends it while also explaining why it is often rejected. While it is commonly viewed as a theological ideal in which happiness is proportioned to virtue, The paper gives an account in which neither feature appears. The highest good is best understood as a state of affairs to be achieved through human agency, Containing the moral perfection of all individuals and the satisfaction of (...) their permissible ends-I.E., One in which all act from the moral law and in doing so achieve their intended ends. The paper shows that the texts contain two distinct conceptions not distinguished by kant-Both a theological and a secular (political) notion. The standard objections apply to the theological, But the secular conception is consistent with kant's conception of moral conduct. Moreover, That the highest good is introduced as an end to be constructed out of the moral law indicates that the secular version is the essential notion. (shrink)

Dasgupta poses a serious challenge to realism about natural properties. He argues that there is no acceptable explanation of why natural properties deserve the value realists assign to them and are consequently absent of value. In response, this paper defines and defends an alternative non-explanatory account of normativity compatible with realism. Unlike Lewis and Sider, who believe it is sufficient to defend realism solely on realist terms, I engage with the challenge on unfriendly grounds by revealing a tu quoque. Dasgupta (...) and anti-realists face a similar challenge to that directed against realism: one that not only undermines the objection to realism by legitimising non-explanatory normativity but leaves them facing a significant dilemma. (shrink)

Super-Humeans argue that the most parsimonious ontology of the natural world compatible with our best physical theories consists exclusively of particles and the distance relations between them. This paper argues by contrast that Super-Humean reduction goes insufficiently far, by showing there to be a more parsimonious ontology compatible with physics: Ultimate-Humeanism. This novel view posits an ontology consisting solely of the particles and distance relations required for the existence of a single brain. Super-Humeans impose conditions on what counts as an (...) ontology of the natural world to avoid their view slipping into this kind of ontology, but these conditions are arbitrarily imposed and once this is exposed, Super-Humeans face a dilemma. Either they can embrace Ultimate-Humeanism as the minimal ontology of the natural world compatible with physics, or (more likely) they can rethink the methodology that got them there. Overall, this paper argues that Super-Humeanism currently lacks principled motivation, outlines a framework for naturalistic ontological reductions, and exposes the consequences of unchecked adherence to a simplicity-driven methodology. (shrink)

Chapter One The most plausible arguments for the identity of mind and body that have been advanced in this century have been for the identity of mental ...

Boyer & Petersen lay out a compelling theory for folk-economic beliefs, focusing on beliefs about markets. However, societies also allocate resources through mechanisms involving power and group decision-making, through the political economy. We encourage future work to keep folkpoliticaleconomic beliefs in mind, and sketch an example involving pollution and climate change mitigation policy.