The origin of insulin‐expressing β‐cells in the adult mammalian pancreas is controversial. During normal tissue turnover and following injury, β‐cells may be replaced by duplication of existing β‐cells.1 However, an alternative source of β‐cells has recently been proposed based on neogenesis from a Ngn3‐positive population present in regenerating pancreatic ducts.2 The appearance of β‐cells from Ngn3‐positive progenitors is reminiscent of normal pancreas development, and Ngn3‐expressing cells isolated from regenerating pancreas can generate the full repertoire of endocrine phenotypes. The isolation and (...) characterisation of the equivalent human progenitors may represent a significant step forward in the hunt for a cure for diabetes. BioEssays 30:617–620, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

Im Mittelpunkt der neun Beiträge aus Deutschland und Frankreich stehen Modelle von Konstruktionen individueller, personaler und kollektiver Identität im alten Israel, in der griechischen Antike, im frühen Judentum sowie im frühen Christentum. Deutlich wird in dieser Zusammenstellung, dass die einzelnen Identitätskonstruktionen nicht nur von religiös-kulturellen Voraussetzungen geprägt, sondern auch von bestimmten Interessen der hinter den Texten stehenden Autoren bzw. Autorengruppen bestimmt sind. Dies erklärt die Unterschiedlichkeit in zentralen Punkten, beispielsweise wie viel Individualität dem Einzelnen als Mitglied einer Gemeinschaft zugestanden wird, (...) welche Rolle "Fremde" in einer Gesellschaft spielen dürfen, und wie Menschen außerhalb einer Gemeinschaft bewertet werden. Mit Beiträgen von Karin Finsterbusch, Denis Fricker, Daniel Gerber, Norbert Jacoby, Bernd Janowski, Pierre Keith, Thierry Legrand, Nathalie Siffer und François Vinel. (shrink)

BackgroundBiobanking biospecimens and consent are common practice in paediatric research. We need to explore children and young people’s (CYP) knowledge and perspectives around the use of and consent to biobanking. This will ensure meaningful informed consent can be obtained and improve current consent procedures.MethodsWe designed a survey, in co-production with CYP, collecting demographic data, views on biobanking, and consent using three scenarios: 1) prospective consent, 2) deferred consent, and 3) reconsent and assent at age of capacity. The survey was disseminated (...) via the Young Person’s Advisory Group North England (YPAGne) and participating CYP’s secondary schools. Data were analysed using a qualitative thematic approach by three independent reviewers (including CYP) to identify common themes. Data triangulation occurred independently by a fourth reviewer.ResultsOne hundred two CYP completed the survey. Most were between 16–18 years (63.7%, N = 65) and female (66.7%, N = 68). 72.3% had no prior knowledge of biobanking (N = 73).Acceptability of prospective consent for biobanking was high (91.2%, N = 93) with common themes: ‘altruism’, ‘potential benefits outweigh individual risk’, 'frugality', and ‘(in)convenience’.Deferred consent was also deemed acceptable in the large majority (84.3%, N = 86), with common themes: ‘altruism’, ‘body integrity’ and ‘sample frugality’. 76.5% preferred to reconsent when cognitively mature enough to give assent (N = 78), even if parental consent was previously in place. 79.2% wanted to be informed if their biobanked biospecimen is reused (N = 80).ConclusionProspective and deferred consent acceptability for biobanking is high among CYP in the UK. Altruism, frugality, body integrity, and privacy are the most important themes. Clear communication and justification are paramount to obtain consent. Any CYP with capacity should be part of the consenting procedure, if possible. (shrink)

The present essay, here published for the first time, is part of a group of four texts on the history of the early phenomenological movement that Theodor Conrad wrote right after World War II. One of these texts known as “Conrads Bericht” was edited by Eberhard Avé-Lallemant and Karl Schuhmann and published in Husserl Studies in 1992. The four original typescripts are preserved in the archive of the Munich Circle of phenomenology at the Bavarian State Library. As the reader (...) will immediately realize, at the center of the present text is a peculiar account of the beginning of the phenomenological tradition, namely, of its first schism. Contrary to the usual thesis according to which the first schism revolved mainly, if not exclusively around the so-called “idealism-realism controversy,” Conrad points out that this was only part of it, and that the first controversy between Husserl and some of his early disciples or students bore on the nature of phenomenology itself. (shrink)

Leibniz' remarkable understanding of Chinese culture was not merely the result of his own acumen, but also of the knowledgeable sources of information available to him through published works and personal correspondence. Most of the materials are preserved in the Niedersächsische Landesbibliothek Hannover. Working from the Systematischen Bandkatalog compiled by Daniel Eberhard Baring in 1720 shortly after Leibniz' death, it is possible to know with some accuracy which books were available for Leibniz' reference. This author has complied a (...) list of 78 such works, most of which were either written by or derived from Christian missionaries in China, of whom the Jesuits were the most prominent. While some of Leibniz' correspondents such as Andreas Müller of Berlin were sinological amateurs and enthusiasts, others such as the Jesuit Joachim Bouvet were learned men, living in intimate contact with the Chinese emperor in Peking. Their letters guaranteed that Leibniz' information on China was among the most accurate available in Europe at that time. (shrink)

ABSTRACTThis article studies multi-stakeholder initiatives as spaces for both deliberation and contestation between constituencies with competing discourses and disputed values, beliefs, and preferences. We review different theoretical perspectives on MSIs, which see them mainly as spaces to find solutions to market problems, as spaces of conflict and bargaining, or as spaces of consensus. In contrast, we build on a contestatory deliberative perspective, which gives equal value to both contestation and consensus. We identify four types of internal contestation which can be (...) present in MSIs—procedural, inclusiveness, epistemic, and ultimate-goal—and argue that embracing contestation and engaging in ongoing revision of provisional agreements, criteria, and goals can enhance the democratic quality of MSIs. Finally, we explore the implications of this perspective for theorizing about the democratic quality in MSIs and about the role of corporations in transnational governance. (shrink)

Predictive processing has recently been advanced as a global cognitive architecture for the brain. I argue that its commitments concerning the nature and format of cognitive representation are inadequate to account for two basic characteristics of conceptual thought: first, its generality—the fact that we can think and flexibly reason about phenomena at any level of spatial and temporal scale and abstraction; second, its rich compositionality—the specific way in which concepts productively combine to yield our thoughts. I consider two strategies for (...) avoiding these objections and I argue that both confront formidable challenges. (shrink)

ABSTRACT A trivalent theory of indicative conditionals automatically enforces Stalnaker's thesis – the equation between probabilities of conditionals and conditional probabilities. This result holds because the trivalent semantics requires, for principled reasons, a modification of the ratio definition of conditional probability in order to accommodate the possibility of undefinedness. I explain how this modification is motivated and how it allows the trivalent semantics to avoid a number of well-known triviality results, in the process clarifying why these results hold for many (...) bivalent theories. In short, the slew of triviality results published in the last 40-odd years need not be viewed as an argument against Stalnaker's thesis: it can be construed instead as an argument for abandoning the bivalent requirement that indicative conditionals somehow be assigned a truth-value in worlds in which their antecedents are false. (shrink)

The notion of ‘revealed preference’ is unclear and should be abandoned. Defenders of the theory of revealed preference have misinterpreted legitimate concerns about the testability of economics as the demand that economists eschew reference to (unobservable) subjective states. As attempts to apply revealed-preference theory to game theory illustrate with particular vividness, this demand is mistaken.

This book is a study of the role of intellect in human action as described by Thomas Aquinas. One of its primary aims is to compare the interpretation of Aristotle by Aquinas with the lines of interpretation offered in contemporary Aristotelian scholarship. The book seeks to clarify the problems involved in the appropriation of Aristotle's theory by a Christian theologian, including such topics as the practical syllogism and the problems of akrasia. Westberg argues that Aquinas was much closer to Aristotle (...) than is often recognized, and he puts forward important new interpretations of the relation of intellect and will in the stages of intention, deliberation, decision, and execution. In the concluding section of the book, he shows how this new interpretation yields fruitful insights on a range of theological topics, including sin, law, love, and the moral virtues. (shrink)

On a Dreyfusian account performers choke when they reflect upon and interfere with established routines of purely embodied expertise. This basic explanation of choking remains popular even today and apparently enjoys empirical support. Its driving insight can be understood through the lens of diverse philosophical visions of the embodied basis of expertise. These range from accounts of embodied cognition that are ultra conservative with respect to representational theories of cognition to those that are more radically embodied. This paper provides an (...) account of the acquisition of embodied expertise, and explanation of the choking effect, from the most radically enactive, embodied perspective, spelling out some of its practical implications and addressing some possible philosophical challenges. Specifically, we propose: an explanation of how skills can be acquired on the basis of ecological dynamics; and a non-linear pedagogy that takes into account how contentful representations might scaffold skill acquisition from a radically enactive perspective. (shrink)

Jeffrey (1983) proposed a generalization of conditioning as a means of updating probability distributions when new evidence drives no event to certainty. His rule requires the stability of certain conditional probabilities through time. We tested this assumption (“invariance”) from the psychological point of view. In Experiment 1 participants offered probability estimates for events in Jeffrey’s candlelight example. Two further scenarios were investigated in Experiment 2, one in which invariance seems justified, the other in which it does not. Results were in (...) rough conformity to Jeffrey (1983)’s principle. (shrink)

John Stuart Mill regards economics as an inexact and separate science which employs a deductive method. This paper analyzes and restates Mill's views and considers whether they help one to understand philosophical peculiarities of contemporary microeconomic theory. The author concludes that it is philosophically enlightening to interpret microeconomics as an inexact and separate science, but that Mill's notion of a deductive method has only a little to contribute.

commentary on Fodor, “Against Darwinism.”.

During the early nineteenth century the Royal Observatory, Greenwich, significantly increased the number of individuals it employed. One of the new roles created was the position of First Assistant, who oversaw the management of astronomical labor at the observatory. This article examines the contribution of Robert Main, who was the first person employed in this role. It shows that, through Robert Main’s duties and tasks, the observatory appears as a hybrid site embodying aspects of the other institutions that formed part (...) of its operational network. Moreover, it demonstrates that the transformation of the observatory during the nineteenth century was driven by his rigorous maintenance of discipline in relation to the daily operations of the site. (shrink)

This article examines methodological individualism in terms of the theory that invariance under intervention is the signal feature of generalizations that serve as a basis for causal explanation. This theory supports the holist contention that macro-level generalizations can explain, but it also suggests a defense of methodological individualism on the grounds that greater range of invariance under intervention entails deeper explanation. Although this individualist position is not threatened by multiple-realizability, an argument for it based on rational choice theory is called (...) into question by experimental results concerning preference reversals. Key Words: methodological individualism • mechanisms • explanation • invariance • preference reversal. (shrink)

In their development of causal decision theory, Allan Gibbard and William Harper advocate a particular method for calculating the expected utility of an action, a method based upon the probabilities of certain counterfactuals. Gibbard and Harper then employ their method to support a two-box solution to Newcomb’s paradox. This paper argues against some of Gibbard and Harper’s key claims concerning the truth-values and probabilities of counterfactuals involved in expected utility calculations, thereby disputing their analysis of Newcomb’s Paradox. If we are (...) right, then Gibbard and Harper’s method of calculating expected utility does not adequately represent rational choice. (shrink)

Over the past few decades, large food banks that collect, warehouse, and redistribute food have become institutionalized across Europe. Although food banks gained increased visibility as important food relief mechanisms during the covid pandemic in 2020 and 2021, the crisis also highlighted their structural weaknesses and the fragility of the charity-based emergency food system. In particular, many European food banks faced higher costs, lower food stocks, uneven food donations, and lower numbers of volunteers and personnel as demand for food relief (...) increased sharply. Also, many food banks lacked personal health and safety equipment for front-line staff and volunteers, many of whom were vulnerable or aged, thus forcing the closure of some charities due to health concerns. Yet, the impact of the pandemic was uneven across the continent as the covid pandemic strengthened some food banks while others were weakened. To explore these dynamics in detail, this paper utilizes in-depth interviews and surveys of key food bank operators in the Netherlands, Norway, and Greece to analyze how and why European food bank systems fared so differently from the pandemic. In short, the findings in this paper reveal how the Norwegian food bank system leveraged its position to increase fundraising and visibility, while the Netherlands food bank system suffered from long-term structural weaknesses, and the Greek food bank system was further embroiled in government tensions that threatened its existence. The preexisting structure of food bank systems, broader political economy, and historical context significantly impacted how food relief networks fared during the pandemic. (shrink)

Scientific psychology and neuroscience are taking increasingly precise and comprehensive pictures of the human mind, both in its physi- cal architecture and its functional processes. Meanwhile, each human mind has an abbreviated view of itself, a self-portrait that captures how it thinks it operates, and that therefore has been remarkably influential. The mind’s self-portrait has as a central feature the idea that thoughts cause actions, and that the self is thus an origin of the body’s actions. This self- portrait is (...) reached through a process of inference of apparent mental cau- sation, and it gives rise to the experience that we are consciously willing what we do. Evidence from several sources suggests that this self-portrait may often be a humble and misleading caricature of the mind’s opera- tion—but one that underlies the feeling of authorship and the acceptance of responsibility for action. (shrink)

The Declaration on Euthanasia (1980) defined euthanasia as “an action or an omission which of itself or by intention causes death, in order that all suffering may in this way be eliminated.” In Evangelium vitae (1995) Pope St. John Paul II defined “euthanasia in the strict sense” using exactly the same words, except that where the declaration has “of itself or [vel] by intention” the encyclical reads “of itself and [et] by intention.” This paper explores the significance of this change, (...) which has been largely ignored and has not been adopted by the Catechism or by the Ethical and Religious Directives. I argue for the superiority of the definition in the declaration. (shrink)

It is a truism to say that we live in a world that has been deeply shaped by imperialism. The history of humanity is, in many ways, a story of the attempted and achieved subjugation of one people by another, and it is unsurprising that such interaction has had profound effects on the contemporary world, affecting cultural understandings of community identity; the composition of, and boundaries between, modern day states; and the distribution of resources between different communities. This chapter addresses (...) the claim that some contemporary states may possess obligations to pay reparations as a result of the lasting effects of a particular form of historic imperialism: colonialism. Claims about the harms and benefits caused by colonialism must make some kind of comparison between the world as it currently is, and a counterfactual state where the injustice which characterised so much of historic interaction between colonisers and the colonised did not occur. Rather than imagining a world where there was no such interaction, this chapter maintains that the appropriate counterfactual is one where relations between different communities were characterized by an absence of domination and exploitation. This means that current day states may possess reparative duties which are much more extensive than is often supposed. (shrink)

Conventional wisdom holds two seemingly opposed beliefs. One is that communities are often much better than individuals at dealing with certain situations or solving certain problems. The other is that crowds are usually, and some say always, at best as intelligent as their least intelligent members and at worst even less. Consistency would seem to be easily re-established by distinguishing between advanced, sophisticated social organizations which afford the supporting communities a high level of collective performance, and primitive, mob-like structures which (...) pull the group towards the lower end of the achievement scale. But this reconciliation meets with some objections. The most familiar ones concern the mixed record of elaborate social systems, which are said to occasionally or even, according to some accounts, systematically produce wrong decisions, poor assessments, disastrous plans, counterproductive measures, etc. A more recent set of objections rests on cases where ‘crowds’, i,e, groups not organized in a sophisticated way, produce good results, in fact, results which better those of most, or even all, members of the group. Such cases are collected in James Surowiecki’s book The Wisdom of Crowds, which argues more generally in favor of an ‘order out of chaos’ view of collective thinking: whether sophisticated or simple, social organizations for the production of knowledge or problem-solving can benefit from the absence of certain individualistc constraints which are traditionally thought to foster excellence in cognitive tasks. This flavor of paradox is enhanced by Surowiecki’s choice of phrase: at the surface level, ‘wisdom of crowds’ conflicts with the well-entrenched cliché of the folly1 of crowds; but at a deeper level, Surowiecki seems to appeal to one frequent connotation of ‘wisdom’ which is precisely its paradoxical character. Whether Surowiecki actually intended to exploit this.. (shrink)

The article explores the relationship between the (etymologically related) notions of haphazardness and happiness in the history of Western philosophy. Although a certain popular wisdom sees in happiness a product of the vagaries of life, philosophers have rather tried to decouple the pursuit of happiness from the haphazard. We can distinguish two ways: the way of the Ancients tries to redefine the parameters of a happy life so as to remove it from haphazardness as much as possible (Aristotle) or even (...) totally (Plato, the Stoics); the way of the Moderns tries instead to subjugate the haphazard either by making us “masters and possessors of nature” by the technique (Descartes) or by setting up mechanisms of compensation based on the calculus of probability (insurances). The question of the sometimes conflicting relationship between the two paths is finally raised. (shrink)

ABSTRACTRevisionists about Aquinas’ teaching on private self-defence take the standard reading to hold that Aquinas applies a version of the Doctrine of Double Effect according to which the intentional killing of a wrongful attacker by a private person is morally prohibited while the non-intentional but foreseeable killing of the attacker is permitted. Revisionists dispute this reading and argue that Aquinas permits the intentional killing of wrongful attackers. I argue that revisionists mischaracterize the standard reading of Aquinas. I consider one of (...) its main proponents, Antonio de Córdoba. When Córdoba condemned the intentional killing of wrongful attackers by private persons, he was not applying DDE. Rather, he was arguing that when you decide to kill an attacker you treat the attacker as a resource for the private end of saving your life. Killing a member of your community is a form of irrevocable social exclusion. This decision ought to be left to the public authorities. The disagreement between the authors defending the standard view and their critics was not about DDE but rather about the moral limits that membership in a community sets on the pursuit of private ends, including the private end of staying alive. (shrink)

In her work Horrendous Evils and the Goodness of God, Marilyn McCord Adams offers an account of the problem of evil that deals with the interaction between certain types of evil and the human capacity for meaning production. This paper attempts to consider certain implications of her presuppositions and, in so doing, to uncover several challenges to her broader project entailed by said implications. More specifically, this paper considers, within the context of Adams’ broader project, the status of perpetrators of (...) horrendous evils with respect to their ability to conceive of said evils, evils that destroy meaning-making capacities in their victims and evils that twist and subvert the meaning-making processes of their victims or observers. (shrink)