Research that is initiated, designed or funded by sponsor agencies based in countries with relatively high social and economic development, and conducted in countries that are relatively less developed, gives rise to many important ethical challenges. Although clinical trials of HIV vaccines began ten years ago in the US and Europe, an increasing number of trials are now being conducted or planned in other countries, including several that are considered “developing” countries. Safeguarding the rights and welfare of individuals participating as (...) research subjects in developing countries is a priority. In September, 1997, the Joint United Nations Programme on HIV/AIDS embarked on a process of international consultation; its purpose was further to define the important ethical issues and to formulate guidance that might facilitate the ethical design and conduct of HIV vaccine trials in international contexts. This paper summarises the major outcomes of the UNAIDS consultative process. (shrink)

I defend Spinoza's claim that extension is an attribute that an indivisible substance, such as God, could have. However, in order to explain why, we must abandon two long held orthodoxies in Spinoza scholarship. First, Spinoza acknowledges only parts that do not depend on their whole. Second, God, considered as natura naturans, has no parts of any kind. Against these orthodoxies, I show that having parts which depend on their whole, for Spinoza, does not entail divisibility and that God, considered (...) as natura naturans, must have such parts in order to be extended. Along the way, we will have a closer look at Spinoza’s mereology and address apparently conflicting statements that Spinoza makes about the relation of part and whole that have long vexed commentators. (shrink)

As Husserl already noticed, artworks themselves have a phenomenological character. This means, however, that to experience artworks as phenomena no “epoché” and no “phenomenological reduction” is necessary. The leading question of my essay is whether, and possibly how, this observation can be methodologically generalized for understanding phenomena. I discuss if, and possibly how, a phenomenological reflection on art allows and even demands a general conception of phenomenology that nevertheless does not confuse artworks with phenomena in general. My intention is to (...) show that and how phenomenality can be clarified with reference to its spatial character. Accordingly, works of architecture that are artworks will play a decisive role in my argument. (shrink)

Scientific exploration and thus our knowledge about the outside world is subject to the conditions of our experience.These conditions are condensed here into an interface model which,besides being physical,has an additional interface structure not reducible to physics. We suggest that this structure can dynamically be characterized by separate modes.Their selection and operation presupposes free will and a rudimentary concept of time and space. Based on some analogies with quantum networks it is argued that the 'observed' gets 'dressed'as a consequence of (...) the observing. Interface dynamics and system dynamics supplement each other without over- determination. (shrink)

The paper is a critical discussion of scholarship on the "Critique of Pure Reason" published during the past ten years. The emphasis is on Anglo-American authors. I identify and discuss three main trends in the field: a shift from the general discussion of transcendental arguments to the analysis and evaluation of particular proofs in Kant; a renewed interest in the doctrine of transcendental idealism and the distinction between things in themselves and appearances; and the emergence of an entire body of (...) literature on Kant's philosophy of mind, centered around the idea of a "transcendental psychology." The main body of the text is supplemented by extensive bibliographical information provided in the notes. (shrink)

Mental time travel and theory of mind develop, both phylo- and ontogenetically, at the same stage. We argue that this synchrony is due to the emergence of a shared competence, namely, the ability to become aware of frames of reference.

This essay presents Mendelssohn’s neglected vindication of theism through a refutation of Spinoza’s philosophy in the Morgenstunden and highlights its relevance for discussions in contemporary philosophy of religion. For this purpose, I (i) contextualise Mendelssohn's argument within the reception of Spinoza at the dawn of the 18th century, (ii) trace the path of Mendelssohn's argument to theism, (iii) and examine Mendelssohn's argument in light of Linda Zagzebski's account of divine omniscience showing that her account is not only incoherent but also (...) undermines the theistic assumption that the world has an existence outside of God. (shrink)

Empathy means understanding another person’s emotional or intentional state by vicariously sharing this state. As opposed to emotional contagion, empathy is characterized by the self–other distinction of subjective experience. Empathy develops in the second year, as soon as symbolic representation and mental imagery set in that enable children to represent the self, to recognize their mirror image, and to identify with another person. In experiments with 126 children, mirror recognition and readiness to empathize with a distressed playmate were investigated. Almost (...) all recognizers showed compassion and tried to help, whereas nonrecognizers were perplexed or remained indifferent. Several motivational consequences of empathy are discussed and its special quality is outlined in comparison with theory of mind and perspective taking. (shrink)

This article compares Kant and Fichte from the double stand- point of identity and difference with regard to two thinkers who were at first united by a master-student relation but who later on drifted apart from each other due to mutual defamation. At the center of the present discussion stands the relationship between spirit of freedom and system’s form which binds Kant and Fichte beyond methodological divergences and doctrinal differ- ences. The critical comparison between Kant and Fichte will be developed (...) in four steps: it will start with the general positioning of Kant within German Idealism, and then move on to Kant’s double critical enterprise of grounding an aprioristic doctrine of principles of nature and freedom; it will later on address the conception championed by Fichte of having pre- sented the “first system of freedom”, and from there it will focus on the manifestations of freedom within Fichte’s philosophical system, with Kant’s position as contrast. (shrink)

Self–other distinction, as documented by mirror self-recognition (MSR), allows for empathy which offers a motivational base for helping a person in need. Kärtner and Keller propose a different, culture-related, possibility of helping based on shared intentional relations and emotional contagion which could explain helping behavior in Indian children not yet capable of MSR. Due to the experimental setting, however, other releasers of children’s sadness and helping behavior have to be considered. An alternative setting is proposed. With respect to MSR, the (...) question of false negatives is discussed. The issues mentioned by Klann-Delius address fundamental theoretical questions that cannot be answered briefly. (shrink)

When the social relevance of robotic applications is addressed today, the use of assistive technology in care settings is almost always the first example. So-called care robots are presented as a solution to the nursing crisis, despite doubts about their technological readiness and the lack of concrete usage scenarios in everyday nursing practice. We inquire into this interconnection of social robotics and care. We show how both are made available for each other in three arenas: innovation policy, care organization, and (...) robotic engineering. First, we analyze the discursive “logics” of care robotics within European innovation policy, second, we disclose how care robotics is encountering a historically grown conflict within health care organization, and third we show how care scenarios are being used in robotic engineering. From this diagnosis, we derive a threefold critique of robotics in healthcare, which calls attention to the politics, historicity, and social situatedness of care robotics in elderly care. (shrink)

There is a distinction between locality and modularity. These two terms have often been used interchangeably in the target article and commentary. Using this distinction we argue in favor of a modularity. In addition we also argue that both PDP-type networks and box-and-arrow models have their own strengths and pitfalls.

Patt's study attempts to explain Kant's doctrine of transcendental idealism through a detailed examination of Kant's theory of sensible intuition. The center of the book is a minute textual exegesis of Kant's direct proof for the doctrine of transcendental idealism in the "Transcendental Aesthetic" of the Critique of Pure Reason, focusing on the arguments concerning the nature of space and time and the conclusions that Kant draws from them. This middle part is preceded by three smaller chapters that examine the (...) Kantian distinction between appearances and things in themselves, the relation between intuition and sensation, and the function of intuition in synthetic judgments. The study concludes with an analysis of Kant's indirect proof of the doctrine of transcendental idealism in the "Transcendental Dialectic," with an emphasis on the treatment of the first two antinomies. No detailed consideration is given to the role of intuitions in Kant's theory of categories and principles in the "Transcendental Analytic.". (shrink)

In spite of the importance of point mutations for evolution and human diseases, their natural spectrum of incidence in different species is not known. Here I propose to determine these spectra by comparing consecutive sequence periods in stretches of repetitive DNA. The article presents the analysis of more than 51,000 such point mutations identified by this approach in the genomes of human, chimpanzee, rat, mouse, pufferfish, zebrafish, and sea squirt. I propose to explain the observed spectra by auto‐mutagenic mechanisms of (...) genome variation involving the inter‐conversions of nucleotides, single base‐pair inversions and their combinations. (shrink)