Ethical reasons are presented for requiring 1) that a proposal for a clinical trial should be accompanied by a thorough review of all previous trials that have examined the same and closely related questions, and 2) that a trial should be approved by a research ethics committee only if the investigator undertakes to register it in an appropriate register of clinical trials as soon as one exists.

Gebhardt draws attention to an important issue. The responsibility for informing and warning patients about adverse effects and how to prevent them, or ….

Although many conferences stimulate a great deal of discussion and practical interest at the time, not so many are followed up to try and estimate what, if any, practical results followed the meeting. This the authors of this study have done. (In Britain the 'medical groups' are voluntary groupings of students at medical schools who meet to discuss ethical problems related to their profession). Sixty-five participants (not all of them students) in the conference on iatrogenic disease replied to the questionnaire, (...) and from the answers it was clear that not only the attitudes of those responding had in some cases been changed but in some positive action had resulted, for example, in the matter of prescribing. This analysis may provide an answer to those who criticize conferences as being a waste of time and money, because much more than could be evaluated from the responses to this survey must have affected all the participants. (shrink)

An Essay on Liberation outlines the new possibilities for contemporary human liberation.

For people to contribute to discourse, they must do more than utter the right sentence at the right time. The basic requirement is that they add to their common ground in an orderly way. To do this, we argue, they try to establish for each utterance the mutual belief that the addressees have understood what the speaker meant well enough for current purposes. This is accomplished by the collective actions of the current contributor and his or her partners, and these (...) result in units of conversation called contributions. We present a model of contributions and show how it accounts for a variety of features of everyday conversations. (shrink)

A. ON THE MEANING OF PHENOMENOLOGY 1. "PHENOMENOLOGY" * "Phenomenology" is, in the 20th century, mainly the name for a philosophical movement whose primary ...

Objective: To explore the experiences of people with a “terminal illness”, focusing on the patients’ perspective of euthanasia and assisted suicide.Method: A qualitative study using narrative interviews was conducted throughout the UK. The views of the 18 people who discussed euthanasia and assisted suicide were explored. These were drawn from a maximum variation sample, who said that they had a “terminal” illness, malignant or non-malignant.Results: That UK law should be changed to allow assisted suicide or voluntary euthanasia was felt strongly (...) by most people. Those who had seen others die were particularly convinced that this should be a right. Some had multiple reasons, including pain and anticipated pain, fear of indignity, loss of control and cognitive impairment. Those who did not want to be a burden also had other reasons for wanting euthanasia. Suicide was contemplated by a few, who would have preferred a change in the law to allow them to end their lives with medical help and in the company of family or friends. The few who opposed a change in UK law, or who felt ambivalent, focused on involuntary euthanasia, cited religious reasons or worried that new legislation might be open to abuse.Conclusion: Qualitative research conducted on people who know they are nearing death is an important addition to the international debate on euthanasia and assisted suicide. Those who had seen others die were particularly convinced that the law should be changed to allow assisted death. (shrink)

The "Darwinian revolution" remains an acceptable phrase to describe the change in thought brought about by the theory of evolution, provided that the revolution is seen as occurring over an extended period of time. The decades from the 1790s through the 1850s are at the focus of this article. Emphasis is placed on the issue of species extinction and on generational shifts in opinion.

Clark highlights a neglected issue in research on language use: the process by which speakers and addressees anchor utterances with respect to individual entities in their common ground. In his review, he identifies the challenges linked to investigations of anchoring, but also displays the pitfalls of evading it.

No detailed description available for "Semantics and Comprehension".

First Published in 1990. Information about individual operas and other types of musical theater is scattered throughout the enormous literature of music. This book is an effort to bring that data together by comprehensively indexing plots and descriptions of individual operatic background, criticism and analysis, musical themes and bibliographical references. The principal audience for this general reference guide will be for the non-specialist, but its hoped that persons specialising in opera would also find it useful.

The mind-body problem is—despite appearances—still the inevitable basic issue of unending discussions in recent philosophy. Various types of epistemologies and metaphysics, European and American, have offered their widely divergent “solutions” of the dreaded Cartesian tangle. Is there any hope of reaching a universally acceptable view?

Explores the place of consciousness in nature, drawing on new ideas in physics to argue that consciousness is a fundamental process of nature like light and electricity, rather than something that appears only in humans. 20,000 first printing.

In everyday joint activities, people coordinate with each other by means not only of linguistic signals, but also of material signals – signals in which they indicate things by deploying material objects, locations, or actions around them. Material signals fall into two main classes: directing-to and placing-for. In directing-to, people request addressees to direct their attention to objects, events, or themselves. In placing-for, people place objects, actions, or themselves in special sites for addressees to interpret. Both classes have many subtypes. (...) Features of material signals were examined in pairs of people who were videotaped as they assembled TV stands, built Lego models, planned furnishings for a house, played piano duets, or bought coffee at Starbucks. In these activities, the pointing and placements were often sustained, creating three phases of signals – initiation, maintenance, and termination – each with its own interpretation. (shrink)

The place of man in Darwin's development of a theory of transmutation has been obscured by his manner of disclosure. Comparing the 1837–1839 period to his entire career as a theorist suggests that it was Darwin's practice to present himself and his work only before the most select scientific audiences, and then in accordance with their expectations. The negative implications of this rule for his publication on man are clear enough: finding no general invitation in science to publish as a (...) theorist and no contemporary scientific audience for the sorts of inquiries he was making on man, he was silent, at least until such time as he could publish on the strength of reputation alone. Now, with the availability of manuscripts from the early period, what was once hidden stands revealed. It is clear from Darwin's notebooks that man played a dual role in the formation of his theory: as a zoological species to be incorporated into the theory and as the primary vehicle for the study of behavior. On the first score, integrating man into the theory provoked Darwin to break with the traditional view of man's place in nature and to reject a major element in the scientific notion of progressive development. On the second score, the study of behavior led Darwin outside natural history and thence, unexpectedly, to Malthus and natural selection.One is left with the certainty that the subject of man was a central element in Darwin's formulation of his species theory. To an extent, then, the public judgment of Darwin was right all along, for the public had always sensed that Darwin spoke to a larger audience than that formed around science. On the basis of new evidence, we can add that Darwin drew from that larger audience as well. There are of course ironies to this conclusion: that Darwin the professional drew so heavily from fields where he was the amateur, that as a transparent man his inner life should prove so at odds with the manner in which he presented himself, and that his arrival at a strong sense of himself—the revolutionary “I” of his notebooks—should occur just as he stepped beyond science to engage the general culture. But when one considers the inherent difficulties of Darwin's subject and the magnitude of his claims respecting man, these ironies are perhaps not surprising at all but those of a kind which might be anticipated. (shrink)

From lectures over the BBC by a Cambridge professor on answers to our problems on the meaning of life.

Science progresses if we succeed in rendering the objects of scientific inquiry more comprehensively or more precisely. Popper tries to formalize this venerable idea. According to him the most comprehensive and most precise description of the world is given by the set T of all true statements. A hypothesis comes the closer to T, or has the more verisimilitude, the more true consequences and the fewer false consequences it implies. Popper proposes to order hypotheses by the inclusion relations between the (...) sets of their true and of their false consequences ("truth contents" and "falsity contents"). A partial ordering would permit one to decide whether the substitution of theory t 1 by t 2 represents scientific progress. But because of the logical relations between the elements of the sets of logical consequences, or contents, false hypotheses cannot be compared. As our theories usually turn out to be false sooner or later, they can seldom be compared as to their verisimilitude and when they can, the result depends only on which theory implies the other and on their truth-values. Popper even tries to define a measure of verisimilitude on the partial ordering. It has to fail for the same reason. In addition he tries to relativize the concept of a content and fails. What is more, any attempt at defining a measure of better or worse correspondence to the whole truth must fail, as there is no justification for saying that any true primitive sentence asserts as much about reality as some other primitive sentence, or more. (shrink)