Policy increasingly requires societally relevant and interdisciplinary science, which prompts questions about science’s orientation to diverse academic and non-academic actors. This paper examines how relevance is practised and negotiated in two evolving interdisciplinary social science fields: marine social sciences and forest policy research. Both fields investigate human relations with specific environments: how people use, manage and govern, live with and value seas and forests. Diverse social and political actors have stakes in the knowledge these fields generate. To whose matters and (...) stakes do researchers respond and orient their research? Are such orientations reflexively discussed and contested? To operationalise relevance, we employ the notion of ‘epistemic commitments’ while adopting a Bourdieusian perspective on scientific fields. Our analysis draws on conference observation, interviews and document analysis. We find diverse epistemic commitments in both fields, but see noticeable differences in their prevalence, reflexivity and contestation. Examining the fields’ socio-historical trajectories, we theorise that these differences are due to field-specific properties: their relative autonomy to negotiate relevance independently from other disciplines and external forces; and the field-specific habitus that impacts the degree to which relevance is a reflexive commitment, or an unconscious practice. The comparative analysis suggests that interdisciplinary scientific fields’ specific institutional histories and relations with societal and policy actors shape relevance practices and the extent to which these are internally contested. (shrink)

This review addresses the 100-year-old Hill equation (published in January 22, 1910), the first formula relating the result of a reversible association (e.g., concentration of a complex, magnitude of an effect) to the variable concentration of one of the associating substances (the other being present in a constant and relatively low concentration). In addition, the Hill equation was the first (and is the simplest) quantitative receptor model in pharmacology. Although the Hill equation is an empirical receptor model (its parameters have (...) only physico-chemical meaning for a simple ligand binding reaction), it requires only minor a priori knowledge about the mechanism of action for the investigated agonist to reliably fit concentration-response curve data and to yield useful results (in contrast to most of the advanced receptor models). Thus, the Hill equation has remained an important tool for physiological and pharmacological investigations including drug discovery, moreover it serves as a theoretical basis for the development of new pharmacological models. (shrink)

This paper proposes an integrated account of the etiology of OCD that accommodates both dysfunctional cognitions and sensorimotor features of compulsive action. It is argued that cognitive/metacognitive theories do not aspire to address all obsessive-compulsive phenomenal properties and that empirical evidence concerning some of these requires the incorporation of motor deficits as an independent factor in a plausible conception of OCD. The difference in agency attribution between obsessive-compulsive persons and schizophrenia patients with delusions of control is also accounted for in (...) terms of bottom-up processes. (shrink)

Introduced by Leon Henkin back in the fifties, the notion of neat reducts is an old venerable notion in algebraic logic. But it is often the case that an unexpected viewpoint yields new insights. Indeed, the repercussions of the fact that the class of neat reducts is not closed under forming subalgebras turn out to be enormous. In this paper we review and, in the process, discuss, some of these repercussions in connection with the algebraic notion of amalgamation. Some new (...) unpublished results concerning neat reducts and amalgamation are given. . Several counterexamples which convey the gist of techniques used in this area are presented two of which are new It is known that the algebraic notion of amalgamation in a class of algebras corresponds to the metalogical notion of interpolation in the corresponding logic. Answers to open question in the recent paper [31] concerning both amalgamation and interpolation are summarized in tabular form at the end of this paper. This paper appears in two parts. The first part contains results on neat reducts. The present second part contains results relating the notion of neat embeddings to various amalgamation properties.1. (shrink)

The dominant philosophical conceptions of obsessive-compulsive behavior present its subject as having a deficiency, usually characterized as volitional, due to which she lacks control and choice in acting. Compulsions (mental or physical) tend to be treated in isolation from the obsessive thoughts that give rise to them. I offer a different picture of compulsive action, one that is, I believe, more faithful to clinical reality. The clue to (most) obsessive-compulsive behavior seems to be the way obsessive thoughts, which are grounded (...) in an irrational cognitive style in matters of risk, danger, and responsibility, motivate compulsions through bizarre means–end reasoning. I show that the patient with obsessive-compulsive disorder (OCD) is not weak and passive with regard to the compulsive act; rather, the act is voluntary and regarded by the patient as an instrument of control. I also defend the idea that OCD-related cognitions are either beliefs or mental states with relevantly similar functional roles. (shrink)

Multiple authorship is the universal solution to multi-tasking in the sciences. Without a team, each with their own set of expertise, and each involved mostly in complementary ways, a research project will likely not advance quickly, or effectively. Consequently, there is a risk that research goals will not be met within a desired timeframe. Research teams that strictly scrutinize their modus operandi select and include a set of authors that have participated substantially in the physical undertaking of the research, in (...) its planning, or who have contributed intellectually to the ideas or the development of the manuscript. Authorship is not an issue that is taken lightly, and save for dishonest authors, it is an issue that is decided collectively by the authors, usually in sync with codes of conduct established by their research institutes or national ministries of education. Science, technology and medicine publishers have, through independent, or sometimes coordinated efforts, also established their own sets of guidelines regarding what constitutes valid authorship. However, these are, for the greater part, merely guidelines. A previous and recent analysis of authorship definitions indicates that the definitions in place regarding authorship and its validity by many leading STM publishers is neither uniform, nor standard, despite several of them claiming to follow the guidelines as set forward by the International Committee of Medical Journal Editors or ICMJE. This disparity extends itself to ghost and guest authorship, two key authorship-related issues that are examined in this paper to assess the extent of discrepancies among the same set of STM publishers and what possible influence they might have on publishing ethics. (shrink)

ABSTRACT The two main directions pursued in the present paper are the following. The first direction was started by Pigozzi in 1969. In [Mak 91] and [Mak 79] Maksimova proved that a normal modal logic has the Craig interpolation property iff the corresponding class of algebras has the superamalgamation property. In this paper we extend Maksimova's theorem to normal multi-modal logics with arbitrarily many, not necessarily unary modalities, and to not necessarily normal multi-modal logics with modalities of ranks smaller than (...) 2. To extend the characterization beyond multi-modal logics, we look at arbitrary algebraizable logics. We will introduce an algebraic property equivalent with the Craig interpolation property in algebraizable logics, and prove that the superamalgamation property implies the Craig interpolation property. The problem of extending the characterization result to non-normal non-unary modal logics also will be discussed. In the second direction pursued herein: for non-normal modal logic with one unary modality Lemmon [Lem 66] gave a possible worlds semantics. Here we give a more general possible worlds semantics for not necessarily normal multi-modal logics with arbitrarily many not necessarily unary modalities. Strongly related to the above is the theorem, proved, e.g., in Jóns son-Tarski [JT 52] and Henkin-Monk-Tarski [HMT 71], that every normal Boolean algebra with operators can be represented as a subalgebra of the complex algebra of some relational structure. We extend this result to not necessarily normal BAO's as follows. We define partial relational structures and show that every not necessarily normal BAO is embeddable into the complex algebra of a partial relational structure. This gives a possible worlds semantics for not necessarily normal multi-modal logics. (shrink)

Gervain et al. discuss both behavioral and neurophysiological AGL studies that investigate rule and structure learning processes in infants. The paper provides an overview of all the major AGL paradigms used to date to investigate infant learning abilities at the level of morpho‐phonology and syntax from a very early age onwards. Gervain et al. also discuss the implications of the results for a general theory of natural language acquisition.

Continuing work initiated by Jónsson, Daigneault, Pigozzi and others; Maksimova proved that a normal modal logic (with a single unary modality) has the Craig interpolation property iff the corresponding class of algebras has the superamalgamation property (cf. [Mak 91], [Mak 79]). The aim of this paper is to extend the latter result to a large class of logics. We will prove that the characterization can be extended to all algebraizable logics containing Boolean fragment and having a certain kind of local (...) deduction property. We also extend this characterization of the interpolation property to arbitrary logics under the condition that their algebraic counterparts are discriminator varieties. We also extend Maksimova's result to normal multi-modal logics with arbitrarily many, not necessarily unary modalities, and to not necessarily normal multi-modal logics with modalities of ranks smaller than 2, too.The problem of extending the above characterization result to no n-normal non-unary modal logics remains open. (shrink)

Gervain et al. discuss both behavioral and neurophysiological AGL studies that investigate rule and structure learning processes in infants. The paper provides an overview of all the major AGL paradigms used to date to investigate infant learning abilities at the level of morpho‐phonology and syntax from a very early age onwards. Gervain et al. also discuss the implications of the results for a general theory of natural language acquisition.

The importance of socio-economic impacts from the introduction and use of genetically modified crops is reflected in increasing efforts to include them in regulatory frameworks. Aiming to identify and understand the present knowledge on SEI of GM crops, we here report the findings from an extensive study of the published international scientific peer-reviewed literature. After applying specified selection criteria, a total of 410 articles are analysed. The main findings include: limited empirical research on SEI of GM crops in the scientific (...) literature; the main focus of the majority of the published research is on a restricted set of monetary economic parameters; proportionally, there are very few empirical studies on social and non-monetary economic aspects; most of the research reports only short-term findings; the variable local contexts and conditions are generally ignored in research methodology and analysis; conventional agriculture is the commonly used comparator, with minimal consideration of other substantially different agricultural systems; and there is the overall tendency to frame the research upon not validated theoretical assumptions, and to over-extrapolate small-scale and short-term specific results to generalized conclusions. These findings point to a lack of empirical and comprehensive research on SEI of GM crops for possible use in decision-making. Broader questions and improved methodologies, assisted by more rigorous peer-review, will be required to overcome current research shortcomings. (shrink)

In the present study, we explored the effects of high arousal on cognitive performance when facing a situation of risk. We also investigated how these effects are moderated by either positive or ne...

Introduced by Leon Henkin back in the fifties, the notion of neat reducts is an old venerable notion in algebraic logic. But it is often the case that an unexpected viewpoint yields new insights. Indeed, the repercussions of the fact that the class of neat reducts is not closed under forming subalgebras turn out to be enormous. In this paper we review and, in the process, discuss, some of these repercussions in connection with the algebraic notion of amalgamation. Some new (...) unpublished results concerning neat reducts and amalgamation are given. . Several counterexamples which convey the gist of techniques used in this area are presented two of which are new . It is known that the algebraic notion of amalgamation in a class of algebras corresponds to the metalogical notion of interpolation in the corresponding logic. Answers to open question in the recent paper [54] concerning both amalgamation and interpolation are summarized in tabular form at the end of this paper. This paper appears in two parts. The present first part contains results on neat reducts. The second part contains results relating the notion of neat embeddings to various amalgamation properties.1. (shrink)

TPPP/p25 is a recently discovered, unstructured protein involved in brain function. It is found predominantly in oligodendrocytes in normal brain but is enriched in neuronal and glial inclusions of Parkinson's disease and other synucleinopathies. Its physiological function seems to be the dynamic stabilization of microtubular ultrastructures, as well as the projections of mature oligodendrocytes and ciliary structures. We reappraise the earlier belief that TPPP/p25 is a brain‐specific protein. We have identified and cloned two shorter (N‐terminal‐free) homologs of TPPP/p25 that behave (...) differently from each other and from TPPP/p25. Two unique cell models have been established and used to study the effect of the unstructured protein on the energy metabolism and the formation of pathological aggregates. Our data suggest that the intracellular level of TPPP/p25 influences the cell differentiation, proliferation and the formation of protein aggregates, and consequently, the etiology of central nervous system diseases. (shrink)

According to estimates more than 400 biobanks currently operate across Europe. The term ‘biobank’ indicates a specific field of genetic study that has quietly developed without any significant critical reflection across European societies. Although scientists now routinely use this phrase, the wider public is still confused when the word ‘bank’ is being connected with the collection of their biological samples. There is a striking lack of knowledge of this field. In the recent Eurobarometer survey it was demonstrated that even in (...) 2010 two-thirds of the respondents had never even heard about biobanks. The term gives the impression that a systematic collection of biological samples can constitute a ‘bank’ of considerable financial worth, where the biological samples, which are insignificant in isolation but are valuable as a collection, can be preserved, analysed and put to ‘profitable use’. By studying the practices of the numerous already existing biobanks, the authors address the following questions: to what extent does the term ‘biobank’ reflect the normative concept of using biological samples for the purposes of biomedical research? Furthermore, is it in harmony with the so far agreed legal–ethical consensus in Europe or does it deliberately pull science to the territory of a new, ambiguous commercial field? In other words, do biobanks constitute a medico-legal fiction or are they substantively different from other biomedical research protocols on human tissues? (shrink)

Drawing on east central European, mainly Hungarian, experience, this paper views—from a different angle—some of the issues raised in international literature in connection with the ethics of applied human geography, and raises new ones. Citing a few examples of various personal, institutional and political economic ‘terrains’ within geography, it intends to underscore the importance of the issue of ‘what kind of geography and what kind of geographers’ in studying the ethics of geographical research. The paper also offers an east central (...) European critical perspective on well‐known issues like relevance, usefulness, values and the relationship between the researcher and research subject and that between the researcher and the client. (shrink)

Our EcoDialogue Center is an educational space for human sustainability within the University of Veracruz. We propose that creating sustainable knowledge requires re-thinking how we conceive ourselves as human beings. This requires paying attention to what we call “the quality of being,” which means caring about and attending to the physical–emotional–mental–spiritual as the foundation of education. This way we can create a space where we can dialogue contemplatively where all dimensions of our lives interact; the physical, the emotional, the communitarian, (...) the social politic, the planetarium, and the spiritual being act with social–environmental responsibility. (shrink)

Part I: Building blocks. 1. Folk convictions -- 2. Doubts about libertarianism -- 3. Nihilism and revisionism -- 4. Building a better theory -- Part II. A theory of moral responsibility. 5. The primacy of reasons -- 6. Justifying the practice -- 7. Responsible agency -- 8. Blame and desert -- 9. History and manipulation --10. Some conclusions.

This study investigated how problem solvers get into and out of a state of impasse while solving difficult problems. 47 participants had to decipher the secret method behind 33 magic tricks while r...

Este artículo explora algunas de las relaciones entre dialéctica y filosofía dentro del programa de una dialéctica modificada de Theodor W. Adorno ¿Cómo pensar la tensión entre las categorías dialécticas y la filosofía desde el prisma de una dialéctica negativa? ¿Qué significa desde el pensamiento de Adorno a liberar a la filosofía y a la dialéctica de su carácter afirmativo? Elaborar estas preguntas es el objetivo de este trabajo.

Many prominent accounts of free will and moral responsibility make use of the idea that agents can be responsive to reasons. Call such theories Reasons accounts. In what follows, I consider the tenability of Reasons accounts in light of situationist social psychology and, to a lesser extent, the automaticity literature. In the first half of this chapter, I argue that Reasons accounts are genuinely threatened by contemporary psychology. In the second half of the paper I consider whether such threats can (...) be met, and at what cost. Ultimately, I argue that Reasons accounts can abandon some familiar assumptions, and that doing so permits us to build a more empirically plausible picture of our agency. (shrink)

We present three natural but distinct formalisations of Einstein’s special principle of relativity, and demonstrate the relationships between them. In particular, we prove that they are logically distinct, but that they can be made equivalent by introducing a small number of additional, intuitively acceptable axioms.

La modificación de la dialéctica que propone el planteamiento de Adorno despliega una crítica inmanente del principio identificatorio que emerge del conflicto entre componente somático y concepto, entre lo idéntico y lo no idéntico. Ello resulta fundamental para comprender la dominación como segunda naturaleza en las formaciones económico-sociales modernas/coloniales. En este trabajo proponemos, en primer lugar, examinar críticamente las relaciones de alteridad que estructuran la experiencia de lo político al interior de la modernidad/colonialidad, y la configuración de la subjetividad en (...) términos sociohistóricos. En segundo lugar, se explora, desde un abordaje decolonial del horizonte analítico de Adorno, la constelación de mecanismos ideológicos vinculados al principio identitario que se condensa en la alteridad colonial, y que, como exponemos en este análisis, convergen finalmente en una metafísica del exterminio, en donde lo particular resulta subsumido por lo universal, y, que se efectualiza como una matriz de dominación en la que se articulan la experiencia de lo abyecto y los procesos de estereotipia que vertebran la construcción simbólica y racial de América. (shrink)

In an attempt to provide a unified model of language-related mental processes, Jackendoff puts forward significant modifications to the generative architecture of the language faculty. While sympathetic to the overall objective of the book, my review points out that one aspect of the proposal – the status of the lexicon – lacks sufficient empirical support.

Many prominent theories of moral responsibility rely on the notion of “tracing,” the idea that responsibility for an outcome can be located in (i.e., “traced back to”) some prior moment of control, perhaps significantly antecedent to the proximate sources of a considered action. In this article, I show how there is a problem for theories that rely on tracing. The problem is connected to the knowledge condition on moral responsibility. Many prima facie good candidate cases for tracing analyses appear to (...) violate the knowledge condition on moral responsibility. So, either we need to dispense with tracing approaches or we must refine our understanding of the knowledge condition or we are responsible less frequently than we suppose. (shrink)

We study the foundation of space-time theory in the framework of first-order logic (FOL). Since the foundation of mathematics has been successfully carried through (via set theory) in FOL, it is not entirely impossible to do the same for space-time theory (or relativity). First we recall a simple and streamlined FOL-axiomatization Specrel of special relativity from the literature. Specrel is complete with respect to questions about inertial motion. Then we ask ourselves whether we can prove the usual relativistic properties of (...) accelerated motion (e.g., clocks in acceleration) in Specrel. As it turns out, this is practically equivalent to asking whether Specrel is strong enough to “handle” (or treat) accelerated observers. We show that there is a mathematical principle called induction (IND) coming from real analysis which needs to be added to Specrel in order to handle situations involving relativistic acceleration. We present an extended version AccRel of Specrel which is strong enough to handle accelerated motion, in particular, accelerated observers. Among others, we show that~the Twin Paradox becomes provable in AccRel, but it is not provable without IND. (shrink)

RESUMEN La modificación de la dialéctica que propone el planteamiento de Adorno despliega una crítica inmanente del principio identificatorio que emerge del conflicto entre componente somático y concepto, entre lo idéntico y lo no idéntico. Ello resulta fundamental para comprender la dominación como segunda naturaleza en las formaciones económico-sociales modernas/coloniales. En este trabajo proponemos, en primer lugar, examinar críticamente las relaciones de alteridad que estructuran la experiencia de lo político al interior de la modernidad/colonialidad, y la configuración de la subjetividad (...) en términos sociohistóricos. En segundo lugar, se explora, desde un abordaje decolonial del horizonte analítico de Adorno, la constelación de mecanismos ideológicos vinculados al principio identitario que se condensa en la alteridad colonial, y que, como exponemos en este análisis, convergen finalmente en una metafísica del exterminio, en donde lo particular resulta subsumido por lo universal, y, que se efectualiza como una matriz de dominación en la que se articulan la experiencia de lo abyecto y los procesos de estereotipia que vertebran la construcción simbólica y racial de América. ABSTRACT The modification of dialectics proposed by Adorno's approach displays an immanent critique of the identifying principle that emerges from the conflict between the somatic component and the concept, between identity and non-identity. This is essential to understand domination as second nature in modern/colonial social economic formations. In this paper, we propose, first of all, to critically examine the relationships of alterity that structure the experience of the political within modernity/ coloniality, and the sociohistorical configuration of subjectivity. Secondly, from a decolonial approach to Adorno's analytical horizon, we explore the constellation of ideological mechanisms linked to the identity principle that are condensed in colonial alterity, and, that, as we expose in this analysis, finally converge in a metaphysics of extermination, where the particular is subsumed by the universal, which is carried out as a matrix of domination in which the experience of the abject and the stereotyping processes that structure the symbolic and racial construction of America are articulated. (shrink)

Nomy Arpaly rejects the model of rationality used by most ethicists and action theorists. Both observation and psychology indicate that people act rationally without deliberation, and act irrationally with deliberation. By questioning the notion that our own minds are comprehensible to us--and therefore questioning much of the current work of action theorists and ethicists--Arpaly attempts to develop a more realistic conception of moral agency.

In recent years, reflection on the relationship between individual moral responsibility and determinism has undergone a remarkable renaissance. Incompatibilists, those who believe moral responsibility is incompatible with determinism, have offered powerful new arguments in support of their views. Compatibilists, those who think moral responsibility is compatible with determinism, have responded with ingenious counterexamples and alternative accounts of responsibility. Despite the admirable elevation of complexity and subtlety within both camps, the trajectory of the literature is somewhat discouraging. Every dialectical stalemate between (...) incompatibilists and compatibilists seems to be superseded by a similar though often more subtle stalemate.1 The stalemates have two sources. On the one hand, incompatibilists again and again find powerful intuitive support from our folk concept. On the other hand, compatibilists seem right to insist that even if determinism were true, this would not mitigate our need for a concept of responsibility. (shrink)

The Luck Problem has existed in one form or another since David Hume, at least. It is perhaps as old as Stoic objections to the Epicurean swerve. Although the general issue admits of different formulations with subtly different emphases, the characterization of it that will serve as my target focuses on “cross-worlds” luck, a kind of luck that arises when the decision-making of agents is indeterministic.

In this article I propose a resolution to the history issue for responsible agency, given a moderate revisionist approach to responsibility. Roughly, moderate revisionism is the view that a plausible and normatively adequate theory of responsibility will require principled departures from commonsense thinking. The history issue is whether morally responsible agency – that is, whether an agent is an apt target of our responsibility-characteristic practices and attitudes – is an essentially historical notion. Some have maintained that responsible agents must have (...) particular sorts of histories, others have argued that no such history is required. Resolution of this contentious issue is connected to a wide range of concerns, including the significance and culpability of different forms of manipulation, the plausibility of important incompatibilist criticisms of compatibilism, and of course, a satisfactory account of moral responsibility. As it turns out, history matters sometimes, but less frequently than we might think. (shrink)