Mobile devices with health apps, direct-to-consumer genetic testing, crowd-sourced information, and other data sources have enabled research by new classes of researchers. Independent researchers, citizen scientists, patient-directed researchers, self-experimenters, and others are not covered by federal research regulations because they are not recipients of federal financial assistance or conducting research in anticipation of a submission to the FDA for approval of a new drug or medical device. This article addresses the difficult policy challenge of promoting the welfare and interests of (...) research participants, as well as the public, in the absence of regulatory requirements and without discouraging independent, innovative scientific inquiry. The article recommends a series of measures, including education, consultation, transparency, self-governance, and regulation to strike the appropriate balance. (shrink)

Peer review is a widely accepted instrument for raising the quality of science. Peer review limits the enormous unstructured influx of information and the sheer amount of dubious data, which in its absence would plunge science into chaos. In particular, peer review offers the benefit of eliminating papers that suffer from poor craftsmanship or methodological shortcomings, especially in the experimental sciences. However, we believe that peer review is not always appropriate for the evaluation of controversial hypothetical science. We argue that (...) the process of peer review can be prone to bias towards ideas that affirm the prior convictions of reviewers and against innovation and radical new ideas. Innovative hypotheses are thus highly vulnerable to being “filtered out” or made to accord with conventional wisdom by the peer review process. Consequently, having introduced peer review, the Elsevier journal Medical Hypotheses may be unable to continue its tradition as a radical journal allowing discussion of improbable or unconventional ideas. Hence we conclude by asking the publisher to consider re-introducing the system of editorial review to Medical Hypotheses. (shrink)

Despite promising early work into the role of immune cells such as eosinophils in adipose tissue (AT) homeostasis, recent findings revealed that elevating the number of eosinophils in AT alone is insufficient for improving metabolic impairments in obese mice. Eosinophils are primarily recognized for their role in allergic immunity and defence against parasitic worms. They have also been detected in AT and appear to contribute to adipose homeostasis and drive energy expenditure, but the underlying mechanisms remain elusive. It has long (...) been recognized that immune cells such as macrophages respond to external signals to regulate adipose homeostasis and energy balance, however, less is known about the relevance of eosinophil activity in AT. As the authors propose in this review, given recent debate over the relative importance of their tissue‐specific abundance, the stage is now set for exploring the functionality and activation states of AT eosinophils. (shrink)

Analysis of sites of newly integrated DNA in cellular genomes is important to several fields, but methods for analyzing and visualizing these datasets are still under development. Here, we describe tools for data analysis and visualization that take as input integration site data from our INSPIIRED pipeline. Paired-end sequencing allows inference of the numbers of transduced cells as well as the distributions of integration sites in target genomes. We present interactive heatmaps that allow comparison of distributions of integration sites to (...) genomic features and that support numerous user-defined statistical tests. To summarize integration site data from human gene therapy samples, we developed a reproducible report format that catalogs sample population structure, longitudinal dynamics, and integration frequency near cancer-associated genes. We also introduce a novel summary statistic, the UC50, which provides a single number summarizing possible clonal expansion. Using these tools, we characterize ongoing longitudinal characterization of a patient from the first trial to treat severe combined immunodeficiency-X1, showing successful reconstitution for 15 years accompanied by persistence of a cell clone with an integration site near the cancer-associated gene CCND2. Software is available at https://github.com/BushmanLab/INSPIIRED. (shrink)

Conceptual analysis has fallen out of favor in political philosophy. The influence of figures like John Rawls and Ronald Dworkin has led political philosophy to focus on questions about what should be done, and to ignore questions about the usage of words. As a result, contemporary political philosophy lacks a shared understanding of the concept of justice, and a considerable amount of disagreement between political philosophers is, upon reflection, traceable to this. In my book, I call for renewed attention to (...) the manner in which the word ‘justice’ is and should be used. Focusing on the late work of G.A. Cohen, I argue that two major debates in contemporary political philosophy: the debate over luck-egalitarianism and the debate over whether justice imposes demands on citizens’ personal lives; are really just conceptual. Whereas some philosophers have been using the term ‘justice’ to refer to one among a plurality of values, others have been using it to refer to institutional rightness. Though the latter use of ‘justice’ is presently more dominant, I argue that much is to be gained from thinking of justice as one value among many. Doing so sheds light on the nature of both democracy and legitimacy, and, paradoxically, makes better sense of the idea that justice is ‘the first virtue of institutions’. (shrink)

In the concluding chapter of Exceeding our Grasp Kyle Stanford outlines a positive response to the central issue raised brilliantly by his book, the problem of unconceived alternatives. This response, called "epistemic instrumentalism", relies on a distinction between instrumental and literal belief. We examine this distinction and with it the viability of Stanford's instrumentalism, which may well be another case of exceeding our grasp.

This paper is concerned with an ambiguous aspect of Kant’s ethics, namely, how moral change is possible. Kant conceives that change is possible, indeed desirable, without making clear the mechanism by which this change occurs. I conclude that one’s moral development must come about through the autonomous rationality of humanity. This allows for the moral law to be held at all times and for the rejection of immoral sentiments and inclinations. Further, it is constant soul-searching that allows one to keep (...) a check on their maxims, facilitating the development of a moral disposition. (shrink)

In his recent monograph on textual criticism, Richard Tarrant discusses the history, problems and practices of diagnosing interpolations in Latin texts, and persuasively argues for ‘restor[ing] interpolation to the editor's armoury’. In the hopes of better arming future editors, I identify a possible interpolation in the second book of Claudian's De Raptu Proserpinae. The passage in question describes the celebrations in the underworld that attend the wedding of Pluto and Proserpina; joining in the holiday mood, the Furies let their snaky (...) hair down to enjoy a drink of wine while they light festive torches for the nuptials :oblitae scelerum formidatique furorisEumenides cratera parant et uina ferocicrine bibunt flexisque minis iam lene canentes 345extendunt socios ad pocula plena cerastaset festas alio succendunt lumine taedas. (shrink)

Wittgenstein’s statement that “if a lion could talk, we would not understand him” seems to be in contradiction with his general understanding of how language works. Some scholars, such as Gary Levvis, have sought to explain Wittgenstein’s point by emphasizing certain features of animals that may prevent us from understanding them. Levvis (1992, 160) suggests that, "If Wittgenstein’s view is correct, then the assignment of rights to animals becomes tricky. I would suggest that before an individual can be assigned rights (...) it is necessary for that individual to be understood.” But in a more traditional reading of Wittgenstein, I focus instead on our practices of attributing meaning to animals' ostensively communicative behavior. In particular, I look at whether we allow expressions of pain to coordinate with our own actions. In cases like this, we sometimes forcefully exclude animals from our communicative practices. The fur industry is an extreme case of this. While furriers might register a fox’s growls, they do not allow foxes to express pain or a desire for freedom. Respecting the moral status of such animals would simultaneously include them in our communicative practices regarding, for example, responses to requests for help, personal space, or basic freedom. (shrink)

I give an account of the compositional semantics of unconditionals that explains their relationship to if -conditionals in the Lewis/Kratzer/Heim tradition. Unconditionals involve an alternative-denoting adjunct that supplies domain restrictions pointwise to a main-clause operator such as a modal. The differences from if -clauses follow from the structure of the adjuncts; both are conditionals in the Lewisian sense. In the course of treating unconditionals, I provide a concrete implementation of conditionals where conditional adjuncts in general are a species of correlative, (...) and show what detaching this hypothesis from if involves. (shrink)

In the physical sciences a realist ontology rests on our ability to demonstrate the actual and real nature of material entities. Realist metaphysics of social entities, most influentially Bhaskar's critical realism, attempt to provide a related philosophical foundation for the social sciences. This paper examines the central issue of what is real about society it concludes that social relations and the organisations they constitute do exist and discusses the conditions of their demonstration. Realist interpretations of Bourdieu's theories are given particular (...) attention in an argument that accepts the necessity of social realism but remains cautious about the development of methodologies able to provide effective demonstration. (shrink)

Wild animal reproduction poses an important moral problem for animal rights theorists. Many wild animals give birth to large numbers of uncared-for offspring, and thus child mortality rates are far higher in nature than they are among human beings. In light of this reproductive strategy – traditionally referred to as the ‘r-strategy’ – does concern for the interests of wild animals require us to intervene in nature? In this paper, I argue that animal rights theorists should embrace fallibility-constrained interventionism: the (...) view that intervention in nature is desirable but should be constrained by our ignorance of the inner workings of ecosystems. Though authors sometimes assume that large-scale intervention requires turning nature into an enormous zoo, I suggest an alternative. With sufficient research, a new form of gene editing called CRISPR promises to one day give us the capacity to intervene without perpetually interfering with wild animals’ liberties. (shrink)

Recent years have seen various forms of honorific public art – statues, monuments, and the like – brought under renewed moral scrutiny. This scrutiny has resulted in some high-profile removals, some defacement and additional contextualization to augment existing objects, and some cases of the status quo prevailing. Scholarly treatment of the issues has similarly resulted in arguments that articulate competing values that support removal, modification or preservation. I bring the insights of these arguments to bear on specifically military commemorations, where (...) I argue that they have ample application, but where they do not exhaust the moral complexity to be confronted. This is true first because military commemoration introduces a novel moral concern of militarism, and second because military commemoration frequently has a distinctively normative function of expressing gratitude. Both these points are most powerfully observed in collections of commemorations, rather than individual monuments, a distinction that deepens ongoing discussions about problematic commemorations. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:What Virgil Should Have Said KYLE GERVAIS Mortem infelicem canimus famamque perennem Sidoniae praeclara ducis quae sustulit alte moenia—multum illa et furiis iactata et amore saucia, deseruit cum foedera barbarus hospes, vique deum quassa et fratris, dum conderet ensem fatiferum profugi sub pectore et iret ad umbras, arma virumque ciens magnam contundere Romam. I sing the tragic death and endless glory Of Sidon’s exiled queen, the famous walls (...) She raised on high, her wild and wounded love When savage guest betrayed his bonded word And gods and brother shook her—till she took The fateful sword he left and sought the shades To call a man in arms to topple Rome. note With thanks to Sarah Shaughnessy for the idea and advice, and to Michael Putnam, who taught me that Dido never really dies in the Aeneid. arion 28.2 fall 2020... (shrink)

Ethicists are typically willing to grant that thick terms (e.g. ‘courageous’ and ‘murder’) are somehow associated with evaluations. But they tend to disagree about what exactly this relationship is. Does a thick term’s evaluation come by way of its semantic content? Or is the evaluation pragmatically associated with the thick term (e.g. via conversational implicature)? In this paper, I argue that thick terms are semantically associated with evaluations. In particular, I argue that many thick concepts (if not all) conceptually entail (...) evaluative contents. The Semantic View has a number of outspoken critics, but I shall limit discussion to the most recent--Pekka Väyrynen--who believes that objectionable thick concepts present a problem for the Semantic View. After advancing my positive argument in favor of the Semantic View (section II), I argue that Väyrynen’s attack is unsuccessful (section III). One reason ethicists cite for not focusing on thick concepts is that such concepts are supposedly not semantically evaluative whereas traditional thin concepts (e.g. good and wrong) are. But if my view is correct, then this reason must be rejected. (shrink)

Venturing into novel terrain poses physical risks to a female and her offspring. Females have a greater tendency to avoid physical harm, while males tend to have larger range sizes and often outperform females in navigation-related tasks. Given this backdrop, we expected that females would explore a novel environment with more caution than males, and that more-cautious exploration would negatively affect navigation performance. Participants explored a novel, large-scale, virtual environment in search of five objects, pointed in the direction of each (...) object from the origin, and then navigated back to the objects. We found that females demonstrated more caution while exploring as reflected in the increased amounts of pausing and revisiting of previously traversed locations. In addition, more pausing and revisiting behaviors led to degradation in navigation performance. Finally, individual levels of trait harm avoidance were positively associated with the amount of revisiting behavior during exploration. These findings support the idea that the fitness costs associated with long-distance travel may encourage females to take a more cautious approach to spatial exploration, and that this caution may partially explain the sex differences in navigation performance. (shrink)

In our 2018 paper, “Hypocrisy and the Standing to Blame,” we offer an argument justifying the Nonhypocrisy Condition on the standing to blame. Benjamin Rossi (2018) has recently offered several criticisms of this view. We defend our account from Rossi’s criticisms and emphasize our account’s unique advantage: explaining why hypocritical blamers lack the standing to blame.

In this chapter, Kyle Ferguson argues for an individualist account of Sellarsian we-intentions. According to the individualist account, we-intentions’ intersubjective form renders them shareable rather than requiring that they be shared. Contrary to collectivist accounts, one may we-intend independently of whether and without presupposing that one's community shares one's we-intentions. After providing textual support, Ferguson proposes and implements a strategy of reportorial ascent, which strengthens the case for the individualist account. Reportorial ascent involves reflecting on the sentences one would (...) use to report or self-ascribe we-intentions. As Ferguson argues, we-intention-reporting sentences have ‘I’ as their subjects, which reveals that their truth conditions, like the performance conditions of their expressive counterparts, are satisfied by the individual who reports or expresses those intentions rather than by the host community. We-intention-reporting sentences, which make explicit both dimensions of independence and shareability, also reveal that intersubjective form is a feature of we-intentions qua mental states rather than a feature of their contents. Ferguson concludes that although the individualist account needs further development, the sketch provided in this chapter is compelling enough to demand that individualism and independence be moved from the periphery to the core of our study of we-intentions in Sellars's practical philosophy. (shrink)

Indigenous peoples often embrace different versions of the concept of food sovereignty. Yet some of these concepts are seemingly based on impossible ideals of food self-sufficiency. I will suggest in this essay that for at least some North American Indigenous peoples, food sovereignty movements are not based on such ideals, even though they invoke concepts of cultural revitalization and political sovereignty. Instead, food sovereignty is a strategy of Indigenous resurgence that negotiates structures of settler colonialism that erase the ecological value (...) of certain foods for Indigenous peoples. (shrink)

Although a safe, effective, and licensed coronavirus vaccine does not yet exist, there is already controversy over how it ought to be allocated. Justice is clearly at stake, but it is unclear what justice requires in the international distribution of a scarce vaccine during a pandemic. Many are condemning ‘vaccine nationalism’ as an obstacle to equitable global distribution. We argue that limited national partiality in allocating vaccines will be a component of justice rather than an obstacle to it. For there (...) are role-based and community-embedded responsibilities to take care of one’s own, which constitute legitimate moral reasons for some identity-related prioritisation. Furthermore, a good form of vaccine nationalism prioritises one’s own without denying or ignoring duties derived from a principle of equal worth, according to which all persons, regardless of citizenship or identity, equally deserve vaccine-induced protection from COVID-19. Rather than dismissing nationalism as a tragic obstacle, it is necessary to acknowledge that a limited form of it is valuable and expresses moral commitments. Only then can one understand our world of competing obligations, a world where cosmopolitan duties of benevolence sometimes conflict with special obligations of community membership. Once these competing obligations are recognised as such, we can begin the work of designing sound ethical frameworks for achieving justice in the global distribution of a coronavirus vaccine and developing practical strategies for avoiding, mitigating or resolving conflicts of duty. (shrink)

A method now popular for fixing the scopes of arguments involves a covert movement operation, named QR (for Quantifier Rule) by Robert May. May envisioned QR as a kind of adjunction operation, attaching the arguments so affected to phrases dominating that argument. From the surface representation in (1a), for instance, QR can fashion the representations in (1b) and (1c) by adjoining the object and/or subject argument to IP. (1) a. [IP Someone [VP loves everyone ]]. b. [IP everyone1 [IP someone (...) [VP loves t1 ]]]. c. [IP someone2 [IP everyone1 [IP t2 [VP loves t1 ]]]] As the representations in (1a,b) suggest, QR has syntactic consequences rather like those displayed by Topicalization, the process that derives (2b) from (2a). (shrink)

Several writers have argued that the state lacks the moral standing to hold socially deprived offenders responsible for their crimes because the state would be hypocritical in doing so. Yet the state is not disposed to make an unfair exception of itself for committing the same sorts of crimes as socially deprived offenders, so it is unclear that the state is truly hypocritical. Nevertheless, the state is disposed to inconsistently hold its citizens responsible, blaming or punishing socially deprived offenders more (...) often or more harshly than other offenders, even when the crimes are the same. The state’s stable disposition to inconsistently hold offenders responsible undermines its standing to hold offenders responsible for the same reasons that hypocrisy undermines standing; instead of making an unfair exception of itself, the state makes an unfair exception of others. Strikingly, this means that the state lacks the standing to hold anyone responsible for a crime for which it is unfairly disposed to hold citizens responsible inconsistently, not just socially deprived offenders. Thus, it is even more urgent that the state regain its moral standing by working toward a justice system that holds offenders responsible consistently. (shrink)

The nearly omnipotent character known only as “Q” dramatically enters the Star Trek universe when he puts all humanity in the person of Captain Jean‐Luc Picard, on trial in the first episode of TNG. Acting as self‐professed prosecutor, judge, and jury, Q promises Picard an “absolutely equitable” trial, only to coerce Picard into pleading “guilty” by threatening to kill his crew. Q could be like the “Leviathan” of Thomas Hobbes (1588‐1679), an absolute sovereign who has the power to keep people (...) from warring with each other, but who can't be held accountable or subject to any civil law in the use of that power. Enlisting Hobbes and Locke, this chapter examines the motives behind Q's enigmatic actions and sees what Q, deep down, might believe about justice. Hobbes begins with a basic right of nature that all people possess: our liberty to ensure the preservation of our own life. (shrink)

Sex selection and disability avoidance receive opposed treatment in bioethics literature, legislative practice and public opinion. However, some theorists question this state of affairs by drawing analogies between the harmful consequences of these practices. This paper shares their disapproval of gender selection and disability avoidance, but bases its resistance to these practices on an examination of the concepts of gender and disability. Here it identifies conceptual confusions as another cause of approval of sex selection and disability avoidance. Further, in clarifying (...) the nature of the concepts at issue, and their relationship with the subjects that they apply to, this discussion highlights the existence of relevant analogies between the concepts of gender and disability. Here the social construction and universality of gender and disability allow their differential treatment to be resisted at the conceptual level, creating a strong foundation for more consequentialist arguments against sex selection and disability avoidance. (shrink)

Every well-read architect in the English-speaking world will soon be familiar with the name of Uriel Birnbaum. For this he will have to thank a philosopher: a German philosopher, the provocative and prolific Peter Sloterdijk1—author of “the best-selling German book of philosophy since World War II,”2 the Kritik der zynischen Vernunft, or Critique of Cynical Reason. But Sloterdijk’s more recent 1998–2004 magnum opus, the three-volume, 2,573-page Sphären, or Spheres, has not yet been fully translated into English. This itself will prove (...) no insignificant task; the book has been variously described as “expansive,” “majestic,” “epic,” “monumental,” and even “megalomaniac,”3 and thus far only the first volume .. (shrink)

The recent edition of theThebaidby Hall, Ritchie, and Edwards launched a successful attack on thecommunis opinioof a bipartite manuscript tradition, with one clearly superior family, and relatively few textual problems. In doing so, they underscored the need for renewed editorial work on the poem. Here I discuss five passages fromThebaid2 that have not received adequate attention from editors.

( ) Di erence in Semantic Displacement a. Total Reconstruction: Mary kaupir ikke skó. ¬ Mary kaupir skó b. Variable Binding: Which book Mary had read e set of propositions such that x Mary had read x, x a book. A guard stands before every bank x if x is a bank then a guard stands before x..