Correct interpretation of the data from integral laboratory tests, including Thrombin Generation Test, requires biochemistry-based mathematical models of blood coagulation. The purpose of this study is to describe the experimental TGT data from healthy donors and hemophilia A and B patients. We derive a simplified ODE model and apply it to analyze the TGT data from healthy donors and HA/HB patients with in vitro added tissue factor pathway inhibitor antibody. This model allows the characterization of hemophilia patients in the space (...) of three most important model parameters. The proposed approach may provide a new quantitative tool for the analysis of experimental TGT. Also, it gives a reduced model of coagulation verified against clinical data to be used in future theoretical large-scale modeling of thrombosis in flow. (shrink)

Open peer commentary on the article “Interactivity and Enaction in Human Cognition” by Matthew Isaac Harvey, Rasmus Gahrn-Andersen & Sune Vork Steffensen. Upshot: To sort out their differences with enactive theory, interactivity theorists would do better to focus on operational closure only insofar as it constitutes a condition of intrinsic normativity or self-regulated coupling.

Dhamma discussion and dissemination and Buddhist philosophy by Supawan Green, a Thai meditation teacher in Birmingham.

A new and thorough investigation of Leibniz's calculator has been carried out. When Burkhardt investigated the calculating machine between 1894 and 1896 he concluded that it could never have functioned since the multiple decimal carrying mechanism was defective. Burkhardt overlooked, however, the fact that the two phases of the adding process are to a great extent independent of each other. By means of a reconstruction it has now been proved that Leibniz's calculator was completely functional.

This article aims to discuss the history of medical history in the British medical undergraduate curriculum and it reviews the main characters and organisations that have attempted to earn it a place in the curriculum. It also reviews the arguments for and against the study of the subject that have been used over the last 160 years.

The activities of religious organizations are aimed primarily at augmenting spiritual values, but are also relevant to the needs of a person's social life. For many centuries, social issues have been important, and they remain relevant today. Right now, they are receiving special attention, because the level of social life in Ukraine is not the best. In this case, the role of the Church as a social institution is ancillary to the healing of society.

For John M. Anderson philosophy, as the love of wisdom, is a concern for what is ultimate. The essays in this volume take to heart this understanding of philosophy, and are therefore responses to the ultimate. The first four essays by Kaelin, Schrag, Baillif and Johnstone, deal with Anderson's own account of ultimacy as it is presented in his reflections on the aesthetic occasion, the experience of the sublime, on freedom and on insight. The concern for what is ultimate is (...) formulated differently by each of the other eight essays. Desmond articulates ways of our encounter with the ultimate by means of what he calls essential perplexity. Gendlin reflects on Aristotle's characterization of thinking as an activity that is ultimate. Biemel and Lingis present death as an aspect of the ultimate. Hersch sees our loss of meaning and value as the result of our refusal of finitude and thus of our denial of the ultimate which reveals itself in this finitude. Ginsberg initiates us into the ultimacy of the human encounter that is dialogue. Verene speaks of the ultimate through his account of the fool. For Kockelmans philosophy, unlike science, deals with what-is as it manifests itself in our encounter with our lived world which is a source of meaning, and in that sense an ultimate. Finally, John M. Anderson writes of the awareness of our becoming more than we are, and does so by bespeaking the origin of the dialogue we are. (shrink)

Objective. Approved medicines are not always sufficient to address the needs of patients so several legal pathways exist to enable access to unapproved medicines for treatment purposes. This article is the first to provide an in-depth analysis of this regulatory framework that governs access to unapproved medicines in Australia with a specific focus on affordability-motivated access. Methods. Legislation, regulations, and guidelines were critically analysed to identify the de jure basis for importation and supply of unapproved medicines in Australia. Results. Most (...) pathways for accessing unapproved medicines do not permit importation or supply for non-clinical justifications such as affordability. This is problematic as it fails to recognize that a medicine being unavailable is equivalent to a medicine being unaffordable for a patient. Better alignment can be achieved by permitting importation and supply of unapproved medicines if justified by good medical practice, which includes considerations of equity and access. It is also shown that the provisions of the Special Access Scheme Category A could be interpreted broadly to expand its use. Conclusions. As medicines become more expensive and cost-barriers to treatment are more prevalent, ignoring affordability as a valid criterion for importing medicines is a significant oversight of current regulation. (shrink)

This chapter examines Soren Kierkegaard's views about the concept of time and history. It suggests that while time and history do not figure prominently in the works of Kierkegaard, the implications of his key concepts can only be understood through the questions of time and history, particularly his ideas about selfhood, existence, and the ethical. The chapter also discusses the different notions of time and history, and considers how time and history come into play in the works of Kierkegaard.

Arrian was better qualified to understand the nature and significance of ‘the pursuit’ in Macedonian warfare than any modern scholar. He had himself fought and commanded in a very similar kind of warfare, and he was keenly interested in the study of military tactics. He was also better informed about the pursuits which Alexander had conducted, because he was able to use the accounts of Alexander's contemporaries, Ptolemy and Aristobulus. Anyone today who wishes to question the veracity of Arrian's reports (...) of these pursuits cannot do so of his own experience. He should therefore turn to comparable pursuits of recent times which have been reported accurately beyond any shadow of doubt. (shrink)

Die Herrschaft des Behaviorismus in der Psychologie ist gebrochen! Das ist die Ausgangsthese dieses Buches, die im Rahmen des Modells revolutionärer Wissenschaftsentwicklung (Kuhn) als Behauptung eines Paradigmawechsels präzisiert wird. Die Argumentation beschränkt sich nicht nur auf den Nachweis des Niedergangs des Behaviorismus, sondern gibt auch konstruktiv das mögliche neue Paradigma an: als Psychologie des reflexiven Subjekts, das wie der Wissenschaftler (subjektive) Theorien aufstellt, überprüft, bewertet. Der Aufriss einer solchen Psychologie des epistemischen Subjekts unter allgemein-, sozial-, pädagogisch- und klinisch-psychologischem Aspekt thematisiert (...) vor allem: die Rationalität der Reflexionen, Normenkritik und -begründung im Austausch von wissenschaftlichen und naiven Theorien sowie die Berücksichtigung von Reflexivität in der therapeutischen Praxis. Die Rückwendung dieser pychologisch-metatheoretischen Perspektiven auf die Wissenschaftstheorie führt auch zu einer neu. (shrink)