Similar to parasites, malignant cells exploit the host for energy, resources and protection, thereby impairing host health and fitness. Although cancer is widespread in the animal kingdom, its impact on life history traits and strategies have rarely been documented. Devil facial tumour disease, a transmissible cancer, afflicting Tasmanian devils, provides an ideal model system to monitor the impact of cancer on host life-history, and to elucidate the evolutionary arms-race between malignant cells and their hosts. Here we provide an overview of (...) parasite-induced host life history adaptations, then both phenotypic plasticity of LH responses and changes in allele frequencies that affect LH traits of Tasmanian devils in response to DFTD are discussed. We conclude that akin to parasites, cancer can directly and indirectly affect devil LH traits and trigger host evolutionary responses. Consequently, it is important to consider oncogenic processes as a selective force in wildlife. Exposure to transmissible cancer cells, i.e., Tasmanian devil facial tumour cells, can cause changes to life history traits either as the result of phenotypic plasticity in response to exposure during the lifetime of the individual or as the result of evolutionary change in LH traits due to selection over generations.Photo credits: Frédéric Thomas, Sarah Peck, Geordie Jennings. (shrink)

Is logic out of this world? This elusive question reveals a tension in our thinking about the basis of logic: both worldly and unworldly answers get something right and yet they conflict. My aim is to clarify the question and explore a conciliatory answer. I focus on a characterization of unworldliness in terms of ground. This allows for a distinction between proximal and distal unworldliness. That in turn reconfigures our approach to the question. It may now be taken as asking (...) for the proximal or the distal basis of logic. This helps alleviate the tension because the answer for the one needn’t conflict with a different answer for the other. I explore a case study culminating in an illustration of how a logical truth may indeed be proximally worldly but distally unworldly. I conclude by considering some potential extensions. (shrink)

The conception of “prospective potency” was defined by its author H.Driesch as “the sum of the possible modes of development of a given part of the embryo”. However, in the language of science the word “potency” usually means “power”, not “possibility”. Therefore this conception from the beginning possessed a certain ambiguity, that it retained up to the present. The distinction of “active” and “passive” potency, introduced by Roux, has found no general acceptance. It appeared necessary to submit the conception of (...) “potency” to a profound analysis. In the first place it is shown, that the ambiguity of this conception vanishes, if we understand by the word “potency” those fundamental properties of the embryonic material, that are responsible for its various developmental possibilities. We can distinguish among these properties the “reactive powers”, by which the embryonic material reacts to inductive stimulations, and its own “developmental tendencies”. These faculties only differ by their strength; a “reactive power” may change into a “tendency”, when its intensity increases during development; conversely, a “tendency” may change into a mere “reactive power” by a decrease of its strength. The determination of the material results from the conflict of its tendencies. The inductive actions interfere by strengthening or weakening different tendencies, and by activating new tendencies by reinforcement of the “reactive powers” of the embryonic material. (shrink)

This essay focuses on a recently prominent notion of ground which is distinctive for how it links metaphysics to explanation. Ground is supposed to serve both as the common factor in diverse in virtue of questions as well as the structuring relation in the project of explaining how some phenomena are “built” from more fundamental phenomena. My aim is to provide an opinionated synopsis of this notion of ground without engaging with others. Ground, so understood, generally resists illumination by appeal (...) to more familiar models of explanation. Nevertheless, its distinctive explanatory and metaphysical aspects guide us on characterizing its explanatory logic and its metaphysical features. Some issues concerning the meta-question of what grounds ground are explored, as well as some recent skeptical challenges to ground. (shrink)

Etic theorizing uses the theorist’s social notions to theorize about their subject. This theorist may claim that Genghis Khan was a war criminal even though his actions predate the enactment of the Geneva Conventions. Brian Epstein considers a modal etic theorist who claims that Genghis Khan would have been a war criminal even if the Geneva Conventions were never enacted. Epstein argues that this has metaphysical import: it requires postulating a novel metaphysical notion of “anchoring.” Drawing from some familiar issues (...) in modal actualism, I argue that modal etic theorizing does not support this postulate. But it does suggest a distinctive kind of modality at work in social reality. (shrink)

Some believe reality is dynamic: time passes, not just in our experience of reality, but objectively, in reality itself. There are many objections to this view. I focus on the rate objection: that time passes only if it passes at the rate of 1 second per second, but that it cannot coherently pass at that rate. Existing replies to this objection do not fully engage with its motivation. My aim is to refute the rate objection. Time can coherently pass at (...) the rate of 1 second per second. This does not conclusively show that time passes, but it removes one of the main obstacles to believing that it does. (shrink)

Chalmers, Manley, and Wasserman's "Metametaphysics" anthology is reviewed.

I defend (metaphysical) ground against recent, unanswered objections aiming to dismiss it from serious philosophical inquiry. Interest in ground stems from its role in the venerable metaphysical project of identifying which facts hold in virtue of others. Recent work on ground focuses on regimenting it. But many reject ground itself, seeing regimentation as yet another misguided attempt to regiment a bad idea (like phlogiston or astrology). I defend ground directly against objections that it is confused, incoherent, or fruitless. This vindicates (...) the very attempt to regiment ground. It also refocuses our attention on the genuine open questions about ground and away from the distracting, unpersuasive reasons for dismissing them. (shrink)

A commonly held view is that a central aim of metaphysics is to give a fundamental account of reality which refers only to the fundamental entities. But a puzzle arises. It is at least a working hypothesis for those pursuing the aim that, first, there must be fundamental entities. But, second, it also seems possible that the world has no foundation, with each entity depending on others. These two claims are inconsistent with the widely held third claim that the fundamental (...) just is the foundational. It is tempting to resolve the puzzle by rejecting the first or second claim, perhaps because it is obscure how the third claim might plausibly be challenged. But I develop a new analysis of fundamentality which challenges the third claim by allowing for an entity to be fundamental without being foundational. The analysis, roughly, is that an entity is fundamental just in case not all facts about it are grounded in facts about other entities. The possibility of fundamentality without foundations not only provides for a novel resolution to the puzzle, but has applications to some live debates: for example, it undermines Jonathan Schaffer's modal argument for priority monism. (shrink)

Interest surges in a distinctively metaphysical notion of ground. But a Schism has emerged between Orthodoxy’s view of ground as inducing a strict partial order structure on reality and Heresy’s rejection of this view. What’s at stake is the structure of reality (for proponents of ground), or even ground itself (for those who think this Schism casts doubt upon its coherence). I defend Orthodoxy against Heresy.

A modern and influential Aristotelian conception of universals combines two ideas: that a universal is immanent in its instantiations, and that its instantiations are partly constructed by this universal. I argue that these two ideas are inconsistent on weaker assumptions than previously recognized.

It may seem strange, in view of the spate of recent literature on the subject, that yet another article should be forthcoming on what is certainly the most familiar, as well as the most vexed, of all Platonic passages. But it is precisely this spate of literature that has impelled me to write. The time seems to have come for an article which, rather than seeking desperately for something new, sets out instead to reaffirm those facts and conclusions that even (...) the most resolutely original of scholars could hardly venture to dispute. This article will therefore be based, not on any of the numerous modern interpretations, but on what Plato himself actually wrote. It will contain a number of tentative suggestions which, to the best of my knowledge, have not been made before. They can, and probably will, be rejected. But its primary purpose remains to restate, whenever possible in Plato's own words, a number of important facts that are at once so simple and so obvious that they seem repeatedly, and especially in recent years, to have been quite forgotten. (shrink)

There has been much recent interest in a distinctively metaphysical kind of determinative explanation: ground. This paper concerns various skeptical challenges to ground’s relevance to metaphysics, such as that it is an empty posit, that the work it is supposed to do is appropriated by other notions, and that it is inapt for specific issues it should serve. I argue against these challenges. My strategy is both critical and constructive. Critical because I argue that versions of these challenges raised by (...) Elizabeth Barnes, Kathrin Koslicki, Mari Mikkola, and Jessica Wilson are not persuasive. Constructive because we may nevertheless learn from them new work for ground. (shrink)

A collection of 37 essays surveying the state of the art on metaphysical ground. -/- Essay authors are: Fatema Amijee, Ricki Bliss, Amanda Bryant, Margaret Cameron, Phil Corkum, Fabrice Correia, Louis deRosset, Scott Dixon, Tom Donaldson, Nina Emery, Kit Fine, Martin Glazier, Kathrin Koslicki, David Mark Kovacs, Stephan Krämer, Stephanie Leary, Stephan Leuenberger, Jon Litland, Marko Malink, Michaela McSweeney, Kevin Mulligan, Alyssa Ney, Asya Passinsky, Francesca Poggiolesi, Kevin Richardson, Stefan Roski, Noel Saenz, Benjamin Schnieder, Erica Shumener, Alexander Skiles, Olla Solomyak, (...) Tuomas Tahko, Naomi Thompson, Kelly Trogdon, Jennifer Wang, Tobias Wilsch, and Justin Zylstra. (shrink)

This paper explores the prospects of combining two views. The first view is metaphysical rationalism : all things have an explanation. The second view is metaphysical essentialism: there are real essences. The exploration is motivated by a conflict between the views. Metaphysical essentialism posits facts about essences. Metaphysical rationalism demands explanations for all facts. But facts about essences appear to resist explanation. I consider two solutions to the conflict. Exemption solutions attempt to exempt facts about essences from the demand for (...) explanation. Explanation solutions attempt to explain facts about essences. I argue that exemption solutions are less promising than explanation solutions. I then consider how explanation solutions might be developed. I suggest that a “generative” approach is most promising. I tentatively conclude that the prospects for combining metaphysical rationalism and metaphysical essentialism turn on the viability of a generative approach. This sets the agenda for defending the combination as well as the more general project of explaining essences. (shrink)

Background: The COVID-19 crisis has had a considerable mental health impact on healthcare workers. High levels of psychological distress are expected to have a significant impact on healthcare systems, warranting the need for evidence-based psychological interventions targeting stress and fostering resilience in this population. Online cognitive behavioral therapy has proved to be effective in targeting stress and promoting resilience. However, online CBT programs targeting stress in healthcare workers are lacking.Objective: The aim of our study is to evaluate the feasibility and (...) acceptability of an internet-based CBT intervention, the My Health Too program we developed during the first COVID-19 epidemic peak in France.Methods: We recruited 10 participants among Alsace region hospital staff during the first peak of the pandemic in France. They were given 1 week to test the website and were then asked to answer an internet survey and a semi-structured phone interview.Results: We conducted a thematic analysis of the content from the phone interviews. Major themes were identified, discussed and coded: the technical aspects, the content of the website and its impact on participants’ emotions and everyday life. Overall, the participants reported finding the website easy to use and interactive. They described the resources as easy to understand, readily usable, and useful in inducing calm and in helping them practice self-compassion.Conclusion: Our results suggest that the My Health Too online CBT program is highly feasible and acceptable to healthcare workers during the highly stressful times of the pandemic peak. The feedback provided helped to improve the program whose efficacy is to be tested. (shrink)

The social world contains institutions, groups, objects, and more. This essay explores a puzzle about the essences of social items. There is widespread consensus against social essences because of problematic presuppositions often made about them. But it is argued that essence can be freed from these presuppositions and their problems. Even so, a puzzle still arises. In a Platonic spirit, essences in general seem detached from the world. In an Aristotelian spirit, social essences in particular seem embedded in the world. (...) The puzzle is that these inclinations are individually plausible but jointly incompatible. The essay has four aims: to clarify and refine the puzzle; to explore the puzzle's implications for essence in general and for social essences in particular; to illustrate the fruitfulness of the general distinction between detached and embedded; and to develop this distinction to sketch a novel solution to the puzzle. (shrink)

This paper raises a problem for the pair of views that universals are immanent in their instantiations and that these instantiations, or states of affairs, are somehow constructed from the instantiated universals. It is argued that the pair is inconsistent. The first view implies that universals are prior to states of affairs, whereas the second view implies that states of affairs are prior to universals. This paper does not attempt to solve this problem, but rather to formulate it precisely. That (...) promises to illuminate how to solve the problem if it can be solved, or why it cannot be solved if it is unsolvable. (shrink)

This paper concerns a distinction between circumstantial truths that hold because of the circumstances and acircumstantial truths that hold regardless of, or transcend, the circumstances. Previous discussions of the distinction tended to focus on its applications, such as to modality, logical truth, and essence. This paper focuses on developing the distinction largely, but not entirely, in abstraction from its potential applications. As such, the paper’s main contribution is to further clarify the distinction itself. An indirect contribution is to help guide (...) its future applications. (shrink)

A state's foreign policy is constrained by parameters that inhere in the structure of the international system and in the nation's own political‐constitutional, social, and economic systems. The latter, domestic parameters, include “public opinion.” Because the public is largely ignorant of foreign affairs, policy‐making elites have wide scope for acting more rationally than would otherwise be possible, although public opinion operates on the second‐order effects of foreign policy (e.g., taxes, casualties)—inviting mismatches of objectives and means. The prevalent nonrational theories of (...) foreign‐policy derivation are themselves largely ignorant of the dominantly rational processes of the state, particularly in its foreign and military functions. (shrink)

When is AI environmentally just? In recent years, increasing attention has been drawn to the environmental impact of AI. Particularly, the development and training of AI systems require significant amounts of energy, water, and raw materials. This raises new ethical questions, such as: when is it (un)justifiable to develop an AI system, considering its environmental impact? This question has been scarcely addressed in the academic literature. To tackle this question, this article draws from the literature on environmental and energy justice. (...) In that field, three categories of justice are distinguished, referring to three elements that can be unjust: the distribution of benefits and burdens (distributive justice), decision-making procedures (procedural justice), and institutionalized social norms (justice as recognition). Based on these distinctions, we outline the criteria for determining the ethical admissibility of AI, given its ecological impact. (shrink)

Impostors are pseudo-problems masquerading as genuine problems. Impostors should be exposed. The problem of change appears genuine. But some, such as Hofweber ( 2009 ) and Rychter ( 2009 ), have recently denounced it as an impostor. They allege that it is mysterious how to answer the meta - problem of saying what problem it is: for even if any problem is genuinely about change per se, they argue, it is either empirical or trivially dissolved by conceptual analysis. There is (...) indeed an impostor in our midst. But it is the meta-problem of change. I defend the appearance that the problem of change is a genuine metaphysical problem about change. This vindicates philosophers’ lasting interest in it. It also illuminates what makes a problem metaphysical, how metaphysics relates to other inquiries, and how best to respond to attempts to undermine metaphysical problems. (shrink)

This book is an anthology of Plato's writings, connected with sections of commentary.

The physicalist credo is that the world is physical. But some phenomena, such as minds, morals, and mathematics, appear to be nonphysical. While an uncompromising physicalism would reject these, a conciliatory physicalism needn’t if it can account for them in terms of an underlying physical basis. Any such account must refer to the nonphysical. But won’t this unavoidable reference to the nonphysical conflict with the physicalist credo? This essay aims to clarify this problem and introduce a novel solution that relies (...) on a distinction between “circumstantial” facts that are based in the circumstances and “acircumstantial” facts that are not. This is used in two ways. First, physicalism is restricted to circumstantial facts: only they must have a physical basis that does not refer to the nonphysical. Second, facts accounting for the nonphysical are not restricted to the circumstantial: they may refer to the nonphysical if they are acircumstantial. Facts about how the physical accounts for the nonphysical therefore do not conflict with the physicalist’s credo. This provides a credible answer to what physicalism could be. (shrink)

Simon Evnine’s Making Objects and Events: A Hylomorphic Theory of Artifacts develops amorphic hylomorphism. I critically discuss three of its main themes. One theme is its attempt to do the work of form without forms. A second theme is the requirement that hylomorphs have ‘metabolisms at work’. A third theme is the use of artifacts as the paradigms for hylomorphs. I will raise some criticisms of each of these themes. Although the themes might at first appear disconnected, I believe the (...) third underwrites the first two. So the criticisms of the third theme also bear on the rest. (shrink)

This chapter will discuss the relation of physicalism to social ontology, and explores problems that social ontology raises for physicalism. Physicalism is often understood to be the view that all facts—the social ones included—are physical facts, or at least are exhaustively determined by physical facts. While this view is widely endorsed, social phenomena challenge physicalism in several ways, both challenging the coherence of claims of physicalism and raising potential counterexamples.

The conception of “prospective potency” was defined by its author H.Driesch as “the sum of the possible modes of development of a given part of the embryo”. However, in the language of science the word “potency” usually means “power”, not “possibility”. Therefore this conception from the beginning possessed a certain ambiguity, that it retained up to the present. The distinction of “active” and “passive” potency, introduced by Roux, has found no general acceptance. It appeared necessary to submit the conception of (...) “potency” to a profound analysis. In the first place it is shown, that the ambiguity of this conception vanishes, if we understand by the word “potency” those fundamental properties of the embryonic material, that are responsible for its various developmental possibilities. We can distinguish among these properties the “reactive powers”, by which the embryonic material reacts to inductive stimulations, and its own “developmental tendencies”. These faculties only differ by their strength; a “reactive power” may change into a “tendency”, when its intensity increases during development; conversely, a “tendency” may change into a mere “reactive power” by a decrease of its strength. The determination of the material results from the conflict of its tendencies. The inductive actions interfere by strengthening or weakening different tendencies, and by activating new tendencies by reinforcement of the “reactive powers” of the embryonic material.La conception de „prospektive Potenz” fut définie par son auteur H.Driesch comme „l'ensemble des modes de développement possibles d'une certaine partie de l'embryon”. Cependant, le, mot „Potenz” dans le langage de la science répond plutôt à la „puissance” qu'à la „possibilité”. De là résulte, que cette conception dès son origine avait une certaine ambiguïté, qui se fait sentir jusqu'à présent. La distinction entre „potentialité active” et „potentialité passive”, proposée par Roux, n'est pas acceptée généralement. Il se trouvait nécessaire, que la conception de „Potenz” fût soumise à une. analyse profonde. D'abord il est démontré, que l'ambiguïté de cette conception disparaît, si on entend par le mot „Potenz” les propriétés fondamentales du matériel embryonnaire, qui sont à la base de ses diverses possibilités de développement. On peut distinguer parmi ces propriétés les „pouvoirs réactifs”, en vertu desquels le matériel embryonnaire répond à des inductions morphogénétiques, et les „tendances propres” du matériel. Ils ne diffèrent que par leur intensité; un „pouvoir réactif” peut se changer en „tendance” par suite d'un renforcement au cours du développement, une „tendance” peut se changer en „pouvoir réactif” par une diminution d'intensité. La détermination du matériel se réalise par une „lutte” entre les tendances. Les actions inductives influent sur cette lutte en renforçant ou en diminuant l'intensité des diverses tendances, et en activant de nouvelles tendances par le renforcement de „pouvoirs réactifs”. (shrink)

In biology, the “field” concept is used in different ways. Therefore, its meaning in biology as compared to that in physics, and the relation between the conceptions of “gradient” and “field” are studied.In physics, scalar fields, vector fields and tensor fields are distinguished. In a scalar field, the variation of the scalar in space is expressed in form of a gradient. For the whole of a scalar field with its derived gradients the term “gradient-field” may be used.In biology, especially in (...) experimental embryology, the field concept is used both in a purely descriptive sense and as a means of causal analysis. To the first group belong the kinematic fields and growth fields. The kinematic field is a vector field; the growth field is generally a tensor field, but may be treated as a gradient-field in the most simple cases. In the causal analysis of development the gradient-field plays an important part, in the form of axial, superficial and spatial gradient-fields. In such a field by the combined action of the scalar and the gradients a great diversity of relations may occur. Probably, both the induction field and the organisation field belong to the class of gradient-fields.Der Feldbegriff wird in der Biologie in sehr verschiedener Weise verwendet. Es wird daher versucht, das Wesen der „biologischen Felder” in Anlehnung an die Physik zu bestimmen, und das Verhältnis zwischen den Begriffen „Gradient” und „Feld” darzustellen.In der Physik unterscheidet man Skalarfelder, Vektorfelder und Tensorfelder. Im Skalarfeld lässt sich der Wechsel der Skalargrösse im Raume durch einen Gradienten darstellen. Für die Gesamtheit eines Skalarfeldes mit seinen abgeleiteten Gradienten wird der Ausdruck „Gradientfeld” vorgeschlagen.In der Biologie, im besonderen in der Entwicklungsmechanik, wird der Feldbegriff bald in rein-beschreibendem Sinne, bald als Mittel zur kausalen Analyse verwendet. Zur ersten Gruppe gehören das Bewegungsfeld und das Wachstumsfeld. Das Bewegungsfeld ist ein Vektorfeld; das Wachstumsfeld ist im allgemeinen ein Tensorfeld, kann aber im einfachsten Falle als ein Gradientfeld betrachtet werden. In der kausalen Analyse der Entwicklungserscheinungen spielt besonders das Gradientfeld eine grosse Rolle; dabei kann es sich um ein axiales, oberflächliches oder räumliches Gradientfeld handeln. Es wird darauf hingewiesen, dass in einem Gradientfelde durch das Zusammenwirken der Skalargrösse und des Gradienten eine grosse Mannigfaltigkeit der Beziehungen auftreten kann. Auch das Induktionsfeld und das Organisationsfeld gehören vermutlich zu den Gradientfeldern. (shrink)

Emerging empirical evidence indicates that discrete emotions are associated with teaching practices and professional experiences of university instructors. However, further investigations are necessary given that university instructors often face high job demands and compromised well-being. Achievement goals, which frame achievement-related thoughts and actions, have been found to describe motivational differences in university instructors and are hypothesized to be associated with their discrete emotions. Moreover, as variation exists in how university instructors respond to job demands regarding their emotional experiences, certain goals (...) may moderate this relationship on the basis of framing different interpretations and reactions to stressors. To investigate these links, 439 instructors (46.7% female) from German and Austrian universities completed a survey assessing their achievement goals, discrete emotions (enjoyment, pride, anger, anxiety, shame, and boredom), and job demands. As hypothesized, multiple regression analyses revealed that achievement goals were differentially and meaningfully associated with discrete emotions. Specifically, learning approach goals were positively related to enjoyment and negatively related to anger and boredom, while learning avoidance goals were positively related to anger. Performance (appearance) approach goals were positively related to pride, and performance (appearance) avoidance goals were positively related to anxiety and shame. Lastly, relational goals were positively related to shame and boredom, and work avoidance goals were negatively related to enjoyment and positively related to shame and boredom. Conclusive moderation effects on the relations between job demands and emotions were not found. Future research avenues aimed at further understanding the supportive role that achievement goals can have for university instructors’ emotional experiences and well-being are discussed. (shrink)

This essay is about the ensuing problem that in general it is nothelpful to talk about non-standard knowledge practices as modeled after our Western ideas of what knowledge is. It negotiates this problem by arguing that artisanal knowledge is an independent and self-contained mode of knowledge and is arranged in three parts. In the first part an outline is given of the key assumptions of the interactionist conception of knowledge that needs to be put in place as an alternative to (...) the basically Kantian mixture of empiricist and rationalist assumptions of the folk model of Western academic thinking about knowledge. In this interactionist conception of knowledgeartisanal knowledge gets center stage. In the second part, the notion of craftknowledge is opened up as much as possible. The third and final part takes upthe question whether craft knowledge is a cultural universal. (shrink)

Ayahuasca, an ancient Amazonian psychedelic tea traditionally used ceremonially among indigenous peoples, has recently become known as a possible treatment for a wide range of disorders. The awareness of this sacred medicine has grown exponentially over the past decade, attracting westerners from a wide variety of backgrounds, hoping to find treatment for a myriad of emotional and physical illnesses, as well as spiritual needs. In the wake of the commercialization and westernization of the use of ayahuasca, and the subsequent proliferation (...) of ayahuasca treatment centers, this paper examines the benefits and possible risks of this form of therapy in an effort to create a safety protocol for Westerners in this context. The most practical approach to increasing safety for Westerners attending these Amazonian treatment centers is to educate the seeker prior to treatment and to provide access to specialized therapeutic aftercare services. (shrink)

An annotated bibliography for metaphysical ground.

An initial review of the Draft Guidance produced in response to the Cadbury Report by the Institute of Chartered Accountants in England and Wales. The author is Principal Consultant, Corporate Social Responsibility Consultants, 86 Iffley Road, London W6 OPF.

In a well-known quotation from Speusippus in the Theologumena Arithmeticae , said to have been derived from Pythagorean sources, especially Philolaus, occur the following sentences: And again a little later: Similarly Sextus Empiricus , drawing evidently on a relatively early Pythagorean source, writes as follows: And Aristotle himself writes of the Pythagoreans : There were, in fact, certain Pythagoreans who equated the number 2 with the line because they regarded the line as ‘length without breadth extended between two points’; and (...) likewise the number 3 was equated with the plane and 4 with the solid. (shrink)