Similar to parasites, cancer cells depend on their hosts for sustenance, proliferation and reproduction, exploiting the hosts for energy and resources, and thereby impairing their health and fitness. Because of this lifestyle similarity, it is predicted that cancer cells could, like numerous parasitic organisms, evolve the capacity to manipulate the phenotype of their hosts to increase their own fitness. We claim that the extent of this phenomenon and its therapeutic implications are, however, underappreciated. Here, we review and discuss what can (...) be regarded as cases of host manipulation in the context of cancer development and progression. We elaborate on how acknowledging the applicability of these principles can offer novel therapeutic and preventive strategies. The manipulation of host phenotype by cancer cells is one more reason to adopt a Darwinian approach in cancer research. -/- . (shrink)

Written by an ardent spokesman for the Libertarian philosophy, this is an important book for Americans, most of whom have been steeped in the concept that their ...

The conclusion of Chrysalus' famouscanticumcomparing the successful duping of his master Nicobulus to the sack of Troy has often been suspected by critics (Plaut.Bacch.976–7):nunc Priamo nostro si est quis emptor, comptionalem senemuendam ego, uenalem quem habeo, extemplo ubi oppidum expugnauero.Now, if there's any buyer for our Priam, I'll sell as a job lot the old man, whom I have for sale as soon as I've stormed the city.The lines are condemned by Leo, Gaiser, and Jocelyn, but defended by Lefèvre and (...) printed by Lindsay, Barsby, Questa (in his first and third editions, but not his second), and most recently De Melo. In addition to qualms about the inconsistency of casting Nicobulus as Priam here when he was Ilium little over thirty lines earlier – an inconsistency which can surely be attributed to the ebullience of Chrysalus rather than the incompetence of an interpolator – the main objection to these lines is their divergence from the mythological tradition about Priam's fate at the sack of Troy. As Jocelyn puts it, ‘The threatsenem uendam… would have been ludicrous to any audience acquainted with the heroic story.’. (shrink)

The Covid-19 pandemic has led to severe shortages of many essential goods and services, from hand sanitizers and N-95 masks to ICU beds and ventilators. Although rationing is not unprecedented, never before has the American public been faced with the prospect of having to ration medical goods and services on this scale.

Cross-national studies of business-related ethicality frequently have concluded that Americans possess higher ethical standards than non-Americans. These conclusions have generally been based on survey responses of relatively small convenience samples of individuals in a very limited number of countries. This article reports a study of the relationship between nationality and business-related ethicality based on survey responses from more than 6300 business students attending 120 colleges and universities in 36 countries. Two well-documented determinants of business ethics (gender and religiosity) were investigated (...) as moderators of the nationality–business ethicality relationship. The major research finding is that, while statistically significant differences were found between the business-related ethicality of American survey participants and the business-related ethicality of the non-American survey participants, the magnitudes of the differences were not substantial. The results of the study suggest that (i) more empirical cross-cultural/national research is required on business-related ethicality and (ii) previous explanations for cross-cultural/national differences in ethics need to be reconsidered before further generalizations are warranted. (shrink)

Is faith that p compatible with disbelief that p? I argue that it is. After surveying some recent literature on the compatibility of propositional and non-propositional forms of faith with the lack of belief, I take the next step and offer several arguments for the thesis that both these forms of faith are also compatible, in certain cases, with outright disbelief. This is contrary to the views of some significant recent commentators on propositional faith, including Robert Audi and Daniel (...) Howard-Snyder. The primary argument revolves around the possibility of maintaining a single faith through drastic changes in cognitive attitude. I argue that once we allow that propositional faith is compatible with weaker cognitive attitudes than belief, such as acceptance or assent, there is prima facie reason to consider propositional faith as sometimes compatible with disbelief. I then consider objections and offer some final reflections on the significance of the thesis. (shrink)

The paper by Salloch and Eriksen (2024) offers an insightful contribution to the ethical debate on Machine Learning-driven Clinical Decision Support Systems (ML_CDSS) and provides much-needed conce...

In this paper we explore the thesis that the role of argumentation in practical reasoning in general and legal reasoning in particular is to justify the use of defeasible rules to derive a conclusion in preference to the use of other defeasible rules to derive a conflicting conclusion. The defeasibility of rules is expressed by means of non-provability claims as additional conditions of the rules.We outline an abstract approach to defeasible reasoning and argumentation which includes many existing formalisms, including default (...) logic, extended logic programming, non-monotonic modal logic and auto-epistemic logic, as special cases. We show, in particular, that the admissibility semantics for all these formalisms has a natural argumentation-theoretic interpretation and proof procedure, which seem to correspond well with informal argumentation. (shrink)

The puzzling case of the broken arm -- Hernias, diets, and drugs -- Why physicians cannot know what will benefit patients -- Sacrificing patient benefit to protect patient rights -- Societal interests and duties to others -- The new, limited, twenty-first-century role for physicians as patient assistants -- Abandoning modern medical concepts: doctor's "orders" and hospital "discharge" -- Medicine can't "indicate": so why do we talk that way? --"Treatments of choice" and "medical necessity": who is fooling whom? -- Abandoning informed (...) consent -- Why physicians get it wrong and the alternatives to consent: patient choice and deep value pairing -- The end of prescribing: why prescription writing is irrational -- The alternatives to prescribing -- Are fat people overweight? -- Beyond prettiness: death, disease, and being fat -- Universal but varied health insurance: only separate is equal -- Health insurance: the case for multiple lists -- Why hospice care should not be a part of ideal health care I: the history of the hospice -- Why hospice care should not be a part of ideal health care II: hospice in a postmodern era -- Randomized human experimentation: the modern dilemma -- Randomized human experimentation: a proposal for the new medicine -- Clinical practice guidelines and why they are wrong -- Outcomes research and how values sneak into finding of fact -- The consensus of medical experts and why it is wrong so often. (shrink)

This paper addresses the recent resurgence of Nagel style reduction in the philosophical literature. In particular, it considers the so-called multiple realizability objection to reductionism presented most forcefully by Sober in 1999. It is argued that this objection misses the point of multiple realizability and that there remain serious problems for reductionist methodologies in science.

The "Nightcap," a relatively nonintrusive and "user-friendly" sleep monitoring system, was used by 11 subjects on 10 consecutive nights in their homes. Eighty-eight sleep mentation reports were obtained after spontaneous awakenings from Nightcap-identified REM sleep and 61 were obtained from NREM awakenings. Sleep mentation was recalled in 83% of REM reports and 54% of NREM reports. The median length of REM reports was 148 words compared to 21 words for NREM reports. Twenty-four percent of the REM reports were over 500 (...) words long; no NREM reports over 500 words were obtained. REM report lengths were lowest during the first 15 min of the REM cycle and longest 15–45 min into the period. In contrast, 7 of the 9 NREM reports more than 100 words long occurred within the first 15 min of NREM periods. The Nightcap thus appears to be an effective and efficient method of collecting large numbers of sleep mentation reports with correlated sleep staging under normal ecological conditions. (shrink)

No other book in the entire history of the world has exerted a greater influence on a larger number of people over a longer period of time than this slim volume. The spiritual cornerstone of the most populous and oldest living civilization on Earth, the Analects has inspired the Chinese and all the peoples of East Asia with its affirmation of a humanist ethics. As the Gospels are to Jesus, the Analects is the only place where we can encounter the (...) real, living Confucius. In this gem-like translation by Simon Leys, Confucius speaks with clarity and brilliance. He emerges as a man of great passion and many enthusiasms, a man of bold action whose true vocation is politics. Confucius (551-479 B.C.) lived in an age of acute cultural and political crisis. Many of his observations mark a world sinking into violence and barbarity. Unable to obtain the leading political role he sought, he endeavored to reform society and salvage civilization through ethical debate, defining for ages to come the public mission of the intellectual. (shrink)

Studie over de filosofie van de in Oostenrijk geboren Engelse wijsgeer.

This essay assesses the rationale for regulating research administrators as carefully as they regulate researchers. The reasons for such regulation are identical: protecting scientific integrity, ensuring responsible use of public funds, addressing the lack of effective recourse for victims, creating negative consequences for misbehaving actors, and addressing high incentives for misconduct. Whereas the reasons compelling us to regulate research administrators are obvious, counterarguments to administrative oversight are based on suggestions that the incidence and prevalence of cases of administrative misconduct are (...) too low to warrant formal regulation. I briefly describe examples of the phenomenon drawn from publicly available records. My analysis suggests that the misconduct of research administrators is both serious and worthy of better oversight. Improved oversight of research administration will help steward tax dollars appropriately and enhance the overall integrity of the scientific record and of the free pursuit of knowledge more generally. (shrink)

The tangle modality is a propositional connective that extends basic modal logic to a language that is expressively equivalent over certain classes of finite frames to the bisimulation-invariant fragments of both first-order and monadic second-order logic. This paper axiomatises several logics with tangle, including some that have the universal modality, and shows that they have the finite model property for Kripke frame semantics. The logics are specified by a variety of conditions on their validating frames, including local and global connectedness (...) properties. Some of the results have been used to obtain completeness theorems for interpretations of tangled modal logics in topological spaces. (shrink)

This volume reflects the breadth of Alexy's philosophy, identifies new areas of inquiry and offers a new impetus to the discourse theory of law.

This book shows that the repeated announcements of the death of Hegel's philosophical system have been premature. Hegel's Philosophy of Freedom, Reality, and God brings to light accomplishments for which Hegel is seldom given credit: unique arguments for the reality of freedom, for the reality of knowledge, for the irrationality of egoism, and for the compatibility of key insights from traditional theism and naturalistic atheism. The book responds in a systematic manner to many of the major criticisms leveled at Hegel's (...) system, from Feuerbach and Kierkegaard to Heidegger and Charles Taylor. It provides detailed interpretations of Hegel's Philosophy of Spirit, large parts of his indispensable Science of Logic, and important parts of his Philosophy of Nature and Philosophy of Right. Unlike many academic books on Hegel, this one treats him very much as a 'live' thinker, whom we can learn from today. (shrink)

February is Black History Month and so healthcare practitioners will soon rummage history books for information about famous African Americans, like Onesimus, the African slave who...

This paper is about two kinds of mental content and how they are related. We are going to call them representation and indication. We will begin with a rough characterization of each. The differences, and why they matter, will, hopefully, become clearer as the paper proceeds.

This is an age of naturalization projects. Much epistemological work has been done toward naturalizing theoretical reason. One might view Hume as seeking to naturalize reason in both the theoretical (roughly, epistemological) and the practical realms. I suggest that whatever else underlies the vitality of Hume's instrumentalism - encapsulated in his view that 'reason is and ought only to be the slave of the passions' - one incentive is the hope of naturalizing practical reason. This paper explores some broadly Humean (...) versions of instrumentalism that are among the most plausible contenders to represent instrumentalism as a contemporary naturalistic position. It first offers a taxonomy of reasons for action and, in that light, formulates a plausible version of instrumentalism. It then raises difficulties for the view, some of them concerning the nature of desire. It also develops an epistemologically significant comparison of desires with beliefs. Given the magnitude of the difficulties, it outlines an alternative account of practical reason. (shrink)

Because of their vastness and rather fragmentary character, the writings of Leibniz leave the student unusually dependent on secondary literature for guidance. That the literature on Leibniz is exceptionally good is all the more reason to welcome the kind of orientation to the riches of both primary and secondary sources that this Companion aims to provide. Announcing itself as “the most accessible and comprehensive guide to Leibniz currently available” for nonspecialists and “a conspectus of recent developments in the interpretation of (...) Leibniz” for specialists, it lives up to both aspirations remarkably well. (shrink)

Numerous labor-management issues possess ethical dimensions and pose ethical questions. In this article, the authors discuss four labor-management issues that present important contemporary problems: union organizing, labor-management negotiations, employee involvement programs, and union obligations of fair representation. In the authors view, labor and management too often view their ethical obligations as beginning and ending at the law''s boundaries. Contemporary business realities suggest that cooperative and enlightened modes of interaction between labor and management seem appropriate.