Biological evolution provides a creative fount of complex and subtle adaptations, often surprising the scientists who discover them. However, because evolution is an algorithmic process that transcends the substrate in which it occurs, evolution’s creativity is not limited to nature. Indeed, many researchers in the field of digital evolution have observed their evolving algorithms and organisms subverting their intentions, exposing unrecognized bugs in their code, producing unexpected adaptations, or exhibiting outcomes uncannily convergent with ones in nature. Such stories routinely reveal (...) creativity by evolution in these digital worlds, but they rarely fit into the standard scientific narrative. Instead they are often treated as mere obstacles to be overcome, rather than results that warrant study in their own right. The stories themselves are traded among researchers through oral tradition, but that mode of information transmission is inefficient and prone to error and outright loss. Moreover, the fact that these stories tend to be shared only among practitioners means that many natural scientists do not realize how interesting and lifelike digital organisms are and how natural their evolution can be. To our knowledge, no collection of such anecdotes has been published before. This paper is the crowd-sourced product of researchers in the fields of artificial life and evolutionary computation who have provided first-hand accounts of such cases. It thus serves as a written, fact-checked collection of scientifically important and even entertaining stories. In doing so we also present here substantial evidence that the existence and importance of evolutionary surprises extends beyond the natural world, and may indeed be a universal property of all complex evolving systems. (shrink)

Mental simulation — such as imagining tilting a glass to figure out the angle at which water would spill — can be a way of coming to know the answer to an internally or externally posed query. Is this form of learning a species of inference or a form of observation? We argue that it is neither: learning through simulation is a genuinely distinct form of learning. On our account, simulation can provide knowledge of the answer to a query even (...) when the basis for that answer is opaque to the learner. Moreover, through repeated simulation, the learner can reduce this opacity, supporting self-training and the acquisition of more accurate models of the world. Simulation is thus an essential part of the story of how creatures like us become effective learners and knowers. (shrink)

How has psychoanalysis developed in France in the years since Lacan so dramatically polarized the field? In this book, Dana Birksted-Breen and Sara Flanders of the British Psychoanalytical Society, and Alain Gibeault of the Paris Psychoanalytical Society provide an overview of how French psychoanalysis has developed since Lacan. Focusing primarily on the work of psychoanalysts from the French Psychoanalytical Association and from the Paris Psychoanalytical Society, the two British psychoanalysts view the evolution of theory as it appears to them (...) from the outside, while the French psychoanalyst explains and elaborates from inside the French psychoanalytic discourse. Seminal and representative papers have been chosen to illuminate what is special about French thinking. A substantial general introduction argues in favour of the specificity of 'French psychoanalysis', tracing its early influences and highlighting specific contemporary developments. Sections are made up of introductory material by Alain Gibeault, followed by illustrative papers in the following categories: the history of psychoanalysis in France the pioneers and their legacy the setting and the process of psychoanalysis phantasy and representation the body and the drives masculine and feminine sexuality psychosis. An excellent introduction to French psychoanalytical debate, _Reading French Psychoanalysis_ sheds a complementary light on thinking that has evolved differently in England and North America. It will be ideal reading for beginners and advanced students of clinical theory as well as experienced psychoanalysts wanting to know more about French Psychoanalytic theory, and how it has developed. (shrink)

Yablo suggests that we can understand the possibility of mental causation by supposing that mental properties determine physical properties, in the classic sense of determination according to which red determines scarlet. Determinates and their determinables do not compete for causal relevance, so if mental and physical properties are related as determinable and determinates, they should not compete for causal relevance either. I argue that this solution won''t work. I first construct a more adequate account of determination than that provided by (...) Yablo. I then consider two common accounts of the mental, token identity theories and dispositional theories, and argue that on neither do mental and physical properties satisfy the requirements for determination. (shrink)

It is unclear whether the regulatory distinction between non-identifiable and identifiable information—information used to determine informed consent practices for the use of clinically derived samples for genetic research—is meaningful to patients. The objective of this study was to examine patients' attitudes and preferences regarding use of anonymous and identifiable clinical samples for genetic research. Telephone interviews were conducted with 1,193 patients recruited from general medicine, thoracic surgery, or medical oncology clinics at five United States academic medical centers. Wanting to know (...) about research being done was important to 72% of patients when samples would be anonymous and to 81% of patients when samples would be identifiable. Only 17% wanted to know about the identifiable scenario but not the anonymous scenario. Curiosity-based reasons were the most common among patients who wanted to know about anonymous samples. Of patients wanting to know about either scenario, approximately 57% would require researchers to seek permission, whereas 43% would be satisfied with notification only. Patients were more likely to support permission in the anonymous scenario if they had more education, were Black, less religious, in better health, more private, and less trusting of researchers. The sample, although not representative of the general population, does represent patients at academic medical centers whose clinical samples may be used for genetic research. Few patients expressed preferences consistent with the regulatory distinction between non-identifiable and identifiable information. Data from this study should cause policy-makers to question whether this distinction is useful in relation to research with previously collected clinically derived samples. (shrink)

The “practice turn” in philosophy of science has strengthened the connections between philosophy and scientific practice. Apart from reinvigorating philosophy of science, this also increases the relevance of philosophical research for science, society, and science education. In this paper, we reflect on our extensive experience with teaching mandatory philosophy of science courses to science students from a range of programs at University of Copenhagen. We highlight some of the lessons we have learned in making philosophy of science “fit for teaching” (...) outside of philosophy circles by taking selected cases from the students’ own field as the starting point. We argue for adapting philosophy of science teaching to particular audiences of science students, and discuss the benefits of drawing on research within science education to inform curriculum and course design. This involves reconsidering teaching resources, assumptions about students, intended learning outcomes, and teaching formats. We also argue that to make philosophy of science relevant and engaging to science students, it is important to consider their potential career trajectories. By anticipating future contexts and situations in which methodological, conceptual, and ethical questions could be relevant, philosophy of science can demonstrate its value in the education of science students. (shrink)

We argue that Kraay's "theistic multiverse" response to the objections to theism [Kraay 2011] is unsuccessful as it simply shifts the problems leveled against theism from the level of possible worlds to the level of possible universes. Furthermore, when we restate the objections at the level of possible universes, we can show how Kraay's conclusion about the uniqueness of the theistic multiverse is undermined.

Mind blanking is a mental state in which attention does not bring any perceptual input into conscious awareness. As this state is still largely unexplored, we suggest that a comprehensive understanding of mind blanking can be achieved through a multifaceted approach combining self-assessment methods, neuroimaging, and neuromodulation. In this article, we explain how EEG and TMS could be combined to help determine whether mind blanking is associated with a lack of mental content or a lack of linguistically or conceptually determinable (...) mental content. We also question whether mind blanking occurs spontaneously or intentionally and whether these two forms are instantiated by the same or different neural correlates. (shrink)

Research illustrates that social movements can fuel new markets and that these markets can create social change, but the role of leaders in this process is less understood. This exploratory interview-based study of the localism movement contributes to such understanding. It articulates the relationship of social movement leaders and the legitimacy of their organizations to new market creation. Specifically, leaders in this study engaged in a dual role to legitimize their organizations and to legitimize the movement. At an organizational level, (...) leaders chose strategies that conformed to a conventional organizational model of the social movement organization as a business network, much like a local chamber of commerce. At a movement level, the SMO’s level of legitimacy influenced the leader’s choice of strategies to grow a “local” market. These strategies aimed, primarily, to shape consumer purchase behavior and, secondarily, to foster the development of producers’ skills, and only in a tertiary way, to alter the nature of exchange. Finally, this study’s findings suggest a tension between the dual roles that may ultimately challenge the efficacy of the movement. (shrink)

This paper studies emotional inferencing triggered by emotion terms using Pragma-Dialectics and the Argumentum Model of Topics. The corpus, in French, is an excerpt of a video-recorded testimony in which a middle school teacher evokes her experience of being in class the day after the Charlie Hebdo attack, thus presenting a case of argumentation in context. The analysis focuses on the argumentative structure and on the rhetorical strategies that trigger emotional inferencing. The emotional inferencing derives from a Locus of Ontological (...) Implication, which links a situation and an emotion, while the culture-bound elements tend to be part of the endoxon. (shrink)

In this paper I discuss in some detail my experience teaching women philosophers in the context of a survey course in ancient Greek philosophy at a small liberal arts college. My aim is to share the peculiar difficulties one may encounter when teaching this topic in a lower-level undergraduate course, difficulties stemming from a multiplicity of methodological hurdles that do not arise when teaching women philosophers in other periods, such as the modern era. In the first section, I briefly review (...) some of what we know about ancient Greek women philosophers, which is not only very little but frustratingly uncertain and highly debated. I devote the second section to some of the scholarly debates surrounding these philosophers’ doctrines, the details of their biographies, and their very existence. The third section is about the corresponding pedagogical challenges, and the fourth and final section describes the strategies I implemented to face those challenges. (shrink)

Advances in genetic research have created the need to inform consumers. Yet, the communication of hereditary risk and of the options for how to deal with it is a difficult task. Due to the abstract nature of genetics, people tend to overestimate or underestimate their risk. This paper addresses the issue of how to communicate risk information on hereditary breast and ovarian cancer through an online application. The core of the paper illustrates the design of OPERA, a risk assessment instrument (...) that applies the UK National Institute of Health and Clinical Excellence's guidelines on the basis of (i) the number of relatives on the same side of the family with the same cancer or cancers that are known to run together; (ii) the ages of these relatives at diagnosis and (iii) the closeness of the family relationship with the person who is doing the assessment. By relying on the argumentation theory, we explain how the communication strategy that OPERA implements is essentially based on Perelman and Olbrechts-Tyteca's deductive argumentation by association. By using as premises “facts” (propositions about reality that can be assumed without further justification) and “truths” (propositions that make connections about facts), OPERA delivers its claims with an ex auctoritate causal link aimed at transferring the audience's acceptance of the cause to the effect. Overall, the design of OPERA rests on its capacity to induce users' active processing of risk information through an appeal to their reasoning faculty. In the conclusion, we present some results from a pilot evaluation of users' acceptance of OPERA. (shrink)

Scepticism in the Sixth Century? Damascius' Doubts and Solutions Concerning First Principles SARA RAPPE THE Doubts and Solutions Concerning First Principles, an aporetic work of the sixth century Neoplatonist Damascius, is distinguished above all by its dialectical subtlety. Although the Doubts and Solutions belongs to the commentary tradi- tion on Plato's Parmenides, its structure and method make it in many ways unique among such exegetical works. The treatise positions itself, at least in part, as a response to Proclus' metaphysical (...) system. Thus the first principles alluded to in its title refer to a metaphysical structure consisting of five central elements, the Ineffable, the One, and the Noetic Triad, which Damascius both adumbrates in opposition to Proclus' as well as subjects to his own, internal critique. In this article, I will be asking whether or not Damascius' critique of Neoplatonic metaphysics is informed or inspired by ancient Scepticism. No doubt this question catches the reader off guard: if the last exponent of an- cient Scepticism is Sextus Empiricus, how could this sixth-century Neo- platonist Scholarch, the last officially appointed Platonic Successor, revert to a tradition that seemingly disappears for well over three centuries? ~ In what ~As is well known, Damascius modifies Proclus' own exposition of the Parmenidean hypothe- ses, positing a first principle to which he gives the title ~the Ineffable." For those interested in a.. (shrink)

Although rhetoric is not a category of ancient Indian philosophy, this paper argues that Śāntarakṣita and Kamalaśīla, 2 eighth-century Indian Buddhist philosophers, can nonetheless be seen to embrace a rhetorical conception of rationality. That is, while these thinkers are strong proponents of rational analysis and philosophical argumentation as tools for attaining certainty, they also uphold the contingent nature of all such processes. Drawing on the categories of the New Rhetoric, this paper argues that these Buddhist thinkers understand philosophical argumentation to (...) be directed at a universal audience of rational beings, where this universal audience is not an actual audience but a rhetorical one constructed through the author’s particular and historically contingent conception of what counts as rational. A reception theory of rationality is one that holds that the rationality of an argument depends upon its acceptance by a rational audience. When philosophers recognize the historically contingent nature of what counts as rational, they can embrace a reception theory of rationality that neither reduces the rational to mere opinion nor restricts it to a single, absolute, and timeless standard. (shrink)

Nonexistence is ubiquitous, yet mysterious. This volume explores some of the most puzzling questions about non-being and nonexistence, from metaphysics to ethics and beyond: the contributors offer answers from diverse philosophical perspectives, drawing on analytic, continental, Buddhist, and Jewish philosophical traditions.

Kant scholars have rarely addressed the centuries-old tradition of casuistry and the concept of conscience in Kant’s writings. This book offers a detailed exploration of the period from Pascal’s Provincial Letters to Kant’s critique of probabilism and discusses his proposal of a (new) casuistry as part of an moral education. / Trotz der Hinweise an wichtigen Stellen in Kants Schriften richtet die Kantforschung ihre Aufmerksamkeit nur selten auf die Jahrhunderte währende Tradition der Kasuistik und den Begriff des Gewissens, der in (...) ihrem Rahmen ausgearbeitet wird. Eingehend untersucht wird in diesem Buch insbesondere der Zeitabschnitt von Pascals »Briefen in die Provinz« bis zu Kants eigener Kritik des Probabilismus und seinem Entwurf einer (neuen) Kasuistik als Teil der ethischen Methodenlehre. (shrink)

Through a historical and documentary analysis, I investigate the possible perceptions and influences that Sor Juana Inés de la Cruz could have had by her exposure to the incipient cultural and social movements at the time of the viceroyalty in New Spain. Throughout her work, she refers to Spain and New Spain. From the first, she collects the literary tradition and transforms it, dedicates poems to the representatives of the monarchy and recognizes her own Spanish heritage; from the second, she (...) collects the Nahua language, Mexican Spanish and the echo of other languages. This agglutination is the result of an integral and conciliatory vision. The work of Sor Juana Inés de la Cruz is a mirror of a modernity underpinned by a proposal of equity, of joint traditions articulated in the prodigy of the word and creative freedom. (shrink)

This paper examines the role of modality resources (e.g., “may”, “often”) in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) in representing behavioral pathology focusing, in particular, on Attention Deficit Hyperactivity Disorder (ADHD). ADHD diagnosis requires reports of non-practitioners (e.g., carers and teachers); an effective understanding of behavioral descriptors by the lay community is thus of paramount importance. The study combines qualitative linguistic discourse analysis and a corpus approach to study the presence and functions of modality, adopting a Systemic (...) Functional perspective towards language. The study argues that in the DSM-5 modality is an important linguistic resource for conveying clinical significance, inferred from graduations of recurrence and probability. However, adopting features of professional discourse in representing behavioral pathology for non-experts, especially when those resources are inherently evaluative, stresses the need of health literacy among the lay social community and accessibility in health communication materials, particularly when non-practitioners are involved in the diagnosis practice. (shrink)

Volume 98, Issue 1, March 2020, Page 209-209.

Background: Caring for a partner with primary malignant brain tumour can be a dramatic life-changing event. Primary malignant brain tumour is known to give poor life expectancy and severe neurological and cognitive symptoms, such as changed behaviour and personality, which demand greater caring responsibilities from spouses. Aim: The aim of the study is to explore ethical dilemmas spouses experience in the everyday care of a partner in treatment for primary malignant brain tumour. Research design, participants and research context: A phenomenological (...) and hermeneutic qualitative descriptive design was adopted as a method for collecting and analysing data. Ten spouses were interviewed twice using an in-depth, semi-structured interview guide. The interviews took place at the spouses’ homes or at the hospital. Ethical consideration: Ethical matters were considered throughout the research process. Permission from The National Committee on Health Research Ethics and the Danish Data Protection Agency was obtained. Findings: The analysis showed that the spouses perceived daily ethical dilemmas in caring for a partner with primary malignant brain tumour. Their life as well as their partner’s life had changed considerably. The main theme that emerged therefore was ‘oscillating in a changing relationship’. This theme was further elaborated in three subthemes that in more detail demonstrated the dilemmas: ‘doing the right thing in unpredictable daily situations’; ‘torn between patience and guilt’; and ‘living in a time of uncertainty, hope and despair’. Conclusion: Caring for a partner with changed behaviour and personality due to primary malignant brain tumour may involve exhausting ethical caring dilemmas. Spouses’ married life may change to a semi-professional asymmetrical relationship, which is challenged by the oscillation between acting responsibly for their partners’ well-being and caring dilemmas with no answer for what the right thing to do is. Mixed feelings of right and wrong, patience and guilt, hope and despair seem to be spousal companions through their partners’ progressing illness. (shrink)

Researchers have argued that bilingual speakers experience less emotion in their second language. However, some studies have failed to find differences in emotionality between first and second lang...

The emergence of Covid‐19 in the United States has revealed a critical weakness in the health care system in the United States. The majority of people in the nation receive health care via employment‐based health insurance from providers in a competitive market. However, neither employment‐based health care nor a competitive health care market can adequately provide treatment during a global pandemic. Employment‐based health care will fail to provide care for a large number of people in any destabilizing economic event, including (...) a pandemic. Competitive for‐profit health care systems distribute limited goods based on markets rather than health care needs. If a global pandemic results in unusually high demand for specific medical supplies, then these will be distributed suboptimally. The combined risk of suboptimal distribution of needed goods and a significant drop in health care access in a global pandemic indicates that the U.S. health care system has serious vulnerabilities that need to be addressed. (shrink)

Positive Prejudice as Interpersonal Ethics examines prejudice not merely as a negative attitude toward others but as a general orientation that enables perception and understanding.

Genome editing with engineered nucleases (GEENs) introduce site‐specific DNA double‐strand breaks (DSBs) and repairs DSBs via nonhomologous end‐joining (NHEJ) pathways that eventually create indels (insertions/deletions) in a genome. Whether the features of indels resulting from gene editing could be customized is asked. A review of the literature reveals how gene editing technologies via NHEJ pathways impact gene editing. The survey consolidates a body of literature that suggests that the type (insertion, deletion, and complex) and the approximate length of indel edits (...) can be somewhat customized with different GEENs and by manipulating the expression of key NHEJ genes. Structural data suggest that binding of GEENs to DNA may interfere with binding of key components of DNA repair complexes, favoring either classical‐ or alternative‐NHEJ. The hypotheses have some limitations, but if validated, will enable scientists to better control indel makeup, holding promise for basic science and clinical applications of gene editing. Also see the video abstract here https://youtu.be/vTkJtUsLi3w. (shrink)

El artículo pretende analizar, a través de la historia, la cuestión de la patologización trans*, que ha contado y cuenta con una oposición bastante amplia por parte de diversos colectivos. El debate político de la cuestión (por medio de la petición de normativas y leyes que regulen determinados aspectos de la identidad) hace que una cuestión individual como es la identidad haya pasado a ser un tema colectivo. Que sea asunto colectivo hace que sea imposible desligar la biología de la (...) medicina, el derecho o la política. Es esta interdisciplinariedad lo que dota hoy en día a la cuestión trans* de tanta relevancia, tampoco exenta de polémica con otros movimientos sociales, como las redes sociales han venido mostrando últimamente. No obstante, es la gran visibilidad que ha obtenido por diferentes medios la cuestión trans* lo que la hace susceptible de múltiples análisis, que, como se ha dicho anteriormente, no se limitan a una única disciplina o a un único punto de vista. (shrink)

La presente investigación centra su interés en el estudio del Teatro de Palacio instaurado por Isabel II en 1849, fundamentalmente a través del análisis de fuentes hemerográficas inéditas; anuncios, ensayos y crónicas difundidas al público general que, complementadas con fuentes docu-mentales tanto del Real Conservatorio Superior de Música de Madrid como del Archivo General de Palacio, nos permitirán profundizar en la infraestructura, intérpretes, representaciones y público de este "teatrino" real hasta su desaparición definitiva en 1851, en que los restos de (...) los sueños de una reina que quiso vivir por encima de sus posibilidades serán trasladados a la institución pedagógica fundada por su madre, el Real Conservatorio de Música y Declamación María Cristina. (shrink)

Cristofano Bertelli’s companion broadsheets, printed in Modena in the 1560s, represent a failed attempt to introduce a new iconographic theme to the Italian print market. Contrary to the vibrant success of transalpine prints representing the Steps of Life with animal analogies, Bertelli’s initiative did not stimulate Italian visual culture to produce the multiple copies, imitations and derivations long enjoyed by this motif in areas north of the Alps. The only other, comparable images to appear in the peninsula in the course (...) of the sixteenth century would seem to be Titian’s allegorical triple portrait, and a pair of large, anonymous woodcuts from the later Cinquecento, possibly made in Venice. The recalcitrance of Counter-Reformation Italy towards this imported topos is difficult to account for, especially when a retail vogue for a similar genre—the multi-vignette moralising broadsheet— was trending in local print markets. There is no direct explanation for the apparent indifference met by Bertelli’s attempt at iconographic innovation. Nonetheless, a cluster of factors relative to print culture and animal lore North and South of the Alps provides indirect but ample evidence to account for the ‘flop’ of Bertelli’s broadsheets. Among these, the Christian visual tradition features prominently, contributing to viewer diffidence towards serial analogies between humans and animals. The market for illustrated books on animals is also considered, as it testifies to a transalpine divide with regard to moralised natural history and, in Italy, an inhospitable cultural climate for the Steps of Life motif. (shrink)

Explores the nature and significance of Petrarch’s indebtedness to Dante in the Rime sparse.

Argues that Socrates’s fundamental role in the dialogues is to guide us toward self-inquiry and self-knowledge. In this highly original and provocative book, Sara Ahbel-Rappe argues that the Platonic dialogues contain an esoteric Socrates who signifies a profound commitment to self-knowledge and whose appearances in the dialogues are meant to foster the practice of self-inquiry. According to Ahbel-Rappe, the elenchus, or inner examination, and the thesis that virtue is knowledge, are tools for a contemplative practice that teaches us how (...) to investigate the mind and its objects directly. In other words, the Socratic persona of the dialogues represents wisdom, which is distinct from and serves as the larger space in which Platonic knowledge—ethics, epistemology, and metaphysics—is constructed. Ahbel-Rappe offers complete readings of the Apology, Charmides, Alcibiades I, Euthyphro, Lysis, Phaedrus, Theaetetus, and Parmenides, as well as parts of the Republic. Her interpretation challenges two common approaches to the figure of Socrates: the thesis that the dialogues represent an “early” Plato who later disavows his reliance on Socratic wisdom, and the thesis that Socratic ethics can best be expressed by the construct of eudaimonism or egoism. (shrink)