Interleukin‐1 receptor‐associated kinase‐1 (IRAK1) is linked to the pathogenesis of atherosclerosis; however, its role in macrophage foam cell formation is not known. Therefore, the present study investigated the role of IRAK1 in lipid uptake, biosynthesis, and efflux in THP‐1 derived macrophages and human monocyte‐derived macrophages (HMDMs). Ox‐LDL (40 μg/mL, 15 minutes–48 hours) treatment induced time‐dependent increase in IRAK1, IRAK4, and Stat1 activation in THP‐1 derived macrophages. IRAK1/4 inhibitor (INH) or IRAK1 siRNA significantly attenuated cholesterol accumulation, DiI‐Ox‐LDL binding, and uptake while (...) cholesterol efflux to apoAI and HDL was enhanced in THP‐1 derived macrophages and HMDMs. Ox‐LDL treatment significantly increased the mRNA expression of CD36, LOX‐1, SR‐A, ABCA1, ABCG1, Caveolin‐1, CYP27A1 while that of SR‐BI was decreased. IRAK1/4 inhibition or IRAK1 knockdown, however, attenuated Ox‐LDL‐induced CD36 expression; augmented ABCA1 and ABCG1 expression while expression of others was unaffected in THP‐1 derived macrophages and HMDMs. Moreover, IRAK1/4 inhibition had no significant effect on genes involved in lipid biosynthesis. In IRAK1/4 INH pre‐treated THP‐1 derived macrophages Ox‐LDL‐induced Stat1 phosphorylation and its binding to CD36 promoter was significantly attenuated while LXRα expression and its binding to the ABCA1/ABCG1 locus, NFATc2 activation and its binding to ABCA1 locus was enhanced. The present study thus demonstrates that IRAK regulates lipid accumulation by modulating CD36‐mediated uptake and ABCA1‐, ABCG1‐dependent cholesterol efflux. Therefore, IRAK1 can be a potential target for preventing macrophage foam cell formation. (shrink)

This study argues that actions taken during a crisis within the responsibility compass impacts reputation. The lens of responsible leadership was chosen from among the different foci of leadership scholarship because of its emphasis on relational and ethical dimensions. The focus of this study was the actions undertaken by the CEOs of United and Delta Airlines after the forceful removal of the passengers and its influence on the reputation capital as measured by the changes in the respective share prices of (...) the airlines. The overarching question was whether there was clear statistical evidence that linked the actions undertaken as part of the crisis management efforts and the reputation of the airlines. Findings from this study suggest that actions taken as part of responsible leadership compass explained the variations in the share prices. In the case of United Airlines almost 70% of the variations in the share prices could be explained by responsible leadership, whereas in the case Delta airlines only 50.6% of the variations in the share value could be predicted based on the role of leadership in crisis management. (shrink)

This article takes direction from the transnational feminist lesbian encounter that took place between the Dutch collective Sister Outsider and Audre Lorde in the 1980s to reflect on the role of archives within transnational feminist research. Drawing on archival materials from the International Archive for the Women’s Movement (IAV) at Atria (Institute on Gender Equality and Women’s History) in Amsterdam in the Netherlands, and the Audre Lorde Papers at Spelman College in Atlanta, Georgia in the United States, I consider how (...) fragmented archives offer stories on kinship, intimacy and loss. Taking into account the ‘absences’ and ‘presences’ (Lewis, 2017) produced in this archival research project, I propose an archival research methodology that is rooted in a practice of ‘orientation’ (Ahmed, 2006a, 2006b), ‘listening’ (Campt, 2017) and ‘intervention’ (Appadurai, 2003). (shrink)

Humans are unique in the animal world in the extent to which their day-to-day behavior is governed by a complex set of rules and principles commonly called norms. Norms delimit the bounds of proper behavior in a host of domains, providing an invisible web of normative structure embracing virtually all aspects of social life. People also find many norms to be deeply meaningful. Norms give rise to powerful subjective feelings that, in the view of many, are an important part of (...) what it is to be a human agent. Despite the vital role of norms in human lives and human behavior, and the central role they play in explanations in the social sciences, there has been very little systematic attention devoted to norms in cognitive science. Much existing research is partial and piecemeal, making it difficult to know how individual findings cohere into a comprehensive picture. Our goal in this essay is to offer an account of the psychological mechanisms and processes underlying norms that integrates what is known and can serve as a framework for future research. (shrink)

Pornographic content is harmful to children's psychological and mental development. In Indonesia, many children are involved in activities and access pornographic content through social media. In some cases, children exposed to pornography will experience a decrease in IQ and mental disorders in terms of sexuality. This type of research is descriptive-qualitative identifying, explaining, and analysing a phenomenon based on variables and primary and secondary data. The purpose of this research is to find out the impact of pornographic content on social (...) media for children's psychology and how the Indonesian government's policy addresses the problem. The results of this study show that the psychological impact of child victims of pornography include: anxiety and stress disorders, sexual perception deviations, identity and body image disorders, decreased social interaction skills, difficulty concentrating on learning and poor self-image. The Indonesian government's policy to protect children from pornography is carried out through penal means using criminal law enforcement instruments, as well as non-penal means, namely cooperation between countries and global child protection organisations, blocking content, and educating understanding of using a healthy internet. (shrink)

Harry Frankfurt’s Unwilling Addict and Willing Addict cases accomplish something fairly unique: they pull apart the predictions of control-based views of moral responsibility and competing self-expression views. The addicts both lack control over their actions but differ in terms of expression of their respective selves. Frankfurt’s own view is that—in line with the predictions of self-expression views—the unwilling addict is not morally responsible for his drug-directed actions while the willing addict is. But is Frankfurt right? In this essay, I put (...) together a systematic defence of Frankfurt’s position. (shrink)

There is an ongoing debate about loss of control in addiction: Some theorists say at least some addicts’ drug-directed desires are irresistible, while others insist that pursuing drugs is a choice. The debate is long-standing and has essentially reached a stalemate. This essay suggests a way forward. I propose an alternative model of loss of control in addiction, one based not on irresistibility, but rather fallibility. According to the model, on every occasion of use, self-control processes exhibit a low, but (...) non-zero, rate of failure due to error. When these processes confront highly recurrent drug-directed desires, the cumulative probability of a self-control lapse steadily grows. The model shows why the following statement—which has an air of paradox—can in fact be true: Each drug-directed desire the addict faces is fully resistible, but the addict nonetheless has significantly diminished control over eventually giving in. (shrink)

According to Dewey, we are responsible for our conduct because it is “ourselves objectified in action”. This idea lies at the heart of an increasingly influential deep self approach to moral responsibility. Existing formulations of deep self views have two major problems: They are often underspecified, and they tend to understand the nature of the deep self in excessively rationalistic terms. Here I propose a new deep self theory of moral responsibility called the Self-Expression account that addresses these issues. The (...) account is composed of two parts. The first part answers the question, What is a deep self? Theorists have tended to favor cognitive views that understand the deep self in terms of rationally formed evaluative judgment. I propose instead a conative view that says one’s deep self consists of a distinctive kind of pro-attitude, cares, and I provide an account of cares in terms of their distinctive psychological functional role. The second part answers the question, When does an action express one’s deep self? I criticize the agentially demanding conditions set out in existing views and propose a more minimalist alternative. I show that the Self-Expression account handles issues that bedeviled traditional deep self views, including how to explain moral responsibility for spontaneous, out of character, and weak-willed actions. (shrink)

Philosophers routinely invoke self‐control in their theorizing, but major questions remain about what exactly self‐control is. I propose a componential account in which an exercise of self‐control is built out of something more fundamental: basic intrapsychic actions called cognitive control actions. Cognitive control regulates simple, brief states called response pulses that operate across diverse psychological systems (think of one's attention being grabbed by a salient object or one's mind being pulled to think about a certain topic). Self‐control ostensibly seems quite (...) different because it regulates complex, temporally extended states such as emotions and cravings. But critically, these complex states also exhibit important componential structure: They rely on response pulses as a key means by which they bring about action. The overall picture is that self‐control consists of skilled sequences of cognitive control directed against extended streams of response pulses that arise from states such as emotions and cravings, thus preventing these states from being effective in action. The account clarifies the “atoms” of self‐control—the elemental units that get combined in complex ways to produce different kinds of self‐control actions. Surprisingly, the account, which is derived from research in cognitive science, aligns nicely with the commonsense conception of self‐control. (shrink)

The debates of the 1980s and 1990s on methodological individualism versus methodological holism have not been adequately resolved. Within analytical Marxism, G.A. Cohen, John Roemer, Jon Elster and others have come down in favour of methodological individualism as part of the effort to make analytical Marxism more 'scientific' and 'rigorous' than earlier versions of Marxism. In doing so they have presented methodological individualism as a necessary ingredient in ridding Marxism of obscurantism. This view is here challenged from a pragmatist philosophical (...) perspective. It is argued that, from such a perspective, the debates between the individualists and holists should have been dissolved rather than resolved in favour of the individualists. It is suggested that such dissolution would even strengthen analytical Marxism by redirecting analytical energies towards real social and political problems in the contemporary world and away from endless methodological debate. (shrink)

It is possible to assert that the present crisis in history on which there has been so much discussion is more specifically a problem affecting the historical sciences in the West rather than in the Afro-Asian countries. In the Afro-Asian countries, particularly those which have either become independent recently or have been able to assert their independence recently, history is considered important in forming a national self-image, help in the processes of national unity, and in the processes of modernization or (...) social change within the nation. The role of history in providing an ideological-cultural framework for national unity and growth is important, for in many of these countries the concept of a nation has not grown out of a long historical process by which people belonging to different race, religion and regions have become emotionally welded together. Rather, nationalism in these countries is a means for bringing about such a unity. The interpretation of the past therefore becomes a matter of wider public concern. In this context, history can hardly be regarded by anyone as irrelevant: it remains a prestigious subject in most universities (not only because it offers a better opportunity for entering into a civil service career), and national historians command a measure of public esteem which is becoming rare elsewhere. On the other hand, history has been displaced from its pre-eminent position in the West. The profession no longer enjoys the prestige which it enjoyed among nineteenth-century intellectuals: many social scientists consider that “the destruction of the conventional historian's conception of history is a necessary stage in the construction of a true science of society”; “a significant number of philosophers seem to have decided that history is either a third-order form of science, related to the social sciences as natural history was once related to the physical sciences, or that it is a second-order form of art, the epistemological value of which is questionable, the aesthetic worth of which is uncertain.”. (shrink)

Recent studies by experimental philosophers demonstrate puzzling asymmetries in people’s judgments about intentional action, leading many philosophers to propose that normative factors are inappropriately influencing intentionality judgments. In this paper, I present and defend the Deep Self Model of judgments about intentional action that provides a quite different explanation for these judgment asymmetries. The Deep Self Model is based on the idea that people make an intuitive distinction between two parts of an agent’s psychology, an Acting Self that contains the (...) desires, means-end beliefs, and intentions that are the immediate causal source of an agent’s actions, and a Deep Self, which contains an agent’s stable and central psychological attitudes, including the agent’s values, principles, life goals, and other more fundamental attitudes. The Deep Self Model proposes that when people are asked to make judgments about whether an agent brought about an outcome intentionally, in addition to standard criteria proposed in traditional models, people also assess an additional ‘Concordance Criterion’: Does the outcome concord with the psychological attitudes of the agent’s Deep Self? I show that the Deep Self Model can explain a very complex pattern of judgment asymmetries documented in the experimental philosophy literature, and does so in a way that has significant advantages over competing models. (shrink)

According to Interest-Relative Invariantism, whether an agent knows that p, or possesses other sorts of epistemic properties or relations, is in part determined by the practical costs of being wrong about p. Recent studies in experimental philosophy have tested the claims of IRI. After critically discussing prior studies, we present the results of our own experiments that provide strong support for IRI. We discuss our results in light of complementary findings by other theorists, and address the challenge posed by a (...) leading intellectualist alternative to our view. (shrink)

Incompatibilists and compatibilists (mostly) agree that there is a strong intuition that a manipulated agent, i.e., an agent who is the victim of methods such as indoctrination or brainwashing, is unfree. They differ however on why exactly this intuition arises. Incompatibilists claim our intuitions in these cases are sensitive to the manipulated agent’s lack of ultimate control over her actions, while many compatibilists argue that our intuitions respond to damage inflicted by manipulation on the agent’s psychological and volitional capacities. Much (...) hangs on this issue because manipulation-based arguments are among the most important for defending incompatibilist views of free will. In this paper, I investigate this issue from a experimental perspective, using a set of statistical methods well suited for identifying the features of hypothetical cases people’s intuitions are responding to. Results strongly support the compatibilist view—subjects’ tendency to judge that a manipulated agent is unfree was found to depend on their judgments that the agent suffers impairments to certain psychological/volitional capacities that compatibilists say are the basis for free will. I discuss the significance of these results for the use of manipulation cases in the philosophical debate about free will. (shrink)

Recently, a number of philosophers have advanced a surprising conclusion: people's judgments about whether an agent brought about an outcome intentionally are pervasively influenced by normative considerations. In this paper, we investigate the ‘Chairman case’, an influential case from this literature and disagree with this conclusion. Using a statistical method called structural path modeling, we show that people's attributions of intentional action to an agent are driven not by normative assessments, but rather by attributions of underlying values and characterological dispositions (...) to the agent. In a second study, we examined people's judgments about what they think drives asymmetric intuitions in the Chairman case and found that people are highly inaccurate in identifying which features of the case their intuitions track. In the final part of the paper, we discuss how the statistical methods used in this study can help philosophers with the critical features problem, the problem of figuring out which among the myriad features present in hypothetical cases are the critical ones that our intuitions are responsive to. We show how the methods used in this study have some advantages over both armchair methods used by traditional philosophers and survey methods used by experimental philosophers. (shrink)

In this paper, we propose a general copula approach to accommodate non-normal continuous mixing distributions in multinomial probit models. In particular, we specify a multivariate mixing distribution that allows different marginal continuous parametric distributions for different coefficients. A new hybrid estimation technique is proposed to estimate the model, which combines the advantageous features of each of the maximum simulated likelihood inference technique and Bhat’s maximum approximate composite marginal likelihood inference approach. The effectiveness of our formulation and inference approach is demonstrated (...) through simulation exercises and an empirical application. (shrink)

Many commonly accepted models for understanding disability use a vertical method in which disability is defined as a category into which people are slotted based on whether or not they fit its definitional criteria. This method, and the models of disability developed in accordance with it, inevitably homogenizes the experiences of disabled people to preserve the integrity of the definition of disability that a given model provides. A hermeneutic investigation and critique of commonly accepted models for understanding disability will provide (...) an epistemological tool that makes it possible both to critique and to augment contemporary models of disability. (shrink)

The side-effect effect, in which an agent who does not speci␣cally intend an outcome is seen as having brought it about intentionally, is thought to show that moral factors inappropriately bias judgments of intentionality, and to challenge standard mental state models of intentionality judgments. This study used matched vignettes to dissociate a number of moral factors and mental states. Results support the view that mental states, and not moral factors, explain the side-effect effect. However, the critical mental states appear not (...) to be desires as proposed in standard models, but rather ‘deeper’ evaluative states including values and core evaluative attitudes. (shrink)

:Reasons-responsiveness theories of moral responsibility are currently among the most popular. Here, I present the fallibility paradox, a novel challenge to these views. The paradox involves an agent who is performing a somewhat demanding psychological task across an extended sequence of trials and who is deeply committed to doing her very best at this task. Her action-issuing psychological processes are outstandingly reliable, so she meets the criterion of being reasons-responsive on every single trial. But she is human after all, so (...) it is inevitable that she will make rare errors. The reasons-responsiveness view, it is claimed, is forced to reach a highly counterintuitive conclusion: she is morally responsible for these rare errors, even though making rare errors is something she is powerless to prevent. I review various replies that a reasons-responsiveness theorist might offer, arguing that none of these replies adequately addresses the challenge. (shrink)

Dasabodhisattuppattikatha Edited and translated into English with an introduction by Dr. H. Saddhatissa. Pali Text Society, London. 166pp. £10.50.

In computational cognitive science, a valuationist picture of human agent architecture has become widespread. At the heart of valuationism is a simple and sweeping claim: Every time an agent acts, they do so on the basis of value representations, which are, roughly, representations of the expected value of one’s response options. In this essay, I do three things. First, I give a systematic, philosophically rich account of the valuationist picture of agency. I also highlight the generality of the model in (...) explaining diverse forms of person-level agency. Second, I discuss connections between the valuationist model and two traditional models in philosophy, the belief/desire model and the decision-theoretic model. Valuationism is related to both, but critical differences remain. Third, I canvas the wide-ranging implications of valuationism for philosophical inquiry. Among other things, valuationism illuminates the elusive boundary between activity and passivity; it flips the standard philosophical understanding of decision around, with decision being a source of, rather than a product of, one’s agency; it reconceptualizes motivation as, in part, a representational phenomenon; it challenges a philosophical dogma that control over action is more extensive than control over belief; and it offers an intriguing “accuracy-based” approach to the normative criticism of agency. (shrink)

The problem of moral compliance is the problem of explaining how moral norms are sustained over extented stretches of time despite the existence of selfish evolutionary incentives that favor their violation. There are, broadly speaking, two kinds of solutions that have been offered to the problem of moral compliance, the reciprocity-based account and the punishment-based account. In this paper, I argue that though the reciprocity-based account has been widely endorsed by evolutionary theorists, the account is in fact deeply implausible. I (...) provide three arguments that suggest that moral norms are sustained by punishment, not reciprocity. But in addition to solving the problem of moral compliance, the punishment-based account provides an additional important theoretical dividend. It points the way for how theorists might build an evolutionary account of a feature of human groups that has long fascinated and troubled social scientists and moral philosophers – the existence of moral diversity. (shrink)

This book analyses the theoretical and philosophical frames of new property, and assesses how its altered metaphysics inscribes itself in the politics of genetic resources. It probes how rights get framed within and by law and attempts to uncover the cunning or duplicitous nature of these rightsthe chasm between their intended benefits and their actual outcomes.

The world of the Hindi heroes of the 1970s, while decked in battle gear, largely belonged to the official state apparatus, either as members of vigilante self-defence squads – of which Bahadur was a pioneer – or bonafide members of the police force, like Inspector Vikram. The costumed superhero only emerged at the end of the Nehruvian period, gradually coming to defy its signature science and rationality. My article seeks to explore questions of the political economy of the superhero genre (...) and the affective valences of the supernatural in imaging/negotiating the national and transnational, through this conjunctural moment of the late 1970s and early 1980s. (shrink)

In this article, I survey four key questions about willpower: How is willpower possible? Why does willpower fail? How does willpower relate to other self-regulatory processes? and What are the connections between willpower and weakness of will? Empirical research into willpower is growing rapidly and yielding some fascinating new findings. This survey emphasizes areas in which empirical progress in understanding willpower helps to advance traditional philosophical debates.