Regulation of microtubule (MT) dynamics is essential for many cellular processes, but the machinery that controls MT dynamics remains poorly understood. MT plus‐end tracking proteins (+TIPs) are a set of MT‐associated proteins that dynamically track growing MT ends and are uniquely positioned to govern MT dynamics. +TIPs associate with each other in a complex array of inter‐ and intra‐molecular interactions known as the “+TIP network.” Why do so many +TIPs bind to other +TIPs? Typical answers include the ideas that these (...) interactions localize proteins where they are needed, deliver proteins to the cortex, and/or create regulatory pathways. We propose an additional and more mechanistic hypothesis: that +TIPs bind each other to create a superstructure that promotes MT assembly by constraining the structural fluctuations of the MT tip, thus acting as a polymerization chaperone. (shrink)

Blindsight is the term commonly used to describe visually guided behaviour elicited by a stimulus falling within the scotoma (blind area) caused by a lesion of the striate cortex. Such is normally held to be unconscious and to be mediated by subcortical pathways involving the superior colliculus. Blindsight is of considerable theoretical importance since it suggests that destriate man is more like destriate monkey than had been previously believed and also because it supports the classical notion of two visual systems. (...) It is also of potential clinical importance, since it has been claimed recently that systematic practice in blindsight can lead to the recovery of normal visual function in patients with cortical lesions. From a review of the literature it is concluded that all of the phenomena of blindsight can be attributed either to light scatter into unimpaired parts of the visual field or to residual vision resulting from spared striate cortex. The possible contribution f other factors is also considered. It is concluded that blindsight studies have generally failed to control for such nonblindsight interpretations partly because of poor methodology and partly because of difficulties in defining the term. (shrink)

This book offers the first comprehensive introduction to wave scattering in nonstationary materials. G. F. Roach's aim is to provide an accessible, self-contained resource for newcomers to this important field of research that has applications across a broad range of areas, including radar, sonar, diagnostics in engineering and manufacturing, geophysical prospecting, and ultrasonic medicine such as sonograms. New methods in recent years have been developed to assess the structure and properties of materials and surfaces. When light, sound, or (...) some other wave energy is directed at the material in question, "imperfections" in the resulting echo can reveal a tremendous amount of valuable diagnostic information. The mathematics behind such analysis is sophisticated and complex. However, while problems involving stationary materials are quite well understood, there is still much to learn about those in which the material is moving or changes over time. These so-called non-autonomous problems are the subject of this fascinating book. Roach develops practical strategies, techniques, and solutions for mathematicians and applied scientists working in or seeking entry into the field of modern scattering theory and its applications. Wave Scattering by Time-Dependent Perturbations is destined to become a classic in this rapidly evolving area of inquiry. (shrink)

Like bundles of homogeneous light or particles that are scattered in physics experiments, says Goris, the homogeneous field of metaphysics was dispersed in the 14th century. He connects that dispersion to the contemporary rejection of metaphysics. His topics are the analysis of concepts, the contested primacy, scattering the homogeneous field of me.

In this work a calculation of the cluster decomposable formalism for relativistic scattering as developed by Lindesay, Markevich, Noyes, and Pastrana (LMNP) is made for an ultra-light quantum model. After highlighting areas of the theory vital for calculation, a description is made of the process to go from the general theory to an eigen-integral equation for bound state problems, and calculability is demonstrated. An ultra-light quantum exchange model is then developed to examine calculability.

In the early twentieth century, viruses had yet to be defined in a material way. Instead, they were known better by what they were not – not bacteria, not culturable, and not visible with a light microscope. As with the ill-defined “gene” of genetics, viruses were microbes whose nature had not been revealed. Some clarity arrived in 1929 when Francis O. Holmes, a scientist at the Boyce Thompson Institute for Plant Research reported that Tobacco mosaic virus could produce local (...) necrotic lesions on tobacco plants and that these lesions were in proportion to dilutions of the inoculum. Holmes’ method, the local lesion assay, provided the first evidence that viruses were discrete infectious particles, thus setting the stage for physicochemical studies of plant viruses. In a field where there are few eponymous methods or diseases, Holmes’ assay continues to be a useful tool for the study of plant viruses. TMV was a success because the local lesion assay “made the virus visible” and standardized the work of virology towards determining the nature of the virus. (shrink)

Multigene delivery and expression systems are emerging as key technologies for many applications in contemporary biology. We have developed new methods for multigene delivery and expression in eukaryotic hosts for a variety of applications, including production of protein complexes for structural biology and drug development, provision of multicomponent protein biologics, and cell‐based assays. We implemented tandem recombineering to facilitate rapid generation of multicomponent gene expression constructs for efficient transformation of mammalian cells, resulting in homogenous cell populations. Analysis of multiple parameters (...) in living cells may require co‐expression of fluorescently tagged sensors simultaneously in a single cell, at defined and ideally controlled ratios. Our method enables such applications by overcoming currently limiting challenges.Here, we review recent multigene delivery and expression strategies and their exploitation in mammalian cells. We discuss applications in drug discovery assays, interaction studies, and biologics production, which may benefit in the future from our novel approach. (shrink)

Principles of Laser Spectroscopy and Quantum Optics is an essential textbook for graduate students studying the interaction of optical fields with atoms. It also serves as an ideal reference text for researchers working in the fields of laser spectroscopy and quantum optics. The book provides a rigorous introduction to the prototypical problems of radiation fields interacting with two- and three-level atomic systems. It examines the interaction of radiation with both atomic vapors and condensed matter systems, the density matrix and the (...) Bloch vector, and applications involving linear absorption and saturation spectroscopy. Other topics include hole burning, dark states, slow light, and coherent transient spectroscopy, as well as atom optics and atom interferometry. In the second half of the text, the authors consider applications in which the radiation field is quantized. Topics include spontaneous decay, optical pumping, sub-Doppler laser cooling, the Heisenberg equations of motion for atomic and field operators, and light scattering by atoms in both weak and strong external fields. The concluding chapter offers methods for creating entangled and spin-squeezed states of matter. Instructors can create a one-semester course based on this book by combining the introductory chapters with a selection of the more advanced material. A solutions manual is available to teachers. Rigorous introduction to the interaction of optical fields with atoms Applications include linear and nonlinear spectroscopy, dark states, and slow light Extensive chapter on atom optics and atom interferometry Conclusion explores entangled and spin-squeezed states of matter Solutions manual. (shrink)

E. Schrödinger's ideas on interpreting quantum mechanics have been recently re-examined by historians and revived by philosophers of quantum mechanics. Such recent re-evaluations have focused on Schrödinger's retention of space–time continuity and his relinquishment of the corpuscularian understanding of microphysical systems. Several of these historical re-examinations claim that Schrödinger refrained from pursuing his 1926 wave-mechanical interpretation of quantum mechanics under pressure from the Copenhagen and Göttingen physicists, who misinterpreted his ideas in their dogmatic pursuit of the complementarity doctrine and the (...) principle of uncertainty. My analysis points to very different reasons for Schrödinger's decision and, accordingly, to a rather different understanding of the dialogue between Schrödinger and N. Bohr, who refuted Schrödinger's arguments. Bohr's critique of Schrödinger's arguments predominantly focused on the results of experiments on the scattering of electrons performed by Bothe and Geiger, and by Compton and Simon. Although he shared Schrödinger's rejection of full-blown classical entities, Bohr argued that these results demonstrated the corpuscular nature of atomic interactions. I argue that it was Schrödinger's agreement with Bohr's critique, not the dogmatic pressure, which led him to give up pursuing his interpretation for 7 yr. Bohr's critique reflected his deep understanding of Schrödinger's ideas and motivated, at least in part, his own pursuit of his complementarity principle. However, in 1935 Schrödinger revived and reformulated the wave-mechanical interpretation. The revival reflected N. F. Mott's novel wave-mechanical treatment of particle-like properties. R. Shankland's experiment, which demonstrated an apparent conflict with the results of Bothe–Geiger and Compton–Simon, may have been additional motivation for the revival. Subsequent measurements have proven the original experimental results accurate, and I argue that Schrödinger may have perceived even the reformulated wave-mechanical approach as too tenuous in light of Bohr's critique. (shrink)

The war in the DRC has resulted in one of the world’s worst humanitarian crisis with over 3.4 million displaced persons scattered throughout the country. An estimated 4 million people have died as a result of the war. The most pressing need to be addressed is the question of justice and accountability for these human rights atrocities in order to achieve a durable peace in the country and also in the Great Lakes region. It is particularly true in post-conflict situations (...) where justice systems have been either partially or completely destroyed, that national courts are not capable of arriving at a uniform stance, or willing to provide justice for atrocities in the immediate future. As a result, international justice seems to be a crucial and last resort that must continue to be fortified against efforts to undermine it. However, even if the ICC achieves its full potential, it faces a number of challenges. Firstly, it is realistically not able to address all situations in which national courts are unwilling or unable to prosecute perpetrators. Secondly, there are temporal and other jurisdictional limitations on what cases the ICC can hear. Accordingly, the ICC will only have the power to try people accused of the gravest human rights violations committed after 1 July 2002; the date the Rome Statute which established the ICC took effect. As a result, only a small number of individuals responsible for the atrocities committed will be tried by this Court. Thirdly, is the establishment, of the Truth and Reconciliation Commission (TRC), one of the civilian institutions that emerged from the peace talks, meant to end impunity or to cover up gross violations of human rights committed in the DRC? It remains to be seen how it will function and interact with the courts. (shrink)

Drawing on remarks scattered through his writings, I argue that Leibniz has a highly distinctive and interesting theory of color. The central feature of the theory is the way in which it combines a nuanced subjectivism about color with a reductive approach of a sort usually associated with objectivist theories of color. After reconstructing Leibniz's theory and calling attention to some of its most notable attractions, I turn to the apparent incompatibility of its subjective and reductive components. I argue that (...) this apparent tension vanishes in light of his rejection of a widely accepted doctrine concerning the nature of bodies and their geometrical qualities. (shrink)

The use of placebo in clinical trials has been repeatedly challenged as being unacceptable from an ethical point of view. The present paper responds to this criticism by taking up the issue in the light of the pertinent provisions of the Helsinki Declaration. Examples from different therapeutic areas are given that highlight the importance of placebo in situations in which its use is acceptable according to the Declaration. Particular emphasis is given to the question of active control trials, which, (...) under conditions of low assay sensitivity, may become an ethically less acceptable approach than the use of a placebo control. (shrink)

Sartre’s scattered commentaries and remarks on theater, published in a variety of media outlets, as well as in the most unlikely of essays, were finally assembled late in Sartre’s career and published in one volume, Un Théâtre de situations, put together by Michel Contat and Michel Rybalka in 1973. Inevitably, a number of later or missing theatrical documents then came to light, and an updated edition of Un Théâtre de situations appeared in 1992. There still remained, however, other documents (...) on theater which for one reason or another were not included in the later volume. Two of these documents are published interviews that Sartre gave to the Russian theater journal, Teatr, in 1956 and 1962. It is those virtually unknown interviews by Sartre on theater that we are pleased to publish here for the first time in English translation. (shrink)

Quantum mechanics seems to portray nature as nonseparable, in the sense that it allows spatiotemporally separated entities to have states that cannot be fully specified without reference to each other. This is often said to implicate some form of “holism.” We aim to clarify what this means, and why this seems plausible. Our core idea is that the best explanation for nonseparability is a “common ground” explanation, which casts nonseparable entities in a holistic light, as scattered reflections of a (...) more unified underlying reality. (shrink)

ArgumentIn the theory-dominated view of scientific experimentation, all relations of theory and experiment are taken on a par; namely, that experiments are performed solely to ascertain the conclusions of scientific theories. As a result, different aspects of experimentation and of the relations of theory to experiment remain undifferentiated. This in turn fosters a notion of theory-ladenness of experimentation (TLE) that is toocoarse-grainedto accurately describe the relations of theory and experiment in scientific practice. By contrast, in this article, I suggest that (...) TLE should be understood as anumbrella conceptthat has different senses. To this end, I introduce a three-fold distinction among the theories of high-energy particle physics (HEP) as background theories, model theories, and phenomenological models. Drawing on this categorization, I contrast two types of experimentation, namely, “theory-driven” and “exploratory” experiments, and I distinguish between the “weak” and “strong” senses of TLE in the context of scattering experiments from the history of HEP. This distinction enables identifying the exploratory character of the deep-inelastic electron-proton scattering experiments – performed at the Stanford Linear Accelerator Center (SLAC) between the years 1967 and 1973 – thereby shedding light on a crucial phase of the history of HEP, namely, the discovery of “scaling,” which was the decisive step towards the construction of quantum chromo-dynamics as a gauge theory of strong interactions. (shrink)

Experiments with evanescent modes and tunneling particles have shown that (i) their signal velocity may be faster than light, (ii) they are described by virtual particles, (iii) they are nonlocal and act at a distance, (iv) experimental tunneling data of phonons, photons, and electrons display a universal scattering time at the tunneling barrier front, and (v) the properties of evanescent, i.e. tunneling modes are not compatible with the special theory of relativity.

We spend a good deal of time thinking about how and when to advise others, and how to respond to other people advising us. However, philosophical discussions of the nature and norms advising have been scattered and somewhat disconnected. The most focused discussion has come from philosophers of language interested in whether advising is a kind of assertive or directive kind of speech act. This paper argues that the ordinary category of advising is much more heterogenous than has been appreciated: (...) it is possible to advise by asserting relevant facts, by issuing directives, and by asking questions and other kinds of adviceless advising. The heterogeneity of advising makes speech act-theoretic accounts of advising look like accounts of special cases, and motivates us to look elsewhere for an account of what advising is. I suggest that we think about advising as a distinctive species of joint practical thinking—which I will call collaborative deliberation—and show how our need for a concept to pick out this kind of joint activity emerges from our practical needs as deliberators. This view helps to shed light on a number of puzzling features of advising and offers some guidance to be better at advising and at being advised. (shrink)

The notions of perceptual normativity and optimality have generated much discussion in the last decade or so in the literature on Merleau-Ponty. Husserl’s position on the topic has been far less extensively investigated. Surprisingly, however, Husserl wrote a great deal about the question of perceptual optimality. Not only are there a considerable number of important passages scattered throughout the manuscripts, the archive also contains a few important full texts on precisely this issue. Given the role of fulfillment for Husserl’s concept (...) of intentionality, this should not really come as a surprise, since the teleological nature of the fulfillment structure terminates in an experience of the optimum. Hence, however marginal this topic might seem at first glance, reflecting on it rapidly leads us to the heart of Husserl’s project and sheds further light on his conception of intentional experience. (shrink)

In these skeptical and disillusioned times, there are still groups of people scattered throughout the world who are trying to live out utopian dreams. These communities challenge the inevitability and morality of dominant political and economic models. By putting utopian religious ethics into practice, they attest to the real possibility of social alternatives. In Seeds of the Kingdom, Anna L. Peterson reflects on the experiences of two very different communities, one inhabited by impoverished former refugees in the mountains of El (...) Salvador and the other by Amish farmers in the Midwestern U.S. What makes these groups stand out among advocates of environmental protection, political justice, and sustainable development is their religious orientation. They aim, without apology, to embody the reign of God on earth. The Salvadoran community is grounded in Roman Catholic social thought, while the Amish adhere to Anabaptist tradition. Peterson offers a detailed portrait of these communities' history, social organization, religious life, environmental values, and agricultural practices. She discovers both practical and ideological commonalities in these two comparatively successful and sustainable communities, including a strong collective identity, deep attachment to local landscapes, a desire to preserve non-human as well as human lives, and, perhaps unexpectedly, a utopian horizon that provides both goals and the hope of reaching them. By examining the process by which people struggle to live according to a transcendent value system, she sheds light on both the actual and the potential place of religion in public life. Peterson argues that the Amish and Salvadoran communities, geographically and culturally removed from the industrialized West, have relevance for the political and environmental problems of the developed world. These communities have succeeded in the face of significant internal and external challenges, offering important practical and theoretical lessons on how to achieve ecological sustainability and social justice in the wider world. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reconsidering Buster Keaton’s HeroinesBarbara E. SavedoffIt has become commonplace to acknowledge that art tends to reflect the prejudices and presuppositions of the age in which it is produced. Such acknowledgement can serve not only to place the prejudicial attitudes expressed by artists and authors in their proper context, it can also reassure us that we have avoided the same prejudices, or at least, that we have achieved a greater (...) awareness of and sensitivity to them. But we should not be too easily reassured by these thoughts of our own enlightened progress, for the prejudices that we think we discover in works of art may sometimes be of our own making.Prejudice is, at least in part, a problem of distorted perception. Freeing oneself of prejudice is thus not simply a matter of disposing of false beliefs; it requires new habits of perception—becoming able to see what one could not see before. Since habits of perception can be deeply ingrained, we may find it difficult to recognize their persistence. Therefore even as we attempt to repudiate prejudicial attitudes, we may find ourselves misled by their continuing distortion of our vision. This can lead not only to continuing bias on our part, it can also lead to unwarranted charges of bias against others. For instance, the distorted vision that can pervade our evaluation of people in real life can also pervade our evaluation of characters in films or novels. When this happens, we may unfairly charge the film or novel with the perpetuation of negative stereotypes. There are also other ways in which we may be misled by our own biases. For example, if we expect to find negative stereotypes in the products of a given age, this may lead us to see the stereotypes that we anticipate—whether they are really there or not. The work of art can thus become a mirror of our own prejudices and preconceptions. [End Page 77]This is, I believe, what has occurred with much of the criticism of the portrayal of women in Buster Keaton’s films. Critical essays, commentaries, and even film-schedule blurbs tend either to downplay the strengths of the heroines in his films or brand them unfairly as stupid and incompetent. This unjust characterization of the heroines has become an unquestioned myth planted early in the minds of Keaton’s audiences. For example, some prints of The General contain an “educational” introduction which, among other things, describes Annabelle as yet another one of Keaton’s scatter-brained heroines. 1 The audience is thus primed to see Keaton’s heroines in this light.In my discussion I will expose the gap between the myths surrounding Keaton’s heroines and the actual characterization of those heroines in the films. I will then explore possible explanations for the durability of the myths by looking at whether there is something about Keaton’s films that provokes these prejudicial readings.IKeaton’s short film, The Balloonatic, begins in an amusement park with the hero vainly pursuing one woman after another until he is finally given a black eye by a young woman he has annoyed with his attentions. Discouraged, he wanders over to watch the launching of a hot air balloon, where he is given a pennant to attach to its top. His task completed, he finds himself atop the runaway balloon. When his rash attempt to shoot a bird perched on the balloon brings him rapidly back down to earth, he discovers himself stranded in the wilderness.The hero quickly sets out to adapt to his wilderness environment, but he is thwarted in his efforts by his inexperience and incompetence in the role of outdoorsman. He tries to fish, but when he casts his line, he catches the hook on his pants. He then dams up a stream so that he can pick up the stranded fish, but unbeknownst to him, they fall through a hole in his creel as soon as he puts them in. When he finally does realize what is happening, his dam breaks and he is carried helplessly down stream by the rush of water. Later in the film, we see the hero trying to... (shrink)

The Sense of I: Conceptualizing Subjectivity: In Indian Philosophy (Sāṃkhya-Yoga) This book discusses the sense of I as it is captured in the Sāṃkhya-Yoga tradition – one of the oldest currents of Indian philosophy, dating back to as early as the 7th c. BCE. The author offers her reinterpretation of the Yogasūtra and Sāṃkhyakārikā complemented with several commentaries, including the writings of Hariharānanda Ᾱraṇya – a charismatic scholar-monk believed to have re-established the Sāṃkhya-Yoga lineage in the early 20th century. The (...) textual analysis of the classical Sanskrit sources and their constructive interpretation is enhanced by some crucial questions and points of dispute commonly picked up in the contemporary philosophy of mind, such as the challenge of ontological and categorical reductionism, the criteria of personal identity, the limits of agency and free will, the ineluctability of self-deception, etc. However, defining the sense of ego (ahaṃkāra) and ‘I-am-ness’ (asmitā) is the main focus of this research. Four chapters composing the study are subsequently devoted to: (1) the methodological assumptions of the present author and the basic historical distinctions relevant to the subject matter, (2) linguistic preconditioning of I-consciousness as well as metaphysical coherency and ambiguity of the concept of subjectivity presented by Sāṃkhya-Yoga philosophers, (3) cognitive and ontological issues concerning the embodied ego being opposed to inactive and contentless consciousness, or the pure self (puruṣa), (4) axiological evaluation of self-discipline and significance of liberation from ego. 1. The method, scope, and problem. In the first chapter, the method of comparative philosophy adopted in this book is introduced by a phenomenological analysis of ‘otherness’ and ‘alienness’ inspired by the considerations of Bernhard Waldenfels and his understanding of xenology. This section is followed by a critical reflection on the incommensurability of the alternative conceptual frameworks, supported by some arguments provided by Ludwik Fleck and Richard E. Nisbett. When explaining the term ‘comparative philosophy’, the author pays special attention to those proponents of the aforementioned current who contributed to the rapprochement of Western and Indian philosophical traditions by tracing both their similarities and divergences. The author makes references to numerous prominent researchers, such as Paul Masson-Oursel, Paul Deussen, Stanisław Schayer, Sarvepalli Radhakrishnan, Bimal K. Matilal, Raimundo Panikkar, Daya Krishna, Wilhelm Halbfass, and many others representing a younger generation. The historical introduction presents a concise survey of the evolution of the Sāṃkhya-Yoga textual tradition, and distinguishes five phases of its development: proto-Sāṃkhya (7th c. BCA – 1st c. CE), pre-classical phase (1st – 5th c. CE), classical Sāṃkhya (3rd – 9th c. CE), post-classical phase (till 14th c.), and neo-classical phase (since 1927). Here, the author also evaluates the primary sources, including Sanskrit commentaries, and the secondary sources in the light of their relevance and usefulness to the constructive interpretation of Yogasūtra and Sāṃkhyakārikā. Then, she makes some methodological remarks concerning the specificity of their reading. This section is concluded with highlighting three main strategies usually applied when interpreting Patañjali’s sūtras: (1) anti-philosophical approach – treating the text as a merely mystical report or the yogic vademecum, (2) anti-mystical perspective – which reads the text as a highly speculative divagation of no much use to a practitioner, (3) mystic-and- philosophical approach – emphasizing the fact that the theory of consciousness presented in Yogasūtra is both philosophically coherent and empirically (or mystically) verified. The author argues for the third, heuristic, perspective mentioned above. The last section of the first chapter aims to problematize the I-concept (aham) and the paradoxical situation of the ego searching for self-knowledge. This part starts with the acknowledgement of the deliberation on non-self (anātman) by Śāntideva, a Buddhist philosopher claiming that one’s own ego ought to be identified with the ego of any other. Then, the author unfolds the fundamental assumptions and scope of the constructive interpretation she wants to develop following K.C. Bhattacharyya’s clues. When explaining her reasons, she stresses both the need to reveal the philosophical meaning of the source materials and, at the same time, the need to make them meaningful on the ground of our contemporary philosophical enquiry. Thus, among the main purposes there is a reliable, scrupulous and careful reconstruction of the historical conception of the self as elaborated on in the classical period of Sāṃkhya-Yoga tradition, as well as reinterpretation of the sense of I as it was grasped by the Sāṃkhya-Yoga thinkers in terms of modern comparative and ‘polylogical’ discourse. 2. Naming I. In the second chapter, a variety of linguistic categories capturing different aspects of subjectivity is discussed in detail. A textual examination is preceded by clarification of the semantic distinctions made by Patañjali, such as a verbal convention (saṃketa) which stands for uniting or overlapping a word (śabda), its meaning (artha) and a mental state of comprehension (pratyaya) that ascribes the word to a particular object. Among the key concepts there is also explained a spontaneous mental activity referring to pseudo-objects posited only by words (vikalpa), which is unwittingly involved in every process of conceptualizing, designating, and naming objects. Such mental states can neither be ‘valid’ nor ‘invalid’, and are believed to unavoidably accompany one’s use of language. These presuppositions testify to Patañjali’s severe criticism towards all verbal conventions that not only affect the way we formulate and construct our views, but also determine the very process of perception. A major section of the chapter contains the analysis of the ambiguous sense of subjectivity and its basic aspects distinguished by the author in the result of a contextual and comparative study of the Sanskrit terms used in Yogasūtra and Sāṃkhyakārikā for naming I-consciousness. The six basic aspects of the self comprise: essentializing oneself, perceiving (something), getting conscious (of something), mastering or owning (something), and being capable of self-identifying as well as disidentifying oneself. A majority of the enumerated predicates ascribed to the self refer to different functions and activities of the empirical ego and the embodied mind. Yet, apart from this intentional, active, reactive, sensing, and objectifiable self Sāṃkhya-Yoga philosophers distinguish a sense of subjectivity going beyond all these psycho-physical characteristics: the self that remains unmanifest, non-active, free from experiencing any joy or pain, said to be the principle of consciousness. The plausibility of its existence as the final cause of the world is to be determined by the embodied ego by virtue of abductive reasoning based on the analysis of all material and psycho-physical phenomena preconditioned by three guṇas that compose the domain of nature (prakṛti). In the subsequent section, three Sanskrit notions – ahaṃkāra, asmitā, and puruṣa, most significant for the Sāṃkhya and Yoga understanding of subjectivity, are discussed closely one after another to expose their semantic, epistemic and metaphysical connotations. The chapter is completed by some pivotal remarks bringing out the problem of discrepancy between the metaphysical position implied by Patañjali and Īśvarakṛṣṇa, and the grammatical instruments applied by them to express it. 3. Cognizing I. The third chapter addresses two important issues in the phenomenology of self-perception, namely the question of psycho-physical dualism explained on the grounds of the considered darśanas, and the spiritual quest for the ideal embodiment of consciousness. While emphasizing the unity of human psycho-physical nature the author refers to several contemporary Western thinkers, such as Maurice Merleau-Ponty, Thomas Nagel, John R. Searle, David Chalmers and others, by making some comparative remarks on the idea of the embodied mind. Furthermore, three arguments for the plurality of selves (puruṣa-bahutva) are reconstructed and critically considered. The arguments given by Īśvarakṛṣṇa (SK 18) include the diversity of ways in which one experiences one’s life and death, the spatio-temporal distinctness of particular embodied egos, and the variations of features manifested by individual selves. The second section of this chapter presents a thorough inquiry into a non-theistic devotion and spiritual pragmatism defended by the adherents of Sāṃkhya- Yoga. God (īśvara) is defined here primarily as an object of meditative practice and a special tool convenient for yogic pedagogy. In the concluding part of this section four functions of devotional practice (īśvara-pranidhāna) are recognized and explained; they embrace: (1) prevention from mental scattering and dispersion, (2) therapy allowing to form some positive perceptual habits and the right cognitive approach, (3) enhancement of morally and spiritually required qualities, and (4) reinforcement of the sense of subjective identity being a complementary method of self-development. 4. Liberating oneself from I. The final chapter consists of three sections. The first one introduces the concept of liberation through action (pravṛtti-dharma), commonly opposed in Indian tradition to the path of renunciation (nivṛtti- dharma). According to Hariharānanda Ᾱraṇya’s interpretation, both Sāṃkhya- Yoga and Buddhism follow the latter one, which in terms of spiritual practice dynamics makes them much closer to each other than it is usually believed. In the subsequent section the idea of liberating oneself from one’s attachment to ego is explained in detail, along with the significance of gradual self-negation. Then the author raises the interpretation of the Sāṃkhya-Yoga perspective on liberation as self-distinction-through-renunciation. The main focus in this section is placed on the sense of agency (kartṛ), the problem of free will, and the criteria of moral and soteriological evaluation of one’s deeds. Some crucial questions on karmic conditioning of self-knowledge in the form of kleśas are also the subject of careful analysis. The next section undertakes the issue of ownership (mamakāra) of one’s activity and self-esteem (abhimāna) involved in spiritual growth. Again, some comparative remarks are made by referring to the Buddhist philosophers’ positions, such as Nāgārjuna, Āryadeva and Candrakīrti. Among others, the Buddhist refutation of the Sāṃkhya-Yoga concept of eternal, inactive, indifferent, irresponsible, and exclusively conscious self (puruṣa) is quoted and partly rejected in favour of the classical Hindu darśanas. In summary, the author emphasized the significance-generating or sense-creating function of I, its engagement in the search for its own raison d’être, its role in self-identification as well as subverting it, and the expediency of liberation from ego. The philosophers of classical Sāṃkhya and Yoga indicate a twofold sense of the self; on the one hand, the only appropriate designation: ‘I’ is true self (puruṣa), a passive and unknowable principle of consciousness whose existence makes the empirical phenomena meaningful. On the other hand, the ‘I’ clearly designates the current sense of the self, expressed as “I think”, “I doubt”, “I suffer”, etc. This second meaning of ‘I’, the specific sense of ‘mineness’, is recognized as a secondary and relative one – thus illusive and troublesome. However, its delusiveness does not mean that the empirical ego is an unreal or non-existent entity. What it implies is that the empirical self-identity is fundamentally inadequate and – according to the Indian thinkers – ought to be unveiled and, ultimately, given up. (shrink)

Historians are now generally agreed that the Darwinian recognition and institutionalization of the polygenist position was more than merely nominal.194 Wallace, Vogt, and Huxley had led the way, and we may add Galton (1869) to the list of those leading Darwinians who incorporated a good deal of polygenist thinking into their interpretions of human history and racial differences.195 Eventually “Mr. Darwin himself,” as Hunt had suggested he might, consolidated the Darwinian endorsement of many features of polygenism. Darwin's Descent of Man (...) was published in the same year that the Anthropological Institute was founded, and it was no coincidence that it was broadly congruent with Knoxian/ Anthropological race science. Recent scholarship has stressed the derivative character of the Descent, and Darwin's views on race were clearly influenced by the earlier interpretations of the abovecited Darwinians.196However, although the Descent was written in the light of the anthropological struggles of the 1860s, it is essential to acknowledge its origins in Darwin's notebooks of the late 1830s and early 1840s. A good deal of the congruence between Darwinian and Knoxian conceptions of race may be traced back to these early notebook constructions. As these document, Darwin, like Knox, brought to his very earliest conceptions of human evolution a “commitment to the idea of human races as discrete biological units with distinct moral and mental traits.”197 The young Darwin had been concerned with the same sorts of questions on racial biological and cultural differences that preoccupied Knox around the same time, and he was committed to as ruthless a naturalism. Apart from their individual and independent debts to Quetelet's “moral statistics,” both Darwin and Knox drew heavily on the general themes of struggle and adaptation in the contemporary “common context” of biological and social thought.198 Given their common context, the broad general similarities between the Knoxian laws of race antagonism and subordination and the Darwinian struggle for existence between races need occasion no strained historical explanation of direct influence.199Nevertheless, in more explicit ways, the Descent does show the conflation of Knoxian/Anthropological and Darwinian racial views, and Darwin located his discussion of these issues squarely within the dispute “of late years” between polygenists and monogenists.200 His mature views on race were shaped by the contemporaneous confrontations and negotiations between the Darwinians and the Anthropologicals. It is within this context that the minor historical puzzle of Darwin's failure to acknowledge Knox's “generic descent” may be explained. Apart from the difficulties of integration and interpretation of his scattered theoretical writings, Knox, through his adoption by Hunt and the Anthropologicals, became identified with anti-Darwinism and therefore with antievolutionism.201 Moreover, Knox, the disreputable and marginal “savage radical” and lately resurrected and equally unsavory “Anthropological,” was hardly an acceptable “precursor.” Yet, paradoxically, it was via the antithetical medium of the Anthropological platform that Knox's race science made an indirect and unacknowledged, but lasting, impact on the Darwinian anthropological model.In the Descent, Darwin argued that racial traits arose very early in the prehistory of man, were not biologically adaptive, and were therefore relatively fixed in character. By viewing race formation as a distant and closed episode of human history, Darwin endorsed the Knoxian categories of race as fixed and unalterable types. Although he thought it irrelevant whether human races were called species or subspecies, he conceded more to the Knoxian view than Huxley by granting that a naturalist confronted for the first time by specimens of Negro and European man “might feel himself fully justified in ranking the races of man as distinct species.”202 Consistent with the Knoxian interpretation, struggle, competition, and survival occurred between racial units rather than between individuals and, in Darwin's view, accounted for the superiority of the Anglo-Saxon and the inevitable triumph of the more intellectual and moral races over the lower and more degraded ones.Darwin was as insistent as Knox on the biological basis of intellectual and moral differences, and, through his tendency to reduce social and cultural differences to biology, he maintained the essential Knoxian/Anthropological link between race and culture.203 For above all, the Descent did much more than offer a naturalistic explanation of human evolution: it proffered social interpretation, justification, and prescription, and its timely appearance gave a powerful boost to the “moralizing naturalism” of Huxley and Galton, and to Spencer's “Social Darwinism.”204 We may draw a straight line from Knox's “moral anatomy,” through Hunt's “anthropology,” and on to “Social Darwinism” and the “social surgeons” of the eugenics movement.The Darwinians did not, of course, we their tendency to naturalize existing economic and social relations to Knox or Hunt and the Anthropologicals—they were simply reflecting the same general intellectual trend that had affected Knox and the Anthropologicals as well. And in the larger context, the forces that had created a climate receptive to Knox's racism had intensified: in the seventies, the need to justify white imperialism and class and racial inequalities was greater than ever. Scientific racism no longer appeared an aberration but the very essence of the scientific study of man, taking on a newfound respectability in the “new” evolutionary anthropology. But in more specific ways, through the struggle between the Darwinians and Anthropologicals for scientific and ideological hegemony, Knox's “moral anatomy” was institutionalized and perpetuated in late Victorian scientific racism. In the process, the delicate balance that Knox had maintained between his radicalism and his racism was outweighed by conservative institutional and social needs, and his “moral anatomy” was retooled — first by Hunt, and then by the Darwinians — to fit those needs. (shrink)

While all of the great philosophers are difficult to read, Heidegger and Wittgenstein seem to be so in striking ways. Their writings are oddly reluctant to yield up to us what we might think of as ‘their philosophical claims’; and both seem to manifest an attitude towards argument unlike that of most contemporary philosophers. This paper will re-consider these features of Heidegger’s and Wittgenstein’s work in the light of some common themes in their understanding of philosophical confusion. Given that (...) understanding, writings that would combat such confusion must meet rather distinctive objectives and, as a result, may be required to take on rather distinctive forms. The paper will explore these possibilities, drawing, in particular, on the motif of ‘recollection’ upon which both Heidegger and Wittgenstein draw, Heidegger's scattered remarks on 'formal indication', and The Sophist lectures’ discussion of Platonic dialectic. (shrink)

Launched in 1982, the so-calledBerliner Wissenschaftsladen e. V.(WILAB) belonged to the scattered West-German ventures in “counter-science”. This article situates the origins of the “Laden” (~ workshop)—an “alternative” spin-off of sorts, spawned from the Technical University of Berlin—in the context of contemporary advances in regional science policy. In this connection, the ailing, de-industrializing “island city” arguably even played a certain pioneering role: elements of its multipronged “innovation offensive”, which peaked in the early-to-mid 1980s, were visible beyond city limits, including the trade (...) showBIG TECHand, notably, theBerlin Center for Innovation and New Enterprises(BIG), the FRG’s first start-up “incubator”, which opened in 1983.In other words, politically-minded scientists in tendency now had to deal with conditions that were less and less conducive to dreams of a “socially engaged” and “non-alienated” (counter-)science. Indeed, while hardly opposed to the new gospel of innovation, it’s not surprising that ventures such as WILAB, committed as they were to the production of “socially useful” science, found themselves increasingly marginalized. It’s as such a marginal venture, my argument goes, that WILAB’s prima facie hopeless attempt to initiate a different, more “humane” information technology sheds an instructive light on the emergence of “entrepreneurial” science in the FRG during the 1970s and 1980s. (shrink)

Engels explained his admiration for Balzac by pointing to an apparent discrepancy between Balzac’s literature and his politics. Despite his sympathies for the French nobility, Balzac’s realism “compelled” him to portray this class in unflattering terms. In this article, I challenge Engels’s reading, arguing that Marx’s scattered remarks on Balzac take us in a different direction. Specifically, I argue that in his remark on Balzac’s The Peasants Marx pinpointed the author’s preoccupation with the spread of bourgeois ideology into the nobility. (...) Building on this remark, I analyze several of Balzac’s works showing that insofar as Balzac lambasted the nobles, his critique was primarily directed towards nobles who had adopted bourgeois ways. In this light, and against Engels’s observation, Balzac’s critique of the nobles appears to stem from his sympathy to aristocratic values rather than conflicting with them. In showing that affinities between Balzac, Marx and Engels did not depend on Balzac expressing anti-noble sentiment, I argue that the admiration the fathers of communism had for the monarchist’s prose exemplifies a partial, yet typical convergence between socialists and conservatives in their critique of modern bourgeois society. (shrink)

The electronic and muonic hydrogen energy levels are calculated very accurately [1] in Quantum Electrodynamics (QED) by coupling the Dirac Equation four vector (c ,mc2) current covariantly with the external electromagnetic (EM) field four vector in QED’s Interactive Representation (IR). The c -Non Exclusion Principle(c -NEP) states that, if one accepts c as the electron/muon velocity operator because of the very accurate hydrogen energy levels calculated, the one must also accept the resulting electron/muon internal spatial and time coordinate operators (ISaTCO) (...) derived directly from c without any assumptions. This paper does not change any of the accurate QED calculations of hydrogen’s energy levels, given the simplistic model of the proton used in these calculations [1]. The Proton Radius Puzzle [2, 3] may indicate that new physics is necessary beyond the Standard Model (SM), and this paper describes the bizarre, and very different, situation when the electron and muon are located “inside” the spatially extended proton with their Centers of Charge (CoCs) orbiting the proton at the speed of light in S energy states. The electron/muon center of charge (CoC) is a structureless point that vibrates rapidly in its inseparable, non-random vacuum whose geometry and time structure are defined by the electron/muon ISaTCO discrete geometry. The electron/muon self mass becomes finite in a natural way due to the ISaTCOs cutting off high virtual photon energies in the photon propagator. The Dirac-Maxwell-Wilson (DMW) Equations are derived from the ISaTCO for the EM fields of an electron/muon, and the electron/muon “look” like point particles in far field scattering experiments in the same way the electric field from a sphere with evenly distributed charge “e” “looks” like a point with the same charge in the far field (Gauss Law). The electron’s/muon’s three fluctuating CoC internal spatial coordinate operators have eight possible eigenvalues [4, 5, 6] that fall on a spherical shell centered on the electron’s CoM with radius in the rest frame. The electron/muon internal time operator is discrete, describes the rapid virtual electron/positron pair production and annihilation. The ISaTCO together create a current that produce spin and magnetic moment operators, and the electron and muon no longer have “intrinsic” properties since the ISaTCO kinematics define spin and magnetic moment properties. (shrink)

The archive of Gustav Shpet contains scattered preparatory materials for his “Lectures on the Theory of Cognition” and his major philosophical work History as a Problem of Logic. Some of these handwritten rough notes are devoted to Kant, indeed some of them have already seen the light of day in the “Kant­ian Journal” (2022, № 3). The notes published below continue to acquaint the reader with Shpet’s creative laboratory. His method of work with the concepts and ideas is instructive (...) in that it enables us to raise questions about the meaning of “positive critique”, its difference from Kant’s own “critical method” and why contemporary historical-philosophical attempts to actualise Kant’s concept of critique have more to do with Shpet’s rather than Kant’s methodology. Of particular relevance today is the authors’ attempt to immerse the Kantian understanding of critique in the context of Shpet’s phenomenologically oriented hermeneutic methodology. (shrink)

Widespread preservation of fossilized biomolecules in many fossil animals has recently been reported in six studies, based on Raman microspectroscopy. Here, we show that the putative Raman signatures of organic compounds in these fossils are actually instrumental artefacts resulting from intense background luminescence. Raman spectroscopy is based on the detection of photons scattered inelastically by matter upon its interaction with a laser beam. For many natural materials, this interaction also generates a luminescence signal that is often orders of magnitude more (...) intense than the light produced by Raman scattering. Such luminescence, coupled with the transmission properties of the spectrometer, induced quasi‐periodic ripples in the measured spectra that have been incorrectly interpreted as Raman signatures of organic molecules. Although several analytical strategies have been developed to overcome this common issue, Raman microspectroscopy as used in the studies questioned here cannot be used to identify fossil biomolecules. (shrink)

The modern corpuscular theory of radiation was born in 1905 when Einstein advanced his light quantum hypothesis; and the steps by which Einstein's hypothesis, after years of profound scepticism, was finally and fully vindicated by Arthur Compton's 1922 scattering experiments constitutes one of the most stimulating chapters in the history of recent physics. To begin to appreciate the complexity of this chapter, however, it is only necessary to emphasize an elementary but very significant point, namely, that while Einstein (...) based his arguments for quanta largely on the behaviour of high-frequency black body radiation or ultra-violet light, Compton experimented with X-rays. A modern physicist accustomed to picturing ultra-violet light and X-radiation as simply two adjacent regions in the electromagnetic spectrum might regard this distinction as hair-splitting. But who in 1905 was sure that X-rays and γ-rays are far more closely related to ultra-violet light than to α-particles, for example? This only became evident after years of painstaking research, so that moving without elaboration from Einstein's hypothesis to Compton's experiments automatically eliminates from consideration an important segment of history—a segment in which a major role was played by William Henry Bragg. (shrink)

A methodological imperative, reproducibility, is proposed for experimental research. This is motivated by recent discussions of normative naturalism as well as the recent interest in the philosophical implications of experimental research. The role of this norm is examined in the context of the routine research procedures in a high-energy scattering experiment. The specific details of the experimental analysis of resonance production in the interaction π +P→ Pπ + π + π - π 0 at 18.5 Ge V/c are discussed (...) in light of the importance of reproducing experimental results. In this context, a more complex meaning of this norm emerges. It is suggested that this type of empirical evaluation of hypothetical imperatives should be at the core of the normative naturalist's program. (shrink)

Embryos and microscopes share a long, remarkable history and biologists have always been intrigued to watch how embryos develop under the microscope. Here we discuss the advances in microscopy which have greatly influenced our current understanding of embryogenesis. We highlight the evolution of microscopes and the optical technologies that have been instrumental in studying various developmental processes. These imaging modalities provide mechanistic insights into the dynamic cellular and molecular events which drive lineage commitment and morphogenetic changes in the developing embryo. (...) We begin the journey with a brief history of microscopy to study embryos. First, we review the principles and optics of light, fluorescence, confocal, and electron microscopy which have been key techniques for imaging cellular and molecular events during embryonic development. Next, we discuss recent key imaging modalities such as light‐sheet microscopy, which are suitable for whole embryo imaging. Further, we highlight imaging techniques like multiphoton and super resolution microscopy for beyond light diffraction limit, high resolution imaging. Lastly, we review some of the scattering‐based imaging methods and techniques used for imaging human embryos. (shrink)

When it is ethically justifiable to stop medical treatment? For many Muslim patients, families, and clinicians this ethical question remains a challenging one as Islamic ethico-legal guidance on such matters remains scattered and difficult to interpret. In light of this gap, we conducted a systematic literature review to aggregate rulings from Islamic jurists and juridical councils on whether, and when, it is permitted to withdraw and/or withhold life-sustaining care. A total of 16 fatwās were found, 8 of which were (...) single-author rulings, and 8 represented the collective view of a juridical council. The fatwās are similar in that nearly all judge that Islamic law, provided certain conditions are met, permits abstaining from life-sustaining treatment. Notably, the justifying conditions appear to rely on physician assessment of the clinical prognosis. The fatwās differ when it comes to what conditions justify withdrawing or withholding life- sustaining care. Our analyses suggest that while notions of futility greatly impact the bioethical discourse regarding with holding and/or withdrawal of treatment, the conceptualization of futility lacks nuance. Therefore, clinicians, Islamic jurists, and bioethicists need to come together in order to unify a conception of medical futility and relate it to the ethics of withholding and/or withdrawal of treatment. (shrink)

In the theory-dominated view of scientific experimentation, all relations of theory and experiment are taken on a par; namely, that experiments are performed solely to ascertain the conclusions of scientific theories. As a result, different aspects of experimentation and of the relation of theory to experiment remain undifferentiated. This in turn fosters a notion of theory-ladenness of experimentation that is too coarse-grained to accurately describe the relations of theory and experiment in scientific practice. By contrast, in this article, I suggest (...) that TLE should be understood as an umbrella concept that has different senses. To this end, I introduce a three-fold distinction among the theories of high-energy particle physics as background theories, model theories and phenomenological models. Drawing on this categorization, I contrast two types of experimentation, namely, “theory-driven” and “exploratory” experiments, and I distinguish between the “weak” and “strong” senses of TLE in the context of scattering experiments from the history of HEP. This distinction enables to identify the exploratory character of the deep-inelastic electron-proton scattering experiments—performed at the Stanford Linear Accelerator Center between the years 1967 and 1973—thereby shedding light on a crucial phase of the history of HEP, namely, the discovery of “scaling”, which was the decisive step towards the construction of quantum chromo-dynamics as a gauge theory of strong interactions. (shrink)

This paper tries to make sense of Kant's scattered remarks about conic sections to see what light they shed on his philosophy of mathematics. It proceeds by confronting his remarks with the source that seems to have informed his thinking about conic sections: the Conica of Apollonius. The paper raises questions about Kant's attitude towards mathematics and the way he understood the cognitive resources available to us to do mathematics.

One of Tocqueville’s best-known empirical claims in Democracy in America is that there is no national-level public administration in the United States. He asserts definitively and repeatedly that “administrative centralization does not exist” there. However, in scattered passages throughout the text, Tocqueville points to multiple federal agencies that contemporary historians and APD scholars characterize as instances of a growing national administrative system, such as the Post Office Department and the Bureau of Indian Affairs. I reevaluate Tocqueville’s treatment of bureaucracy in (...) America in light of this evidence. I contend that Tocqueville, perhaps in spite of himself, reveals even the most paradigmatic examples of active, democratic self-government in Democracy in America—townships and other voluntary associations—to be embedded in and causally supported by a network of interrelated, centralized public administrative institutions. Crucially, Tocqueville never resolves the tension between his acknowledgment of the causal power of these institutions and his claims that they do not exist. This new picture of the empirical and normative complexity of Tocqueville’s treatment of bureaucratic institutions offers a rich set of conceptual resources for contesting, among other claims, the political construction of nostalgia for a lost age of do-it-yourself White settler democracy in a time before bureaucracy in America. (shrink)

Intentional explanation, according to Elster, seeks to elucidate an action by showing that it was intentionally conducted, in order to bring about certain goals . Intentional actions furthermore, are rational actions: they imply that agents establish a connection between the goals they target and the means that are appropriate to reach them, by way of different beliefs about the means, the goals and the environment. But how should we understand intentional actions in the light of philosophical research on emotions, (...) rationality, and normativity? This question is the departure point of this article. Various philosophers have analyzed the relationships between rationality and emotion, those between emotion and normativity, and those between emotion and intentional action. Nonetheless, their theses are scattered and do not offer an integrative view on how rationality, normativity and emotions work from the standpoint of intentional explanation. By using de Sousa’s distinction between the epistemic and the strategic modes of rationality as a theoretical framework, this article proposes therefore to remedy this deficit by unifying these philosophical insights with the goal of elaborating a theory of intentional explanation which brings together rationality, normativity and emotions. (shrink)

In the recent literature on the ontology and metaphysics of words, Jerrold J. Katz’ type-realist or ‘Platonist’ view is often mentioned but never spelt out in detail. This is perhaps understandable in light of the fact that his most developed statements on this matter are effectively offshoots of his main discourse in Realistic Rationalism (Katz, 1998a). His direct statements about the metaphysics of words are few and far between and are scattered across the text. This situation has often led (...) to misunderstandings or misconstruals about the exact nature of his view, some of which is buried in footnotes, and some of which must be reconstructed. Hence, criticisms of Katz’ approach have been wide of the mark or otherwise unproductive. In this article, I provide a remedy for this situation by drawing together and abstracting the relevant material regarding the metaphysics of words from its context and reconstructing the theory. I also develop the view further through resolving some potential problems and omissions, and by responding to recent criticism that the approach has received in the burgeoning literature on the philosophy of words. I hope that this will help to clarify the theory and lead to further debate and development on all sides of the discussion. (shrink)

Although ever-increasing numbers of women in the United States have been choosing small-business ownership in an apparent attempt to escape their well-documented inequality in the labor market, in this country, small businesses owned by women tend to be less successful than those owned by men. This article brings together the scattered pieces of data available in order to shed light on women's inability to gain greater parity with men in the small-business arena in the United States. Analysis suggests that (...) U.S. women's influx into small capitalism results from their movement into expanding, but highly competitive, industrial niches that are relatively unattractive to men. The authors find that these woman-owned businesses are concentrated within traditionally female-typed fields with lower average business receipts than male-typed fields. Moreover, even within the same industrial subcategories, women owners achieve less economic success than men owners. Although some of the immediate barriers faced by U.S. women in the small-business arena-such as lack of access to capital and government contracts-differ from those that confront women employees, the underlying causes are similar. The authors' discussion suggests that women in the United States carry their labor market disadvantage with them to the small-business sphere, where it is compounded by new manifestations of the same institutional barriers. (shrink)