Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

Classic studies of explanation, such as those of Hempel and Bromberger, took it for granted that an explanation-seeking question of the form "Why P?" should be understood as asking about the proposition P. This view has been recently challenged by Bas van Fraassen and Alan Garfinkel. They acknowledge that some questions have the surface form "Why P?", but they hold that a correct reading for why-questions should take the form "Why P (rather than Q)?", where Q is a contrasting alternative. (...) This contrast theory is discussed here. It is argued that, properly understood, the contrast theory and the propositional approach can and should give equivalent readings to why-questions. (shrink)

Top-down feedback does not benefit speech recognition; on the contrary, it can hinder it. No experimental data imply that feedback loops are required for speech recognition. Feedback is accordingly unnecessary and spoken word recognition is modular. To defend this thesis, we analyse lexical involvement in phonemic decision making. TRACE (McClelland & Elman 1986), a model with feedback from the lexicon to prelexical processes, is unable to account for all the available data on phonemic decision making. The modular Race model (Cutler (...) & Norris 1979) is likewise challenged by some recent results, however. We therefore present a new modular model of phonemic decision making, the Merge model. In Merge, information flows from prelexical processes to the lexicon without feedback. Because phonemic decisions are based on the merging of prelexical and lexical information, Merge correctly predicts lexical involvement in phonemic decisions in both words and nonwords. Computer simulations show how Merge is able to account for the data through a process of competition between lexical hypotheses. We discuss the issue of feedback in other areas of language processing and conclude that modular models are particularly well suited to the problems and constraints of speech recognition. Key Words: computational modeling; feedback; lexical processing; modularity; phonemic decisions; reading; speech recognition; word recognition. (shrink)

This book represents a considerable revision and expansion of Public Choice II. Six new chapters have been added, and several chapters from the previous edition have been extensively revised. The discussion of empirical work in public choice has been greatly expanded. As in the previous editions, all of the major topics of public choice are covered. These include: why the state exists, voting rules, federalism, the theory of clubs, two-party and multiparty electoral systems, rent seeking, bureaucracy, interest groups, dictatorship, the (...) size of government, voter participation, and political business cycles. Normative issues in public choice are also examined including a normative analysis of the simple majority rule, Bergson–Samuelson social welfare functions, the Arrow and Sen impossibility theorems, Rawls's social contract theory and the constitutional political economy of Buchanan and Tullock. (shrink)

ABSTRACTThis paper compares Margaret Archer’s morphogenetic critical realism and Michel Foucault’s implicit discursive realism. It argues that there is a surprisingly high degree of correspondence between the two social ontologies. Specifically, both ontologies suggest that there are three largely autonomous domains in operation: cultural, structural, and agentive. Yet, while each of these domains have a level of independence, yet they are also partially constituted by the content and form of the others. This paper discusses the potential to integrate the two (...) approaches in such a way as to overcome their respective short-comings, namely the underdevelopment of culture in Archer’s ontology, and the underdevelopment of social agency in Foucault’s ontology. (shrink)

The call for ‘sustainable degrowth’ has recently turned into a focal point of critical social and ecological debate, as well as a framework for diverse strands of activism. So far, little is known about the motives, attitudes and practices of grassroots activists within the degrowth spectrum. This article presents results of a survey conducted at the 2014 International Degrowth Conference, revealing both the presence of a widely shared basic consensus among respondents and their broad division into five distinguishable sub-currents. A (...) cluster analysis shows that degrowth provides a framework for a diversity of critical and transformational approaches. We identify and describe five such currents: eco-radical sufficiency-oriented critics of civilisation; moderate immanent reformers; a transitory group of voluntarist-pacifist idealists; the modernist rationalist Left; and the alternative practical Left. (shrink)

Suppose that you are engaging with someone who is your oppressor, or someone who espouses a heinous view like Nazism or a ridiculous view like flat-earthism. In contexts like these, there is a disparity between you and your interlocutor, a dramatic normative difference across which you are in the right and they are in the wrong. As theorists of humility, we find these contexts puzzling. Humility seems like the *last* thing oppressed people need and the *last* thing we need in (...) dealing with those whose views are heinous or ridiculous. Responding to such people via humility seems uncalled for, even inappropriate. But how could this be, given that humility is a *virtue*? The purpose of the paper is to explore this puzzle. We explain what the puzzle is and then attempt to draw some lessons from it: first, the lesson that the importance of humility is limited in several ways, and second, the lesson that humility nonetheless has several important roles to play, even for people who are in the right in contexts of disparity. (shrink)

Edmund Husserl, founder of the phenomenological movement, is usually read as an idealist in his metaphysics and an instrumentalist in his philosophy of science. In _Nature’s Suit_, Lee Hardy argues that both views represent a serious misreading of Husserl’s texts. Drawing upon the full range of Husserl’s major published works together with material from Husserl’s unpublished manuscripts, Hardy develops a consistent interpretation of Husserl’s conception of logic as a theory of science, his phenomenological account of truth and rationality, (...) his ontology of the physical thing and mathematical objectivity, his account of the process of idealization in the physical sciences, and his approach to the phenomenological clarification and critique of scientific knowledge. Offering a jargon-free explanation of the basic principles of Husserl’s phenomenology, _Nature’s Suit_ provides an excellent introduction to the philosophy of Edmund Husserl as well as a focused examination of his potential contributions to the philosophy of science. While the majority of research on Husserl’s philosophy of the sciences focuses on the critique of science in his late work, _The Crisis of European Sciences_, Lee Hardy covers the entire breadth of Husserl’s reflections on science in a systematic fashion, contextualizing Husserl’s phenomenological critique to demonstrate that it is entirely compatible with the theoretical dimensions of contemporary science. (shrink)

Summary A recurrent theme in the philosophical literature on the special theory of relativity is the question as to the reality of the Lorentz contraction. It is often suggested that there is a difference between the Lorentz-FitzGerald contraction in the pre-relativistic ether theory and the Lorentz contraction from special relativity in the sense that the former is a real contraction of matter conditioned by dynamical laws, whereas the latter should be compared with the apparent changes in the size of objects (...) when the perspective of the observer changes. It is here shown, however, that the same laws of nature which are operative in the Lorentz-FitzGerald contraction also condition the relativistic Lorentz contraction. The relevant distinction therefore is not between the reality of the two contractions. What is at issue is the difference in explanatory structure of the pre-relativistic theory on the one hand and the special theory of relativity on the other. In the course of the argument the question of the conventionality of simultaneity is also discussed. (shrink)

The significance of A. N. Whitehead’s contribution to 20th century metaphysics has become widely recognized. The focus on the novelty of his process ontology, however, has led to a view that isolates him from the mainstream of the tradition of Western philosophy. Hence, it is often overlooked that on the methodological level Whitehead is a pragmatist, whose much quoted indebtedness to William James is reflected in the project of his speculative metaphysics. A detailed analysis of the respective theories of truth (...) and knowledge in James and Whitehead illustrates their common methodological approach and allows us to assess the role of Whiteheadian thinking within the pragmatist tradition. James advances a form of epistemic conservatism that supplements the pragmatic idea of a concept’s cash-value with the demand for internal consistency. New beliefs have to fit in the totality of all previously accepted convictions in order to become accepted as true. James argues his case on three levels – a psychological, an epistemological and a pragmatic one – and develops a theory of truth that comprises an empirical and a rational dimension. Whitehead takes up this two-sided approach, but modifies the idea of genetic consistency into that of systematic coherence. The fundamental concepts of an ontological theory must not be isolated from each other to allow for a cosmology which is both rational and satisfies the pragmatic test of applicability. With the close relation of James and Whitehead in mind, the latter can be identified as the ‘missing link’ that bridges the gap between the so-called classical pragmatism and its more analytic versions as advanced by Quine, Lewis and Rescher. (shrink)

Paul Busch has emphasized on various occasions the importance for physics of going beyond a merely instrumentalist view of quantum mechanics. Even if we cannot be sure that any particular realist interpretation describes the world as it actually is, the investigation of possible realist interpretations helps us to develop new physical ideas and better intuitions about the nature of physical objects at the micro level. In this spirit, Paul Busch himself pioneered the concept of “unsharp quantum reality”, according to which (...) there is an objective non-classical indeterminacy—a lack of sharpness—in the properties of individual quantum systems. We concur with Busch’s motivation for investigating realist interpretations of quantum mechanics and with his willingness to move away from classical intuitions. In this article we try to take some further steps on this road. In particular, we pay attention to a number of prima facie implausible and counter-intuitive aspects of realist interpretations of unitary quantum mechanics. We shall argue that from a realist viewpoint, quantum contextuality naturally leads to “perspectivalism” with respect to properties of spatially extended quantum systems, and that this perspectivalism is important for making relativistic covariance possible. (shrink)

In the work of Nietzsche, sacrifice can only sacrifice itself over and over because what it seeks to overcome makes this sacrifice of itself both necessary and useless . The truth is eternally postponed in a necessary sacrificial gesture that can only sacrifice itself, thereby rendering itself useless . In the attempt to step beyond nihilism, that is, in the attempt to negate nihilism, one repeats the negation characteristic of nihilism. One becomes inextricably implicated in the move of nihilistic sacrifice. (...) The sacrifice of the sacrifice characteristic of nihilism , that is, the sacrifice of sacrifice, can only take place as the impossibility of its realization. One, therefore, produces or performs an interminable step/not beyond, an incessant step beyond that eternally returns. (shrink)

I start with a critical discussion of some attempts to ground epistemic normativity in curiosity. Then I develop three positive proposals. The first of these proposals is more or less purely philosophical; the second two reside at the interdisciplinary borderline between philosophy and psychology. The proposals are independent and rooted in different literatures. Readers uninterested in the first proposal (and the critical discussion preceding it) may nonetheless be interested in the second two proposals, and vice versa. -/- The proposals are (...) as follows. First I argue that, among several ways in which the notion of curiosity might be used to delineate significant truths from trivial ones, a particular way is the most promising. Second, I argue that curiosity has some underappreciated epistemic roles involving memory. Third, I argue that curiosity has some underappreciated epistemic roles involving coherence. (shrink)

In order to account fully for morality, Dennis Krebs departs from traditional approaches to morality that suggest that children acquire morals through ...

Recent studies have revealed a drop in the ability of physicians to empathize with their patients. It is argued that empathy training needs to be provided to both medical students and physicians in order to improve patient care. While it may be true that empathy would lead to better patient care, it is important that the right theory of empathy is being encouraged. This paper examines and critiques the prominent explanation of empathy being used in medicine. Focusing on the component (...) of empathy that allows us to understand others, it is argued that this understanding is accomplished through a simulation. However, simulation theory is not the best explanation of empathy for medicine, since it involves a limited perspective in which to understand the patient. In response to the limitations and objections to simulation theory, interaction theory is presented as a promising alternative. This theory explains the physicians understanding of patients from diverse backgrounds as an ability to learn and apply narratives. By explaining how we understand others, without limiting our ability to understand various others, interaction theory is more likely than simulation theory to provide better patient care, and therefore is a better theory of empathy for the medical field. (shrink)

The Common Cause Principle, stating that correlations are either consequences of a direct causal link between the correlated events or are due to a common cause, is assessed from the perspective of its viability and it is argued that at present we do not have strictly empirical evidence that could be interpreted as disconfirming the principle. In particular it is not known whether spacelike correlations predicted by quantum field theory can be explained by properly localized common causes, and EPR correlations (...) are known to be unexplainable only by common causes that are required to satisfy conditions that are empirically not tested. (shrink)

Colonius suggests that, in using standard set theory as the language in which to express our computational-level theory of human memory, we would need to violate the axiom of foundation in order to express meaningful memory bindings in which a context is identical to an item in the list. We circumvent Colonius's objection by allowing that a list item may serve as a label for a context without being identical to that context. This debate serves to highlight the value of (...) specifying memory operations in set theoretic notation, as it would have been difficult if not impossible to formulate such an objection at the algorithmic level. (shrink)

Star Trek becomes an ideal vehicle for modern narratives exploring the nature of being human in a technological age. In its fifty years of robots, androids, cyborgs, and alien others on the small and big screens, Star Trek has played a function not unlike that of Greek myth. Whether dealing with Greek gods such as Apollo, salt‐craving beasts and Hortas, or hive minds and androids, Star Trek fashions moderns’ myths that provoke reflection on what it means to be human and (...) transformations that either preserve or destroy one's humanity. It is seen that the feminist model in the long processes of development of the android Data, liberated Borg drone Seven of Nine, and Voyager's holographic Doctor, and their struggle to understand, if not finally attain, humanity. As children who were insufficiently socialized into their own families, these three characters face the difficult task of reconstituting families aboard Enterprise or Voyager. (shrink)

This is written as a dialogue with the central question, “What constitutes the essence of a ‘good’ businessperson?” Written in the form of a Platonic dialogue, this is an imaginary exchange between Socrates and Agoricus, the fictitious son of a well-respected businessperson of Athens at a time of unethical business practice. Various qualities are entertained in terms of defining a successful and good businessperson, including producing quality products at low prices, effectivesales techniques, creativity and innovation, respectful treatment of the customer, (...) business “know-how” (e.g. accounting), contributing to the community welfare, as well as being honest and trustworthy. Eventually the discussion winds its way to a kind of care and concern for customer welfare and satisfaction, leaving the initial question partially answered, while raising another question related to the proper way of teaching business. Connections to classical and contemporary business readings are made throughout the dialogue by the use of footnotes. The dialogue could be used with various graduate and undergraduate audiences, and it can be used in various ways, including class discussion regarding whether business should be conceived as a profession and whether ethical conduct lies at the heart of business. This only adopts the format of a Platonic dialogue for purposes of exploring the question. However, the dialogue does not claim to representthe ideas or position that Socrates or Plato might take on the question at hand. (shrink)

Mentoring is a natural setting for senior employees to render ethics advice and consultation to junior employees. Two studies examined the question of whether those who mentor are more practically wise than those who do not. Although four different measures of practical wisdom were used, no differences were detected. However, mentors were shown to be more politically skilled than non-mentors.

Courses in the philosophy of law provide philosophy departments an opportunity to focus on timely and relevant questions affecting the lives of undergraduates as well as attract students interested in the legal profession to the study of philosophy. This review article examines four recent texts in philosophy of law, three anthologies and a single-authored introductory text, and discusses their suitability to the classroom. After an overview identifying key features of each text, several comparative points are made relevant to teaching philosophy (...) of law. The diversity of issues, cases, and approaches to philosophy of law evinced by these textbooks suggests that the faculty member selecting texts should choose carefully. (shrink)

In this study I argue that Husserl’s phenomenology is compatible with a realistic interpretation of scientific theories. That said, I distinguish between the realistic interpretation of scientific theories and scientific realism. The former holds that the theoretical terms of a scientific theory are intended to refer, and that if we have good reason to believe that a scientific theory is true then we also have good reason to believe the entities it refers to exist. Scientific realism holds that the world (...) as described by the physical sciences not only exists, it is the only world that exists—the world of everyday perceptual experience must be demoted to the status of a mere appearance. My case for the compatibility of Husserl’s phenomenology with a realistic interpretation of scientific theories is based on a distinction between scientific laws and scientific theories. I hold that Husserl’s instrumentalism, if one can call it that, is restricted to an interpretation of scientific laws; accordingly, his anti-realism is directed against the reification of ideal objects constructed in the course of the exact mathematical representation of scientific laws, not against the theoretical entities postulated in the explanation of those laws. At the end of the study I seek to allay the fear that if one adopts a realistic interpretation of scientific theories one is thereby committed to some version of scientific realism. (shrink)

Exploring nursing expertise: nurses talk nursingIt has become increasingly important for practitioners to articulate their expertise in modern healthcare settings that demand high levels of accountability and evidence‐based practice. The material presented within this article has been interpreted drawing from discourse analysis1to help explore the discourses that shape and influence understandings of nursing practice. What we present are extracts from four of the 35 participant nurses who applied to take part in the Royal College of Nursing Institute's Expertise in Practice (...) (pilot) Project (EPP). The material presented is used to provide a starting point for exploring how nurses talk about and construct expertise in nursing practice. The four nurse participants’ clinical practice areas cover palliative care, mental health, intensive care and fertility care. The material reveals high levels of intensity in the nurse–patient relationship, ‘maverick’ nursing practices and ongoing reflexivity. All of these aspects appear to capitalize on expertise as a ‘catalyst’ that alters treatment pathways and maximizes patient‐centred outcomes. Exploring a discourse of nursing expertise exposes the tacit situated nature of professional practice that is heterogeneous and most difficult to articulate and explain. It is proposed that expertise tends to be understood from traditional and dominant discourses of medicine, management and technology. Explaining expertise in practice exposes non‐conventional practice that in itself can be isolating and challenging to the status quo of contemporary health‐care. (shrink)

The ultimatum game is a simple bargaining situation where the behavior of people frequently contradicts the optimal strategy according to classical game theory. Thus, according to many scholars, the commonly observed behavior should be considered irrational. We argue that this putative irrationality stems from a wrong conception of metanormativity (the study of norms about the establishment of norms). After discussing different metanormative conceptions, we defend a Quinean, naturalistic approach to the evaluation of norms. After reviewing empirical literature on the ultimatum (...) game, we argue that the common behavior in the ultimatum game is rational and justified. We therefore suggest that the norms of economic rationality should be amended. (shrink)

Points-based grading, though now traditional, faces powerful critiques: Such grading creates a low road to passing, it undermines motivation, it wastes time, and it causes stress. It creates an illusion of mathematical precision. It is unfriendly to necessary conditions for satisfactory performance. This paper defends the alternative of specifications grading. Specifications grading grades only on whether work meets a set of expectations for satisfactory performance, with the expectations set at a high but reachable level. With a high bar also comes (...) opportunities to revise unsatisfactory work. I summarize arguments from the literature in support of the system, but I also give account of my two-year experiment in philosophy courses with specifications grading. Compared with points-based grading, specifications grading appears to motivate students better and helps them learn more. I consider objections from both traditionalists and so-called ‘ungraders.’ The former hope to secure the benefits of specifications grading while still keeping points. The latter favor eliminating grading altogether. (shrink)

(2008). 2007 AESA Presidential Address Conflict of the Faculties: Democratic Progressivism in the Age of “No Child Left Behind”. Educational Studies: Vol. 43, No. 2, pp. 94-113.