A radical implication of Hume’s theory of motivation is that it makes no sense, strictly speaking, to call actions rational or irrational. So, he claims, it is not contrary to reason for me to prefer the destruction of the world to getting a scratch on my finger.

Graphical AbstractGene editing with engineered nucleases introduce double-strand breaks that are repaired by error-prone nonhomologous end-joining (NHEJ). In article number 1900126, Sara G. Trimidal et al. propose that the length and type or resulting indels can now be controlled by editing with different engineered nucleases or by manipulating the expression of NHEJ genes.

Genome editing with engineered nucleases (GEENs) introduce site‐specific DNA double‐strand breaks (DSBs) and repairs DSBs via nonhomologous end‐joining (NHEJ) pathways that eventually create indels (insertions/deletions) in a genome. Whether the features of indels resulting from gene editing could be customized is asked. A review of the literature reveals how gene editing technologies via NHEJ pathways impact gene editing. The survey consolidates a body of literature that suggests that the type (insertion, deletion, and complex) and the approximate length of indel edits (...) can be somewhat customized with different GEENs and by manipulating the expression of key NHEJ genes. Structural data suggest that binding of GEENs to DNA may interfere with binding of key components of DNA repair complexes, favoring either classical‐ or alternative‐NHEJ. The hypotheses have some limitations, but if validated, will enable scientists to better control indel makeup, holding promise for basic science and clinical applications of gene editing. Also see the video abstract here https://youtu.be/vTkJtUsLi3w. (shrink)

The inhuman in the humanities : Darwin and the ends of man -- Deleuze, Bergson, and the concept of life -- Bergson, Deleuze, and difference -- Feminism, materialism, and freedom -- The future of feminist theory : dreams for new knowledges -- Differences disturbing identity : Deleuze and feminism -- Irigaray and the ontology of sexual difference -- Darwin and the split between natural and sexual selection -- Sexual difference as sexual selection : Irigarayan reflections on Darwin -- Art and (...) the animal -- Living art and the art of life : women's painting from the western desert. (shrink)

One of the alleged advantages of a constructivist theory in metaethics is that the theory avoids the epistemological problems with moral realism while reaping many of realism's benefits. According to evolutionary debunking arguments, the epistemological problem with moral realism is that the evolutionary history of our moral beliefs makes it hard to see how our moral beliefs count as knowledge of moral facts, realistically construed. Certain forms of constructivism are supposed to be immune to this argument, giving the view a (...) key advantage. This paper considers the challenge that evolutionary debunking arguments pose for the possibility of moral knowledge and concludes that such arguments do not reveal any advantages for constructivism. Furthermore, once we consider how defenders of moral knowledge should best respond to this epistemological objection, constructivists may face more difficulties, not less, explaining how our moral beliefs represent moral knowledge. (shrink)

THE TITLE OF THIS ESSAY, "READING MORE THAN LOLITA IN TEHRAN," IS meant to invoke Azar Nafisi's Reading Lolita in Tehran, a memoir documenting how Western literary classics have the ability to change and improve the lives of people living under theocratic rule. In 1995, after resigning from her job as a professor at a university in Tehran, Nafisi invited seven of her best women students to attend a weekly study of Vladimir Nabokov, F. Scott Fitzgerald, Jane Austen, and other (...) authors she believed would provide the women with examples of how to successfully assert their autonomy despite great odds. (shrink)

What counts as an individual in the living world? What does it mean for a living thing to remain the same through time, while constantly changing? Immunology answers these questions with its theory of "self" and "nonself" which has dominated the field since the 1940s. Thomas Pradeu argues that this theory is inadequate, because immune responses to self constituents and immune tolerance of foreign entities are the rule, not the exception.

This article examines three divergent constructions about the salience of legal gender in lay people’s everyday lives and readiness to decertify gender. In our interviews (and survey data), generally participants minimised the importance of legal gender. The central argument in this article is that feminist socio-legal scholars applying legal consciousness studies to legal reform topics should find scrutinizing the construction of interview talk useful. We illustrate this argument by adapting and applying Ewick and Silbey’s (1998) ‘The Common Place of Law: (...) Stories from Everyday Life', ‘before’, ‘with’ and ‘against’ typology to interview talk about legal gender, and critique their cognitivist approach by offering a constructionist alternative. In our analysis, we offer a detailed discursive explication of three key legal consciousness themes. These themes offer a balanced representation of a dataset problematically ‘skewed’ towards sex-based rights feminist perspectives, namely that ‘before’ legal gender is an anti-decertification account, decertification would be risky for natal females; a ‘with’ legal gender construction is neither for nor against decertification per se, though the impact of decertification is produced in accounts as limited and unimportant; and ‘against’ legal gender is a pro-decertification classification, as not abolished legal gender is constructed as harmful to already marginalised groups. In concluding, we explore the reasoning for the lack of readiness for decertification currently, and return to the value of examining the construction of lay discourse about legal matters as talk is a form of social action. We suggest that applying discursive analysis to themes in legal consciousness studies enables a refocusing on the how rather than purely the what of divergent legal consciousnesses, and that this approach is a fruitful addition to feminist socio-legal studies. (shrink)

Normals display selective deficits in morphology and syntax under adverse processing conditions. Digit loads do not impair processing of passives and object relatives but do impair processing of grammatical morphemes. Perceptual degradation and temporal compression selectively impair several aspects of grammar, including passives and object relatives. Hence we replicate Caplan & Waters's specific findings but reach opposite conclusions, based on wider evidence.

Gangestad & Simpson present an evolutionary functional analysis of mating strategies. This commentary interprets their argument using a central concept from life history theory, return from investment. Incorporating return from investment allows further specification of costs and benefits from short-term mating in women as well as men and in ecological settings of high environmental variation in mortality and resource availability.

Intergenerational justice and democratic theory -- A narrative turn -- Archê, finitude, and community in Aristophanes -- Mothers, powerlessness, and intergenerational agency in Euripides -- Freedom, responsibility, and transgenerational orientation in Aeschylus -- Art, space, and possibilities for intergenerational justice in our time.

Patient and family emotional harm after medical errors may be profound. At an Agency for Healthcare Research and Quality conference to establish a research agenda on this topic, the authors used visual images as a gateway to personal reflections among diverse stakeholders. Themes identified included chaos and turmoil, profound isolation, organizational denial, moral injury and betrayal, negative effects on families and communities, importance of relational skills, and healing effects of human connection. The exercise invited storytelling, enabled psychological safety, and fostered (...) further collaborative discussion. The authors discuss implications for quality/safety, educational innovation, and qualitative research. (shrink)

This paper examines trust as a fundamental aspect of fiduciary relationships in education. The specific relationship under examination is that of academic employee and university employer. Both have the value of trust assigned to them as an implicit part of their social and professional contract. The setting is Australia, but the principles apply to any democratic jurisdiction and educational level or location, where fiduciary principles are a pre-condition for healthy and trustworthy working relationships. The paper firstly discusses the meaning and (...) application of ‘trust’ and ‘fiduciary’, and considers the codes that regulate fiduciary relationships in education. It then asks what happens if and when the fiduciary duties and obligations are not upheld, advancing that question through an employment law case against an Australian university, for alleged breach of the Fair Work Act. The analysis shows what may be the outcome when fiduciary trust between employee and employer is breached, how it may happen, and the consequences of this. The aim of the paper is to throw light on the value of trust for robust working relationships in academic life. Ultimately, the paper shows that trust is axiomatic to a working system of justice in a healthy educational workplace. (shrink)

Of other ancient writers, call into question the traditional view that katharsis in the Poetics is a homeopathic process - one in which pity and fear affect emotions like themselves. She maintains, instead, that Aristotle considered katharsis to be an allopathic process in which pity and fear purge the soul of shameless, antisocial, and aggressive emotions. While exploring katharsis, Tragic Pleasures analyzes the closely related question of how the Poetics treats the.

De Bie et al. posit thatthe best way to describe the person who would receive current AWT is as a “fetal neonate” or fetonate. Neonatal pertains to the fact that the subject is removed from the wom...

Walker Percy was both a medical doctor and a serious Catholic—a scientist and a religious believer. He thought, however, that science had become hegemonic in the twentieth century and that it was incapable of answering the most fundamental needs of human beings. He thus leveled a critique of the scientific method and its shortcomings in failing to address the individual person over against the group. In response to these shortcomings Percy postulates a religious understanding of human life, one in which (...) man's life is understood as a pilgrimage or a search. The person who searches may not find the “object” of his search during his earthly life, but it is likely that he will come to a better understanding of himself by means of it. (shrink)

This paper argues for answers to two questions, and then identifies a tension between the two answers. First, regarding the implications of moral ignorance for moral responsibility: “Do false moral views exculpate?” Does believing that one is acting morally permissibly render one blameless? It does not. Second, in moral epistemology: “Can moral testimony provide moral knowledge?” It can (even granting some worries about moral deference). The tension: If moral testimony can provide moral knowledge, then surely it can provide justified false (...) moral belief. But surely there is no blameworthiness in a case in which a person acts on a justified false moral belief. So surely some false moral views do exculpate. This tension can be resolved by adoption of the view that moral testimony cannot provide justified false moral belief; this view relies on the fact that whether a belief is justified is sensitive to an agent’s total evidence. (shrink)

In this paper I evaluate the theoretical and normative validity of Arendt's idea of a public sphere. My discussion is organised under three related headings. First, an exploration of the theme of ‘plurality’ in Arendt's work. This is connected, second, with a distinctive account of the role of ‘representation’ in political life. Third, the relation between ethics and politics, and the particular normativity of Arendt's concept of politics. Finally, I go on to a consideration of how Arendt's scheme of plurality (...) and public political life draw our attention to the themes of political capacity and resistance, risk and public encounter, and an account of the frictional, indeed rebarbative, nature of politics. The aim of the paper is to make clear that these themes remain significant for current debates about participatory deficits and about standards of public conduct. (shrink)

Examination of the subversive nature of philosophy as its students challenge the authority and practices of government agencies and organizations. Draws a series of connections between philosophically oriented protesters and questioners of authority ranging from Socrates to 2004 protesters at the U.S. Republican party’s presidential convention in 2004.

This article describes the relations between academic psychology and psychical research in Britain during the inter-war period, in the context of the fluid boundaries between mainstream psychology and both psychical research and popular psychology. Specifically, the involvement with Harry Price of six senior academic psychologists: William McDougall, William Brown, J. C. Flugel, Cyril Burt, C. Alec Mace and Francis Aveling, is described. Personal, metaphysical and socio-historical factors in their collaboration are discussed. It is suggested that the main reason for their (...) mutual attraction was their common engagement in a delicate balancing act between courting popular appeal on the one hand and the assertion of scientific expertise and authority on the other. Their interaction is typical of the boundary work performed at this transitional stage in the development of psychology as a discipline. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:The Cambridge History of Philosophy in Late AntiquityJohn RistLloyd P. Gerson, editor. The Cambridge History of Philosophy in Late Antiquity. 2 vols. Cambridge-New York: Cambridge University Press, 2010. Pp. 1313. Cloth, $240.00.1313 pages, including 915 pages of text and 200 of bibliography; 51 authors—in about 800 words! The editor of the present Cambridge History makes plain that his new two-volume monument is the successor to Armstrong’s Cambridge History (...) of Late Greek and Early Medieval Philosophy—8 contributors—and is intended to build on its strengths and correct its deficiencies in the light of some 40 years of highly successful investigation of the thought of late antiquity. The result is a professional structure in which the “giants” (Plotinus and Augustine) are awarded comparatively modest coverage, while figures often neglected, such as Damascius, of whom our understanding has greatly increased of late, are given much more space. Damascius secures 30 pages: the only individual to get more is Porphyry (33), while Augustine has 29 and Plotinus 24 (four more than Hierocles). There are those (as Tacitus might have put it) who will fear that the wood has been lost for the trees, and at least it must be said that one overall impression of these volumes is that some of their authors are recounting what will be of interest to a worldwide group of aficionados whose number can be counted on the fingers of a mutilated hand—and the importance of which lies less in philosophical achievement than in the handing on of a great tradition.Gilbert Ryle is supposed to have asserted that in France everyone can talk about philosophy but that there are no philosophers; some of Gerson’s more philosophically minded readers may find their prejudices confirmed that in late antiquity there were many who talked about Plato and Aristotle but few who understood what they were trying to do. For it is clear that a general theme of the present volumes is that in late antiquity philosophers were largely concerned to “interpret” Plato and (especially after Porphyry) Aristotle while occasionally seizing the opportunity not merely to rubbish their similarly-engaged predecessors but to add (if shamefacedly) something of their own. Except, that is, for the Christians, whose enterprise was very different and who, quite properly, are more visible in Gerson’s account of late antique thought than in that of Armstrong (though there remain strange omissions in a work on this scale: Methodius, Ambrose, Evagrius).Gerson has tried to contextualize his story by including short (and helpful) historical introductions by Elizabeth DePalma Digeser to the various epochs with which his volumes are concerned, and which can perhaps be divided into four sections: pre-Plotinian Platonism [End Page 136] (plus extras) from Cicero to Numenius; later pagan Platonism, including extensive treatment of the Neoplatonic commentators on Aristotle; Christian thought before Constantine; and later Christian philosophy-cum-theology. Rounding off the volume are introductions to the transition from “ancient” to “medieval” thought in the Latin West (Gersh), in Byzantium—a remarkably honest presentation of a largely stagnant philosophical world by Ierodiakonou and Zografidis—and (in a magisterial improvement on what is to be found in Armstrong) in Islam (Cristina d’Ancona) where (inter multa alia) the roots of the virtually inevitable later destruction of a flourishing philosophical tradition founded by al-Kindi and al-Farabi are identified in the more “orthodox” and theocratic approach—here there are Byzantine parallels—of the followers of al-Ash’ari (885).Gerson’s readers can inspect philosophical wisdom and conceptual muddle among late antique intellectuals—Christians, a few Muslims, pagans—down to Scotus Eriugena and al-Farabi. But some of them may suspect that an opportunity has been lost to reflect on the origins and nature of early Christian thought, and to ask why Christians soon jumped for Platonism rather than Stoicism (Aristotle, let alone Epicurus, was not—yet—considered a serious option)—and that is not intended as criticism of the excellent, if brief, treatment of important Christian thinkers such as Origen. But it was an adventure for Christians to begin to philosophize, and when they embarked on this adventure—here the significance... (shrink)

Moral disengagement is a process whereby the self-regulatory mechanisms that would otherwise sanction unethical conduct can be selectively disabled. The present research proposed that moral disengagement might be adopted in the endorsement of asylum seeker policies in Australia, and in order to test this, a scale was developed and was validated in two studies. Factor analysis demonstrated that a 2-factor, 16-item structure had the best fit, and the construct validity of the scale was supported. Results provide evidence for the use (...) of moral disengagement in the context of asylum seekers as a means of rationalizing conduct that may otherwise be sanctioned. (shrink)

This book looks at business ethics from the perspective of the business practitioner, but with the rigour of the moral philosopher. Intended for introductory students of business, commerce and management studies, Business Ethics at Work begins by setting business clearly in the context of creating value for its owners, and develops a practical ethical decision model which can be simply and relevantly applied to the hard moral choices with which business people are faced day to day. Against this background, some (...) of the major ethical issues which arise in business are explored, for example, in human resource management, finance, marketing and advertising, the management of the environment and corporate governance. In conclusion the book looks at the nature of ethical audit and argues that for the business of the future, the identification of its ethical values and their integration into its policies and practices will be a crucial ingredient of success. (shrink)

The concept of vulnerability is widely used in bioethics, particularly in research ethics and public health ethics. The traditional approach construes vulnerability as inherent in individuals or the groups to which they belong and views vulnerability as requiring special protections. Florencia Luna and other bioethicists continue to challenge traditional ways of conceptualizing and applying the term. Luna began proposing a layered approach to this concept and recently extended this proposal to offer two new concepts to analyze the concept of vulnerability, (...) namely understanding external conditions that trigger vulnerability and layers of vulnerability with cascading effects. Luna's conception of vulnerability is useful, which we demonstrate by applying her layered view and the new analyses in multiple contexts. We begin by outlining Luna's view and we use vignettes from healthcare involving transgender patients, the care of patients in psychiatric contexts, and research involving prisoners to illustrate how each part of Luna's concept elucidates important moral issues. (shrink)

What happens when adjudication signals its own artifice? Or when jurisprudence is animated by what Maksymilian Del Mar calls ‘legal artifacts’ that invite us to suspend certain of our prevailing no...

Sea of Troubles shows teachers how literature and informational texts can work together to enhance each other and, by extension, enhance students’ abilities to critically think and respond to the sea of troubles that pervades society.

This article will examine the phase of Nishida’s thought in which he turns to the historical world and present the benefits of this turn to his overall philosophical project. In “The Philosophy of History in the ‘Later’ Nishida,” Woo-Sung Huh claims that Nishida Kitaro’s attempt to integrate history into his earlier writings on self-consciousness is a “wrong turn.” I will demonstrate how Huh’s criticism of Nishida’s writings on history stems from Huh’s own ontological assumption that consciousness and the historical world (...) occupy distinct realms. Leveling this criticism against Nishida causes the reader to miss Nishida’s greatest insight, namely that there is no such distinction; there is only one reality of consciousness and materiality. Nishida’s emphasis on the historical world makes his earlier claim that consciousness is inseparable from things more robust. I will argue that by expanding his earlier focus on consciousness to include the formative power of created physical objects and human bodies on consciousness, Nishida’s philosophy is actually strengthened. (shrink)

Dream interpretation is a common practice in psychotherapy. In the research presented in this article, each participant saw a clinician who interpreted a recent dream report to be a sign that the participant had had a mildly traumatic experience before age 3 years, such as being lost for an extended time or feeling abandoned by his or her parents. This dream intervention caused a majority of participants to become more confident that they had had such an experience, even though they (...) had previously denied it. These findings have implications for the use of dream material in clinical settings. In particular, the findings point to the possibility that dream interpretation may have unexpected side effects if it leads to beliefs about the past that may, in fact, be false. (shrink)

O objetivo do presente trabalho é analisar, por meio da metáfora do jogo de quebra-cabeças, o caráter da ciência no pensamento de Kuhn. Pretendemos mostrar que, além dos aspectos históricos e psicossociais que se destacam como a grande novidade de sua abordagem, há uma outra que emerge da prática da ciência normal, cujo enfoque, destoa da tradição. Trata-se da ênfase que ele dá a própria atividade de investigação da ciência, mais precisamente ao caráter dos problemas a serem pesquisados e a (...) forma de solucioná-los. (shrink)