“Exercise starts and ends in the brain”: this was the title of a review article authored by Dr. Bengt Kayser back in 2003. In this piece of work, the author highlights that pioneer studies have primarily focused on the cardiorespiratory-muscle axis to set the human limits to whole-body exercise tolerance. In some circumstances, however, exercise cessation may not be solely attributable to these players: the central nervous system is thought to hold a relevant role as the ultimate site of exercise (...) termination. In fact, there has been a growing interest relative to the “brain” response to exercise in chronic cardiorespiratory diseases, and its potential implication in limiting the tolerance to physical exertion in patients. To reach these overarching goals, non-invasive techniques, such as near-infrared spectroscopy and transcranial magnetic stimulation, have been successfully applied to get insights into the underlying mechanisms of exercise limitation in clinical populations. This review provides an up-to-date outline of the rationale for the “brain” as the organ limiting the tolerance to physical exertion in patients with cardiorespiratory diseases. We first outline some key methodological aspects of neuromuscular function and cerebral hemodynamics assessment in response to different exercise paradigms. We then review the most prominent studies, which explored the influence of major cardiorespiratory diseases on these outcomes. After a balanced summary of existing evidence, we finalize by detailing the rationale for investigating the “brain” contribution to exercise limitation in hitherto unexplored cardiorespiratory diseases, an endeavor that might lead to innovative lines of applied physiological research. (shrink)

The starting point of this conversation with philosopher Mathieu Triclot is the issue of the causal contribution of video game playing in school shootings. Triclot explains the limitations of current psychological approaches regarding video game violence. He further develops on the peculiar features of the video game medium and how they relate to the problem of violence. Triclot eventually shows that, although players may relate to virtual violence in very different ways, violence in video games is not merely a (...) subjective phenomenon. He highlights that some “regimes of experience,” which got stable in the video game culture, cultivate a toxic relation to violence. (shrink)

This pioneering book demonstrates the crucial importance of Wittgenstein's philosophy of mathematics to his philosophy as a whole. Marion traces the development of Wittgenstein's thinking in the context of the mathematical and philosophical work of the times, to make coherent sense of ideas that have too often been misunderstood because they have been presented in a disjointed and incomplete way. In particular, he illuminates the work of the neglected 'transitional period' between the Tractatus and the Investigations.

Bringing Pierre Bourdieu to Science and Technology Studies Content Type Journal Article Pages 263-273 DOI 10.1007/s11024-011-9174-2 Authors Mathieu Albert, Wilson Centre and Department of Psychiatry, Faculty of Medicine, University of Toronto, 200 Elizabeth Street , Eaton-South 1-581, Toronto, ON M5G 2C4, Canada Daniel Lee Kleinman, Department of Community and Environmental Sociology, University of Wisconsin-Madison, 348 Agricultural Hall 1450 Linden Drive, Madison, WI 53706, USA Journal Minerva Online ISSN 1573-1871 Print ISSN 0026-4695 Journal Volume Volume 49 Journal Issue Volume 49, (...) Number 3. (shrink)

High-fidelity cultural transmission, rather than brute intelligence, is the secret of our species’ success, or so many cultural evolutionists claim. It has been selected because it ensures the spread, stability and longevity of beneficial cultural traditions, and it supports cumulative cultural change. To play these roles, however, fidelity must be a causally-efficient property of cultural transmission. This is where the grain problem comes in and challenges the explanatory potency of fidelity. Assessing the degree of fidelity of any episode or mechanism (...) of cultural transmission always depends upon an investigator’s choice of grain of description at which cultural traditions are being studied. The fidelity of cultural transmission then appears to be relative to the granularity at which one approaches cultural variation, and since there is a multiplicity of grains of description by which the same tradition can be studied, there results a multiplicity of measures of fidelity for a same event or mechanism of cultural transmission. If this is correct, because fidelity is always relative to the grain of description dictated by the local and specific research interests of the investigator, then there seems to be no fact of the matter as to whether cultural transmission is faithful or not, independently from a researcher’s framework of analysis. The aims of this paper are to offer a conceptual clarification of the grain problem in cultural evolution, to assess its causes, to unpack its epistemological implications, and to examine its reach and consequences for a science of cultural evolution. (shrink)

For a population to undergo evolution by natural selection, it is assumed that the constituents of the population form parent-offspring lineages, that is, that they must reproduce. I challenge this assumption by dividing the notion of reproduction into two subprocesses, that is, multiplication and inheritance, that produce parent-offspring lineages between the parts of a population, and I show that their population-level roles, generation and memory, respectively, can be effected by processes that do not rely on such local-level lineages. I further (...) argue that these two population-level processes, not local parent-offspring lineages, are necessary conditions for a population to undergo Darwinian evolution. (shrink)

A Polish space is not always homeomorphic to a computably presented Polish space. In this article, we examine degrees of non-computability of presenting homeomorphic copies of compact Polish spaces. We show that there exists a $\mathbf {0}'$ -computable low $_3$ compact Polish space which is not homeomorphic to a computable one, and that, for any natural number $n\geq 2$, there exists a Polish space $X_n$ such that exactly the high $_{n}$ -degrees are required to present the homeomorphism type of $X_n$. (...) Along the way we investigate the computable aspects of Čech homology groups. We also show that no compact Polish space has a least presentation with respect to Turing reducibility. (shrink)

The development of symbolic logic is often presented in terms of a cumulative story of consecutive innovations that led to what is known as modern logic. This narrative hides the difficulties that this new logic faced at first, which shaped its history. Indeed, negative reactions to the emergence of the new logic in the second half of the nineteenth century were numerous and we study here one case, namely logic at Oxford, where one finds Lewis Carroll, a mathematical teacher who (...) promoted symbolic logic, and John Cook Wilson, the Wykeham Professor of Logic who notoriously opposed it. An analysis of their disputes on the topic of logical symbolism shows that their opposition was not as sharp as it might look at first, as Cook Wilson was not so much opposed to the « symbolic » character of logic, but the intrusion of mathematics and what he perceived to be the futility of some of its problems, for logicians and philosophers alike. (shrink)

Prior work on weakness of will has assumed that it is a thoroughly psychological phenomenon. At least, it has assumed that ordinary attributions of weakness of will are purely psychological attributions, keyed to the violation of practical commitments by the weak-willed agent. Debate has recently focused on which sort of practical commitment, intention or normative judgment, is more central to the ordinary concept of weakness of will. We report five experiments that significantly advance our understanding of weakness of will attributions (...) by showing that the ordinary concept of weakness of will is less thoroughly psychological than the philosophical debate has assumed. We begin by showing that a sizable minority of people attribute weakness of will even in the absence of a violated commitment (Experiment 1). We then show that weakness of will attributions are sensitive to two important non-psychological factors. First, for actions stereotypically associated with weakness of will, the absence of certain commitments often triggers weakness of will attributions (Experiments 2–4). Second, the quality of an action’s outcome affects the extent to which an agent is viewed as weak-willed: actions with bad consequences are more likely to be viewed as weak-willed (Experiment 5). Our most important finding is that the ordinary concept of weakness of will is sensitive to two non-psychological factors and is thus much broader than philosophers have thus far imagined. We conclude by suggesting a two-tier model that unites our findings with traditional philosophical theorizing about weakness of will. (shrink)

In fungi, cell fusion between genetically unlike individuals triggers a cell death reaction known as the incompatibility reaction. In Podospora anserina, the genes controlling this process belong to a gene family encoding STAND proteins with an N‐terminal cell death effector domain, a central NACHT domain and a C‐terminal WD‐repeat domain. These incompatibility genes are extremely polymorphic, subject to positive Darwinian selection and display a remarkable genetic plasticity allowing for constant diversification of the WD‐repeat domain responsible for recognition of non‐self. Remarkably, (...) the architecture of these proteins is related to pathogen‐recognition receptors ensuring innate immunity in plants and animals. Here, we hypothesize that these P. anserina incompatibility genes could be components of a yet‐unidentified innate immune system of fungi. As already proposed in the case of plant hybrid necrosis or graft rejection in mammals, incompatibility could be a by‐product of pathogen‐driven divergence in host defense genes. (shrink)

Plagiarism is a crime against academy. It deceives readers, hurts plagiarized authors, and gets the plagiarist undeserved benefits. However, even though these arguments do show that copying other people’s intellectual contribution is wrong, they do not apply to the copying of words. Copying a few sentences that contain no original idea (e.g. in the introduction) is of marginal importance compared to stealing the ideas of others. The two must be clearly distinguished, and the ‘plagiarism’ label should not be used for (...) deeds which are very different in nature and importance. (shrink)

According to Clifford Geertz, the purpose of anthropology is not to explain culture but to explicate it. That should cause us to rethink our relationship with machine learning. It is, we contend, perfectly possible that machine learning algorithms, which are unable to explain, and could even be unexplainable themselves, can still be of critical use in a process of explication. Thus, we report on an experiment with anthropological AI. From a dataset of 175K Facebook comments, we trained a neural network (...) to predict the emoji reaction associated with a comment and asked a group of human players to compete against the machine. We show that a) the machine can reach the same accuracy as the players, b) it fails in roughly the same ways as the players, and c) easily predictable emoji reactions tend to reflect unambiguous situations where interpretation is easy. We therefore repurpose the failures of the neural network to point us to deeper and more ambiguous situations where interpretation is hard and explication becomes both necessary and interesting. We use this experiment as a point of departure for discussing how experiences from anthropology, and in particular the tension between formalist ethnoscience and interpretive thick description, might contribute to debates about explainable AI. (shrink)

We present the inconsistency-adaptive deontic logic DP r , a nonmonotonic logic for dealing with conflicts between normative statements. On the one hand, this logic does not lead to explosion in view of normative conflicts such as O A ∧ O ∼A, O A ∧ P ∼A or even O A ∧ ∼O A. On the other hand, DP r still verifies all intuitively reliable inferences valid in Standard Deontic Logic (SDL). DP r interprets a given premise set ‘as normally (...) as possible’ with respect to SDL. Whereas some SDL-rules are verified unconditionally by DP r , others are verified conditionally. The latter are applicable unless they rely on formulas that turn out to behave inconsistently in view of the premises. This dynamic process is mirrored by the proof theory of DP r. (shrink)

Whistle-blowing is generally considered from the viewpoint of professional morality. Morality rejects the idea of choice and the interests of the professional as immoral. Yet the dreadful retaliations against the messengers of the truth make it necessary for morality to leave a way out of whistle-blowing. This is why it forges rights (sometimes called duties) to trump the duty to the public prescribed by professional codes. This serves to hide the obvious fact that whether to blow the whistle is indeed (...) a choice, not a matter of objective duty. One should also notice that if it fails to achieve anything then blowing the whistle was the wrong decision (or maybe the right decision that nobody would want to make). There is nevertheless a tendency to judge it based on the motivation of the whistle blower. In a way, whistle blowers should strive to act like saints. Yet, it is logically impossible to hold both whistle-blowing as mandatory and whistle-blowers as heroes or saints. Moreover, this tends to value the great deeds of a few over the lives of the many, which is incompatible with the basic assumptions of morality. But consistency is not a main feature of professional morality. (shrink)

Social transmission is at the core of cultural evolutionary theory. It occurs when a demonstrator uses mental representations to produce some public displays which in turn allow a learner to acquire similar mental representations. Although cultural evolutionists do not dispute this view of social transmission, they typically abstract away from the multistep nature of the process when they speak of cultural variants at large, thereby referring both to variation and evolutionary change in mental representations as well as in their corresponding (...) public displays. This conflation suggests that differentiating each step of the transmission process is redundant. In this paper, I examine different forms of interplay between the multistep nature of social transmission and the metric spaces used by cultural evolutionists to measure cultural variation and to model cultural change. I offer a conceptual analysis of what assumptions seem to be at work when cultural evolutionists conflate the complex causal sequence of social transmission as a single space of variation in which populations evolve. To this aim, I use the framework of variation spaces, a formal framework commonly used in evolutionary biology, and I develop two theoretical concepts, ‘technique’ and ‘technical space’, for addressing cases where the complexity of social transmission defies the handy assumption of a single variation space for cultural change. (shrink)

The use of physical models of molecular structures as research tools has been central to the development of biochemistry and molecular biology. Intriguingly, it has received little attention from scholars of science. In this paper, I argue that these physical models are not mere three-dimensional representations but that they are in fact very special research tools: they are cognitive augmentations. Despite the fact that they are external props, these models serve as cognitive tools that augment and extend the modeler’s cognitive (...) capacities and performance in molecular modeling tasks. This cognitive enhancement is obtained because of the way the modeler interacts with these models, the models’ materiality contributing to the solving of the molecule’s structure. Furthermore, I argue that these material models and their component parts were designed, built and used specifically to serve as cognitive facilitators and cognitive augmentations. (shrink)

In this paper, elementary but hitherto overlooked connections are established between Wittgenstein's remarks on mathematics, written during his transitional period, and free-variable finitism. After giving a brief description of theTractatus Logico-Philosophicus on quantifiers and generality, I present in the first section Wittgenstein's rejection of quantification theory and his account of general arithmetical propositions, to use modern jargon, as claims (as opposed to statements). As in Skolem's primitive recursive arithmetic and Goodstein's equational calculus, Wittgenstein represented generality by the use of free (...) variables. This has the effect that negation of unbounded universal and existential propositions cannot be expressed. This is claimed in the second section to be the basis for Wittgenstein's criticism of the universal validity of the law of excluded middle. In the last section, there is a brief discussion of Wittgenstein's remarks on real numbers. These show a preference, in line with finitism, for a recursive version of the continuum. (shrink)

In this paper, I examine the transmission of some ideas of the pragmatist tradition to Wittgenstein, in his ‘middle period,’ through the intermediary of F. P. Ramsey, with whom he had numerous fruitful discussions at Cambridge in 1929. I argue more specifically that one must first come to terms with Ramsey’s own views in 1929, and explain how they differ from views expressed in earlier papers from 1925-27, so a large part of this paper is devoted to this task. One (...) is then in a better position to understand the impact of Ramsey’s astute critique of Wittgenstein’s Tractatus Logico-Philosophicus in conjunction with his pragmatism, and explain how it may have set into motion the ‘later’ Wittgenstein. I then argue that Ramsey introduced his notion of ‘variable hypothetical’ as a rule, not a proposition, on pragmatist grounds and that Wittgenstein picked this up in 1929, along with a more ‘dynamic’ view of meaning than the ‘static’ view of the Tractatus, and that this explains in part Wittgenstein’s turn to his ‘later philosophy.’. (shrink)

The cumulative open-endedness of human cultures represents a major break with the social traditions of nonhuman species. As traditions are altered and the modifications retained along the cultural lineage, human populations are capable of producing complex traits that no individual could have figured out on its own. For cultures to produce increasingly complex traditions, improvements and modifications must be kept for the next generations to build upon. High-fidelity transmission would thus act as a ratchet, retaining modifications and allowing the historical (...) buildup of complex traditions. Mechanisms acting against slippage are important, of course, but cultures also need to move forward for the ratchet to retain anything important. In this article, I argue that studies of modification-generating processes and the many ways they shape cumulative culture have been overlooked. Key to a better understanding of cultural modification processes is taking seriously that cultural traditions consist of complex, hierarchically structured recipes. Taking such structures seriously and assessing the different ways they can vary in cultural design space, a novel picture for the onset of cumulative cultural evolution emerges. I argue that a possible impediment for cumulative culture in nonhuman animals may in fact reside not so much in the fidelity of their social transmission but rather in the constraints, internal and external, on their capacity to modify complex, hierarchically structured cultural recipes. (shrink)

We propose a logic of abduction that (i) provides an appropriate formalization of the explanatory conditional, and that (ii) captures the defeasible nature of abductive inference. For (i), we argue that explanatory conditionals are non-classical, and rely on Brian Chellas’s work on conditional logics for providing an alternative formalization of the explanatory conditional. For (ii), we make use of the adaptive logics framework for modeling defeasible reasoning. We show how our proposal allows for a more natural reading of explanatory relations, (...) and how it overcomes problems faced by other systems in the literature. (shrink)

John Cook Wilson (1849–1915) was Wykeham Professor of Logic at New College, Oxford and the founder of ‘Oxford Realism’, a philosophical movement that flourished at Oxford during the first decades of the 20th century. Although trained as a classicist and a mathematician, his most important contribution was to the theory of knowledge, where he argued that knowledge is factive and not definable in terms of belief, and he criticized ‘hybrid’ and ‘externalist’ accounts. He also argued for direct realism in perception, (...) criticizing both empiricism and idealism, and argued for a moderate nominalist view of universals as being in rebus and only ‘apprehended’ by their particulars. His influence helped swaying Oxford away from idealism and, through figures such as H. A. Prichard, Gilbert Ryle, or J. L. Austin, his ideas were also to some extent at the origin of ‘moral intuitionism’ and ‘ordinary language philosophy’ which defined much of Oxford philosophy until the second half of the twentieth-century. Nevertheless, his name and legacy were all but forgotten for generations after World War II. Still, his views on knowledge are with us today, being in part at work in the writings of philosophers as diverse as John McDowell, Charles Travis, and Timothy Williamson. (shrink)

Since cheating is obviously wrong, arguments against it need only be mentioned in passing. But the argument of unfair advantage absurdly takes education to be essentially a race of all against all; moreover, it ignores that many cases of unfair advantages are widely accepted. On the other hand, the fact that cheating can hamper learning does not mean that punishing cheating will necessarily favour learning, so that this argument does not obviously justify sanctioning cheaters.

This article traces the history of the Susceptible, Infected, Recovered (SIR) model in early 20th-century epidemiology (1904–27). The aim is to test the hypothesis that the active stance taken by Ross, Hudson, McKendrick, and Kermack represents a turn in the history of modern epidemiology, shifting the classical method of statistical epidemiology from a data-based model to a theory-based model. The article shows that epidemiological modeling is based on a mathematical simplification of epidemics at the time of the microbiological complexification of (...) epidemiology. What were the implications of the mathematical theory of epidemics for the development of modern epidemiology? How can epidemic dynamics be expressed mathematically without compromising the biological representation? This is exactly what is at stake here: from the work of Ross to the standardization of the SIR model by McKendrick and Kermack, modeling has been confronted with the problem of relating its equations to the facts. (shrink)

This article focuses on defective conditionals ? namely indicative conditionals whose antecedents are false and whose truth-values therefore cannot be determined. The problem is to decide which formal connective can adequately represent this usage. Classical logic renders defective conditionals true whereas traditional mathematics dismisses them as irrelevant. This difference in treatment entails that, at the propositional level, classical logic validates some sentences that are intuitively false in plane geometry. With two proofs, I show that the same flaw is shared by (...) a family of trivalent logics. I go on to examine the strict conditional and its derivatives. This family is the only one to avoid the faulty inference but it does so without addressing the status of the truth-value assigned to defective conditionals. (shrink)